JPWO2021138195A5 - - Google Patents

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JPWO2021138195A5
JPWO2021138195A5 JP2022540464A JP2022540464A JPWO2021138195A5 JP WO2021138195 A5 JPWO2021138195 A5 JP WO2021138195A5 JP 2022540464 A JP2022540464 A JP 2022540464A JP 2022540464 A JP2022540464 A JP 2022540464A JP WO2021138195 A5 JPWO2021138195 A5 JP WO2021138195A5
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sensor
time
processor
sample
breath
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JP2022540464A
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JP2023509643A (en
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Priority claimed from PCT/US2020/066837 external-priority patent/WO2021138195A1/en
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Claims (15)

呼気センサ装置であって、
ユーザからサンプル呼気を受け取るように構成されたハウジングを有するサンプリングユニットと、
前記ハウジング内に配置され、前記ハウジング内に受け入れられたときに前記サンプル呼気と流体連通するセンサと、
前記センサと電気的に通信するプロセッサとを備え、
前記プロセッサは、前記センサが、前記サンプル気から検出されたほぼ一定の濃度レベルのCOから、検出された周囲レベルのCOまで曝露されたときの消散時間を決定するように構成され、
前記プロセッサは、前記消散時間及び前記ほぼ一定の濃度レベルから前記周囲レベルへの減少に基づいて時定数を計算するように更に構成され、
前記プロセッサは、前記センサの過渡応答に前記時定数を適用して、前記センサを較正する際のドリフトを考慮するように更に構成されている、呼気センサ装置。
An exhalation sensor device,
a sampling unit having a housing configured to receive a sample of exhaled breath from a user;
a sensor disposed within the housing and in fluid communication with the sample exhaled breath when received within the housing;
a processor in electrical communication with the sensor;
the processor is configured to determine a dissipation time when the sensor is exposed from a substantially constant concentration level of CO detected from the sample exhaled breath to a detected ambient level of CO;
the processor is further configured to calculate a time constant based on the dissipation time and the decrease from the substantially constant concentration level to the ambient level;
The exhalation sensor device, wherein the processor is further configured to apply the time constant to a transient response of the sensor to account for drift in calibrating the sensor.
前記プロセッサは、前記時定数を計算する前に前記センサにエージング係数を適用して、時間の経過に伴うセンサ劣化を考慮するように更に構成されている、請求項1に記載の装置。 2. The apparatus of claim 1, wherein the processor is further configured to apply an aging factor to the sensor to account for sensor degradation over time before calculating the time constant. 前記プロセッサは、前記センサを較正して前記過渡応答及び定常状態応答におけるドリフトを考慮するように構成されている、請求項1に記載の装置。 2. The apparatus of claim 1, wherein the processor is configured to calibrate the sensor to account for drift in the transient and steady state responses. 前記プロセッサは、前記サンプル気を吐き出す前に、所定期間にわたって息を止めるように前記ユーザに指示を与えるように更に構成され、及び任意に、前記プロセッサは、前記サンプル呼気を前記センサから消散させるように前記ユーザに指示を与えるように更に構成されている、請求項1に記載の方法。 The processor is further configured to instruct the user to hold his breath for a predetermined period of time before exhaling the sample exhalation , and optionally, the processor causes the sample exhalation to dissipate from the sensor. 2. The method of claim 1, further configured to instruct the user to : センサを較正する方法であって、
前記センサがサンプル気からほぼ一定の濃度レベルのCOを検出するまで、ユーザから前記サンプル気を受け取ることと、
前記ほぼ一定の濃度レベルのCOが周囲レベルのCOに消散するまでの時間の長さを決定することと、
前記時間の長さ及び前記ほぼ一定の濃度レベルから前記周囲レベルへの減少に基づいて時定数を計算することと、
前記センサの過渡応答に前記時定数を適用することによって、前記センサを較正してドリフトを考慮することとを含む、方法。
A method of calibrating a sensor, the method comprising:
receiving the sample breath from a user until the sensor detects a substantially constant concentration level of CO from the sample breath ;
determining the length of time for the substantially constant concentration level of CO to dissipate to an ambient level of CO;
calculating a time constant based on the length of time and the decrease from the substantially constant concentration level to the ambient level;
calibrating the sensor to account for drift by applying the time constant to a transient response of the sensor.
前記時定数を計算する前に前記センサにエージング係数を適用して、時間の経過に伴うセンサ劣化を考慮することを更に含む、請求項に記載の方法。 6. The method of claim 5 , further comprising applying an aging factor to the sensor before calculating the time constant to account for sensor degradation over time. 前記エージング係数は、ある期間にわたる前記センサの温度及び湿度への曝露に依存し、及び任意に、前記エージング係数は、年間2%~5%の範囲である、請求項2に記載のシステム又は請求項に記載の方法。 The system or claim of claim 2, wherein the aging factor depends on temperature and humidity exposure of the sensor over a period of time, and optionally, the aging factor ranges from 2% to 5% per year. The method described in Section 6 . 前記センサを較正して定常状態応答のドリフトを考慮することを更に含む、請求項に記載の方法。 6. The method of claim 5 , further comprising calibrating the sensor to account for steady state response drift. 前記サンプル呼気を受け取ることは、前記サンプル呼気を前記センサが配置されているサンプリングユニットに受け取ることを含む、請求項に記載の方法。 6. The method of claim 5 , wherein receiving the sample breath includes receiving the sample breath into a sampling unit in which the sensor is located. 前記サンプル呼気を受け取ることは、前記サンプル気を吐き出す前に、所定期間にわたって息を止めるように前記ユーザに指示を与えることを更に含及び任意に、前記サンプル呼気を前記センサから消散させるように前記ユーザに指示を与えることを更に含む、請求項に記載の方法。 Receiving the sample breath further includes instructing the user to hold his breath for a predetermined period of time before exhaling the sample breath , and optionally allowing the sample breath to dissipate from the sensor. 6. The method of claim 5 , further comprising instructing the user to . 呼気センサ装置であって、
ユーザからサンプル呼気を受け取るように構成されたハウジングを有するサンプリングユニットと、
前記ハウジング内に配置され、前記ハウジング内に受け入れられたときに前記サンプル呼気と流体連通するセンサと、
前記センサと電気的に通信するプロセッサであって、前記プロセッサは、前記サンプル呼気で感知された生物学的パラメータに対応する測定値を前記センサから受信するように構成されている、プロセッサとを備え、
前記プロセッサは、前記センサの初期較正から経過する時間の長さに基づいて前記測定値にエージング係数を適用して、前記時間の長さにわたる前記センサの劣化率を考慮するように構成され、
前記プロセッサは、前記センサが前記時間の長さにわたって曝露される1つ以上の環境要因に基づいて前記エージング係数を修正するように更に構成されている、呼気センサ装置。
An exhalation sensor device,
a sampling unit having a housing configured to receive a sample of exhaled breath from a user;
a sensor disposed within the housing and in fluid communication with the sample exhaled breath when received within the housing;
a processor in electrical communication with the sensor, the processor configured to receive from the sensor a measurement corresponding to a biological parameter sensed in the sample exhaled breath; ,
the processor is configured to apply an aging factor to the measurements based on a length of time that has elapsed since initial calibration of the sensor to account for a rate of degradation of the sensor over the length of time;
The exhalation sensor device, wherein the processor is further configured to modify the aging factor based on one or more environmental factors to which the sensor is exposed for the length of time.
前記プロセッサは、1年という時間の長さごとに前記測定値に3%の前記エージング係数を適用するように構成されている、請求項11に記載の装置。 12. The apparatus of claim 11 , wherein the processor is configured to apply the aging factor of 3% to the measurements for each length of time of one year. 前記プロセッサは、前記センサが前記時間の長さにわたって曝露される温度レベル及び湿度レベルに基づいて前記エージング係数を修正するように構成されている、請求項11に記載の装置。 12. The apparatus of claim 11 , wherein the processor is configured to modify the aging factor based on a temperature and humidity level to which the sensor is exposed for the length of time. 比較的低い保管温度が比較的低い劣化率に対応する、及び/又は、比較的高い保管温度が比較的高い劣化率に対応する、請求項13に記載の装置。 14. The apparatus of claim 13 , wherein a relatively low storage temperature corresponds to a relatively low rate of deterioration and/or a relatively high storage temperature corresponds to a relatively high rate of deterioration . 比較的低い相対湿度が比較的高い劣化率に対応する、及び/又は、比較的高い相対湿度が比較的低い劣化率に対応する、請求項13に記載の装置。 14. The apparatus of claim 13 , wherein a relatively low relative humidity corresponds to a relatively high rate of deterioration and/or a relatively high relative humidity corresponds to a relatively low rate of deterioration .
JP2022540464A 2019-12-31 2020-12-23 Breath sensor calibration method and device Pending JP2023509643A (en)

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US201962955558P 2019-12-31 2019-12-31
US62/955,558 2019-12-31
PCT/US2020/066837 WO2021138195A1 (en) 2019-12-31 2020-12-23 Breath sensor calibration methods and apparatus

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US (2) US11957451B2 (en)
EP (1) EP4084684A4 (en)
JP (1) JP2023509643A (en)
KR (1) KR20220123089A (en)
CN (1) CN114901139A (en)
AU (1) AU2020417219A1 (en)
BR (1) BR112022012868A2 (en)
CA (1) CA3166435A1 (en)
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