JPWO2021125176A1 - - Google Patents
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- Publication number
- JPWO2021125176A1 JPWO2021125176A1 JP2021565592A JP2021565592A JPWO2021125176A1 JP WO2021125176 A1 JPWO2021125176 A1 JP WO2021125176A1 JP 2021565592 A JP2021565592 A JP 2021565592A JP 2021565592 A JP2021565592 A JP 2021565592A JP WO2021125176 A1 JPWO2021125176 A1 JP WO2021125176A1
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0679—Cells of the gastro-intestinal tract
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
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- C12N2500/00—Specific components of cell culture medium
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- C12N2500/38—Vitamins
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/12—Hepatocyte growth factor [HGF]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2306—Interleukin-6 (IL-6)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2311—Interleukin-11 (IL-11)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/237—Oncostatin M [OSM]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/42—Notch; Delta; Jagged; Serrate
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C12N2503/00—Use of cells in diagnostics
- C12N2503/04—Screening or testing on artificial tissues
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- C12N2510/00—Genetically modified cells
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- C12N2511/00—Cells for large scale production
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- C12N2513/00—3D culture
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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JP2019226717 | 2019-12-16 | ||
PCT/JP2020/046781 WO2021125176A1 (ja) | 2019-12-16 | 2020-12-15 | 増殖性肝オルガノイド、代謝活性化肝オルガノイド、及びそれらの使用 |
Publications (1)
Publication Number | Publication Date |
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JPWO2021125176A1 true JPWO2021125176A1 (ja) | 2021-06-24 |
Family
ID=76478751
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2021565592A Pending JPWO2021125176A1 (ja) | 2019-12-16 | 2020-12-15 |
Country Status (5)
Country | Link |
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US (1) | US20220298485A1 (ja) |
EP (1) | EP4079756A4 (ja) |
JP (1) | JPWO2021125176A1 (ja) |
CN (1) | CN114787338A (ja) |
WO (1) | WO2021125176A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023068247A1 (ja) * | 2021-10-19 | 2023-04-27 | Jsr株式会社 | 生体模倣システム及びその製造方法 |
CN114317444B (zh) * | 2022-03-10 | 2022-05-27 | 北京大橡科技有限公司 | 肠癌类器官培养液、培养试剂组合及培养方法 |
CN117286094A (zh) * | 2023-09-27 | 2023-12-26 | 中国人民解放军军事科学院军事医学研究院 | 一种人类器官来源外泌体的制备方法及其应用 |
CN117431203B (zh) * | 2023-12-20 | 2024-03-22 | 苏州瑞徕生物科技有限公司 | 一种增强体外培养肝细胞凝血因子表达的培养添加物及其应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201111244D0 (en) * | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
EP2956538B1 (en) * | 2013-02-13 | 2018-11-14 | Wake Forest University Health Sciences | Bioengineered liver constructs and methods relating thereto |
CN108431209B (zh) * | 2015-06-12 | 2023-02-10 | 新加坡科技研究局 | 肝脏干细胞的衍生和成熟肝细胞类型及其用途 |
EP3350313A4 (en) * | 2015-09-15 | 2019-06-12 | Agency For Science, Technology And Research (A*star) | DERIVATION OF HEPATIC ORGANOIDS FROM HUMAN PLURIPOTENT STEM CELLS |
WO2019185017A1 (zh) * | 2018-03-30 | 2019-10-03 | 中国科学院上海生命科学研究院 | 用于肝细胞培养及肝脏类器官制备的培养基 |
WO2019222853A1 (en) * | 2018-05-25 | 2019-11-28 | Valorisation-Hsj, Limited Partnership | Process for making cell populations of the hepatic lineage from endodermal cells and cellular compositions comprising same |
JP2020092700A (ja) * | 2018-12-06 | 2020-06-18 | Jsr株式会社 | 肝臓オルガノイドの製造方法、肝臓オルガノイド製造用培地、肝臓オルガノイド、細胞製剤、及び被験物質の評価方法 |
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2020
- 2020-12-15 EP EP20903681.3A patent/EP4079756A4/en active Pending
- 2020-12-15 WO PCT/JP2020/046781 patent/WO2021125176A1/ja unknown
- 2020-12-15 CN CN202080085827.0A patent/CN114787338A/zh active Pending
- 2020-12-15 JP JP2021565592A patent/JPWO2021125176A1/ja active Pending
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2022
- 2022-06-10 US US17/806,398 patent/US20220298485A1/en active Pending
Also Published As
Publication number | Publication date |
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WO2021125176A1 (ja) | 2021-06-24 |
EP4079756A1 (en) | 2022-10-26 |
US20220298485A1 (en) | 2022-09-22 |
CN114787338A (zh) | 2022-07-22 |
EP4079756A4 (en) | 2024-01-24 |
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