JPWO2021110923A5

JPWO2021110923A5 -

Info

Publication number: JPWO2021110923A5
Application number: JP2022533500A
Authority: JP
Publication date: 2023-12-11

Claims

(i) a self-assembling peptide comprising the sequence of SEQ ID NO: 21, wherein the self-assembling peptide is essentially present in the dental care product in an assembled form, and (ii) is pharmaceutically acceptable. A dental care product comprising a base, wherein the dental care product comprises an essentially solid base selected from the group consisting of chewing gum, soft chews, toffee, gelatin gum, chewing gum, chewing gum, troches, or tablets. product,
The dental care product is a non-abrasive dental care product.

The self-assembling peptide in organized form is embedded in a pharmaceutically acceptable base, which is preferably a gum base comprising components selected from the group comprising polymers, plasticizers and/or resins. The dental treatment product of claim 1.

The gum base is
a) Butadiene-styrene rubber, isobutylene-isoprene copolymer, paraffin, petroleum-based (way), petroleum wax synthesis, polyisobutylene polyvinyl acetate, polyisobutadiene and isobutylene-isoprene copolymer, polybutene, polybutadiene and polyisobutylene, etc. low molecular weight elastomers, vinyl polymer elastomers such as polyvinyl acetate, polyethylene, vinyl copolymer elastomers such as vinyl acetate/vinyl laurate, vinyl acetate/vinyl stearate, ethylene/vinyl acetate, polyvinyl alcohol, or mixtures thereof. and/or b) Chicle, Chiquibal, Crown Gum, Gutta Hankan, Masaranduba Balata, Masaranduba Chocolate, Nispero, Rosdinha, Venezuelan Chicle, Jelutong, Lechesaspi, Pendare, Perillo, Leche de Vaca ( 3. A dental treatment product according to claim 2, comprising natural ingredients selected from the group consisting of: leche de vaca), niger gutta, horn, chirte, and natural gum.

Dental treatment product according to any one of claims 1 to 3, comprising gelatin, pectin, egg white, lecithin, maltitol/sorbitol or starch.

Dental treatment product according to any one of claims 1 to 4 , wherein the concentration of the self-assembling peptide is 0.1-5000 mg/kg, preferably about 5-15 mg/kg.

6. A dental care product according to any one of claims 1 to 5 , wherein the peptide comprises the sequence SEQ ID NO:22.

1, 3 or 20; preferably, the self-assembling peptide comprises a sequence having at least 80% sequence identity to one of the sequences SEQ ID NO. The dental treatment product according to any one of Items 1 to 6 .

Dental treatment product according to any one of claims 1 to 7, comprising no more than 0.4% by weight of mineral particles having a size of at least 0.1 μm,
Here, if desired, the dental treatment product comprises:
a) a polyol selected from the group comprising xylitol, erythritol and sorbitol;
b) a salt selected from the group comprising calcium carbonate and phosphate and having a MOSH hardness of less than 3;
A dental treatment product comprising at least one further ingredient selected from the group comprising: c) pyrophosphate; and d) a pH control agent.

9. A method for preparing a dental treatment product according to any one of claims 1 to 8 , comprising the steps of: a) providing a matrix of organized self-assembling peptides;
b) providing a pharmaceutically acceptable base , preferably a gum base, wherein steps a) and b) can be carried out in any order;
c) homogenizing the assembled self-assembling peptide matrix and the pharmaceutically acceptable carrier, optionally together with other ingredients;
d) forming a dental care product; and e) optionally packaging the dental care product.

Dental care product according to any one of claims 1-8, obtainable by the method of claim 9.

Any of claims 1-8 and 10, for use in reducing further demineralization of a tooth surface in a subject having demineralized teeth, comprising orally administering a dental treatment product into the subject's mouth. A dental care product according to clause 1 , wherein preferably the dental care product is maintained in the mouth for at least 3 minutes.

The subject is associated with a reduction in remineralization of teeth selected from the group comprising xerostomia, hyposalivation, bruxism, dentin hypersensitivity and/or acid erosion, optionally acid erosion associated with hyposalivation. 12. A dental care product for use according to claim 11 with a disease or condition.

Dental care product for use according to any one of claims 11 or 12, wherein the dental care product is chewed by the subject, preferably chewing for 5 minutes increases salivary flow by at least 10 times. .

11-13, wherein upon chewing, the gum base cleans the tooth surface and the matrix of organized self-assembling peptides provides a film on the tooth surface that reduces or prevents further demineralization of the tooth surface. A dental care product for use as described in any one of the following.

Dental care product for use according to any one of claims 11-14, wherein the dental care product reduces the incidence of dental caries.