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JPWO2021003280A5
JPWO2021003280A5 JP2021572882A JP2021572882A JPWO2021003280A5 JP WO2021003280 A5 JPWO2021003280 A5 JP WO2021003280A5 JP 2021572882 A JP2021572882 A JP 2021572882A JP 2021572882 A JP2021572882 A JP 2021572882A JP WO2021003280 A5 JPWO2021003280 A5 JP WO2021003280A5
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food composition
animal food
animal
source
curcuminoids
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JP2022538385A (en
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Priority claimed from PCT/US2020/040516 external-priority patent/WO2021003280A1/en
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本出願全体を通して引用されているいずれの特許、特許出願、公報、製品説明、及びプロトコルについて、これら全ての開示は、あらゆる目的のために、その全体が参照により本出願に援用される。
以下、本発明の好ましい実施形態を項分け記載する。
実施形態１
アレルギー性炎症性皮膚疾患の予防及び／又は治療方法において使用するための：
（ｉ）グリチルリチンの供給源と；
（ｉｉ）１つ以上のクルクミノイドの供給源と
の組み合わせを含む、動物用食品組成物。
実施形態２
前記１つ以上のクルクミノイドは、一般式（Ｉ）：

Figure 2021003280000001
の化合物、前記化合物の薬学的に許容可能な塩、互変異性体、又は立体異性体であり、ここでＲ１及びＲ２は独立して、水素原子、メトキシ、メチル、ヒドロキシル又はエトキシ基である、実施形態１に記載の動物用食品組成物。
実施形態３
前記１つ以上のクルクミノイドは、クルクミン、デメトキシクルクミン、メトキシクルクミン、テトラヒドロクルクミン、及びこれらの組み合わせからなる群から選択される、実施形態１又は２に記載の動物用食品組成物。
実施形態４
前記動物用食品組成物は、栄養的に完全な動物用食品組成物からなる、実施形態１～３のいずれかに記載の動物用食品組成物。
実施形態５
（ｉ）前記グリチルリチンの供給源はカンゾウからなり；及び／又は
（ｉｉ）前記１つ以上のクルクミノイドの供給源はウコンからなる、実施形態１～４のいずれかに記載の動物用食品組成物。
実施形態６
前記動物用食品組成物は、リノール酸を更に含む、実施形態１～５のいずれかに記載の動物用食品組成物。
実施形態７
前記動物用食品組成物は、ＥＰＡ／ＤＨＡ、タウリン、ルテイン、ビタミンＥ、又はこれらの組み合わせを更に含む、実施形態１～６のいずれかに記載の動物用食品組成物。
実施形態８
前記アレルギー性炎症性皮膚疾患は、アトピー性皮膚炎、ノミアレルギー性皮膚炎、じんましん、血管浮腫、吸入性アレルギー、吸入性アレルギー性皮膚炎、食物アレルギー性皮膚炎、接触性皮膚炎、粟粒性皮膚炎、好酸球性肉芽腫症、頭頸部掻痒症、及び全身性掻痒症からなる群から選択される、実施形態１～７のいずれかに記載の動物用食品組成物。
実施形態９
アレルギー性炎症性皮膚疾患の予防及び／又は治療方法において使用するための：
（ｉ）グリチルリチンの供給源を含む第１の部分；及び
（ｉｉ）１つ以上のクルクミノイドの供給源を含む第２の部分
を含む、キット。
実施形態１０
（ｉ）グリチルリチンの供給源と；
（ｉｉ）１つ以上のクルクミノイドの供給源と
の組み合わせを含む、動物用食品組成物であって、
前記動物用食品組成物はキブルからなり、及び／又は前記動物用食品組成物はタンパク質の供給源を更に含む、動物用食品組成物。
実施形態１１
前記動物用食品組成物は、栄養的に完全な食品組成物からなる、実施形態１０に記載の動物用食品組成物。
実施形態１２
（ｉ）前記グリチルリチンの供給源は、カンゾウからなり；及び／又は
（ｉｉ）前記１つ以上のクルクミノイドの供給源は、ウコンからなる、実施形態１０若しくは１１に記載の動物用食品組成物、又は実施形態９に記載のキット。
実施形態１３
リノール酸を更に含む、実施形態１０～１２のいずれか１項に記載の動物用食品組成物、又は実施形態９若しくは１８に記載のキット。
実施形態１４
ＥＰＡ／ＤＨＡ、タウリン、ルテイン、ビタミンＥ、又はこれらの組み合わせを更に含む、実施形態１０～１３のいずれかに記載の動物用食品組成物、又は実施形態９、１２若しくは１３に記載のキット。
実施形態１５
ａ）グリチルリチンの供給源と１つ以上のクルクミノイドの供給源とを混合して混合物を提供するステップ；及び
ｂ）前記混合物を加熱するステップ
を含む、実施形態１０～１４のいずれかに記載の動物用食品組成物の製造方法。
実施形態１６
必要がある動物のアレルギー性炎症性皮膚疾患の予防及び／又は治療方法であって、前記方法は：
（ｉ）グリチルリチンの供給源；及び
（ｉｉ）１つ以上のクルクミノイドの供給源
を含む動物用食品組成物を投与するステップを含む、方法。
実施形態１７
前記１つ以上のクルクミノイドは、一般式（Ｉ）：
Figure 2021003280000002
 の化合物、前記化合物の薬学的に許容可能な塩、互変異性体、又は立体異性体であり、ここでＲ１及びＲ２は独立して、水素原子、メトキシ、メチル、ヒドロキシル又はエトキシ基である、実施形態１６に記載の方法。
実施形態１８
前記１つ以上のクルクミノイドは、クルクミン、デメトキシクルクミン、メトキシクルクミン、テトラヒドロクルクミン、及びこれらの組み合わせからなる群から選択される、実施形態１６に記載の方法。
実施形態１９
前記グリチルリチンの供給源はカンゾウである、実施形態１６に記載の方法。
実施形態２０
前記動物用食品組成物は、カンゾウ及びウコンを含む、実施形態１６に記載の方法。
実施形態２１
前記アレルギー性炎症性皮膚疾患は、アトピー性皮膚炎、ノミアレルギー性皮膚炎、じんましん、血管浮腫、吸入性アレルギー、吸入性アレルギー性皮膚炎、食物アレルギー性皮膚炎、接触性皮膚炎、粟粒性皮膚炎、好酸球性肉芽腫症、頭頸部掻痒症、及び全身性掻痒症からなる群から選択される、実施形態１６に記載の方法。
実施形態２２
前記動物用食品組成物は、リノール酸、ＥＰＡ／ＤＨＡ、タウリン、ルテイン、ビタミンＥ、又はこれらの組み合わせを更に含む、実施形態１６に記載の方法。
実施形態２３
前記動物はイヌ科動物である、実施形態１６に記載の方法。
実施形態２４
前記イヌ科動物はイヌである、実施形態２３に記載の方法。 The disclosures of all patents, patent applications, publications, product descriptions, and protocols cited throughout this application are hereby incorporated by reference in their entirety for all purposes.
Hereinafter, preferred embodiments of the present invention will be described item by item.
Embodiment 1
For use in a method of prevention and/or treatment of allergic inflammatory skin diseases:
(i) a source of glycyrrhizin;
(ii) one or more curcuminoid sources;
An animal food composition comprising a combination of
Embodiment 2
The one or more curcuminoids have the general formula (I):
Figure 2021003280000001
 or a pharmaceutically acceptable salt, tautomer, or stereoisomer of said compound, wherein R1 and R2 are independently a hydrogen atom, a methoxy, methyl, hydroxyl or ethoxy group; The animal food composition of embodiment 1.
Embodiment 3
3. The animal food composition of embodiment 1 or 2, wherein the one or more curcuminoids are selected from the group consisting of curcumin, demethoxycurcumin, methoxycurcumin, tetrahydrocurcumin, and combinations thereof.
Embodiment 4
The animal food composition of any of embodiments 1-3, wherein said animal food composition comprises a nutritionally complete animal food composition.
Embodiment 5
(i) the source of glycyrrhizin consists of licorice; and/or
(ii) The animal food composition of any of embodiments 1-4, wherein said source of one or more curcuminoids consists of turmeric.
Embodiment 6
The animal food composition of any of embodiments 1-5, wherein said animal food composition further comprises linoleic acid.
Embodiment 7
7. The animal food composition of any of embodiments 1-6, wherein the animal food composition further comprises EPA/DHA, taurine, lutein, vitamin E, or combinations thereof.
Embodiment 8
The allergic inflammatory skin diseases include atopic dermatitis, flea allergy dermatitis, urticaria, angioedema, inhalation allergy, inhalation allergic dermatitis, food allergic dermatitis, contact dermatitis, and miliary skin. The animal food composition of any of embodiments 1-7, wherein the animal food composition is selected from the group consisting of inflammation, eosinophilic granulomatosis, head and neck pruritus, and generalized pruritus.
Embodiment 9
For use in a method of prevention and/or treatment of allergic inflammatory skin diseases:
(i) a first portion comprising a source of glycyrrhizin; and
(ii) a second portion comprising one or more sources of curcuminoids;
kit, including
Embodiment 10
(i) a source of glycyrrhizin;
(ii) one or more curcuminoid sources;
An animal food composition comprising a combination of
An animal food composition, wherein said animal food composition comprises kibble and/or wherein said animal food composition further comprises a source of protein.
Embodiment 11
11. The animal food composition of embodiment 10, wherein said animal food composition comprises a nutritionally complete food composition.
Embodiment 12
(i) the source of glycyrrhizin consists of licorice; and/or
(ii) The animal food composition of embodiment 10 or 11, or the kit of embodiment 9, wherein the one or more curcuminoid sources consist of turmeric.
Embodiment 13
The animal food composition of any one of embodiments 10-12, or the kit of embodiment 9 or 18, further comprising linoleic acid.
Embodiment 14
The animal food composition of any of embodiments 10-13, or the kit of embodiments 9, 12 or 13, further comprising EPA/DHA, taurine, lutein, vitamin E, or combinations thereof.
Embodiment 15
a) mixing a source of glycyrrhizin with a source of one or more curcuminoids to provide a mixture; and
b) heating said mixture
A method of making an animal food composition according to any of embodiments 10-14, comprising
Embodiment 16
A method for the prevention and/or treatment of allergic inflammatory skin diseases in an animal in need thereof, said method comprising:
(i) a source of glycyrrhizin; and
(ii) one or more sources of curcuminoids
A method comprising administering an animal food composition comprising:
Embodiment 17
The one or more curcuminoids have the general formula (I):
Figure 2021003280000002
 or a pharmaceutically acceptable salt, tautomer, or stereoisomer of said compound, wherein R1 and R2 are independently a hydrogen atom, a methoxy, methyl, hydroxyl or ethoxy group; 17. The method of embodiment 16.
Embodiment 18
17. The method of embodiment 16, wherein the one or more curcuminoids are selected from the group consisting of curcumin, demethoxycurcumin, methoxycurcumin, tetrahydrocurcumin, and combinations thereof.
Embodiment 19
17. The method of embodiment 16, wherein the source of glycyrrhizin is licorice.
Embodiment 20
17. The method of embodiment 16, wherein the animal food composition comprises licorice and turmeric.
Embodiment 21
The allergic inflammatory skin diseases include atopic dermatitis, flea allergy dermatitis, urticaria, angioedema, inhalation allergy, inhalation allergic dermatitis, food allergic dermatitis, contact dermatitis, and miliary skin. 17. The method of embodiment 16, selected from the group consisting of inflammation, eosinophilic granulomatosis, head and neck pruritus, and generalized pruritus.
Embodiment 22
17. The method of embodiment 16, wherein the animal food composition further comprises linoleic acid, EPA/DHA, taurine, lutein, vitamin E, or combinations thereof.
Embodiment 23
17. The method of embodiment 16, wherein said animal is a canine.
Embodiment 24
24. The method of embodiment 23, wherein said canine is a dog.

Claims (13)

（ｉ）グリチルリチンの供給源と；
（ｉｉ）１つ以上のクルクミノイドの供給源と
の組み合わせを含む、動物用食品組成物。 ( i) a source of glycyrrhizin;
(ii) an animal food composition comprising a combination with one or more curcuminoid sources; 前記１つ以上のクルクミノイドは、一般式（Ｉ）：
Figure 2021003280000003
 の化合物、前記化合物の薬学的に許容可能な塩、互変異性体、又は立体異性体であり、ここでＲ１及びＲ２は独立して、水素原子、メトキシ、メチル、ヒドロキシル又はエトキシ基である、請求項１に記載の動物用食品組成物。 The one or more curcuminoids have the general formula (I):
Figure 2021003280000003
 or a pharmaceutically acceptable salt, tautomer, or stereoisomer of said compound, wherein R 1 and R 2 are independently hydrogen atoms, methoxy, methyl, hydroxyl or ethoxy groups 2. The animal food composition of claim 1, wherein a 前記１つ以上のクルクミノイドは、クルクミン、デメトキシクルクミン、メトキシクルクミン、テトラヒドロクルクミン、及びこれらの組み合わせからなる群から選択される、請求項１又は２に記載の動物用食品組成物。 3. The animal food composition of claim 1 or 2, wherein the one or more curcuminoids are selected from the group consisting of curcumin, demethoxycurcumin, methoxycurcumin, tetrahydrocurcumin, and combinations thereof. 前記動物用食品組成物は、栄養的に完全な動物用食品組成物からなる、請求項１～３のいずれか１項に記載の動物用食品組成物。 The animal food composition of any one of claims 1-3, wherein the animal food composition comprises a nutritionally complete animal food composition. （ｉ）前記グリチルリチンの供給源はカンゾウからなり；及び／又は
（ｉｉ）前記１つ以上のクルクミノイドの供給源はウコンからなる、請求項１～４のいずれか１項に記載の動物用食品組成物。 The animal food composition of any one of claims 1-4, wherein (i) the source of glycyrrhizin consists of licorice; and/or (ii) the source of one or more curcuminoids consists of turmeric. thing. 前記動物用食品組成物は、リノール酸を更に含む、請求項１～５のいずれか１項に記載の動物用食品組成物。 The animal food composition of any one of claims 1-5, wherein the animal food composition further comprises linoleic acid. 前記動物用食品組成物は、ＥＰＡ／ＤＨＡ、タウリン、ルテイン、ビタミンＥ、又はこれらの組み合わせを更に含む、請求項１～６のいずれか１項に記載の動物用食品組成物。 The animal food composition of any one of claims 1-6, wherein the animal food composition further comprises EPA/DHA, taurine, lutein, vitamin E, or combinations thereof. 前記（ｉ）グリチルリチンの供給源を含む第１の部分；及び
前記（ｉｉ）１つ以上のクルクミノイドの供給源を含む第２の部分を含む、キットである、請求項１～７のいずれか１項に記載の動物用食品組成物。 (i) a first portion comprising a source of glycyrrhizin; and
The animal food composition of any one of claims 1-7, wherein the animal food composition is a kit, comprising (ii) a second part comprising one or more sources of curcuminoids. 前記動物用食品組成物はキブルからなり、及び／又は前記動物用食品組成物はタンパク質の供給源を更に含む、請求項１～８のいずれかに記載の動物用食品組成物。 The animal food composition of any of claims 1-8, wherein said animal food composition comprises kibble and/or said animal food composition further comprises a source of protein. 動物のアレルギー性炎症性皮膚疾患の予防及び／又は治療方法において使用するための動物用食品組成物である、請求項１～９のいずれかに記載の動物用食品組成物。The animal food composition according to any one of claims 1 to 9, which is an animal food composition for use in a method for preventing and/or treating allergic inflammatory skin diseases in animals. 前記アレルギー性炎症性皮膚疾患は、アトピー性皮膚炎、ノミアレルギー性皮膚炎、じんましん、血管浮腫、吸入性アレルギー、吸入性アレルギー性皮膚炎、食物アレルギー性皮膚炎、接触性皮膚炎、粟粒性皮膚炎、好酸球性肉芽腫症、頭頸部掻痒症、及び全身性掻痒症からなる群から選択される、請求項１０に記載の動物用食品組成物。 The allergic inflammatory skin diseases include atopic dermatitis, flea allergy dermatitis, urticaria, angioedema, inhalation allergy, inhalation allergic dermatitis, food allergic dermatitis, contact dermatitis, and miliary skin. 11. The animal food composition of claim 10 , selected from the group consisting of pruritus, eosinophilic granulomatosis, head and neck pruritus, and generalized pruritus. 前記動物はイヌ科動物である、請求項１～１１のいずれか１項に記載の動物用食品組成物。 The animal food composition of any one of claims 1-11 , wherein the animal is a canine. 前記イヌ科動物はイヌである、請求項１２に記載の動物用食品組成物。
13. The animal food composition of claim 12 , wherein said canine animal is a dog.
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