JPWO2020219908A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2020219908A5
JPWO2020219908A5 JP2021563030A JP2021563030A JPWO2020219908A5 JP WO2020219908 A5 JPWO2020219908 A5 JP WO2020219908A5 JP 2021563030 A JP2021563030 A JP 2021563030A JP 2021563030 A JP2021563030 A JP 2021563030A JP WO2020219908 A5 JPWO2020219908 A5 JP WO2020219908A5
Authority
JP
Japan
Prior art keywords
amino acid
host cell
sequence
dna sequence
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021563030A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022530055A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/029855 external-priority patent/WO2020219908A1/fr
Publication of JP2022530055A publication Critical patent/JP2022530055A/ja
Publication of JPWO2020219908A5 publication Critical patent/JPWO2020219908A5/ja
Pending legal-status Critical Current

Links

JP2021563030A 2019-04-25 2020-04-24 拡張されたdna標的化範囲を有する操作されたcas9 Pending JP2022530055A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962838498P 2019-04-25 2019-04-25
US62/838,498 2019-04-25
PCT/US2020/029855 WO2020219908A1 (fr) 2019-04-25 2020-04-24 Cas9 modifiée à plage de ciblage d'adn élargie

Publications (2)

Publication Number Publication Date
JP2022530055A JP2022530055A (ja) 2022-06-27
JPWO2020219908A5 true JPWO2020219908A5 (fr) 2023-04-20

Family

ID=72941444

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021563030A Pending JP2022530055A (ja) 2019-04-25 2020-04-24 拡張されたdna標的化範囲を有する操作されたcas9

Country Status (12)

Country Link
US (1) US20220204954A1 (fr)
EP (1) EP3958914A4 (fr)
JP (1) JP2022530055A (fr)
KR (1) KR20220025708A (fr)
CN (1) CN114206394A (fr)
AU (1) AU2020261071A1 (fr)
BR (1) BR112021021306A2 (fr)
CA (1) CA3137903A1 (fr)
IL (1) IL287541A (fr)
MX (1) MX2021012966A (fr)
SG (1) SG11202111814XA (fr)
WO (1) WO2020219908A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117866926A (zh) * 2024-03-07 2024-04-12 珠海舒桐医疗科技有限公司 一种CRISPR-FrCas9蛋白突变体及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10202589B2 (en) * 2015-03-03 2019-02-12 The General Hospital Corporation Engineered CRISPR-Cas9 nucleases with altered PAM specificity
WO2016205759A1 (fr) * 2015-06-18 2016-12-22 The Broad Institute Inc. Modification et optimisation de systèmes, de méthodes, d'enzymes et d'échafaudages guides d'orthologues de cas9 et variant pour la manipulation de séquences
US9512446B1 (en) * 2015-08-28 2016-12-06 The General Hospital Corporation Engineered CRISPR-Cas9 nucleases
WO2018027078A1 (fr) * 2016-08-03 2018-02-08 President And Fellows Of Harard College Éditeurs de nucléobases d'adénosine et utilisations associées
JP7456605B2 (ja) * 2016-12-23 2024-03-27 プレジデント アンド フェローズ オブ ハーバード カレッジ Pcsk9の遺伝子編集
CN111201317B (zh) * 2017-09-05 2024-04-05 国立大学法人东京大学 经修饰的Cas9蛋白及其用途

Similar Documents

Publication Publication Date Title
US11946040B2 (en) Adenine DNA base editor variants with reduced off-target RNA editing
JP2019536425A5 (fr)
JP7324713B2 (ja) 改善された精度および特異性を有する塩基エディター
JP6835726B2 (ja) Crisprハイブリッドdna/rnaポリヌクレオチドおよび使用方法
Karn et al. Protein structural domains in the Caenorhabditis elegans unc-54 myosin heavy chain gene are not separated by introns.
JP2022526695A (ja) 遺伝子編集における非意図的な変異の阻害
JP2021166514A5 (fr)
CA3129158A1 (fr) Editeurs de base adenosine desaminase et leurs methodes d'utilisation pour modifier une nucleobase dans une sequence cible
JP2020534795A (ja) ファージによって支援される連続的進化(pace)を用いて塩基編集因子を進化させるための方法および組成物
JPWO2019236566A5 (fr)
WO2021042062A2 (fr) Éditeurs combinatoires d'adénine et de cytosine à base d'adn
CA3140093A1 (fr) Procedes d'edition d'un polymorphisme mononucleotidique au moyen de systemes d'editeur de base programmables
WO2020077138A2 (fr) Variants d'éditeur de base d'adn pour la réduction sélective d'édition d'arn indésirable (secure)
CA3228222A1 (fr) Systemes crispr de classe ii, de type v
JPWO2021050571A5 (fr)
US20190241911A1 (en) Engineered guide rna and uses thereof
JPWO2020219908A5 (fr)
JP2022533842A (ja) 一塩基置換蛋白質およびそれを含む組成物
RU2021134280A (ru) Сконструированный cas9 с расширенным диапазоном направленного воздействия на днк
JP2024501892A (ja) 新規の核酸誘導型ヌクレアーゼ
Rutkai et al. Analysis of insertion into secondary attachment sites by phage λ and by int mutants with altered recombination specificity
KR20220025708A (ko) 확장된 dna 표적 범위를 갖는 조작된 cas9
JPWO2020160514A5 (fr)
WO2022050413A1 (fr) Complexe contenant une cytidine désaminase miniaturisé pour modifier l'adn double brin
JPWO2021102390A5 (fr)