JPWO2020208604A5

JPWO2020208604A5 -

Info

Publication number: JPWO2020208604A5
Application number: JP2021560436A
Authority: JP
Publication date: 2023-04-18

Claims

A device for cooling tissue, objects or spaces, comprising:
a vacuum chamber having cooling walls designed to be positioned over the tissue, object or space to be cooled;
a water spray device designed to spray water into the vacuum chamber or onto the cooling wall;
a vacuum of 0.02 atm (2026.5 Pa) or less sufficient to cause accelerated evaporation of the water and cooling of the cooling wall to a temperature required to cool the tissue, object or space; A device designed to be maintained in a vacuum chamber.

the vacuum chamber includes one or more thermal sensors;
The maintaining of the vacuum is achieved by a computer designed to obtain temperature data from the one or more thermal sensors and control one or more of the water flow rate, vacuum pressure, and electrolyte solution to the desired temperature and/or or to control the rate of cooling and/or to compensate for various confounding factors in heat flow into the vacuum chamber.
A device according to claim 1 .

3. Apparatus according to claim 1 or 2 , wherein the vacuum chamber is formed as an open vacuum bell opening to the side sealed to the tissue, object or space and the cooling wall is the surface of the tissue or object. .

wherein said vacuum chamber is formed as a vacuum bell enclosed in a flat thermally conductive platen, said platen designed to be placed in thermal contact with said tissue, object or space. Item 3. The device according to Item 1 or 2.

5. The apparatus of claim 4, wherein the platens are coated with a non-metallic anti-stick separation material designed to prevent sticking .

The non-metallic anti-adhesive separation material is designed to prevent adhesion and consequent tissue damage due to freezing of water between the tissue or tissue or object to be cooled and the platen. 6. The device according to claim 5.

7. Apparatus according to any one of the preceding claims , wherein the water has an electrolyte in solution selected to lower the freezing point of the water to a desired temperature.

8. Apparatus according to any one of the preceding claims , wherein the tissue to be cooled is tissue of a human patient.

9. The apparatus of claim 8 , wherein the tissue to be cooled is the patient's adipose tissue.

10. The device of claim 8 or 9 , wherein said cooling of said tissue is designed to reduce pain.

9. The apparatus of claim 8 , wherein said cooling of said tissue is designed to lighten skin and/or reduce hypopigmentation.

9. The apparatus of claim 8 , wherein the tissue to be cooled is within the digestive tract.

9. The device of claim 8 , wherein the tissue to be cooled is within an airway.

14. The apparatus of claim 13 , wherein the tissue to be cooled comprises goblet cells to be disrupted.

9. The apparatus of claim 8 , wherein the tissue to be cooled contains malignant cells to be removed.

9. The tissue of claim 8 , wherein the tissue to be cooled contains unwanted benign cells that are selectively sensitive to cold, and the cooling is designed to destroy these unwanted benign cells. Device.

8. Apparatus according to any one of the preceding claims , wherein the space to be cooled is an enclosed space to be cooled to a freezing or freezing temperature.

8. Apparatus according to any one of the preceding claims , wherein the space to be cooled is a room to be cooled to air conditioning temperature.

5. The apparatus of claim 4, wherein the vacuum chamber is formed as an enclosed volume with a cooling wall on one side, the cooling wall configured to be placed in physical contact with the tissue of a patient.

2. The apparatus of claim 1, further comprising a valve configured to alternately connect the vacuum chamber to a vacuum or vent the vacuum chamber using an air inlet.

A method of cooling an object or space comprising:
placing a vacuum chamber in thermal contact with an object or space to be cooled;
spraying water from a sprayer into the vacuum chamber;
Maintaining a vacuum of 0.02 atm (2026.5 Pa) or less in the vacuum chamber sufficient to cause accelerated evaporation of the water and cooling of the object, or space, to a desired temperature below its ambient temperature. and a method.

the vacuum chamber includes one or more thermal sensors;
The step of maintaining the vacuum obtains temperature data from the one or more thermal sensors and controls the desired temperature by a computer designed to control one or more of the water flow rate, vacuum pressure, and electrolyte solution. and/or to control the rate of cooling and/or to compensate for various confounding factors in heat flow into the vacuum chamber.
22. The method of claim 21 .

23. A method according to claim 21 or 22 , wherein the vacuum chamber is formed as an open vacuum bell opening to the side closed to the object or space.

21. The vacuum chamber is formed as a vacuum bell enclosed in a flat thermally conductive platen, the platen being designed to be placed in thermal contact with the object or space. 24. The method of any one of 23 .

25. The method of claim 24 , wherein the platen is coated with a non-metallic anti-stick separation material designed to prevent adhesion of the object to be cooled and the platen.

26. The method of any one of claims 21-25 , wherein the water has an electrolyte in solution selected to lower the freezing point of the water to a desired temperature.