JPWO2020175690A5 - - Google Patents
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- Publication number
- JPWO2020175690A5 JPWO2020175690A5 JP2021502657A JP2021502657A JPWO2020175690A5 JP WO2020175690 A5 JPWO2020175690 A5 JP WO2020175690A5 JP 2021502657 A JP2021502657 A JP 2021502657A JP 2021502657 A JP2021502657 A JP 2021502657A JP WO2020175690 A5 JPWO2020175690 A5 JP WO2020175690A5
- Authority
- JP
- Japan
- Prior art keywords
- bifidobacterium
- composition
- acid
- hydroxyphenyl
- bifidobacterium longum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 claims description 28
- 241001608472 Bifidobacterium longum Species 0.000 claims description 21
- 229940009291 bifidobacterium longum Drugs 0.000 claims description 21
- 241000186000 Bifidobacterium Species 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 16
- 241000894006 Bacteria Species 0.000 claims description 13
- 230000015572 biosynthetic process Effects 0.000 claims description 12
- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 claims description 12
- 241001076388 Fimbria Species 0.000 claims description 11
- 230000000968 intestinal effect Effects 0.000 claims description 9
- 230000001939 inductive effect Effects 0.000 claims description 6
- 241000193403 Clostridium Species 0.000 claims description 3
- 244000005700 microbiome Species 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 125000004464 hydroxyphenyl group Chemical group 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 1
- 238000012360 testing method Methods 0.000 description 15
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 241000699670 Mus sp. Species 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 241000193470 Clostridium sporogenes Species 0.000 description 7
- 210000003608 fece Anatomy 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 239000002609 medium Substances 0.000 description 5
- 101000986239 Streptococcus parasanguinis Manganese ABC transporter substrate-binding lipoprotein Proteins 0.000 description 4
- 239000002207 metabolite Substances 0.000 description 4
- 238000001262 western blot Methods 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 210000004081 cilia Anatomy 0.000 description 3
- 238000012790 confirmation Methods 0.000 description 3
- 210000002490 intestinal epithelial cell Anatomy 0.000 description 3
- 210000004347 intestinal mucosa Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 102000016943 Muramidase Human genes 0.000 description 2
- 108010014251 Muramidase Proteins 0.000 description 2
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 2
- 239000002033 PVDF binder Substances 0.000 description 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 2
- 238000003916 acid precipitation Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 101150091425 fimB gene Proteins 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 235000010335 lysozyme Nutrition 0.000 description 2
- 239000004325 lysozyme Substances 0.000 description 2
- 229960000274 lysozyme Drugs 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 108010009719 mutanolysin Proteins 0.000 description 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 2
- 238000001878 scanning electron micrograph Methods 0.000 description 2
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 2
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- NWCHELUCVWSRRS-SECBINFHSA-N (2r)-2-hydroxy-2-phenylpropanoic acid Chemical compound OC(=O)[C@@](O)(C)C1=CC=CC=C1 NWCHELUCVWSRRS-SECBINFHSA-N 0.000 description 1
- PLVPPLCLBIEYEA-WAYWQWQTSA-N (z)-3-(1h-indol-3-yl)prop-2-enoic acid Chemical compound C1=CC=C2C(\C=C/C(=O)O)=CNC2=C1 PLVPPLCLBIEYEA-WAYWQWQTSA-N 0.000 description 1
- SVTBKBTZCWQLGX-UHFFFAOYSA-N 2-(4-hydroxyphenyl)prop-2-enoic acid Chemical compound OC(=O)C(=C)C1=CC=C(O)C=C1 SVTBKBTZCWQLGX-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- JVGVDSSUAVXRDY-UHFFFAOYSA-N 3-(4-hydroxyphenyl)lactic acid Chemical compound OC(=O)C(O)CC1=CC=C(O)C=C1 JVGVDSSUAVXRDY-UHFFFAOYSA-N 0.000 description 1
- XGILAAMKEQUXLS-UHFFFAOYSA-N 3-(indol-3-yl)lactic acid Chemical compound C1=CC=C2C(CC(O)C(O)=O)=CNC2=C1 XGILAAMKEQUXLS-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 238000003917 TEM image Methods 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000011536 extraction buffer Substances 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- PLVPPLCLBIEYEA-UHFFFAOYSA-N indoleacrylic acid Natural products C1=CC=C2C(C=CC(=O)O)=CNC2=C1 PLVPPLCLBIEYEA-UHFFFAOYSA-N 0.000 description 1
- 230000000503 lectinlike effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 229910000489 osmium tetroxide Inorganic materials 0.000 description 1
- 239000012285 osmium tetroxide Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000003762 quantitative reverse transcription PCR Methods 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-N trans-cinnamic acid Chemical compound OC(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-N 0.000 description 1
- 238000011222 transcriptome analysis Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019036309 | 2019-02-28 | ||
| JP2019036309 | 2019-02-28 | ||
| PCT/JP2020/008457 WO2020175690A1 (ja) | 2019-02-28 | 2020-02-28 | ビフィドバクテリウム属細菌の線毛形成誘導用の組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2020175690A1 JPWO2020175690A1 (enExample) | 2020-09-03 |
| JPWO2020175690A5 true JPWO2020175690A5 (enExample) | 2022-04-15 |
| JP7302797B2 JP7302797B2 (ja) | 2023-07-04 |
Family
ID=72239830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021502657A Active JP7302797B2 (ja) | 2019-02-28 | 2020-02-28 | ビフィドバクテリウム属細菌の線毛形成誘導用の組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US12239619B2 (enExample) |
| EP (1) | EP3932484A4 (enExample) |
| JP (1) | JP7302797B2 (enExample) |
| CN (2) | CN118178372A (enExample) |
| WO (1) | WO2020175690A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7659980B2 (ja) | 2020-09-30 | 2025-04-10 | 森永乳業株式会社 | 芳香族乳酸を含む組成物の製造方法 |
| WO2024057782A1 (ja) * | 2022-09-16 | 2024-03-21 | 丸善製薬株式会社 | 脳の機能改善剤及び脳の機能改善用組成物 |
| CN116350653A (zh) * | 2023-02-21 | 2023-06-30 | 江南大学 | 肝素及其盐在靶向调节肠道菌群代谢物中的应用 |
| WO2025100480A1 (ja) * | 2023-11-08 | 2025-05-15 | 慶應義塾 | 組成物、飲食品、及び病原性細菌又は病原性真菌に起因する疾患の検査及び診断を補助する方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61224984A (ja) * | 1985-03-30 | 1986-10-06 | Taki Chem Co Ltd | ビフィドバクテリウム属細菌の増殖剤 |
| JPS6379586A (ja) * | 1986-09-24 | 1988-04-09 | Taki Chem Co Ltd | ビフイドバクテリウム属細菌の増殖剤 |
| JP4997365B1 (ja) | 2011-10-04 | 2012-08-08 | ケミ・コム・ジャパン株式会社 | 塩味増強剤による塩味増強法及び食塩含有飲食品の減塩方法 |
| KR20170017176A (ko) * | 2015-08-05 | 2017-02-15 | (주)아모레퍼시픽 | 장 내 유산균 증가용 조성물 및 이를 이용한 유산균 생산 방법 |
| BR112018076609B1 (pt) | 2016-12-15 | 2023-02-14 | Société des Produits Nestlé S.A. | Composição alimentícia para animais de estimação, seus usos, e métodos não terapêutico para modular a quantidade e para medição de uma alteração na quantidade de pelo menos uma dentre bifidobacterium, lactobacillus ou clostridium perfringens |
-
2020
- 2020-02-28 WO PCT/JP2020/008457 patent/WO2020175690A1/ja not_active Ceased
- 2020-02-28 EP EP20762963.5A patent/EP3932484A4/en active Pending
- 2020-02-28 US US17/433,755 patent/US12239619B2/en active Active
- 2020-02-28 JP JP2021502657A patent/JP7302797B2/ja active Active
- 2020-02-28 CN CN202410180043.6A patent/CN118178372A/zh active Pending
- 2020-02-28 CN CN202080017273.0A patent/CN113518645A/zh active Pending
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