JPWO2020161217A5 - - Google Patents
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- JPWO2020161217A5 JPWO2020161217A5 JP2021545897A JP2021545897A JPWO2020161217A5 JP WO2020161217 A5 JPWO2020161217 A5 JP WO2020161217A5 JP 2021545897 A JP2021545897 A JP 2021545897A JP 2021545897 A JP2021545897 A JP 2021545897A JP WO2020161217 A5 JPWO2020161217 A5 JP WO2020161217A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- liver
- constipation
- cholestasis
- syndrome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 206010010774 Constipation Diseases 0.000 claims 16
- 210000004185 Liver Anatomy 0.000 claims 9
- 206010008635 Cholestasis Diseases 0.000 claims 7
- 239000003613 bile acid Substances 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 231100000359 cholestasis Toxicity 0.000 claims 6
- 201000001493 benign recurrent intrahepatic cholestasis Diseases 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 201000009673 liver disease Diseases 0.000 claims 5
- 208000004624 progressive familial intrahepatic 1 Cholestasis Diseases 0.000 claims 5
- 201000002150 progressive familial intrahepatic cholestasis Diseases 0.000 claims 5
- 206010012601 Diabetes mellitus Diseases 0.000 claims 4
- 208000002551 Irritable Bowel Syndrome Diseases 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 208000004622 Abetalipoproteinemia Diseases 0.000 claims 3
- 210000000941 Bile Anatomy 0.000 claims 3
- 206010010356 Congenital anomaly Diseases 0.000 claims 3
- 206010016654 Fibrosis Diseases 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000004761 fibrosis Effects 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 201000010874 syndrome Diseases 0.000 claims 3
- 238000003786 synthesis reaction Methods 0.000 claims 3
- 230000002194 synthesizing Effects 0.000 claims 3
- 206010003210 Arteriosclerosis Diseases 0.000 claims 2
- 210000000013 Bile Ducts Anatomy 0.000 claims 2
- 206010007554 Cardiac failure Diseases 0.000 claims 2
- 208000008787 Cardiovascular Disease Diseases 0.000 claims 2
- 208000003167 Cholangitis Diseases 0.000 claims 2
- 206010008609 Cholangitis sclerosing Diseases 0.000 claims 2
- 206010072268 Drug-induced liver injury Diseases 0.000 claims 2
- 208000010008 Familial Hypobetalipoproteinemia Diseases 0.000 claims 2
- 208000008665 Gastrointestinal Disease Diseases 0.000 claims 2
- 206010019280 Heart failure Diseases 0.000 claims 2
- 206010019708 Hepatic steatosis Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 206010021972 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000001024 Intrahepatic Cholestasis Diseases 0.000 claims 2
- 201000005099 Langerhans-cell histiocytosis Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000008338 Non-alcoholic Fatty Liver Disease Diseases 0.000 claims 2
- 206010053219 Non-alcoholic steatohepatitis Diseases 0.000 claims 2
- 108009000135 Nonalcoholic fatty liver disease Proteins 0.000 claims 2
- 206010033645 Pancreatitis Diseases 0.000 claims 2
- 206010074151 Parenteral nutrition associated liver disease Diseases 0.000 claims 2
- 208000003251 Pruritus Diseases 0.000 claims 2
- 210000002966 Serum Anatomy 0.000 claims 2
- 201000001883 cholelithiasis Diseases 0.000 claims 2
- 230000001684 chronic Effects 0.000 claims 2
- 201000003662 chylomicron retention disease Diseases 0.000 claims 2
- 231100000595 drug-induced hepatitis Toxicity 0.000 claims 2
- 229940079593 drugs Drugs 0.000 claims 2
- 230000004129 fatty acid metabolism Effects 0.000 claims 2
- 201000002146 gastrointestinal system disease Diseases 0.000 claims 2
- 201000004408 hypobetalipoproteinemia Diseases 0.000 claims 2
- 230000035935 pregnancy Effects 0.000 claims 2
- 201000000742 primary sclerosing cholangitis Diseases 0.000 claims 2
- 231100000240 steatosis hepatitis Toxicity 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 102100006243 ABCB11 Human genes 0.000 claims 1
- 101710025669 ABCB11 Proteins 0.000 claims 1
- 102100014002 ABCB4 Human genes 0.000 claims 1
- 101700085131 ABCB4 Proteins 0.000 claims 1
- 201000001563 Aagenaes syndrome Diseases 0.000 claims 1
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims 1
- 208000002353 Alcoholic Hepatitis Diseases 0.000 claims 1
- 206010002022 Amyloidosis Diseases 0.000 claims 1
- 206010002023 Amyloidosis Diseases 0.000 claims 1
- 206010002388 Angina unstable Diseases 0.000 claims 1
- 206010003658 Atrial fibrillation Diseases 0.000 claims 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
- 201000011497 Barrett's esophagus Diseases 0.000 claims 1
- 206010004137 Barrett's oesophagus Diseases 0.000 claims 1
- 208000006766 Bile Reflux Diseases 0.000 claims 1
- 206010004637 Bile duct stone Diseases 0.000 claims 1
- 210000003445 Biliary Tract Anatomy 0.000 claims 1
- 230000035639 Blood Levels Effects 0.000 claims 1
- 102100009546 CYP27A1 Human genes 0.000 claims 1
- 101710036518 CYP27A1 Proteins 0.000 claims 1
- 208000005846 Cardiomyopathy Diseases 0.000 claims 1
- 208000002177 Cataract Diseases 0.000 claims 1
- 206010053684 Cerebrohepatorenal syndrome Diseases 0.000 claims 1
- 208000001088 Cerebrotendinous Xanthomatosis Diseases 0.000 claims 1
- 208000006990 Cholangiocarcinoma Diseases 0.000 claims 1
- 206010010317 Congenital absence of bile ducts Diseases 0.000 claims 1
- OMFXVFTZEKFJBZ-HJTSIMOOSA-N Corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 claims 1
- 206010011401 Crohn's disease Diseases 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 208000008960 Diabetic Foot Diseases 0.000 claims 1
- 201000010374 Down syndrome Diseases 0.000 claims 1
- 206010058108 Dyslipidaemia Diseases 0.000 claims 1
- 208000006881 Esophagitis Diseases 0.000 claims 1
- 208000009866 Extrahepatic Cholestasis Diseases 0.000 claims 1
- 208000004930 Fatty Liver Diseases 0.000 claims 1
- 108060003412 GRP Proteins 0.000 claims 1
- 208000001130 Gallstone Diseases 0.000 claims 1
- 108009000020 Glucose Homeostasis Proteins 0.000 claims 1
- 102000015779 HDL Lipoproteins Human genes 0.000 claims 1
- 206010003820 Hepatic autoimmune disease Diseases 0.000 claims 1
- 208000006454 Hepatitis Diseases 0.000 claims 1
- 208000005252 Hepatitis A Diseases 0.000 claims 1
- 208000002672 Hepatitis B Diseases 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 208000005331 Hepatitis D Diseases 0.000 claims 1
- 206010019728 Hepatitis alcoholic Diseases 0.000 claims 1
- 206010019799 Hepatitis viral Diseases 0.000 claims 1
- 208000009576 Hypercholesterolemia Diseases 0.000 claims 1
- 206010060378 Hyperinsulinaemia Diseases 0.000 claims 1
- 206010062060 Hyperlipidaemia Diseases 0.000 claims 1
- 208000006575 Hypertriglyceridemia Diseases 0.000 claims 1
- 206010020914 Hypervitaminosis Diseases 0.000 claims 1
- 206010020915 Hypervitaminosis Diseases 0.000 claims 1
- 102000018358 Immunoglobulins Human genes 0.000 claims 1
- 108060003951 Immunoglobulins Proteins 0.000 claims 1
- 206010022489 Insulin resistance Diseases 0.000 claims 1
- 206010061255 Ischaemia Diseases 0.000 claims 1
- 206010023126 Jaundice Diseases 0.000 claims 1
- 208000001083 Kidney Disease Diseases 0.000 claims 1
- 206010061227 Lipid metabolism disease Diseases 0.000 claims 1
- 206010054805 Macroangiopathy Diseases 0.000 claims 1
- 208000008466 Metabolic Disease Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 206010028289 Muscle atrophy Diseases 0.000 claims 1
- 210000002027 Muscle, Skeletal Anatomy 0.000 claims 1
- 208000010125 Myocardial Infarction Diseases 0.000 claims 1
- 206010051606 Necrotising colitis Diseases 0.000 claims 1
- 208000004995 Necrotizing Enterocolitis Diseases 0.000 claims 1
- 206010029149 Nephropathy Diseases 0.000 claims 1
- 206010029151 Nephropathy Diseases 0.000 claims 1
- 206010029331 Neuropathy peripheral Diseases 0.000 claims 1
- 208000010333 North American Indian Childhood Cirrhosis Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010030216 Oesophagitis Diseases 0.000 claims 1
- 208000002865 Osteopetrosis Diseases 0.000 claims 1
- 210000000496 Pancreas Anatomy 0.000 claims 1
- 206010061536 Parkinson's disease Diseases 0.000 claims 1
- 206010062585 Peripheral arterial occlusive disease Diseases 0.000 claims 1
- 206010063985 Phytosterolaemia Diseases 0.000 claims 1
- 208000007232 Portal Hypertension Diseases 0.000 claims 1
- 208000000876 Primary Bile Acid Malabsorption Diseases 0.000 claims 1
- 206010057969 Reflux gastritis Diseases 0.000 claims 1
- 206010038435 Renal failure Diseases 0.000 claims 1
- 206010038444 Renal failure chronic Diseases 0.000 claims 1
- 206010061481 Renal injury Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 206010038932 Retinopathy Diseases 0.000 claims 1
- 101710017705 SUCLG1 Proteins 0.000 claims 1
- 208000002227 Sitosterolemia Diseases 0.000 claims 1
- 208000007718 Stable Angina Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 206010044688 Trisomy 21 Diseases 0.000 claims 1
- 101700075834 UTP4 Proteins 0.000 claims 1
- 102100013268 UTP4 Human genes 0.000 claims 1
- 208000007814 Unstable Angina Diseases 0.000 claims 1
- 201000004525 Zellweger syndrome Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 230000001058 adult Effects 0.000 claims 1
- 201000001320 atherosclerosis Diseases 0.000 claims 1
- 230000003190 augmentative Effects 0.000 claims 1
- 201000001490 benign recurrent intrahepatic cholestasis 1 Diseases 0.000 claims 1
- 201000001488 benign recurrent intrahepatic cholestasis 2 Diseases 0.000 claims 1
- 201000005271 biliary atresia Diseases 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 201000008031 cardiomyopathy Diseases 0.000 claims 1
- 201000009331 choledocholithiasis Diseases 0.000 claims 1
- 201000000522 chronic kidney disease Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 201000003883 cystic fibrosis Diseases 0.000 claims 1
- 230000003111 delayed Effects 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 201000010870 diseases of metabolism Diseases 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 230000002496 gastric Effects 0.000 claims 1
- 230000001434 glomerular Effects 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 230000014101 glucose homeostasis Effects 0.000 claims 1
- 230000002440 hepatic Effects 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 201000010284 hepatitis E Diseases 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 230000003451 hyperinsulinaemic Effects 0.000 claims 1
- 201000008980 hyperinsulinism Diseases 0.000 claims 1
- 230000001771 impaired Effects 0.000 claims 1
- 201000002450 inherited metabolic disease Diseases 0.000 claims 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 1
- 201000002161 intrahepatic cholestasis of pregnancy Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 201000004044 liver cirrhosis Diseases 0.000 claims 1
- 200000000011 liver disorder Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 201000000585 muscular atrophy Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 230000000414 obstructive Effects 0.000 claims 1
- 201000006195 perinatal necrotizing enterocolitis Diseases 0.000 claims 1
- 230000000750 progressive Effects 0.000 claims 1
- 238000010992 reflux Methods 0.000 claims 1
- 200000000008 restenosis Diseases 0.000 claims 1
- 230000033764 rhythmic process Effects 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 201000009594 systemic scleroderma Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 201000001862 viral hepatitis Diseases 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
Claims (5)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN201911004690 | 2019-02-06 | ||
IN201911004690 | 2019-02-06 | ||
SE1950464 | 2019-04-12 | ||
SE1950464-6 | 2019-04-12 | ||
IN201911049981 | 2019-12-04 | ||
IN201911049981 | 2019-12-04 | ||
PCT/EP2020/052942 WO2020161217A1 (en) | 2019-02-06 | 2020-02-06 | Benzothiadiazepine compounds and their use as bile acid modulators |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2022519370A JP2022519370A (en) | 2022-03-23 |
JPWO2020161217A5 true JPWO2020161217A5 (en) | 2023-02-01 |
JP7504109B2 JP7504109B2 (en) | 2024-06-21 |
Family
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