JPWO2020161099A5 - - Google Patents
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- JPWO2020161099A5 JPWO2020161099A5 JP2021545766A JP2021545766A JPWO2020161099A5 JP WO2020161099 A5 JPWO2020161099 A5 JP WO2020161099A5 JP 2021545766 A JP2021545766 A JP 2021545766A JP 2021545766 A JP2021545766 A JP 2021545766A JP WO2020161099 A5 JPWO2020161099 A5 JP WO2020161099A5
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- 239000000523 sample Substances 0.000 claims 41
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 15
- 239000008103 glucose Substances 0.000 claims 15
- 238000000034 method Methods 0.000 claims 12
- 238000005259 measurement Methods 0.000 claims 4
- 238000012544 monitoring process Methods 0.000 claims 3
- 238000004590 computer program Methods 0.000 claims 2
- 238000004364 calculation method Methods 0.000 claims 1
- 210000003722 extracellular fluid Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 238000005070 sampling Methods 0.000 claims 1
Claims (15)
センサと、メモリと、プロセッサとを含むCGMデバイスを提供するステップと、
前記センサに定電圧電位を印加し、前記定電圧電位から結果として生じる一次電流信号を測定し、測定された一次電流信号を前記メモリ内に記憶するステップと、
一次電流信号の測定間で、前記センサに精査電位変調シーケンスを適用し、前記精査電位変調シーケンスから結果として生じる精査電位変調電流信号を測定し、測定された精査電位変調電流信号を前記メモリ内に記憶するステップと、
各一次電流信号について、グルコース値を決定するために、前記一次電流信号と、前記一次電流信号に関連する複数の前記測定された精査電位変調電流信号とを用いるステップと
を含み、
前記グルコース値の決定が、
前記精査電位変調シーケンスの電位ステップ内の測定された第１の精査電位変調電流によって除算された、測定された終期精査電位変調電流、
前記精査電位変調シーケンスの、より前の電位ステップの測定された終期精査電位変調電流によって除算された、より後の電位ステップの測定された終期精査電位変調電流、
前記精査電位変調シーケンスの、より前の電位ステップの測定された第１の精査電位変調電流によって除算された、より後の電位ステップの測定された終期精査電位変調電流、及び
前記精査電位変調シーケンスの、より前の電位ステップの測定された終期精査電位変調電流によって除算された、より後の電位ステップの測定された第１の精査電位変調電流、
の少なくとも１つを計算することを含む、方法。 A method of compensating for errors during continuous glucose monitoring (CGM) measurements, comprising:
providing a CGM device including a sensor, a memory, and a processor;
applying a constant voltage potential to the sensor, measuring a primary current signal resulting from the constant voltage potential, and storing the measured primary current signal in the memory;
between measurements of the primary current signal, applying a probe potential modulation sequence to the sensor, measuring a probe potential modulated current signal resulting from the probe potential modulation sequence, and storing the measured probe potential modulated current signal in the memory. a step of memorizing;
using the primary current signal and a plurality of the measured probe potential modulated current signals associated with the primary current signal to determine a glucose level for each primary current signal ;
Determining the glucose level comprises:
a measured terminal probing potential-modulated current divided by a measured first probing potential-modulated current in a potential step of said probing potential-modulated sequence;
a measured end probe potential modulation current of a later potential step divided by a measured end probe potential modulation current of an earlier potential step of the probe potential modulation sequence;
a measured final probe potential modulation current of a later potential step divided by a measured first probe potential modulation current of an earlier potential step of the probe potential modulation sequence; and
a measured first probe potential modulation current of a later potential step divided by a measured terminal probe potential modulation current of an earlier potential step of said probe potential modulation sequence;
A method comprising calculating at least one of
一次電流信号が参照CGMセンサについて測定される前または後に、前記参照CGMセンサに適用される精査電位変調シーケンスに応答して前記参照CGMセンサについて測定された複数の精査電位変調電流信号に基づいて予測式を作成するステップと、
センサと、メモリと、プロセッサとを含むCGMデバイスを提供するステップと、
前記予測式を前記CGMデバイスの前記メモリ内に記憶するステップと、
前記プロセッサによって実行されると、前記CGMデバイスに、
定電圧電位を前記センサに印加させ、前記定電圧電位から結果として生じる一次電流信号を測定させ、測定された一次電流信号を前記メモリ内に記憶させることと、
一次電流信号の測定間で、精査電位変調シーケンスを前記センサに適用させ、前記精査電位変調シーケンスから結果として生じる精査電位変調電流信号を測定させ、測定された精査電位変調電流信号を前記メモリ内に記憶させることと、
各一次電流信号について、グルコース値を決定するために、前記一次電流信号と、前記一次電流信号に関連する複数の前記測定された精査電位変調電流信号と、前記記憶された予測式とを使用させることであって、前記グルコース値の決定が、
前記精査電位変調シーケンスの電位ステップ内の測定された第１の精査電位変調電流によって除算された、測定された終期精査電位変調電流、
前記精査電位変調シーケンスの、より前の電位ステップの測定された終期精査電位変調電流によって除算された、より後の電位ステップの測定された終期精査電位変調電流、
前記精査電位変調シーケンスの、より前の電位ステップの測定された第１の精査電位変調電流によって除算された、より後の電位ステップの測定された終期精査電位変調電流、及び
前記精査電位変調シーケンスの、より前の電位ステップの測定された終期精査電位変調電流によって除算された、より後の電位ステップの測定された第１の精査電位変調電流、
の少なくとも１つを計算することを含む、使用させることと、
決定されたグルコース値を前記CGMデバイスのユーザに伝達させることと、を行わせる、
コンピュータプログラムコードを前記CGMデバイスの前記メモリ内に記憶するステップと
を含む方法。 A method of making a continuous glucose monitoring (CGM) device, comprising:
prediction based on a plurality of probe potential modulated current signals measured about the reference CGM sensor in response to a probe potential modulation sequence applied to the reference CGM sensor before or after the primary current signal is measured about the reference CGM sensor; creating an expression;
providing a CGM device including a sensor, a memory, and a processor;
storing the prediction formula in the memory of the CGM device;
When executed by the processor, the CGM device will:
applying a constant voltage potential to the sensor, measuring a primary current signal resulting from the constant voltage potential, and storing the measured primary current signal in the memory;
between measurements of the primary current signal, applying a probe potential modulation sequence to the sensor, measuring a probe potential modulated current signal resulting from the probe potential modulation sequence, and storing the measured probe potential modulated current signal in the memory. to remember and
for each primary current signal, using said primary current signal, said plurality of said measured probe potential modulated current signals associated with said primary current signal, and said stored prediction formula to determine a glucose level; wherein the determination of the glucose level comprises:
a measured terminal probing potential-modulated current divided by a measured first probing potential-modulated current in a potential step of said probing potential-modulated sequence;
a measured end probe potential modulation current of a later potential step divided by a measured end probe potential modulation current of an earlier potential step of the probe potential modulation sequence;
a measured final probe potential modulation current of a later potential step divided by a measured first probe potential modulation current of an earlier potential step of the probe potential modulation sequence; and
a measured first probe potential modulation current of a later potential step divided by a measured terminal probe potential modulation current of an earlier potential step of said probe potential modulation sequence;
causing to use, including calculating at least one of
causing the determined glucose value to be communicated to a user of the CGM device;
storing computer program code in said memory of said CGM device.
間質液から電流信号を生成するように構成されたセンサと、
プロセッサと、
前記プロセッサに結合されたメモリと、
前記プロセッサに結合されたトランスミッタ回路と
を有するウェアラブル部分を備え、
前記メモリが、参照センサに印加された定電圧電位の印加によって生成された一次電流信号と、一次電流信号測定間で適用された精査電位変調シーケンスの適用によって生成された複数の精査電位変調電流信号とに基づく予測式を含み、
前記メモリが、前記プロセッサによって実行されると、前記CGMデバイスに、
前記センサと前記ウェアラブル部分のメモリとを使用して一次電流信号を測定および記憶させることと、
前記一次電流信号に関連する複数の精査電位変調電流信号を測定および記憶させることと、
グルコース値を計算するために、前記一次電流信号と、前記複数の精査電位変調電流信号と、前記記憶された予測式とを使用させることであって、前記グルコース値の計算が、
前記精査電位変調シーケンスの電位ステップ内の測定された第１の精査電位変調電流によって除算された、測定された終期精査電位変調電流、
前記精査電位変調シーケンスの、より前の電位ステップの測定された終期精査電位変調電流によって除算された、より後の電位ステップの測定された終期精査電位変調電流、
前記精査電位変調シーケンスの、より前の電位ステップの測定された第１の精査電位変調電流によって除算された、より後の電位ステップの測定された終期精査電位変調電流、及び
前記精査電位変調シーケンスの、より前の電位ステップの測定された終期精査電位変調電流によって除算された、より後の電位ステップの測定された第１の精査電位変調電流、
の少なくとも１つを計算することを含む、使用させることと、
前記グルコース値を前記CGMデバイスのユーザに伝達させることと、を行わせる、
その中に記憶されたコンピュータプログラムコードを含む、
CGMデバイス。 A continuous glucose monitoring (CGM) device comprising:
a sensor configured to generate a current signal from interstitial fluid;
a processor;
a memory coupled to the processor;
a transmitter circuit coupled to the processor; and a wearable portion having:
The memory stores a primary current signal generated by application of a constant voltage potential applied to a reference sensor and a plurality of probe potential modulated current signals produced by application of a probe potential modulation sequence applied between primary current signal measurements. contains a prediction formula based on and
When the memory is executed by the processor, the CGM device:
measuring and storing a primary current signal using the sensor and memory of the wearable portion;
measuring and storing a plurality of probing potential modulated current signals associated with the primary current signal;
using the primary current signal, the plurality of probing potential-modulated current signals, and the stored prediction formula to calculate a glucose level, wherein the calculation of the glucose level comprises:
a measured terminal probing potential-modulated current divided by a measured first probing potential-modulated current in a potential step of said probing potential-modulated sequence;
a measured end probe potential modulation current of a later potential step divided by a measured end probe potential modulation current of an earlier potential step of the probe potential modulation sequence;
a measured final probe potential modulation current of a later potential step divided by a measured first probe potential modulation current of an earlier potential step of the probe potential modulation sequence; and
a measured first probe potential modulation current of a later potential step divided by a measured terminal probe potential modulation current of an earlier potential step of said probe potential modulation sequence;
causing to use, including calculating at least one of
causing the glucose value to be communicated to a user of the CGM device;
including computer program code stored therein,
CGM device.
前記センサに結合され、前記センサによって生成された電流信号を測定するように構成された電流感知回路と、
前記電流感知回路に結合され、前記測定された電流信号からデジタル化された電流信号を生成するように構成されたサンプリング回路と
を含む、請求項１３に記載のCGMデバイス。 The wearable portion is
a current sensing circuit coupled to the sensor and configured to measure a current signal produced by the sensor;
and a sampling circuit coupled to the current sensing circuit and configured to generate a digitized current signal from the measured current signal.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962801592P | 2019-02-05 | 2019-02-05 | |
| US62/801,592 | 2019-02-05 | ||
| PCT/EP2020/052673 WO2020161099A1 (en) | 2019-02-05 | 2020-02-04 | Apparatus and methods for probing sensor operation of continuous analyte sensing and auto-calibration |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022519854A JP2022519854A (en) | 2022-03-25 |
| JPWO2020161099A5 true JPWO2020161099A5 (en) | 2023-02-09 |
| JP7494194B2 JP7494194B2 (en) | 2024-06-03 |
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| JP2021545766A Active JP7494194B2 (en) | 2019-02-05 | 2020-02-04 | Apparatus and method for probing sensor operation for continuous analyte sensing and automatic calibration - Patents.com |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11547330B2 (en) |
| EP (1) | EP3920798A1 (en) |
| JP (1) | JP7494194B2 (en) |
| CN (1) | CN113490454A (en) |
| TW (1) | TWI839458B (en) |
| WO (1) | WO2020161099A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US11950904B2 (en) | 2020-08-04 | 2024-04-09 | Ascensia Diabetes Care Holdings Ag | Non-steady-state determination of analyte concentration for continuous glucose monitoring by potential modulation |
| US20220395199A1 (en) * | 2021-06-11 | 2022-12-15 | Medtronic Minimed, Inc. | Adjustable glucose sensor initialization sequences |
| CN115877009A (en) * | 2021-09-29 | 2023-03-31 | 苏州睿感医疗科技有限公司 | Continuous blood glucose correction method and device and electronic equipment |
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- 2020-02-04 JP JP2021545766A patent/JP7494194B2/en active Active
- 2020-02-04 WO PCT/EP2020/052673 patent/WO2020161099A1/en unknown
- 2020-02-05 TW TW109103528A patent/TWI839458B/en active
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- 2020-02-05 US US16/782,974 patent/US11737688B2/en active Active
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