CN115877009A - Continuous blood glucose correction method and device and electronic equipment - Google Patents

Continuous blood glucose correction method and device and electronic equipment Download PDF

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Publication number
CN115877009A
CN115877009A CN202111148201.2A CN202111148201A CN115877009A CN 115877009 A CN115877009 A CN 115877009A CN 202111148201 A CN202111148201 A CN 202111148201A CN 115877009 A CN115877009 A CN 115877009A
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state
sensor
output current
steady
corrected
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请求不公布姓名
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Suzhou Ruigan Medical Technology Co ltd
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Suzhou Ruigan Medical Technology Co ltd
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Priority to CN202111148201.2A priority Critical patent/CN115877009A/en
Priority to PCT/CN2022/113237 priority patent/WO2023051075A1/en
Publication of CN115877009A publication Critical patent/CN115877009A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1495—Calibrating or testing of in-vivo probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose

Abstract

The application provides a continuous blood glucose correction method, a continuous blood glucose correction device and electronic equipment, and relates to the field of medical science and technology. Wherein, the continuous blood sugar correction method comprises the following steps: firstly, the transient output current and the steady output current of the sensor can be respectively collected according to a set correction period. Then, the sensitivity coefficient of the sensor can be determined according to the current value and the variation characteristic of the transient output current. Finally, the steady state output current can be corrected according to the sensitivity coefficient, and the blood glucose value can be determined based on the corrected steady state output current. Therefore, automatic correction of blood sugar can be realized, and continuous blood sugar correction efficiency is improved.

Description

Continuous blood glucose correction method and device and electronic equipment
[ technical field ] A method for producing a semiconductor device
The application relates to the field of medical science and technology, in particular to a continuous blood glucose correction method, a continuous blood glucose correction device and electronic equipment.
[ background ] A method for producing a semiconductor device
Continuous Glucose Monitoring (CGM) systems contact Glucose in interstitial fluid through a subcutaneous sensor, and when the voltage applied to the sensor reaches a predetermined level, a Glucose redox reaction is induced, which in turn converts chemical signals into electrical signals and generates a detection current. The detection current may be further converted to a blood glucose value based on the correlation of interstitial fluid glucose level to blood glucose level.
However, the detection accuracy of CGM is affected by the performance of the sensor, which deteriorates with the lapse of time. Therefore, it is necessary to periodically correct the blood glucose detection result of CGM to ensure the detection accuracy of CGM in the case where the sensor performance is degraded. The currently common calibration method is to collect the blood of a patient at regular time for detection, and then input the detected blood sugar value into the CGM as a calibration value. However, this method is very painful and difficult to achieve high frequency correction; moreover, manual blood sampling detection and manual input of correction values into the CGM are required, so that the operation is inconvenient.
[ summary of the invention ]
The embodiment of the application provides a continuous blood sugar correction method and device and electronic equipment, which can realize automatic blood sugar correction and improve the continuous blood sugar correction efficiency.
In a first aspect, an embodiment of the present application provides a continuous blood glucose correction method, including: respectively collecting transient output current and steady output current of a sensor according to a set correction period; determining the sensitivity coefficient of the sensor according to the current value and the change characteristic of the transient output current; and correcting the steady-state output current according to the sensitivity coefficient, and determining the blood sugar value based on the corrected steady-state output current.
In one possible implementation, the transient output current is output when a transient voltage is applied to the sensor, and the steady-state output current is output when a steady-state voltage is applied to the sensor; wherein the voltage value of the transient voltage varies with time and the voltage waveform of the transient voltage comprises any one or combination of: a square wave; pulse waves; triangular waves; a step wave; a trapezoidal wave; a linear wave; a white noise wave; a sine wave.
In one possible implementation manner, the correcting the steady-state output current according to the sensitivity coefficient includes: correcting the original comprehensive state parameters of the sensor according to the sensitivity coefficient; and correcting the steady-state output current of the sensor by using the corrected comprehensive state parameters.
In one possible implementation manner, the correcting the original comprehensive state parameter of the sensor according to the sensitivity coefficient includes: detecting the human body temperature in the current test environment; determining a state correction value according to the human body temperature and the sensitivity coefficient; and correcting the original comprehensive state parameters of the sensor by using the state correction value.
In one possible implementation, the correcting the steady-state output current of the sensor by using the corrected comprehensive state parameter includes: determining a change rate between the corrected comprehensive state parameter and the original comprehensive state parameter; and determining that the sensor is in an attenuation state according to the change rate and the parameter value of the corrected comprehensive state parameter, and correcting the steady-state output current of the sensor by using the corrected comprehensive state parameter.
In one possible implementation manner, determining that the sensor is in the attenuation state according to the change rate and the corrected parameter value of the integrated state parameter includes: and if the change rate is in a first threshold interval and the corrected comprehensive state parameter is smaller than a second threshold interval, the sensor is in an attenuation state.
In a second aspect, an embodiment of the present application provides a continuous blood glucose correction device, including: the acquisition module is used for respectively acquiring transient output current and steady output current of the sensor according to a set correction period; the determining module is used for determining a sensitivity coefficient of the sensor according to the current value and the change characteristic of the transient output current; and the execution module is used for correcting the steady-state output current according to the sensitivity coefficient and determining the blood sugar value based on the corrected steady-state output current.
In a third aspect, an embodiment of the present application provides an electronic device, including: at least one processor; and at least one memory communicatively coupled to the processor, wherein: the memory stores program instructions executable by the processor, the processor being capable of performing the method of the first aspect when invoked by the processor.
In a fourth aspect, embodiments of the present application provide a computer-readable storage medium storing computer instructions for causing a computer to perform the method according to the first aspect.
In the above technical solution, firstly, the transient output current and the steady-state output current of the sensor can be respectively collected according to a set correction period. Then, the sensitivity coefficient of the sensor can be determined according to the current value and the variation characteristic of the transient output current. Finally, the steady state output current can be corrected according to the sensitivity coefficient, and the blood glucose value can be determined based on the corrected steady state output current. Therefore, automatic correction of blood sugar can be realized, and continuous blood sugar correction efficiency is improved.
[ description of the drawings ]
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
FIG. 1 is a flowchart of a continuous glucose correction method according to an embodiment of the present disclosure;
FIG. 2 is a voltage diagram of a continuous glucose correction method according to an embodiment of the present disclosure;
FIG. 3 is a schematic current diagram illustrating a continuous glucose correction method according to an embodiment of the present disclosure;
FIG. 4 is a graph illustrating a variation of a sensor integrated state parameter according to an embodiment of the present disclosure;
FIG. 5 is a schematic structural diagram of a continuous glucose calibration device according to an embodiment of the present disclosure;
fig. 6 is a schematic structural diagram of an electronic device according to an embodiment of the present application.
[ detailed description ] A
For better understanding of the technical solutions of the present application, the following detailed descriptions of the embodiments of the present application are provided with reference to the accompanying drawings.
It should be understood that the embodiments described are only a few embodiments of the present application, and not all embodiments. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without making any creative effort belong to the protection scope of the present application.
The terminology used in the embodiments of the present application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used in the examples of this application and the appended claims, the singular forms "a", "an", and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.
Embodiments of the present application may provide a continuous blood glucose correction apparatus, which may be used to perform the continuous blood glucose correction method provided by the embodiments of the present application. The continuous blood glucose correction device may be any continuous blood glucose monitoring device, which is not limited in this application.
Fig. 1 is a flowchart of a continuous blood glucose calibration method according to an embodiment of the present disclosure, and as shown in fig. 1, the continuous blood glucose calibration method may include:
step 101, respectively collecting transient output current and steady output current of the sensor according to a set correction period.
Continuous blood glucose monitoring devices generally include three main components, a sensor, a transmitter, and a receiver. Wherein the sensor is typically placed subcutaneously in contact with glucose in interstitial fluid. After the continuous blood sugar monitoring equipment is powered on, a preset voltage can be applied to the sensor, so that the redox reaction of glucose in interstitial fluid can be caused, and an electric signal can be generated. Further, the generated electrical signal may be received by a transmitter and transmitted to a receiver by means of bluetooth communication or the like. The receiver may be based on algorithmic principles to convert the received electrical signals into blood glucose values for display.
In the embodiment of the application, the blood glucose monitoring device can comprise two stages, namely a transient voltage stage and a steady voltage stage when voltage is applied to the sensor in each operation process. The duration of the two phases may be the same, and may be, for example, 140 seconds.
The voltage applied in the transient voltage stage is a variable voltage, and the voltage value of the variable voltage varies with time, and for example, the voltage waveform of the transient voltage may be any one or a combination of more of a square wave, a pulse wave, a triangular wave, a step wave, a trapezoidal wave, a linear wave, a white noise wave, a sine wave, and the like.
Accordingly, the voltage applied in the steady-state voltage phase is a stable voltage having a voltage value equal to a predetermined voltage value required for the oxidation (reduction) reaction of glucose. Thus, during the steady-state voltage phase, the redox reaction of glucose in interstitial fluid is mainly initiated. In practical implementation, the preset voltage value may be 0.3-0.6V.
For ease of understanding, FIG. 2 shows one possible implementation of applying a voltage to the sensor. As shown in fig. 2, the triangular wave voltage corresponds to a transient process, and the constant voltage of 0.5V corresponds to a steady-state process. V tn-2 、V tn The peak voltage value and the trough voltage value before the steady state process are respectively, and the values in the figure are respectively 0.7V and 0.2V. It should be noted that fig. 2 is only an exemplary implementation and is not intended to limit the embodiments of the present application.
Based on the above description, the embodiments of the present application may respectively collect the output currents in the transient voltage phase and the steady voltage phase, that is, the transient output current and the steady output current, according to the set correction period. It is understood that the transient output current is the current value generated by the transient voltage phase redox reaction, and the steady state output current is the current value generated by the steady state voltage phase redox reaction. The period duration of the set correction period may be set according to actual needs, and may be 5 minutes, for example.
For ease of understanding, fig. 3 provides a possible schematic diagram of the output current. The output current shown in fig. 3 corresponds to the applied voltage of fig. 2. As shown in FIG. 3, I s Representing steady state output current, I tn-2 Indicating the peak voltage value V tn-2 Corresponding transient output current, I tn Indicating the above-mentioned trough voltage value V tn The corresponding transient output current.
And 102, determining the sensitivity coefficient of the sensor according to the current value and the change characteristic of the transient output current.
During normal use of the sensor, due to the influence of various factors (aging of sensor components, fluctuation of human body environment, attenuation of reactive enzyme and the like), the sensitivity and the performance of the sensor are attenuated to different degrees along with the prolonging of the use time. Based on the attenuation of the sensitivity and performance of the sensor, the transient output current and the steady output current fluctuate with the prolonging of the service time of the sensor, thereby influencing the blood sugar detection precision.
Based on the above description, the embodiment of the application may learn the current value and the change characteristic of the transient output current to obtain the corresponding relationship between the current value and the change characteristic of the transient output current and the sensitivity coefficient of the sensor. Thus, the sensitivity coefficient of the sensor can be determined according to the current value and the variation characteristic of the transient output current.
And 103, correcting the steady-state output current according to the sensitivity coefficient, and determining the blood sugar value based on the corrected steady-state output current.
In the embodiment of the application, firstly, the original comprehensive state parameters of the sensor can be corrected according to the sensitivity coefficient.
Considering the influence of the human body temperature on the monitoring precision, the embodiment of the application can detect the human body temperature in the current testing environment through the temperature sensor. Then, the state correction value may be determined according to the human body temperature and the sensitivity coefficient.
After the state correction value is determined, the original comprehensive state parameter of the sensor can be corrected by using the state correction value, so that the comprehensive state parameter of the sensor in the current testing environment is obtained.
Wherein, the original comprehensive state parameter refers to the comprehensive state parameter before the current continuous blood sugar correction operation is executed. Particularly, in the case where the current continuous blood glucose correction operation is the first continuous blood glucose correction operation, the original integrated state parameter is equal to the standard value of the sensor input when the device is shipped.
The steady state output current of the sensor can then be corrected using the corrected integrated state parameters, and the blood glucose value determined based on the corrected steady state output current.
In the embodiment of the application, the change rate between the corrected comprehensive state parameter and the original comprehensive state parameter can be determined.
Further, after the sensor is determined to be in the attenuation state according to the change rate and the corrected parameter value of the comprehensive state parameter, the corrected comprehensive state parameter can be used for correcting the steady-state output current of the sensor.
Specifically, if the change rate is in a first threshold interval and the corrected integrated state parameter is smaller than a second threshold interval, it is determined that the sensor is in the attenuation state.
The values of the first threshold interval and the second threshold interval can be determined according to a variation curve of the comprehensive state parameter K of the sensor under a standard condition.
For the convenience of understanding, fig. 4 is a schematic diagram showing the variation curve of the integrated state parameter K of the continuous blood glucose sensor under different conditions. Wherein the predicted value of K is a variation curve of K under the standard condition. The predicted value K may be a variation curve of the sensor at different stages within a service life (e.g., 15 days) tested in a standard laboratory environment before the sensor leaves a factory. The variation curve can be input into the sensor as a standard value.
After the sensor is determined to be in the attenuation state, the steady-state output current of the sensor, namely the current generated by the glucose oxidation-reduction reaction, can be corrected by using the corrected comprehensive state parameters. Specifically, the steady-state output current may be divided by the corrected integrated state parameter to obtain a corrected steady-state output current. The blood glucose value may then be determined based on the corrected steady state output current.
Further, if the change rate is in a first threshold interval and the modified integrated state parameter is in a second threshold interval, it may be determined that the sensor is in a normal state. Then, the blood glucose value may be determined directly based on the steady state output current.
If the change rate is smaller than the first threshold interval and the corrected comprehensive state parameter is smaller than the second threshold interval, the sensor can be considered to be damaged or reach the maximum service life, and the sensor can be determined to be in a state to be replaced.
Furthermore, the embodiment of the application can also provide a user reminding function for feeding back the execution information of continuous blood sugar correction to the user. For example, a voice or text prompt may be issued to the user at the beginning and/or end of the continuous glucose correction. Further, when it is determined that the sensor is in the attenuation state and the correction operation is performed, the user may be prompted that the correction operation is performed. When the sensor is determined to be in a normal state, the current state can be indicated to be normal. When the sensor is determined to be in a state to be replaced, the user can be prompted to replace the sensor in time. Therefore, the user can timely know the current operation execution state, and the user experience is improved.
In the above technical solution, firstly, the transient output current and the steady output current of the sensor may be respectively collected according to a set correction period. Then, the sensitivity coefficient of the sensor can be determined according to the current value and the variation characteristic of the transient output current. Finally, the steady state output current can be corrected according to the sensitivity coefficient, and the blood glucose value can be determined based on the corrected steady state output current. Therefore, automatic correction of blood sugar can be realized, and continuous blood sugar correction efficiency is improved. In addition, according to the continuous blood glucose correction method, fingertip blood does not need to be collected, pain is not caused to the user, and user experience is effectively improved.
Fig. 5 is a schematic structural diagram of a continuous blood glucose correction device according to an embodiment of the present disclosure. As shown in fig. 5, the continuous blood glucose correction apparatus may include: an acquisition module 41, a determination module 42 and an execution module 43.
The collecting module 41 is configured to collect the transient output current and the steady output current of the sensor according to a set correction period.
And a determining module 42, configured to determine a sensitivity coefficient of the sensor according to the current value and the variation characteristic of the transient output current.
And the execution module 43 is configured to correct the steady-state output current according to the sensitivity coefficient, and determine a blood glucose value based on the corrected steady-state output current.
In a specific implementation manner, the apparatus further includes: a power module 44, wherein the transient output current is output when the power module 44 applies a transient voltage to the sensor, and the steady output current is output when the power module 44 applies a steady voltage to the sensor; wherein the voltage value of the transient voltage varies with time and the voltage waveform comprises any one or a combination of: square waves; pulse waves; triangular waves; a step wave; a trapezoidal wave; a linear wave; a white noise wave; a sine wave.
In a specific implementation manner, the execution module 43 is specifically configured to correct the original comprehensive state parameter of the sensor according to the sensitivity coefficient; and correcting the steady-state output current of the sensor by using the corrected comprehensive state parameters.
In a specific implementation manner, the apparatus further includes: the temperature detection module 45 is used for detecting the human body temperature under the current test environment; the execution module 43 is specifically configured to determine a state correction value according to the human body temperature and the sensitivity coefficient; and correcting the original comprehensive state parameters of the sensor by using the state correction value.
In a specific implementation manner, the executing module 43 is specifically configured to: determining the change rate between the corrected comprehensive state parameter and the original comprehensive state parameter; and determining that the sensor is in an attenuation state according to the change rate and the corrected parameter value of the comprehensive state parameter, and correcting the steady-state output current of the sensor by using the corrected comprehensive state parameter.
In a specific implementation manner, if the change rate is in the first threshold interval and the modified integrated state parameter is smaller than the second threshold interval, the execution module 43 determines that the sensor is in the attenuation state.
In this embodiment, first, the collecting module 41 may collect the transient output current and the steady output current of the sensor according to a set calibration period. The determination module 42 may then determine the sensitivity coefficient of the sensor according to the current value and the variation characteristic of the transient output current. Finally, the execution module 43 may correct the steady-state output current according to the sensitivity coefficient, and determine the blood glucose value based on the corrected steady-state output current. Therefore, automatic correction of blood sugar can be realized, and continuous blood sugar correction efficiency is improved.
Fig. 6 is a schematic structural diagram of an electronic device according to an embodiment of the present application. As shown in fig. 6, the electronic device may include at least one processor; and at least one memory communicatively coupled to the processor, wherein: the memory stores program instructions executable by the processor, and the processor calls the program instructions to execute the continuous blood glucose correction method provided by the embodiment of the application.
The electronic device may be a continuous blood glucose monitoring device, and the embodiment does not limit the specific form of the electronic device.
FIG. 6 illustrates a block diagram of an exemplary electronic device suitable for use in implementing embodiments of the present application. The electronic device shown in fig. 6 is only an example, and should not bring any limitation to the functions and the scope of use of the embodiments of the present application.
As shown in fig. 6, the electronic device is in the form of a general purpose computing device. Components of the electronic device may include, but are not limited to: one or more processors 410, a memory 430, and a communication bus 440 that connects the various system components (including the memory 430 and the processors 410).
Communication bus 440 represents one or more of any of several types of bus structures, including a memory bus or memory controller, a peripheral bus, an accelerated graphics port, and a processor or local bus using any of a variety of bus architectures. These architectures include, but are not limited to, industry Standard Architecture (ISA) bus, micro Channel Architecture (MAC) bus, enhanced ISA bus, video Electronics Standards Association (VESA) local bus, and Peripheral Component Interconnect (PCI) bus, to name a few.
Electronic devices typically include a variety of computer system readable media. Such media may be any available media that is accessible by the electronic device and includes both volatile and nonvolatile media, removable and non-removable media.
Memory 430 may include computer system readable media in the form of volatile Memory, such as Random Access Memory (RAM) and/or cache Memory. The electronic device may further include other removable/non-removable, volatile/nonvolatile computer system storage media. Although not shown in FIG. 6, a magnetic disk drive for reading from and writing to a removable nonvolatile magnetic disk (e.g., a "floppy disk") and an optical disk drive for reading from or writing to a removable nonvolatile optical disk (e.g., a Compact disk Read Only Memory (CD-ROM), a Digital versatile disk Read Only Memory (DVD-ROM), or other optical media) may be provided. In these cases, each drive may be connected to the communication bus 440 by one or more data media interfaces. Memory 430 may include at least one program product having a set (e.g., at least one) of program modules that are configured to carry out the functions of embodiments of the application.
A program/utility having a set (at least one) of program modules may be stored in the memory 430, such program modules including, but not limited to, an operating system, one or more application programs, other program modules, and program data, each of which examples or some combination thereof may include an implementation of a network environment. The program modules generally perform the functions and/or methodologies of the embodiments described herein.
The electronic device may also communicate with one or more external devices (e.g., keyboard, pointing device, display, etc.), one or more devices that enable a user to interact with the electronic device, and/or any devices (e.g., network card, modem, etc.) that enable the electronic device to communicate with one or more other computing devices. Such communication may occur via communication interface 420. Furthermore, the electronic device may also communicate with one or more networks (e.g., a Local Area Network (LAN), a Wide Area Network (WAN), and/or a public Network such as the Internet) via a Network adapter (not shown in FIG. 6) that may communicate with other modules of the electronic device via the communication bus 440. It should be appreciated that although not shown in FIG. 6, other hardware and/or software modules may be used in conjunction with the electronic device, including but not limited to: microcode, device drivers, redundant processing units, external disk drive Arrays, disk array (RAID) systems, tape Drives, data backup storage systems, and the like.
The processor 410 executes various functional applications and data processing, such as implementing the continuous blood glucose correction method provided by the embodiments of the present application, by executing programs stored in the memory 430.
The embodiment of the present application further provides a computer-readable storage medium, where the computer-readable storage medium stores computer instructions, and the computer instructions enable the computer to execute the continuous blood glucose correction method provided in the embodiment of the present application.
The computer-readable storage medium described above may take any combination of one or more computer-readable media. The computer readable medium may be a computer readable signal medium or a computer readable storage medium. A computer readable storage medium may be, for example, but not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination of the foregoing. More specific examples (a non-exhaustive list) of the computer readable storage medium would include the following: an electrical connection having one or more wires, a portable computer diskette, a hard disk, a Random Access Memory (RAM), a Read Only Memory (ROM), an Erasable Programmable Read Only Memory (EPROM) or flash Memory, an optical fiber, a portable compact disc Read Only Memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing. In the context of this document, a computer readable storage medium may be any tangible medium that can contain, or store a program for use by or in connection with an instruction execution system, apparatus, or device.
A computer readable signal medium may include a propagated data signal with computer readable program code embodied therein, for example, in baseband or as part of a carrier wave. Such a propagated data signal may take any of a variety of forms, including, but not limited to, electro-magnetic, optical, or any suitable combination thereof. A computer readable signal medium may be any computer readable medium that is not a computer readable storage medium and that can communicate, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device.
Program code embodied on a computer readable medium may be transmitted using any appropriate medium, including but not limited to wireless, wireline, optical fiber cable, RF, etc., or any suitable combination of the foregoing.
In the description of the present specification, reference to the description of "one embodiment," "some embodiments," "an example," "a specific example," or "some examples" or the like means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present application. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Moreover, various embodiments or examples and features of various embodiments or examples described in this specification can be combined and combined by one skilled in the art without being mutually inconsistent.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present application, "plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.
Any process or method descriptions in flow charts or otherwise described herein may be understood as representing modules, segments, or portions of code which include one or more executable instructions for implementing steps of a custom logic function or process, and alternate implementations are included within the scope of the preferred embodiment of the present application in which functions may be executed out of order from that shown or discussed, including substantially concurrently or in reverse order, depending on the functionality involved, as would be understood by those reasonably skilled in the art of the present application.
In the several embodiments provided in the present application, it should be understood that the disclosed system, apparatus and method may be implemented in other ways. For example, the above-described apparatus embodiments are merely illustrative, and for example, the division of the units is only one logical division, and there may be other divisions in actual implementation, for example, a plurality of units or components may be combined or integrated into another system, or some features may be omitted, or not executed. In addition, the shown or discussed mutual coupling or direct coupling or communication connection may be an indirect coupling or communication connection through some interfaces, devices or units, and may be in an electrical, mechanical or other form.
In addition, functional units in the embodiments of the present application may be integrated into one processing unit, or each unit may exist alone physically, or two or more units are integrated into one unit. The integrated unit may be implemented in the form of hardware, or in the form of hardware plus a software functional unit.
The above description is only a preferred embodiment of the present application and should not be taken as limiting the present application, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present application should be included in the protection scope of the present application.

Claims (14)

1. A method of continuous glucose correction, comprising:
respectively collecting transient output current and steady output current of the sensor according to a set correction period;
determining a sensitivity coefficient of the sensor according to the current value and the change characteristic of the transient output current;
and correcting the steady-state output current according to the sensitivity coefficient, and determining the blood sugar value based on the corrected steady-state output current.
2. The method of claim 1, wherein the transient output current is output when a transient voltage is applied to the sensor and the steady state output current is output when a steady state voltage is applied to the sensor;
wherein the voltage value of the transient voltage varies with time and the voltage waveform of the transient voltage comprises any one or a combination of more of: square waves; pulse waves; triangular waves; a step wave; a trapezoidal wave; a linear wave; a white noise wave; a sine wave.
3. The method of claim 1, wherein correcting the steady state output current according to the sensitivity coefficient comprises:
correcting the original comprehensive state parameters of the sensor according to the sensitivity coefficient;
and correcting the steady-state output current of the sensor by using the corrected comprehensive state parameters.
4. The method of claim 3, wherein modifying the raw integrated state parameter of the sensor based on the sensitivity factor comprises:
detecting the human body temperature in the current test environment;
determining a state correction value according to the human body temperature and the sensitivity coefficient;
and correcting the original comprehensive state parameters of the sensor by using the state correction value.
5. The method of claim 4, wherein correcting the steady state output current of the sensor using the modified integrated state parameter comprises:
determining a change rate between the corrected comprehensive state parameter and the original comprehensive state parameter;
and determining that the sensor is in an attenuation state according to the change rate and the parameter value of the corrected comprehensive state parameter, and correcting the steady-state output current of the sensor by using the corrected comprehensive state parameter.
6. The method of claim 5, wherein determining that the sensor is in a decaying state based on the rate of change and the parameter value of the modified integrated state parameter comprises:
and if the change rate is in a first threshold interval and the corrected comprehensive state parameter is smaller than a second threshold interval, the sensor is in an attenuation state.
7. A continuous glucose correction device, comprising:
the acquisition module is used for respectively acquiring transient output current and steady output current of the sensor according to a set correction period;
the determining module is used for determining the sensitivity coefficient of the sensor according to the current value and the change characteristic of the transient output current;
and the execution module is used for correcting the steady-state output current according to the sensitivity coefficient and determining the blood sugar value based on the corrected steady-state output current.
8. The apparatus of claim 7, further comprising:
a power module, the transient output current being output when the power module applies a transient voltage to the sensor, the steady state output current being output when the power module applies a steady state voltage to the sensor;
wherein the voltage value of the transient voltage varies with time and the voltage waveform of the transient voltage comprises any one or a combination of more of: square waves; pulse waves; a triangular wave; a step wave; a trapezoidal wave; a linear wave; a white noise wave; a sine wave.
9. The apparatus of claim 7, wherein the execution module is specifically configured to:
correcting the original comprehensive state parameters of the sensor according to the sensitivity coefficient;
and correcting the steady-state output current of the sensor by using the corrected comprehensive state parameters.
10. The apparatus of claim 9, further comprising:
the temperature detection module is used for detecting the human body temperature under the current test environment;
the execution module is specifically used for determining a state correction value according to the human body temperature and the sensitivity coefficient; and correcting the original comprehensive state parameters of the sensor by using the state correction value.
11. The apparatus of claim 10, wherein the execution module is specifically configured to:
determining a change rate between the corrected comprehensive state parameter and the original comprehensive state parameter;
and determining that the sensor is in an attenuation state according to the change rate and the parameter value of the corrected comprehensive state parameter, and correcting the steady-state output current of the sensor by using the corrected comprehensive state parameter.
12. The apparatus of claim 11, wherein the rate of change is within a first threshold interval and the modified integrated condition parameter is less than a second threshold interval, the execution module determines that the sensor is in a decay state.
13. An electronic device, comprising:
at least one processor; and at least one memory communicatively coupled to the processor, wherein:
the memory stores program instructions executable by the processor, the processor invoking the program instructions to perform the method of any of claims 1 to 6.
14. A computer-readable storage medium, storing computer instructions, the computer instructions causing the computer to perform the method of any of claims 1 to 6.
CN202111148201.2A 2021-09-29 2021-09-29 Continuous blood glucose correction method and device and electronic equipment Pending CN115877009A (en)

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