JPWO2020154649A5

JPWO2020154649A5 -

Info

Publication number: JPWO2020154649A5
Application number: JP2021543300A
Authority: JP
Publication date: 2022-12-27

Claims

Coronary artery plaque using image data collected from computed tomography (CT) scans along blood vessels, the image information including radiodensity values of coronary artery plaque and perivascular tissue located adjacent to the coronary artery plaque. A method for characterization of tissue data and perivascular tissue data, comprising:
quantifying radiodensity within regions of coronary artery plaque in the image data;
quantifying radiodensity in at least one region of corresponding perivascular tissue adjacent to the coronary artery plaque in the image data;
determining a slope of the quantified radiodensity values within the coronary artery plaque and the quantified radiodensity values within the corresponding perivascular tissue;
determining a ratio of the quantified radiodensity values within the coronary artery plaque and the corresponding perivascular tissue;
said gradient of said quantified radiodensity values in said coronary plaque and said corresponding perivascular tissue, or said ratio of said radiodensity value of said coronary plaque and said radiodensity value of said corresponding perivascular tissue; assessing the quality of the coronary artery plaque by analyzing one or more of
A method performed by one or more computer hardware processors configured to execute computer-executable instructions on a non-transitory computer storage medium.

2. The method of claim 1, wherein the perivascular tissue comprises at least one of coronary lumen, fat, coronary plaque, or myocardium.

2. The method of claim 1 , further comprising: receiving the image data at a data storage component over a network.

2. The method of claim 1 , further comprising generating a patient report including at least one of a diagnosis, prognosis, or recommended treatment for the patient based on the characterization of the coronary plaque.

Quantifying the radiodensity within at least one region of perivascular tissue comprises quantifying the radiodensity of the scan information for coronary artery plaque and fatty tissue in each of one or more regions or layers of perivascular tissue. A method according to any one of claims 1 to 4 , comprising

The method of any one of claims 1-4 , wherein the radiodensity of the scan information is quantified for low radiodensity plaques in each of one or more regions or layers of coronary artery plaque.

2. The method of claim 1, wherein the coronary plaque radiodensity value and the perivascular tissue radiodensity value are average radiodensities.

2. The method of claim 1, wherein the coronary plaque radiodensity value and the perivascular tissue radiodensity value are maximum radiodensities.

2. The method of claim 1, wherein the coronary plaque radiodensity value and the perivascular tissue radiodensity value are minimal radiodensities.

2. The method of claim 1, wherein the quantified radiodensity is a transformed numerical radiodensity value of the image data.

The quantified radiodensity was measured by iodinated contrast agent, contrast agent type, injection rate, aortic contrast agent opacification, left ventricular blood pool opacification, signal-to-noise, contrast-to-noise, tube voltage, milliamps, cardiac gating 2. The method of claim 1, which considers patient- and CT-specific parameters including one or more of scanning method, single and multi-energy image acquisition, CT scanner type, heart rate, cardiac rhythm, or blood pressure.

2. The method of claim 1, further comprising: reporting the quantified radiodensities of the coronary plaque and the perivascular tissue as a gradient.

The quantified radiodensities of the coronary plaque and the perivascular tissue are reported as a ratio of the slope of the gradient from the coronary plaque to the perivascular tissue adjacent to the coronary plaque . A method according to any one of paragraphs .

5. The method of any one of claims 1-4 , wherein the quantified radiodensities of the coronary plaque and the perivascular tissue are reported as the difference in radiodensity values from the coronary plaque relative to the perivascular tissue. the method of.

The image data is collected from a CT scan along the length of at least one of the right coronary artery, the left anterior descending artery, the left circumflex artery, or branches thereof, or the aorta, or the carotid artery, or the femoral artery, or the renal artery. 2. The method of claim 1, wherein:

2. The method of claim 1, wherein the data is data from a CT scan along the length of a non-coronary reference vessel.

21. The method of claim 20, wherein the non-coronary reference vessel is the aorta.

2. The method of claim 1 , wherein the radio density is quantified in Hounsfield units.

2. The method of claim 1, wherein radio density is quantified in absolute material density when multi-energy CT is performed.

One or more regions or layers of perivascular tissue extend from the outer wall of the vessel to an edge distance, said edge distance being the radiodensity of the adipose tissue (i) anatomically scanned in a healthy vessel A fixation that reaches a minimum value in the area, or (ii) decreases by a relative percentage of at least 10%, or (iii) decreases by some relative percentage relative to the baseline radiodensity value in the same vessel type without disease. 2. The method of claim 1, wherein the distance is

one or more regions or layers of said coronary artery plaque extend from the outer wall of the vessel to an edge distance, said edge distance at which adipose tissue radiodensity (i) reaches a maximum within said plaque, or 2. The method of claim 1, wherein (ii) increases by a relative percentage of at least 10%, or (iii) is a fixed distance that varies by a relative percentage relative to the lowest radiodensity value within the plaque.

The baseline radiodensity value is the average radiodensity quantified in a layer of perivascular tissue located within a fixed layer or region surrounding the outer vessel wall measured by thickness, area, or volume. 21. The method of claim 20 .

21. The method of claim 20 , wherein the baseline perivascular tissue radiodensity is the radiodensity quantified for adipose tissue in a layer of perivascular tissue proximal to the outer wall of the vessel.

21. The method of claim 20 , wherein the baseline perivascular tissue radiodensity is the quantified radiodensity for water in a layer of perivascular tissue proximal to the outer wall of the vessel.

determining a plot of the change in quantified radiodensity versus baseline radiodensity in each of the one or more concentric layers of perivascular tissue versus distance from the outer wall of the vessel to the edge distance;
determining the area of the region bounded by the plot of quantified change in radiodensity and the plot of baseline radiodensity versus the distance from the outer wall of the vessel to the edge distance;
dividing the area by the quantified radiodensity measured at a distance from the outer wall of the vessel;
The distance is less than or greater than the radius of the vessel such that the quantified radiodensity of adipose tissue is less than 5% compared to the baseline radiodensity of adipose tissue in the same type of vessel without disease. 2. The method of claim 1, wherein the distance from the outer surface of the blood vessel is greatly reduced.

determining a plot of change in quantified radiodensity versus baseline radiodensity in each of the one or more concentric layers of coronary artery plaque tissue versus the distance from the outer wall of the vessel to the inner surface of the plaque;
determining the area of the region bounded by the quantified change in radiodensity plot and the baseline radiodensity plot against the distance from the outer wall of the vessel to the inner surface of the plaque;
dividing the area by the quantified radiodensity measured at a distance from the outer wall of the vessel;
The distance is less than or greater than the radius of the vessel such that the quantified radiodensity of adipose tissue is less than 5% compared to the baseline radiodensity of adipose tissue in the same type of vessel without disease. 2. The method of claim 1, wherein the distance from the outer surface of the blood vessel is greatly reduced.

The quantified radiodensities of the coronary artery plaque and the perivascular tissue were measured using iodinated contrast agent, contrast agent type, injection rate, aortic contrast agent opacification, left ventricular blood pool opacification, signal to noise, contrast agent to normalizing to CT scan parameters including one or more of noise, tube voltage, milliamps, methods of cardiac gating, single and multi-energy image acquisition, CT scanner type, heart rate, cardiac rhythm, or blood pressure. When,
normalizing the quantified radiodensity of coronary plaque-associated perivascular fat to distant perivascular fat;
and normalizing the quantified radiodensity of the coronary plaque to distant coronary plaque.

quantifying other high-risk plaque characteristics such as remodeling, volume, patchy calcification, etc., and further characterizing said high-risk plaque based on one or more of said high-risk plaque characteristics. Item 1. The method according to item 1.

2. The method of claim 1, wherein assessing the coronary plaque quality is based in part on plaque heterogeneity comprising a mixture of calcium and non-calcified plaque.

The step of evaluating a property of the coronary artery plaque includes identifying the coronary artery plaque as a high-risk plaque if the coronary artery plaque has a high likelihood of causing ischemia based on comparison with pre-classified patient image data. 2. The method of claim 1, comprising identifying.

The step of evaluating the properties of the coronary artery plaque includes determining the coronary artery plaque as a high-risk plaque if the coronary artery plaque has a high possibility of rapidly progressing based on comparison with pre-classified patient image data. 2. The method of claim 1, comprising identifying.

The step of assessing the quality of the coronary artery plaque identifies the coronary artery plaque as high-risk plaque if the coronary artery plaque is likely not to calcify based on comparison with pre-classified patient imaging data. 2. The method of claim 1, comprising the step of:

Assessing the quality of the coronary artery plaque includes determining whether the coronary artery plaque is non-responsive to medical treatment, non-reversible, or non-stabilizing based on comparison to pre-classified patient imaging data. 2. The method of claim 1, comprising identifying the coronary artery plaque as high risk plaque if the risk is high.