JPWO2020141180A5 - - Google Patents
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- Publication number
- JPWO2020141180A5 JPWO2020141180A5 JP2021538443A JP2021538443A JPWO2020141180A5 JP WO2020141180 A5 JPWO2020141180 A5 JP WO2020141180A5 JP 2021538443 A JP2021538443 A JP 2021538443A JP 2021538443 A JP2021538443 A JP 2021538443A JP WO2020141180 A5 JPWO2020141180 A5 JP WO2020141180A5
- Authority
- JP
- Japan
- Prior art keywords
- water
- liquid nicotine
- nicotine formulation
- solvents
- immiscible
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- SNICXCGAKADSCV-JTQLQIEISA-N Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 21
- 229960002715 Nicotine Drugs 0.000 claims 21
- 239000007788 liquid Substances 0.000 claims 21
- 229930015196 nicotine Natural products 0.000 claims 21
- 239000000203 mixture Substances 0.000 claims 20
- 238000009472 formulation Methods 0.000 claims 19
- 239000002904 solvent Substances 0.000 claims 15
- 239000000443 aerosol Substances 0.000 claims 6
- 150000007524 organic acids Chemical class 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 235000005985 organic acids Nutrition 0.000 claims 3
- 238000005192 partition Methods 0.000 claims 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N Oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- 150000001298 alcohols Chemical class 0.000 claims 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 2
- LCTONWCANYUPML-UHFFFAOYSA-N pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 claims 2
- 239000003021 water soluble solvent Substances 0.000 claims 2
- 229960000583 Acetic Acid Drugs 0.000 claims 1
- 229960000448 Lactic acid Drugs 0.000 claims 1
- JOOXCMJARBKPKM-UHFFFAOYSA-N Levulinic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 claims 1
- -1 MIGLYOL® Chemical compound 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- 229940107700 Pyruvic Acid Drugs 0.000 claims 1
- URAYPUMNDPQOKB-UHFFFAOYSA-N Triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 1
- 229960002622 Triacetin Drugs 0.000 claims 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N Triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 claims 1
- 235000019437 butane-1,3-diol Nutrition 0.000 claims 1
- PUPZLCDOIYMWBV-UHFFFAOYSA-N butylene glycol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 239000001087 glyceryl triacetate Substances 0.000 claims 1
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 229940040102 levulinic acid Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 235000013772 propylene glycol Nutrition 0.000 claims 1
- 239000001069 triethyl citrate Substances 0.000 claims 1
- 235000013769 triethyl citrate Nutrition 0.000 claims 1
Claims (15)
一つ以上の水混和性溶媒と、
２０℃で約１００ｍｇ／ｍＬ以下の水溶解度を有する一つ以上の水不混和性溶媒と、
一つ以上の水溶性有機酸と、を含み、
前記液体ニコチン製剤が約２重量パーセント以上の水不混和性溶媒含有量を有する、液体ニコチン製剤。 A liquid nicotine formulation for use in an aerosol generating system comprising:
one or more water-miscible solvents;
one or more water-immiscible solvents having a water solubility of about 100 mg/mL or less at 20° C.;
one or more water-soluble organic acids;
A liquid nicotine formulation, wherein said liquid nicotine formulation has a water-immiscible solvent content of greater than or equal to about 2 weight percent.
一つ以上の水混和性溶媒と、
２０℃で約０．０５以上の分配係数（ｌｏｇ Ｐ）を有する一つ以上の水不混和性溶媒と、
一つ以上の水溶性有機酸と、を含み、
前記液体ニコチン製剤が約２重量パーセント以上の水不混和性溶媒含有量を有する、液体ニコチン製剤。 A liquid nicotine formulation for use in an aerosol generating system comprising:
one or more water-miscible solvents;
one or more water-immiscible solvents having a partition coefficient (log P) of about 0.05 or greater at 20°C;
one or more water-soluble organic acids;
A liquid nicotine formulation, wherein said liquid nicotine formulation has a water-immiscible solvent content of greater than or equal to about 2 weight percent.
請求項１～１２のいずれか一項に記載の液体ニコチン製剤と、
前記液体ニコチン製剤からエアロゾルを発生させるように構成されたアトマイザーと、を備える、エアロゾル発生システム。 An aerosol generating system comprising:
A liquid nicotine formulation according to any one of claims 1 to 12;
an atomizer configured to generate an aerosol from the liquid nicotine formulation.
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18215983.0 | 2018-12-31 | ||
| EP18215966 | 2018-12-31 | ||
| EP18215976.4 | 2018-12-31 | ||
| EP18215964.0 | 2018-12-31 | ||
| EP18215969 | 2018-12-31 | ||
| EP18215969.9 | 2018-12-31 | ||
| EP18215964 | 2018-12-31 | ||
| EP18215976 | 2018-12-31 | ||
| EP18215983 | 2018-12-31 | ||
| EP18215966.5 | 2018-12-31 | ||
| PCT/EP2019/087198 WO2020141180A1 (en) | 2018-12-31 | 2019-12-31 | Liquid nicotine formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022516149A JP2022516149A (en) | 2022-02-24 |
| JPWO2020141180A5 true JPWO2020141180A5 (en) | 2023-01-11 |
Family
ID=69104449
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021538443A Pending JP2022516149A (en) | 2018-12-31 | 2019-12-31 | Liquid nicotine preparation |
| JP2021531581A Pending JP2022515983A (en) | 2018-12-31 | 2019-12-31 | Liquid nicotine preparation |
| JP2021538442A Pending JP2022516895A (en) | 2018-12-31 | 2019-12-31 | Liquid nicotine preparation containing a partially water-soluble solvent |
| JP2021538444A Pending JP2022516896A (en) | 2018-12-31 | 2019-12-31 | Low-viscosity liquid nicotine preparation |
| JP2021531580A Pending JP2022515021A (en) | 2018-12-31 | 2019-12-31 | Liquid nicotine preparation containing water-immiscible solvent |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021531581A Pending JP2022515983A (en) | 2018-12-31 | 2019-12-31 | Liquid nicotine preparation |
| JP2021538442A Pending JP2022516895A (en) | 2018-12-31 | 2019-12-31 | Liquid nicotine preparation containing a partially water-soluble solvent |
| JP2021538444A Pending JP2022516896A (en) | 2018-12-31 | 2019-12-31 | Low-viscosity liquid nicotine preparation |
| JP2021531580A Pending JP2022515021A (en) | 2018-12-31 | 2019-12-31 | Liquid nicotine preparation containing water-immiscible solvent |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US11992038B2 (en) |
| EP (5) | EP3905900B1 (en) |
| JP (5) | JP2022516149A (en) |
| KR (5) | KR20210108394A (en) |
| CN (5) | CN113163845B (en) |
| BR (5) | BR112021010593A2 (en) |
| MX (5) | MX2021007625A (en) |
| WO (5) | WO2020141176A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022516149A (en) * | 2018-12-31 | 2022-02-24 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | Liquid nicotine preparation |
| KR102416605B1 (en) | 2021-08-17 | 2022-07-05 | 한국과학기술원 | Circuit for sensing multi-level voltage of bit line |
| IT202100027086A1 (en) * | 2021-10-21 | 2023-04-21 | Alberto Patarchi | PORTABLE REGULATOR FOR THE TREATMENT OR PREVENTION OF AN INFECTION OR DISEASE CAUSED BY A VIRUS |
| CN113912585B (en) * | 2021-11-09 | 2023-02-24 | 深圳萨特瓦生物科技有限公司 | Composite nicotine salt, preparation method and application thereof, electronic cigarette oil and electronic cigarette |
| KR20240012197A (en) * | 2022-07-20 | 2024-01-29 | 주식회사 케이티앤지 | Liquid inhalant formulation for use in surface wave atomizer, and cartridge and apparatus for generating aerosol using the formulation |
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-
2019
- 2019-12-31 JP JP2021538443A patent/JP2022516149A/en active Pending
- 2019-12-31 JP JP2021531581A patent/JP2022515983A/en active Pending
- 2019-12-31 US US17/419,374 patent/US11992038B2/en active Active
- 2019-12-31 EP EP19831772.9A patent/EP3905900B1/en active Active
- 2019-12-31 US US17/418,928 patent/US20220053817A1/en active Pending
- 2019-12-31 BR BR112021010593-0A patent/BR112021010593A2/en unknown
- 2019-12-31 MX MX2021007625A patent/MX2021007625A/en unknown
- 2019-12-31 WO PCT/EP2019/087193 patent/WO2020141176A1/en active Search and Examination
- 2019-12-31 US US17/419,442 patent/US20220071270A1/en active Pending
- 2019-12-31 WO PCT/EP2019/087202 patent/WO2020141184A1/en active Search and Examination
- 2019-12-31 MX MX2021007626A patent/MX2021007626A/en unknown
- 2019-12-31 KR KR1020217020778A patent/KR20210108394A/en active Search and Examination
- 2019-12-31 EP EP19831770.3A patent/EP3905898B1/en active Active
- 2019-12-31 KR KR1020217019593A patent/KR20210108384A/en unknown
- 2019-12-31 EP EP19831769.5A patent/EP3905897A1/en active Pending
- 2019-12-31 WO PCT/EP2019/087198 patent/WO2020141180A1/en active Search and Examination
- 2019-12-31 EP EP19831771.1A patent/EP3905899A1/en active Pending
- 2019-12-31 BR BR112021009726-0A patent/BR112021009726A2/en unknown
- 2019-12-31 US US17/419,513 patent/US20220079210A1/en active Pending
- 2019-12-31 BR BR112021010284-1A patent/BR112021010284A2/en unknown
- 2019-12-31 JP JP2021538442A patent/JP2022516895A/en active Pending
- 2019-12-31 WO PCT/EP2019/087195 patent/WO2020141177A1/en unknown
- 2019-12-31 MX MX2021007624A patent/MX2021007624A/en unknown
- 2019-12-31 WO PCT/EP2019/087196 patent/WO2020141178A1/en active Search and Examination
- 2019-12-31 BR BR112021010222-1A patent/BR112021010222A2/en unknown
- 2019-12-31 EP EP19831773.7A patent/EP3905901A1/en active Pending
- 2019-12-31 JP JP2021538444A patent/JP2022516896A/en active Pending
- 2019-12-31 CN CN201980079569.2A patent/CN113163845B/en active Active
- 2019-12-31 US US17/419,528 patent/US20220079211A1/en active Pending
- 2019-12-31 KR KR1020217020911A patent/KR20210109548A/en unknown
- 2019-12-31 JP JP2021531580A patent/JP2022515021A/en active Pending
- 2019-12-31 CN CN201980080351.9A patent/CN113242696B/en active Active
- 2019-12-31 CN CN201980079943.9A patent/CN113163847B/en active Active
- 2019-12-31 CN CN201980079924.6A patent/CN113163846B/en active Active
- 2019-12-31 BR BR112021010614-6A patent/BR112021010614A2/en unknown
- 2019-12-31 CN CN201980079953.2A patent/CN113163848B/en active Active
- 2019-12-31 KR KR1020217020193A patent/KR20210108390A/en unknown
- 2019-12-31 MX MX2021007627A patent/MX2021007627A/en unknown
- 2019-12-31 MX MX2021007623A patent/MX2021007623A/en unknown
- 2019-12-31 KR KR1020217021107A patent/KR20210110314A/en unknown
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