JPWO2020141178A5 - - Google Patents
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- Publication number
- JPWO2020141178A5 JPWO2020141178A5 JP2021538442A JP2021538442A JPWO2020141178A5 JP WO2020141178 A5 JPWO2020141178 A5 JP WO2020141178A5 JP 2021538442 A JP2021538442 A JP 2021538442A JP 2021538442 A JP2021538442 A JP 2021538442A JP WO2020141178 A5 JPWO2020141178 A5 JP WO2020141178A5
- Authority
- JP
- Japan
- Prior art keywords
- water
- nicotine formulation
- liquid nicotine
- weight percent
- soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- SNICXCGAKADSCV-JTQLQIEISA-N Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 19
- 229960002715 Nicotine Drugs 0.000 claims 19
- 238000009472 formulation Methods 0.000 claims 19
- 239000007788 liquid Substances 0.000 claims 19
- 239000000203 mixture Substances 0.000 claims 19
- 229930015196 nicotine Natural products 0.000 claims 19
- 239000002904 solvent Substances 0.000 claims 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 8
- 239000000443 aerosol Substances 0.000 claims 5
- 150000007524 organic acids Chemical class 0.000 claims 2
- 238000005192 partition Methods 0.000 claims 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N Triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 1
- 229960002622 Triacetin Drugs 0.000 claims 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N Triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 235000019437 butane-1,3-diol Nutrition 0.000 claims 1
- PUPZLCDOIYMWBV-UHFFFAOYSA-N butylene glycol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 1
- 239000003995 emulsifying agent Substances 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 239000001087 glyceryl triacetate Substances 0.000 claims 1
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- 235000013772 propylene glycol Nutrition 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000001069 triethyl citrate Substances 0.000 claims 1
- 235000013769 triethyl citrate Nutrition 0.000 claims 1
Claims (14)
水、および、
２０℃で約２０ｍｇ／ｍｌ～約１００ｍｇ／ｍｌの水溶解度を有する、一つ以上の部分的水溶性の水不混和性溶媒を含み、
前記液体ニコチン製剤が、約５重量パーセント以上の水含有量、および約２重量パーセント～約３０重量パーセントの部分的水溶性の水不混和性溶媒の含有量を有する、液体ニコチン製剤。 A liquid nicotine formulation for use in an aerosol generating system comprising:
water, and
one or more partially water-soluble water-immiscible solvents having a water solubility of about 20 mg/ml to about 100 mg/ml at 20°C;
A liquid nicotine formulation, wherein the liquid nicotine formulation has a water content of about 5 weight percent or more and a partially water-soluble water-immiscible solvent content of about 2 weight percent to about 30 weight percent.
水、および、
２０℃で約０．０５～約０．５の分配係数（ｌｏｇ Ｐ）を有する一つ以上の部分的水溶性の水不混和性溶媒を含み、
前記液体ニコチン製剤が、約５重量パーセント以上の水含有量、および約２重量パーセント～約３０重量パーセントの部分的水溶性の水不混和性溶媒の含有量を有する、液体ニコチン製剤。 A liquid nicotine formulation for use in an aerosol generating system comprising:
water, and
one or more partially water-soluble water-immiscible solvents having a partition coefficient (log P) of about 0.05 to about 0.5 at 20°C;
A liquid nicotine formulation, wherein the liquid nicotine formulation has a water content of about 5 weight percent or more and a partially water-soluble water-immiscible solvent content of about 2 weight percent to about 30 weight percent.
前記液体ニコチン製剤からエアロゾルを発生させるように構成されたアトマイザーと、を含む、エアロゾル発生システム。 A liquid nicotine formulation according to any one of claims 1 to 11;
an atomizer configured to generate an aerosol from the liquid nicotine formulation.
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18215976 | 2018-12-31 | ||
| EP18215966 | 2018-12-31 | ||
| EP18215964.0 | 2018-12-31 | ||
| EP18215966.5 | 2018-12-31 | ||
| EP18215983.0 | 2018-12-31 | ||
| EP18215964 | 2018-12-31 | ||
| EP18215969.9 | 2018-12-31 | ||
| EP18215983 | 2018-12-31 | ||
| EP18215969 | 2018-12-31 | ||
| EP18215976.4 | 2018-12-31 | ||
| PCT/EP2019/087196 WO2020141178A1 (en) | 2018-12-31 | 2019-12-31 | Liquid nicotine formulation comprising partially water-soluble solvent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022516895A JP2022516895A (en) | 2022-03-03 |
| JPWO2020141178A5 true JPWO2020141178A5 (en) | 2023-01-11 |
Family
ID=69104449
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021538442A Pending JP2022516895A (en) | 2018-12-31 | 2019-12-31 | Liquid nicotine preparation containing a partially water-soluble solvent |
| JP2021531580A Pending JP2022515021A (en) | 2018-12-31 | 2019-12-31 | Liquid nicotine preparation containing water-immiscible solvent |
| JP2021538443A Pending JP2022516149A (en) | 2018-12-31 | 2019-12-31 | Liquid nicotine preparation |
| JP2021531581A Pending JP2022515983A (en) | 2018-12-31 | 2019-12-31 | Liquid nicotine preparation |
| JP2021538444A Pending JP2022516896A (en) | 2018-12-31 | 2019-12-31 | Low-viscosity liquid nicotine preparation |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021531580A Pending JP2022515021A (en) | 2018-12-31 | 2019-12-31 | Liquid nicotine preparation containing water-immiscible solvent |
| JP2021538443A Pending JP2022516149A (en) | 2018-12-31 | 2019-12-31 | Liquid nicotine preparation |
| JP2021531581A Pending JP2022515983A (en) | 2018-12-31 | 2019-12-31 | Liquid nicotine preparation |
| JP2021538444A Pending JP2022516896A (en) | 2018-12-31 | 2019-12-31 | Low-viscosity liquid nicotine preparation |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US20220071270A1 (en) |
| EP (5) | EP3905899A1 (en) |
| JP (5) | JP2022516895A (en) |
| KR (5) | KR20210108384A (en) |
| CN (5) | CN113163845B (en) |
| BR (5) | BR112021010222A2 (en) |
| MX (5) | MX2021007623A (en) |
| WO (5) | WO2020141178A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210108384A (en) * | 2018-12-31 | 2021-09-02 | 필립모리스 프로덕츠 에스.에이. | liquid nicotine formulation |
| KR102416605B1 (en) | 2021-08-17 | 2022-07-05 | 한국과학기술원 | Circuit for sensing multi-level voltage of bit line |
| IT202100027086A1 (en) * | 2021-10-21 | 2023-04-21 | Alberto Patarchi | PORTABLE REGULATOR FOR THE TREATMENT OR PREVENTION OF AN INFECTION OR DISEASE CAUSED BY A VIRUS |
| CN113912585B (en) * | 2021-11-09 | 2023-02-24 | 深圳萨特瓦生物科技有限公司 | Composite nicotine salt, preparation method and application thereof, electronic cigarette oil and electronic cigarette |
| KR20240012197A (en) * | 2022-07-20 | 2024-01-29 | 주식회사 케이티앤지 | Liquid inhalant formulation for use in surface wave atomizer, and cartridge and apparatus for generating aerosol using the formulation |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060018840A1 (en) * | 2004-06-28 | 2006-01-26 | Nektar Therapeutics | Aerosolizable formulation comprising nicotine |
| JP2006109784A (en) * | 2004-10-15 | 2006-04-27 | Mitsubishi Gas Chem Co Inc | Method for producing paclitaxel |
| US9314524B2 (en) * | 2007-12-31 | 2016-04-19 | Calla Therapeutics Llc | Topical formulations of Flucytosine |
| US20120325228A1 (en) * | 2011-06-23 | 2012-12-27 | Williams Jonnie R | Alkaloid composition for e-cigarette |
| DE102011114094A1 (en) * | 2011-09-21 | 2013-03-21 | F. Holzer Gmbh | Stimulating and invigorating nasal spray and nose drops |
| NZ626974A (en) * | 2012-03-27 | 2016-09-30 | Nicoccino Ab | Nicotine formulation |
| WO2015006465A1 (en) * | 2013-07-10 | 2015-01-15 | Ahkeo Ventures LLC | Inhalable compositions comprising caffeine, methods of use and an apparatus for using the same |
| MX2016002844A (en) * | 2013-09-19 | 2016-06-17 | Philip Morris Products Sa | Aerosol-generating system for generating nicotine salt particles. |
| US10292424B2 (en) * | 2013-10-31 | 2019-05-21 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a pressure-based aerosol delivery mechanism |
| CN103598672A (en) * | 2013-11-28 | 2014-02-26 | 刘秋明 | Electronic cigarette liquid solvent and electronic cigarette liquid |
| WO2015084544A1 (en) * | 2013-12-05 | 2015-06-11 | Ploom, Inc. | Nicotine liquid formulations for aerosol devices and methods thereof |
| US20150313275A1 (en) * | 2014-04-30 | 2015-11-05 | Altria Client Services, Inc. | Liquid aerosol formulation of an electronic smoking article |
| US20170079319A1 (en) * | 2014-05-21 | 2017-03-23 | Mcneil Ab | Liquid formulation comprising nicotine for aerosol administration |
| MX2017000489A (en) * | 2014-07-11 | 2017-04-27 | Philip Morris Products Sa | Aerosol-forming cartridge comprising a liquid nicotine source. |
| EP3679815B1 (en) * | 2014-07-11 | 2022-09-21 | Philip Morris Products S.A. | Aerosol-generating system with improved air flow control |
| CN104256885B (en) * | 2014-08-05 | 2015-12-30 | 云南中烟工业有限责任公司 | A kind of tobacco juice for electronic smoke solvent |
| GB2535427A (en) * | 2014-11-07 | 2016-08-24 | Nicoventures Holdings Ltd | Solution |
| GB2532062A (en) * | 2014-11-07 | 2016-05-11 | Nicoventures Holdings Ltd | Container |
| CN104473323A (en) * | 2014-12-03 | 2015-04-01 | 河南中烟工业有限责任公司 | Electronic cigarette atomizing agent |
| CN104585880B (en) * | 2015-01-20 | 2018-06-08 | 湖北中烟工业有限责任公司 | A kind of Mint Essence solvent for cigarette dripping pill |
| CN104939305B (en) * | 2015-05-20 | 2016-04-20 | 湖南中烟工业有限责任公司 | A kind of tobacco extract and electronic cigarette liquid |
| US20160345621A1 (en) * | 2015-06-01 | 2016-12-01 | San Li | Pre-vapor formulation of an electronic vaping device and/or methods of manufacturing the same |
| GB2542389A (en) * | 2015-09-17 | 2017-03-22 | Kind Consumer Ltd | Simulated cigarette |
| US10327472B2 (en) * | 2015-09-25 | 2019-06-25 | Altria Client Services Llc | Pre-vaporization formulation for controlling acidity in an e-vaping device |
| CN106562469A (en) * | 2015-10-07 | 2017-04-19 | 惠州市吉瑞科技有限公司 | Electronic cigarette tobacco liquid |
| KR102661607B1 (en) * | 2015-11-02 | 2024-04-30 | 필립모리스 프로덕츠 에스.에이. | Aerosol generating system including vibrating member |
| GB2544468A (en) * | 2015-11-12 | 2017-05-24 | Jaytee Biosciences Ltd | Liquid formulation |
| US20170216172A1 (en) * | 2016-01-29 | 2017-08-03 | The Procter & Gamble Company | Composition for Enhancing Hair Fiber Properties |
| US20170325494A1 (en) * | 2016-05-16 | 2017-11-16 | Lunatech, Llc | Liquid composition containing nicotine from non-tobacco source for use with electronic vaporizing devices |
| KR102490177B1 (en) * | 2016-05-27 | 2023-01-20 | 필립모리스 프로덕츠 에스.에이. | Aerosol-generating article with liquid indicator |
| US20170348494A1 (en) * | 2016-06-06 | 2017-12-07 | Nicholas A. Havercroft | Pulmonary device, method and system for delivering a pharmaceutical product to an individual |
| CN106036990B (en) * | 2016-08-03 | 2018-10-12 | 华健 | A kind of compound alcohol electronic cigarette atomizing liquid |
| US11785677B2 (en) * | 2017-06-08 | 2023-10-10 | Altria Client Services Llc | Cartridge having a susceptor material |
| KR20210108384A (en) * | 2018-12-31 | 2021-09-02 | 필립모리스 프로덕츠 에스.에이. | liquid nicotine formulation |
-
2019
- 2019-12-31 KR KR1020217019593A patent/KR20210108384A/en unknown
- 2019-12-31 MX MX2021007623A patent/MX2021007623A/en unknown
- 2019-12-31 JP JP2021538442A patent/JP2022516895A/en active Pending
- 2019-12-31 MX MX2021007627A patent/MX2021007627A/en unknown
- 2019-12-31 MX MX2021007625A patent/MX2021007625A/en unknown
- 2019-12-31 CN CN201980079569.2A patent/CN113163845B/en active Active
- 2019-12-31 CN CN201980079943.9A patent/CN113163847B/en active Active
- 2019-12-31 US US17/419,442 patent/US20220071270A1/en active Pending
- 2019-12-31 EP EP19831771.1A patent/EP3905899A1/en active Pending
- 2019-12-31 US US17/419,513 patent/US20220079210A1/en active Pending
- 2019-12-31 CN CN201980080351.9A patent/CN113242696B/en active Active
- 2019-12-31 JP JP2021531580A patent/JP2022515021A/en active Pending
- 2019-12-31 EP EP19831770.3A patent/EP3905898B1/en active Active
- 2019-12-31 JP JP2021538443A patent/JP2022516149A/en active Pending
- 2019-12-31 BR BR112021010222-1A patent/BR112021010222A2/en unknown
- 2019-12-31 WO PCT/EP2019/087196 patent/WO2020141178A1/en active Search and Examination
- 2019-12-31 US US17/419,528 patent/US20220079211A1/en active Pending
- 2019-12-31 US US17/418,928 patent/US20220053817A1/en active Pending
- 2019-12-31 WO PCT/EP2019/087202 patent/WO2020141184A1/en active Search and Examination
- 2019-12-31 EP EP19831773.7A patent/EP3905901A1/en active Pending
- 2019-12-31 JP JP2021531581A patent/JP2022515983A/en active Pending
- 2019-12-31 MX MX2021007624A patent/MX2021007624A/en unknown
- 2019-12-31 BR BR112021010593-0A patent/BR112021010593A2/en unknown
- 2019-12-31 KR KR1020217020911A patent/KR20210109548A/en unknown
- 2019-12-31 BR BR112021009726-0A patent/BR112021009726A2/en unknown
- 2019-12-31 WO PCT/EP2019/087198 patent/WO2020141180A1/en active Search and Examination
- 2019-12-31 CN CN201980079924.6A patent/CN113163846B/en active Active
- 2019-12-31 WO PCT/EP2019/087193 patent/WO2020141176A1/en active Search and Examination
- 2019-12-31 EP EP19831772.9A patent/EP3905900B1/en active Active
- 2019-12-31 CN CN201980079953.2A patent/CN113163848B/en active Active
- 2019-12-31 WO PCT/EP2019/087195 patent/WO2020141177A1/en unknown
- 2019-12-31 KR KR1020217020778A patent/KR20210108394A/en active Search and Examination
- 2019-12-31 KR KR1020217021107A patent/KR20210110314A/en unknown
- 2019-12-31 KR KR1020217020193A patent/KR20210108390A/en unknown
- 2019-12-31 EP EP19831769.5A patent/EP3905897A1/en active Pending
- 2019-12-31 BR BR112021010284-1A patent/BR112021010284A2/en unknown
- 2019-12-31 US US17/419,374 patent/US20220071269A1/en active Pending
- 2019-12-31 JP JP2021538444A patent/JP2022516896A/en active Pending
- 2019-12-31 BR BR112021010614-6A patent/BR112021010614A2/en unknown
- 2019-12-31 MX MX2021007626A patent/MX2021007626A/en unknown
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