JPWO2020123938A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2020123938A5 JPWO2020123938A5 JP2021533530A JP2021533530A JPWO2020123938A5 JP WO2020123938 A5 JPWO2020123938 A5 JP WO2020123938A5 JP 2021533530 A JP2021533530 A JP 2021533530A JP 2021533530 A JP2021533530 A JP 2021533530A JP WO2020123938 A5 JPWO2020123938 A5 JP WO2020123938A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- polypeptide
- item
- antigen
- items
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 451
- 229920001184 polypeptide Polymers 0.000 claims description 443
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 443
- 108091007433 antigens Proteins 0.000 claims description 182
- 239000000427 antigen Substances 0.000 claims description 180
- 102000036639 antigens Human genes 0.000 claims description 180
- 239000012634 fragment Substances 0.000 claims description 157
- 210000004027 cell Anatomy 0.000 claims description 128
- -1 CD86 Proteins 0.000 claims description 81
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 63
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 61
- 230000011664 signaling Effects 0.000 claims description 57
- 108010027179 Tacrolimus Binding Proteins Proteins 0.000 claims description 50
- 102000018679 Tacrolimus Binding Proteins Human genes 0.000 claims description 50
- 230000000139 costimulatory effect Effects 0.000 claims description 46
- 239000003446 ligand Substances 0.000 claims description 42
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims description 41
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims description 41
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims description 36
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims description 34
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims description 34
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 34
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims description 33
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims description 33
- 108091008874 T cell receptors Proteins 0.000 claims description 33
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 33
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims description 31
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 31
- 206010028980 Neoplasm Diseases 0.000 claims description 31
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims description 31
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 31
- 102100031940 Epithelial cell adhesion molecule Human genes 0.000 claims description 30
- 108090000623 proteins and genes Proteins 0.000 claims description 29
- 102000004169 proteins and genes Human genes 0.000 claims description 29
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 27
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims description 26
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims description 26
- 102100038078 CD276 antigen Human genes 0.000 claims description 26
- 102100038083 Endosialin Human genes 0.000 claims description 26
- 102100024964 Neural cell adhesion molecule L1 Human genes 0.000 claims description 26
- 229960002930 sirolimus Drugs 0.000 claims description 25
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 24
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims description 24
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 24
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims description 24
- 101000884275 Homo sapiens Endosialin Proteins 0.000 claims description 24
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 24
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 24
- 101710185679 CD276 antigen Proteins 0.000 claims description 23
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims description 21
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims description 21
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims description 21
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 21
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims description 21
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims description 21
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 21
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims description 21
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims description 21
- 102100027913 Peptidyl-prolyl cis-trans isomerase FKBP1A Human genes 0.000 claims description 19
- 108010006877 Tacrolimus Binding Protein 1A Proteins 0.000 claims description 19
- 102100027207 CD27 antigen Human genes 0.000 claims description 18
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 18
- 102000001301 EGF receptor Human genes 0.000 claims description 17
- 108060006698 EGF receptor Proteins 0.000 claims description 17
- 101000836765 Homo sapiens Protein amnionless Proteins 0.000 claims description 17
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims description 17
- 102100027097 Protein amnionless Human genes 0.000 claims description 17
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims description 17
- 239000003431 cross linking reagent Substances 0.000 claims description 17
- 101000920667 Homo sapiens Epithelial cell adhesion molecule Proteins 0.000 claims description 16
- 102100026094 C-type lectin domain family 12 member A Human genes 0.000 claims description 14
- 101710188619 C-type lectin domain family 12 member A Proteins 0.000 claims description 14
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims description 14
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 claims description 14
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 claims description 14
- 102100024965 Caspase recruitment domain-containing protein 11 Human genes 0.000 claims description 14
- 102100028757 Chondroitin sulfate proteoglycan 4 Human genes 0.000 claims description 14
- 102100030340 Ephrin type-A receptor 2 Human genes 0.000 claims description 14
- 101710116743 Ephrin type-A receptor 2 Proteins 0.000 claims description 14
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims description 14
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims description 14
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims description 14
- 101000761179 Homo sapiens Caspase recruitment domain-containing protein 11 Proteins 0.000 claims description 14
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims description 14
- 101001010823 Homo sapiens Receptor tyrosine-protein kinase erbB-4 Proteins 0.000 claims description 14
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims description 14
- 102100024032 Linker for activation of T-cells family member 1 Human genes 0.000 claims description 14
- 102100034709 Lymphocyte cytosolic protein 2 Human genes 0.000 claims description 14
- 102100037020 Melanoma antigen preferentially expressed in tumors Human genes 0.000 claims description 14
- 101710178381 Melanoma antigen preferentially expressed in tumors Proteins 0.000 claims description 14
- 108010012255 Neural Cell Adhesion Molecule L1 Proteins 0.000 claims description 14
- 102100026181 Placenta-specific protein 1 Human genes 0.000 claims description 14
- 108050005093 Placenta-specific protein 1 Proteins 0.000 claims description 14
- 101710120463 Prostate stem cell antigen Proteins 0.000 claims description 14
- 102100036735 Prostate stem cell antigen Human genes 0.000 claims description 14
- 102100037686 Protein SSX2 Human genes 0.000 claims description 14
- 102100029981 Receptor tyrosine-protein kinase erbB-4 Human genes 0.000 claims description 14
- 102100029198 SLAM family member 7 Human genes 0.000 claims description 14
- 102100029453 T-cell receptor-associated transmembrane adapter 1 Human genes 0.000 claims description 14
- 108010060889 Toll-like receptor 1 Proteins 0.000 claims description 14
- 208000008383 Wilms tumor Diseases 0.000 claims description 14
- 208000026448 Wilms tumor 1 Diseases 0.000 claims description 14
- 102100022748 Wilms tumor protein Human genes 0.000 claims description 14
- 101710127857 Wilms tumor protein Proteins 0.000 claims description 14
- SRHNADOZAAWYLV-XLMUYGLTSA-N alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](NC(C)=O)[C@H](O)O[C@@H]2CO)O[C@H]2[C@H]([C@H](O)[C@H](O)[C@H](C)O2)O)O[C@H](CO)[C@H](O)[C@@H]1O SRHNADOZAAWYLV-XLMUYGLTSA-N 0.000 claims description 14
- 108010039524 chondroitin sulfate proteoglycan 4 Proteins 0.000 claims description 14
- 108090000229 Claudin-6 Proteins 0.000 claims description 13
- 102100031507 Fc receptor-like protein 5 Human genes 0.000 claims description 13
- 101710157460 Hematopoietic cell signal transducer Proteins 0.000 claims description 13
- 101000846908 Homo sapiens Fc receptor-like protein 5 Proteins 0.000 claims description 13
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims description 13
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims description 13
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 13
- 102100033579 Trophoblast glycoprotein Human genes 0.000 claims description 13
- SSOORFWOBGFTHL-OTEJMHTDSA-N (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-5-carbamimidamido-1-[[(2S)-5-carbamimidamido-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-oxopentanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O SSOORFWOBGFTHL-OTEJMHTDSA-N 0.000 claims description 12
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims description 12
- 235000002198 Annona diversifolia Nutrition 0.000 claims description 12
- 102100032912 CD44 antigen Human genes 0.000 claims description 12
- 108010058905 CD44v6 antigen Proteins 0.000 claims description 12
- 102100025221 CD70 antigen Human genes 0.000 claims description 12
- 102100036466 Delta-like protein 3 Human genes 0.000 claims description 12
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims description 12
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims description 12
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims description 12
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims description 12
- 101000928513 Homo sapiens Delta-like protein 3 Proteins 0.000 claims description 12
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 claims description 12
- 101000991061 Homo sapiens MHC class I polypeptide-related sequence B Proteins 0.000 claims description 12
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 claims description 12
- 101001005725 Homo sapiens Melanoma-associated antigen 10 Proteins 0.000 claims description 12
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims description 12
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims description 12
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims description 12
- 101001064779 Homo sapiens Plexin domain-containing protein 2 Proteins 0.000 claims description 12
- 101000880770 Homo sapiens Protein SSX2 Proteins 0.000 claims description 12
- 101100101727 Homo sapiens RAET1L gene Proteins 0.000 claims description 12
- 101001132524 Homo sapiens Retinoic acid early transcript 1E Proteins 0.000 claims description 12
- 101001094545 Homo sapiens Retrotransposon-like protein 1 Proteins 0.000 claims description 12
- 101000607316 Homo sapiens UL-16 binding protein 5 Proteins 0.000 claims description 12
- 101000607320 Homo sapiens UL16-binding protein 2 Proteins 0.000 claims description 12
- 101000607318 Homo sapiens UL16-binding protein 3 Proteins 0.000 claims description 12
- 102100020793 Interleukin-13 receptor subunit alpha-2 Human genes 0.000 claims description 12
- 101710112634 Interleukin-13 receptor subunit alpha-2 Proteins 0.000 claims description 12
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 claims description 12
- 108010010995 MART-1 Antigen Proteins 0.000 claims description 12
- 102000016200 MART-1 Antigen Human genes 0.000 claims description 12
- 102100030301 MHC class I polypeptide-related sequence A Human genes 0.000 claims description 12
- 102100030300 MHC class I polypeptide-related sequence B Human genes 0.000 claims description 12
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 claims description 12
- 102100025049 Melanoma-associated antigen 10 Human genes 0.000 claims description 12
- 102100034256 Mucin-1 Human genes 0.000 claims description 12
- 102100023123 Mucin-16 Human genes 0.000 claims description 12
- 102100029527 Natural cytotoxicity triggering receptor 3 ligand 1 Human genes 0.000 claims description 12
- 101710201161 Natural cytotoxicity triggering receptor 3 ligand 1 Proteins 0.000 claims description 12
- 102100031889 Plexin domain-containing protein 2 Human genes 0.000 claims description 12
- 102100040120 Prominin-1 Human genes 0.000 claims description 12
- 102100033964 Retinoic acid early transcript 1E Human genes 0.000 claims description 12
- 102100035721 Syndecan-1 Human genes 0.000 claims description 12
- 102100040010 UL-16 binding protein 5 Human genes 0.000 claims description 12
- 102100039989 UL16-binding protein 2 Human genes 0.000 claims description 12
- 102100040011 UL16-binding protein 3 Human genes 0.000 claims description 12
- 102100040013 UL16-binding protein 6 Human genes 0.000 claims description 12
- 241001416177 Vicugna pacos Species 0.000 claims description 12
- 239000000539 dimer Substances 0.000 claims description 12
- 102000006495 integrins Human genes 0.000 claims description 12
- 108010044426 integrins Proteins 0.000 claims description 12
- 239000010445 mica Substances 0.000 claims description 12
- 229910052618 mica group Inorganic materials 0.000 claims description 12
- 101150047061 tag-72 gene Proteins 0.000 claims description 12
- 239000013638 trimer Substances 0.000 claims description 12
- 102000005962 receptors Human genes 0.000 claims description 11
- 108020003175 receptors Proteins 0.000 claims description 11
- 101000818543 Homo sapiens Tyrosine-protein kinase ZAP-70 Proteins 0.000 claims description 10
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims description 10
- 102100021125 Tyrosine-protein kinase ZAP-70 Human genes 0.000 claims description 10
- 230000004913 activation Effects 0.000 claims description 10
- 230000015572 biosynthetic process Effects 0.000 claims description 10
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims description 10
- 101150013553 CD40 gene Proteins 0.000 claims description 9
- 102100032937 CD40 ligand Human genes 0.000 claims description 9
- 102100035793 CD83 antigen Human genes 0.000 claims description 9
- 102100037904 CD9 antigen Human genes 0.000 claims description 9
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims description 9
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 claims description 9
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims description 9
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 claims description 9
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims description 9
- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 claims description 9
- 101001047640 Homo sapiens Linker for activation of T-cells family member 1 Proteins 0.000 claims description 9
- 101000971513 Homo sapiens Natural killer cells antigen CD94 Proteins 0.000 claims description 9
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims description 9
- 101000634846 Homo sapiens T-cell receptor-associated transmembrane adapter 1 Proteins 0.000 claims description 9
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims description 9
- 101000763537 Homo sapiens Toll-like receptor 10 Proteins 0.000 claims description 9
- 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 claims description 9
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 claims description 9
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims description 9
- 101000669460 Homo sapiens Toll-like receptor 5 Proteins 0.000 claims description 9
- 101000669406 Homo sapiens Toll-like receptor 6 Proteins 0.000 claims description 9
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims description 9
- 101000800483 Homo sapiens Toll-like receptor 8 Proteins 0.000 claims description 9
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims description 9
- 101710195102 Lymphocyte cytosolic protein 2 Proteins 0.000 claims description 9
- 102100021462 Natural killer cells antigen CD94 Human genes 0.000 claims description 9
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims description 9
- 102100027208 T-cell antigen CD7 Human genes 0.000 claims description 9
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims description 9
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims description 9
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 claims description 9
- 102100027009 Toll-like receptor 10 Human genes 0.000 claims description 9
- 102100024333 Toll-like receptor 2 Human genes 0.000 claims description 9
- 102100024324 Toll-like receptor 3 Human genes 0.000 claims description 9
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims description 9
- 102100039357 Toll-like receptor 5 Human genes 0.000 claims description 9
- 102100039387 Toll-like receptor 6 Human genes 0.000 claims description 9
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims description 9
- 102100033110 Toll-like receptor 8 Human genes 0.000 claims description 9
- 102100033117 Toll-like receptor 9 Human genes 0.000 claims description 9
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 9
- 101000914496 Homo sapiens T-cell antigen CD7 Proteins 0.000 claims description 8
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims description 8
- ZHYGVVKSAGDVDY-QQQXYHJWSA-N 7-o-demethyl cypher Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](O)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 ZHYGVVKSAGDVDY-QQQXYHJWSA-N 0.000 claims description 7
- BUROJSBIWGDYCN-GAUTUEMISA-N AP 23573 Chemical compound C1C[C@@H](OP(C)(C)=O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 BUROJSBIWGDYCN-GAUTUEMISA-N 0.000 claims description 7
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims description 7
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 claims description 7
- 229960005167 everolimus Drugs 0.000 claims description 7
- KASDHRXLYQOAKZ-ZPSXYTITSA-N pimecrolimus Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@@H](Cl)[C@H](OC)C1 KASDHRXLYQOAKZ-ZPSXYTITSA-N 0.000 claims description 7
- 229960005330 pimecrolimus Drugs 0.000 claims description 7
- 229960001302 ridaforolimus Drugs 0.000 claims description 7
- 229960001967 tacrolimus Drugs 0.000 claims description 7
- 229960000235 temsirolimus Drugs 0.000 claims description 7
- QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 claims description 7
- YYSFXUWWPNHNAZ-PKJQJFMNSA-N umirolimus Chemical compound C1[C@@H](OC)[C@H](OCCOCC)CC[C@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 YYSFXUWWPNHNAZ-PKJQJFMNSA-N 0.000 claims description 7
- 229950007775 umirolimus Drugs 0.000 claims description 7
- CGTADGCBEXYWNE-JUKNQOCSSA-N zotarolimus Chemical compound N1([C@H]2CC[C@@H](C[C@@H](C)[C@H]3OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@@]4(O)[C@H](C)CC[C@H](O4)C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C3)OC)C[C@H]2OC)C=NN=N1 CGTADGCBEXYWNE-JUKNQOCSSA-N 0.000 claims description 7
- 229950009819 zotarolimus Drugs 0.000 claims description 7
- 102000014914 Carrier Proteins Human genes 0.000 claims description 5
- 101001090688 Homo sapiens Lymphocyte cytosolic protein 2 Proteins 0.000 claims description 5
- 101710192730 Linker for activation of T-cells family member 1 Proteins 0.000 claims description 5
- 101710113863 T-cell receptor-associated transmembrane adapter 1 Proteins 0.000 claims description 5
- 108091008324 binding proteins Proteins 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 5
- RJBDSRWGVYNDHL-XNJNKMBASA-N (2S,4R,5S,6S)-2-[(2S,3R,4R,5S,6R)-5-[(2S,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(E,2R,3S)-3-hydroxy-2-(octadecanoylamino)octadec-4-enoxy]oxan-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-5-amino-6-[(1S,2R)-2-[(2S,4R,5S,6S)-5-amino-2-carboxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxan-2-yl]oxy-1,3-dihydroxypropyl]-4-hydroxyoxane-2-carboxylic acid Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3NC(C)=O)[C@H](O[C@@]3(C[C@@H](O)[C@H](N)[C@H](O3)[C@H](O)[C@@H](CO)O[C@@]3(C[C@@H](O)[C@H](N)[C@H](O3)[C@H](O)[C@H](O)CO)C(O)=O)C(O)=O)[C@H]2O)[C@H](O)[C@H]1O)[C@@H](O)\C=C\CCCCCCCCCCCCC RJBDSRWGVYNDHL-XNJNKMBASA-N 0.000 claims description 4
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims description 4
- 108090000015 Mesothelin Proteins 0.000 claims description 4
- 102000003735 Mesothelin Human genes 0.000 claims description 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 4
- 206010006187 Breast cancer Diseases 0.000 claims description 3
- 208000026310 Breast neoplasm Diseases 0.000 claims description 3
- 102000003886 Glycoproteins Human genes 0.000 claims description 3
- 108090000288 Glycoproteins Proteins 0.000 claims description 3
- 101000884279 Homo sapiens CD276 antigen Proteins 0.000 claims description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 3
- 102000043129 MHC class I family Human genes 0.000 claims description 3
- 108091054437 MHC class I family Proteins 0.000 claims description 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 3
- 201000005202 lung cancer Diseases 0.000 claims description 3
- 208000020816 lung neoplasm Diseases 0.000 claims description 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 3
- 201000001441 melanoma Diseases 0.000 claims description 3
- 201000002528 pancreatic cancer Diseases 0.000 claims description 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 3
- 102000012440 Acetylcholinesterase Human genes 0.000 claims description 2
- 108010022752 Acetylcholinesterase Proteins 0.000 claims description 2
- 208000023275 Autoimmune disease Diseases 0.000 claims description 2
- 206010005003 Bladder cancer Diseases 0.000 claims description 2
- 206010005949 Bone cancer Diseases 0.000 claims description 2
- 208000018084 Bone neoplasm Diseases 0.000 claims description 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 2
- 101710120600 Cancer/testis antigen 1 Proteins 0.000 claims description 2
- 102100039510 Cancer/testis antigen 2 Human genes 0.000 claims description 2
- 101710120595 Cancer/testis antigen 2 Proteins 0.000 claims description 2
- 102000003846 Carbonic anhydrases Human genes 0.000 claims description 2
- 108090000209 Carbonic anhydrases Proteins 0.000 claims description 2
- 102100040835 Claudin-18 Human genes 0.000 claims description 2
- 108050009324 Claudin-18 Proteins 0.000 claims description 2
- 102300047802 Cutaneous T-cell lymphoma-associated antigen 1 isoform 1 Human genes 0.000 claims description 2
- 101710144543 Endosialin Proteins 0.000 claims description 2
- 101600098482 Homo sapiens Cutaneous T-cell lymphoma-associated antigen 1 (isoform 1) Proteins 0.000 claims description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
- 206010025323 Lymphomas Diseases 0.000 claims description 2
- 208000034578 Multiple myelomas Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 102100037891 Plexin domain-containing protein 1 Human genes 0.000 claims description 2
- 108050009432 Plexin domain-containing protein 1 Proteins 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 108010029485 Protein Isoforms Proteins 0.000 claims description 2
- 102000001708 Protein Isoforms Human genes 0.000 claims description 2
- 101710149284 Protein SSX2 Proteins 0.000 claims description 2
- 206010038389 Renal cancer Diseases 0.000 claims description 2
- 206010039491 Sarcoma Diseases 0.000 claims description 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 2
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 2
- 206010057644 Testis cancer Diseases 0.000 claims description 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 2
- 101150042088 UL16 gene Proteins 0.000 claims description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims description 2
- 108010034265 Vascular Endothelial Growth Factor Receptors Proteins 0.000 claims description 2
- 229940022698 acetylcholinesterase Drugs 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 210000002950 fibroblast Anatomy 0.000 claims description 2
- 102000006815 folate receptor Human genes 0.000 claims description 2
- 108020005243 folate receptor Proteins 0.000 claims description 2
- 150000002270 gangliosides Chemical class 0.000 claims description 2
- 201000010536 head and neck cancer Diseases 0.000 claims description 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 2
- 201000005787 hematologic cancer Diseases 0.000 claims description 2
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims description 2
- 201000010982 kidney cancer Diseases 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 201000007270 liver cancer Diseases 0.000 claims description 2
- 208000014018 liver neoplasm Diseases 0.000 claims description 2
- 201000000849 skin cancer Diseases 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims description 2
- 201000003120 testicular cancer Diseases 0.000 claims description 2
- 201000002510 thyroid cancer Diseases 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 102100038449 Claudin-6 Human genes 0.000 claims 2
- 102000010956 Glypican Human genes 0.000 claims 2
- 108050001154 Glypican Proteins 0.000 claims 2
- 108050007237 Glypican-3 Proteins 0.000 claims 2
- 102100027010 Toll-like receptor 1 Human genes 0.000 claims 2
- 101710190034 Trophoblast glycoprotein Proteins 0.000 claims 2
- 241000282832 Camelidae Species 0.000 claims 1
- 101000882898 Homo sapiens Claudin-6 Proteins 0.000 claims 1
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims 1
- 241000282842 Lama glama Species 0.000 claims 1
- 108010086911 MICB antigen Proteins 0.000 claims 1
- 108010006700 Receptor Tyrosine Kinase-like Orphan Receptors Proteins 0.000 claims 1
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims 1
- 230000004927 fusion Effects 0.000 description 106
- 239000013598 vector Substances 0.000 description 21
- 239000003795 chemical substances by application Substances 0.000 description 16
- 238000000034 method Methods 0.000 description 14
- 238000003776 cleavage reaction Methods 0.000 description 13
- 230000007017 scission Effects 0.000 description 13
- 102100027205 B-cell antigen receptor complex-associated protein alpha chain Human genes 0.000 description 12
- 102100027203 B-cell antigen receptor complex-associated protein beta chain Human genes 0.000 description 12
- 102000003859 Claudin-6 Human genes 0.000 description 12
- 101000914489 Homo sapiens B-cell antigen receptor complex-associated protein alpha chain Proteins 0.000 description 12
- 101000914491 Homo sapiens B-cell antigen receptor complex-associated protein beta chain Proteins 0.000 description 12
- 102000001068 Neural Cell Adhesion Molecules Human genes 0.000 description 12
- 108010069196 Neural Cell Adhesion Molecules Proteins 0.000 description 12
- 102000008229 Toll-like receptor 1 Human genes 0.000 description 12
- 244000303258 Annona diversifolia Species 0.000 description 11
- 102100032530 Glypican-3 Human genes 0.000 description 11
- 101001014668 Homo sapiens Glypican-3 Proteins 0.000 description 11
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 description 11
- 101000801433 Homo sapiens Trophoblast glycoprotein Proteins 0.000 description 11
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 description 11
- 238000004132 cross linking Methods 0.000 description 11
- JLIDBLDQVAYHNE-YKALOCIXSA-N (+)-Abscisic acid Chemical compound OC(=O)/C=C(/C)\C=C\[C@@]1(O)C(C)=CC(=O)CC1(C)C JLIDBLDQVAYHNE-YKALOCIXSA-N 0.000 description 10
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 description 10
- 102000004631 Calcineurin Human genes 0.000 description 10
- 108010042955 Calcineurin Proteins 0.000 description 10
- 102000001493 Cyclophilins Human genes 0.000 description 10
- 108010068682 Cyclophilins Proteins 0.000 description 10
- 101000693708 Homo sapiens Sarcolipin Proteins 0.000 description 10
- 101000607306 Homo sapiens UL16-binding protein 1 Proteins 0.000 description 10
- 108020003285 Isocitrate lyase Proteins 0.000 description 10
- 102100025538 Sarcolipin Human genes 0.000 description 10
- 108010002687 Survivin Proteins 0.000 description 10
- 102100040012 UL16-binding protein 1 Human genes 0.000 description 10
- 229940127276 delta-like ligand 3 Drugs 0.000 description 10
- 102100025466 Carcinoembryonic antigen-related cell adhesion molecule 3 Human genes 0.000 description 8
- 229930105110 Cyclosporin A Natural products 0.000 description 8
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 8
- 108010036949 Cyclosporine Proteins 0.000 description 8
- 101000914337 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 3 Proteins 0.000 description 8
- 101000702132 Homo sapiens Protein spinster homolog 1 Proteins 0.000 description 8
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 8
- 108010022394 Threonine synthase Proteins 0.000 description 8
- 101001038499 Yarrowia lipolytica (strain CLIB 122 / E 150) Lysine acetyltransferase Proteins 0.000 description 8
- 102000004419 dihydrofolate reductase Human genes 0.000 description 8
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 8
- 229930191978 Gibberellin Natural products 0.000 description 5
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 5
- FCRACOPGPMPSHN-UHFFFAOYSA-N desoxyabscisic acid Natural products OC(=O)C=C(C)C=CC1C(C)=CC(=O)CC1(C)C FCRACOPGPMPSHN-UHFFFAOYSA-N 0.000 description 5
- IXORZMNAPKEEDV-UHFFFAOYSA-N gibberellic acid GA3 Natural products OC(=O)C1C2(C3)CC(=C)C3(O)CCC2C2(C=CC3O)C1C3(C)C(=O)O2 IXORZMNAPKEEDV-UHFFFAOYSA-N 0.000 description 5
- 239000003448 gibberellin Substances 0.000 description 5
- 229960000485 methotrexate Drugs 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 102000001253 Protein Kinase Human genes 0.000 description 4
- 241000700605 Viruses Species 0.000 description 4
- 108060006633 protein kinase Proteins 0.000 description 4
- 230000003612 virological effect Effects 0.000 description 4
- JLIDBLDQVAYHNE-LXGGSRJLSA-N 2-cis-abscisic acid Chemical compound OC(=O)/C=C(/C)\C=C\C1(O)C(C)=CC(=O)CC1(C)C JLIDBLDQVAYHNE-LXGGSRJLSA-N 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 229960001265 ciclosporin Drugs 0.000 description 3
- 102000040430 polynucleotide Human genes 0.000 description 3
- 108091033319 polynucleotide Proteins 0.000 description 3
- 239000002157 polynucleotide Substances 0.000 description 3
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 3
- 229960001082 trimethoprim Drugs 0.000 description 3
- 239000013603 viral vector Substances 0.000 description 3
- 241000713704 Bovine immunodeficiency virus Species 0.000 description 2
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 2
- 241000214054 Equine rhinitis A virus Species 0.000 description 2
- 241000713800 Feline immunodeficiency virus Species 0.000 description 2
- 241000710198 Foot-and-mouth disease virus Species 0.000 description 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 2
- 241000713340 Human immunodeficiency virus 2 Species 0.000 description 2
- 241000713311 Simian immunodeficiency virus Species 0.000 description 2
- 241001648840 Thosea asigna virus Species 0.000 description 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 2
- 230000001177 retroviral effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 description 2
- 206010003445 Ascites Diseases 0.000 description 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 description 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 241000713756 Caprine arthritis encephalitis virus Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000710188 Encephalomyocarditis virus Species 0.000 description 1
- 241000713730 Equine infectious anemia virus Species 0.000 description 1
- 102000009465 Growth Factor Receptors Human genes 0.000 description 1
- 108010009202 Growth Factor Receptors Proteins 0.000 description 1
- 206010066476 Haematological malignancy Diseases 0.000 description 1
- 241000175212 Herpesvirales Species 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 208000029462 Immunodeficiency disease Diseases 0.000 description 1
- 102000016978 Orphan receptors Human genes 0.000 description 1
- 108070000031 Orphan receptors Proteins 0.000 description 1
- 240000007019 Oxalis corniculata Species 0.000 description 1
- 208000002151 Pleural effusion Diseases 0.000 description 1
- 206010046865 Vaccinia virus infection Diseases 0.000 description 1
- 208000010094 Visna Diseases 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 230000008472 epithelial growth Effects 0.000 description 1
- 208000009724 equine infectious anemia Diseases 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 210000004700 fetal blood Anatomy 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
- 239000012642 immune effector Substances 0.000 description 1
- 230000007813 immunodeficiency Effects 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000002993 trophoblast Anatomy 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024188998A JP2025010249A (ja) | 2018-12-14 | 2024-10-28 | 二量体形成剤調節性免疫受容体複合体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862779971P | 2018-12-14 | 2018-12-14 | |
| US62/779,971 | 2018-12-14 | ||
| US201962835659P | 2019-04-18 | 2019-04-18 | |
| US62/835,659 | 2019-04-18 | ||
| PCT/US2019/066223 WO2020123938A1 (en) | 2018-12-14 | 2019-12-13 | Dimerizing agent regulated immunoreceptor complexes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024188998A Division JP2025010249A (ja) | 2018-12-14 | 2024-10-28 | 二量体形成剤調節性免疫受容体複合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022513460A JP2022513460A (ja) | 2022-02-08 |
| JPWO2020123938A5 true JPWO2020123938A5 (enExample) | 2022-12-20 |
| JP7636650B2 JP7636650B2 (ja) | 2025-02-27 |
Family
ID=71077012
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021533530A Active JP7636650B2 (ja) | 2018-12-14 | 2019-12-13 | 二量体形成剤調節性免疫受容体複合体 |
| JP2024188998A Pending JP2025010249A (ja) | 2018-12-14 | 2024-10-28 | 二量体形成剤調節性免疫受容体複合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024188998A Pending JP2025010249A (ja) | 2018-12-14 | 2024-10-28 | 二量体形成剤調節性免疫受容体複合体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20220031750A1 (enExample) |
| EP (1) | EP3895052A4 (enExample) |
| JP (2) | JP7636650B2 (enExample) |
| KR (1) | KR20210104772A (enExample) |
| CN (1) | CN113366479A (enExample) |
| AU (1) | AU2019396553A1 (enExample) |
| CA (1) | CA3123084A1 (enExample) |
| IL (1) | IL283897A (enExample) |
| WO (1) | WO2020123938A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200110326A (ko) * | 2017-12-14 | 2020-09-23 | 블루버드 바이오, 인코포레이티드. | Daric 인터류킨 수용체 |
| US12291560B2 (en) | 2018-12-14 | 2025-05-06 | Regeneron Pharmaceuticals, Inc. | Dimerizing agent regulated immunoreceptor complexes |
| EP3966243A1 (en) | 2019-05-04 | 2022-03-16 | Inhibrx, Inc. | Clec12a-binding polypeptides and uses thereof |
| SG11202111927QA (en) | 2019-05-08 | 2021-11-29 | 2Seventy Bio Inc | Cll-1 targeted immunotherapies |
| WO2022099176A1 (en) * | 2020-11-09 | 2022-05-12 | 2Seventy Bio, Inc. | Aml targeted immunotherapies |
| BR112023022765A2 (pt) | 2021-05-05 | 2024-01-02 | Immatics Biotechnologies Gmbh | Proteínas de ligação ao antígeno que ligam especificamente o prame |
| WO2022266075A1 (en) * | 2021-06-14 | 2022-12-22 | Caribou Biosciences, Inc. | Methods and materials for treating cancer using car constructs with an intracellular domain comprising a stap domain and a kinase domain or a stap domain and a phosphatase domain |
| CN113528455A (zh) * | 2021-07-19 | 2021-10-22 | 广州百暨基因科技有限公司 | 表达嵌合抗原受体的γδT细胞 |
| CN114736306B (zh) * | 2022-03-01 | 2024-04-19 | 中国科学院深圳先进技术研究院 | 一种受化学调控的蛋白酶工具及其配套底物 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
| US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| GB8918616D0 (en) | 1989-08-15 | 1989-09-27 | Univ Glasgow | Herpes simplex virus type 1 mutant |
| DE69123979T2 (de) | 1990-10-12 | 1997-04-30 | Max Planck Gesellschaft | Abgeänderte ribozyme |
| US5652094A (en) | 1992-01-31 | 1997-07-29 | University Of Montreal | Nucleozymes |
| US5804413A (en) | 1992-07-31 | 1998-09-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Herpes simplex virus strains for gene transfer |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| GB9415319D0 (en) | 1994-07-29 | 1994-09-21 | Medical Res Council | HSV viral vector |
| US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6093570A (en) | 1995-06-07 | 2000-07-25 | The University Of North Carolina At Chapel Hill | Helper virus-free AAV production |
| US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| WO1999006583A1 (en) | 1997-07-31 | 1999-02-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Targeted hsv vectors |
| US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
| FR2777909B1 (fr) | 1998-04-24 | 2002-08-02 | Pasteur Institut | Utilisation de sequences d'adn de structure triplex pour le tranfert de sequences de nucleotides dans des cellules, vecteurs recombinants contenant ces sequences triplex |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| AU4328801A (en) | 2000-02-24 | 2001-09-03 | Xcyte Therapies Inc | Simultaneous stimulation and concentration of cells |
| US6692736B2 (en) | 2000-03-24 | 2004-02-17 | Cell Genesys, Inc. | Cell-specific adenovirus vectors comprising an internal ribosome entry site |
| WO2001092551A2 (en) | 2000-06-01 | 2001-12-06 | University Of North Carolina At Chapel Hill | Duplexed parvovirus vectors |
| EP1385946B1 (en) | 2001-05-01 | 2009-12-23 | National Research Council Of Canada | A system for inducible expression in eukaryotic cells |
| AU2003202908A1 (en) | 2002-01-03 | 2003-07-24 | The Trustees Of The University Of Pennsylvania | Activation and expansion of t-cells using an engineered multivalent signaling platform |
| FR2872170B1 (fr) | 2004-06-25 | 2006-11-10 | Centre Nat Rech Scient Cnrse | Lentivirus non interactif et non replicatif, preparation et utilisations |
| CN101124328A (zh) | 2004-12-15 | 2008-02-13 | 北卡罗来纳查佩尔山大学 | 嵌合载体 |
| WO2010093784A2 (en) | 2009-02-11 | 2010-08-19 | The University Of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
| ES2683695T3 (es) | 2010-01-12 | 2018-09-27 | The University Of North Carolina At Chapel Hill | Repeticiones terminales invertidas restrictivas para vectores virales |
| ES2628889T3 (es) | 2010-02-05 | 2017-08-04 | The University Of North Carolina At Chapel Hill | Composiciones y métodos para la transducción mejorada del parvovirus |
| US10196444B2 (en) * | 2013-07-29 | 2019-02-05 | Bluebird Bio, Inc. | Multipartite signaling proteins and uses thereof |
| ES2857226T3 (es) * | 2014-03-15 | 2021-09-28 | Novartis Ag | Receptor de antígeno quimérico regulable |
| CN109311984A (zh) | 2016-03-11 | 2019-02-05 | 蓝鸟生物公司 | 基因组编辑的免疫效应细胞 |
| AU2017250773A1 (en) | 2016-04-14 | 2018-11-08 | 2Seventy Bio, Inc. | Salvage chimeric antigen receptor systems |
| WO2018127585A1 (en) * | 2017-01-06 | 2018-07-12 | Txcell | Monospecific regulatory t cell population with cytotoxicity for b cells |
-
2019
- 2019-12-13 US US17/312,120 patent/US20220031750A1/en active Pending
- 2019-12-13 CN CN201980091143.9A patent/CN113366479A/zh active Pending
- 2019-12-13 WO PCT/US2019/066223 patent/WO2020123938A1/en not_active Ceased
- 2019-12-13 EP EP19896568.3A patent/EP3895052A4/en active Pending
- 2019-12-13 AU AU2019396553A patent/AU2019396553A1/en active Pending
- 2019-12-13 JP JP2021533530A patent/JP7636650B2/ja active Active
- 2019-12-13 CA CA3123084A patent/CA3123084A1/en active Pending
- 2019-12-13 KR KR1020217021631A patent/KR20210104772A/ko active Pending
-
2021
- 2021-06-10 IL IL283897A patent/IL283897A/en unknown
-
2024
- 2024-10-28 JP JP2024188998A patent/JP2025010249A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6633081B2 (ja) | 細胞 | |
| AU2021307614B2 (en) | Engineered immune cell for allotransplantation | |
| JP6336684B2 (ja) | Ｐｄ−ｌ１によって誘導される免疫寛容の低減 | |
| JP2022116230A (ja) | 免疫療法用改変細胞 | |
| JP2019518425A5 (enExample) | ||
| EP4219693A1 (en) | Chimeric antigen receptor targeting cd7 and use thereof | |
| JP2020521759A (ja) | 免疫トレランスを調節するための多機能性の抗体−リガンド・トラップ | |
| FI3703750T3 (fi) | B-solujen maturaatioantigeenille spesifisiä kimeerisiä antigeenireseptoreita ja koodaavia polynukleotideja | |
| Muhammad et al. | CAR T-cells for cancer therapy | |
| Griffin et al. | Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152) | |
| WO2017176525A1 (en) | Car having replicated binding motifs in a co-stimulatory domain | |
| CN114015656A (zh) | 用于同种异体移植的工程化免疫细胞 | |
| US20230235052A1 (en) | Humanized cd19 antibody and use thereof | |
| JP2018537076A5 (enExample) | ||
| KR20210135987A (ko) | Cd86 변이체 면역조절 단백질 및 그의 용도 | |
| JP2023527194A (ja) | 腫瘍微小環境を逆転させる融合タンパク質及びその使用 | |
| JPWO2020123938A5 (enExample) | ||
| KR20220143057A (ko) | Cd2 활성화를 갖는 키메라 항원 수용체 | |
| EP4613781A1 (en) | Immune rejection-resistant engineered cell | |
| CN117187185A (zh) | 一种工程化免疫细胞及其用途 | |
| CN114729305A (zh) | 用于免疫治疗的嵌合抗原受体、制备方法及其应用 | |
| US12281150B2 (en) | T cell disease treatment targeting TAG-72 | |
| JPWO2021211948A5 (enExample) | ||
| JPWO2021162521A5 (enExample) | ||
| US20210079111A1 (en) | Cd19-cd20 bispecific and dual passway car-t and methods for use thereof |