JPWO2020096772A5 - - Google Patents
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- JPWO2020096772A5 JPWO2020096772A5 JP2021525333A JP2021525333A JPWO2020096772A5 JP WO2020096772 A5 JPWO2020096772 A5 JP WO2020096772A5 JP 2021525333 A JP2021525333 A JP 2021525333A JP 2021525333 A JP2021525333 A JP 2021525333A JP WO2020096772 A5 JPWO2020096772 A5 JP WO2020096772A5
- Authority
- JP
- Japan
- Prior art keywords
- blood sample
- centrifuged blood
- centrifuged
- processing device
- transparent container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Claims (16)
前記遠心分離機にかけられた血液サンプルが入っている透明容器と、
前記遠心分離機にかけられた血液サンプルを照光するための照明光源であって、前記遠心分離機にかけられた血液サンプルを、前記透明容器の重心軸に対して斜角を成すように配置された照明光源と、
前記遠心分離機にかけられた血液サンプルを撮像するように、前記透明容器の反対側に配設されたデジタルカメラと、
前記遠心分離機にかけられた血液サンプル画像を処理して、前記遠心分離機にかけられた血液サンプルの成分層の相対位置を判定するための処理装置と、
を備え、
前記処理装置は、前記遠心分離機にかけられた血液サンプルの表面との機械的接触によって、前記表面の位置を検知するための液面レベルセンサを備え、
前記処理装置は、前記遠心分離機にかけられた血液サンプルの前記成分層の前記相対位置と、前記遠心分離機にかけられた血液サンプルの前記表面の前記位置とに基づいて、前記成分層の実際の位置を判定する、
血液サンプル処理装置。 A blood sample processing device for imaging a centrifuged blood sample, comprising:
a transparent container containing the centrifuged blood sample;
an illumination light source for illuminating the centrifuged blood sample, wherein the illumination is arranged such that the centrifuged blood sample forms an oblique angle with respect to the center axis of the transparent container. a light source;
a digital camera disposed on the opposite side of the transparent container to image the centrifuged blood sample;
a processing device for processing the centrifuged blood sample image to determine relative positions of constituent layers of the centrifuged blood sample;
with
the processing unit comprises a liquid level sensor for sensing the position of the centrifuged blood sample surface by mechanical contact with the surface;
Based on the relative position of the component layer of the centrifuged blood sample and the position of the surface of the centrifuged blood sample, the processing device determines the actual component layer of the component layer. determine the position,
Blood sample processing device .
請求項１に記載の血液サンプル処理装置。 the illumination source uses monochromatic light below the wavelength of yellow;
A blood sample processing device according to claim 1.
請求項１に記載の血液サンプル処理装置。 the illumination source uses multiple wavelengths of light below yellow wavelengths;
A blood sample processing device according to claim 1.
請求項３に記載の血液サンプル処理装置。 wherein the plurality of wavelengths of light are selected to accentuate each of the clean puffy coat layer and the transition layer;
4. A blood sample processing device according to claim 3 .
請求項１に記載の血液サンプル処理装置。 the illumination source illuminates the centrifuged blood sample at a 30 degree angle to the transparent container;
A blood sample processing device according to claim 1.
請求項１に記載の血液サンプル処理装置。 wherein the digital camera is a color digital camera;
A blood sample processing device according to claim 1.
請求項１に記載の血液サンプル処理装置。 further comprising an external reference for determining the actual position of the component layer of the centrifuged blood sample;
A blood sample processing device according to claim 1.
請求項１に記載の血液サンプル処理装置。 further comprising a pipette for removing the component layer of the centrifuged blood sample from the transparent container;
A blood sample processing device according to claim 1.
前記血液サンプルを透明容器の中に入れることと、
前記遠心分離機にかけられた血液サンプルを、前記透明容器の重心軸に対して斜角を成すように配置された照明光源で照光することと、
前記遠心分離機にかけられた血液サンプルを、前記透明容器の反対側に配設されたデジタルカメラで撮像することと、
前記遠心分離機にかけられた血液サンプルの画像を処理して、前記遠心分離機にかけられた血液サンプルの成分層の相対位置を判定することと、
液面レベルセンサと前記遠心分離機にかけられた血液サンプルの表面との機械的接触によって、前記表面の位置を検知することと、
前記遠心分離機にかけられた血液サンプルの前記成分層の前記相対位置と、前記遠心分離機にかけられた血液サンプルの前記表面の前記位置とに基づいて、前記成分層の実際の位置を判定すること、
を含む、方法。 A method of analyzing a centrifuged blood sample comprising:
placing the blood sample in a transparent container;
illuminating the centrifuged blood sample with an illumination light source positioned at an oblique angle to the center axis of the transparent container;
imaging the centrifuged blood sample with a digital camera disposed on the opposite side of the transparent container;
processing an image of the centrifuged blood sample to determine relative positions of component layers of the centrifuged blood sample;
sensing the position of the surface of the centrifuged blood sample by mechanical contact between a liquid level sensor and the surface of the centrifuged blood sample;
Determining the actual position of the component layer based on the relative position of the component layer of the centrifuged blood sample and the position of the surface of the centrifuged blood sample. ,
A method , including
請求項９に記載の、遠心分離機にかけられた血液サンプルを分析する方法。 further comprising illuminating the centrifuged blood sample using monochromatic light of less than yellow wavelengths;
10. The method of analyzing a centrifuged blood sample according to claim 9 .
請求項９に記載の、遠心分離機にかけられた血液サンプルを分析する方法。 further comprising illuminating the blood sample using multiple wavelengths of light below yellow wavelengths;
10. The method of analyzing a centrifuged blood sample according to claim 9 .
請求項１１に記載の、遠心分離機にかけられた血液サンプルを分析する方法。 further comprising selecting the plurality of wavelengths of light to accentuate each of a clean pia layer and a transition layer;
12. The method of analyzing a centrifuged blood sample according to claim 11 .
することをさらに含む、
請求項９に記載の、遠心分離機にかけられた血液サンプルを分析する方法。 further comprising illuminating the centrifuged blood sample at a 30 degree angle to the transparent container;
10. The method of analyzing a centrifuged blood sample according to claim 9 .
請求項９に記載の、遠心分離機にかけられた血液サンプルを分析する方法。 further comprising using a color digital camera for said digital camera;
10. The method of analyzing a centrifuged blood sample according to claim 9 .
請求項９に記載の、遠心分離機にかけられた血液サンプルを分析する方法。 further comprising using an external reference to determine the actual position of the component layer of the centrifuged blood sample;
10. The method of analyzing a centrifuged blood sample according to claim 9 .
請求項９に記載の、遠心分離機にかけられた血液サンプルを分析する方法。 further comprising removing the component layer of the centrifuged blood sample from the transparent container using a pipette;
10. The method of analyzing a centrifuged blood sample according to claim 9 .
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16/184,494 | 2018-11-08 | ||
| US16/184,494 US11386551B2 (en) | 2018-11-08 | 2018-11-08 | Method and apparatus for buffy coat imaging |
| PCT/US2019/057535 WO2020096772A1 (en) | 2018-11-08 | 2019-10-23 | Method and apparatus for buffy coat imaging |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022507121A JP2022507121A (en) | 2022-01-18 |
| JPWO2020096772A5 true JPWO2020096772A5 (en) | 2022-10-28 |
| JP7250925B2 JP7250925B2 (en) | 2023-04-03 |
Family
ID=68582340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021525333A Active JP7250925B2 (en) | 2018-11-08 | 2019-10-23 | Method and apparatus for puffy-coat imaging |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11386551B2 (en) |
| EP (1) | EP3877747A1 (en) |
| JP (1) | JP7250925B2 (en) |
| KR (1) | KR102504240B1 (en) |
| CN (1) | CN112997063A (en) |
| AU (1) | AU2019375858A1 (en) |
| BR (1) | BR112021008799A2 (en) |
| CA (1) | CA3118716A1 (en) |
| WO (1) | WO2020096772A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210033197A (en) * | 2019-09-18 | 2021-03-26 | 엘지전자 주식회사 | Robot and method for calculating level of liquid in the liquid container |
| JP2023069603A (en) * | 2021-11-08 | 2023-05-18 | 株式会社日立ハイテク | Biological sample measurement device |
| GB2617833A (en) * | 2022-04-19 | 2023-10-25 | Entia Ltd | An analysis apparatus and method |
| CN116086894B (en) * | 2023-04-10 | 2023-07-25 | 北京市春立正达医疗器械股份有限公司 | Blood cell monitoring and guiding assembly after separation and method |
Family Cites Families (25)
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| JP2501460B2 (en) * | 1988-03-23 | 1996-05-29 | オリンパス光学工業株式会社 | How to measure hematocrit |
| JPH02195261A (en) * | 1989-01-25 | 1990-08-01 | Shimadzu Corp | Apparatus for sampling blood serum |
| JPH0337568A (en) * | 1989-07-03 | 1991-02-18 | Fuji Photo Film Co Ltd | Biochemical analyzer |
| JPH05312804A (en) * | 1991-04-03 | 1993-11-26 | Keyence Corp | Measuring method for erythrocyte sedimentation rate and its measuring device |
| JPH04372861A (en) * | 1991-06-24 | 1992-12-25 | Fuji Photo Film Co Ltd | Detecting apparatus of liquid level |
| JP3429345B2 (en) * | 1993-11-30 | 2003-07-22 | セファテクノロジー株式会社 | Light projection position control device and sample volume measurement device in transparent container |
| JP3132342B2 (en) | 1995-07-07 | 2001-02-05 | 松下電器産業株式会社 | Specimen test method and device |
| JP2000162215A (en) * | 1998-11-30 | 2000-06-16 | Ids:Kk | Specimen treatment tube element and feed system thereof |
| JP2001108506A (en) * | 1999-10-13 | 2001-04-20 | Aloka Co Ltd | Layer boundary surface detecting device |
| FR2858251B1 (en) * | 2003-07-29 | 2005-10-28 | Diagyr | METHOD FOR BALANCING A ROTARY TRAY OF A CENTRIFUGE AND CENTRIFUGE EMPLOYING THE PROCESS |
| GB0422358D0 (en) * | 2004-10-08 | 2004-11-10 | Rts Thurnall Plc | Determination of the boundaries between fractions and extraction of selected fractions in a fractional sample |
| WO2006106962A1 (en) * | 2005-03-31 | 2006-10-12 | Kabushiki Kaisha Toshiba | Fluorescent measuring device, fluorescent measuring method, container for fluorescent measurement, and method for manufacturing the container for fluorescent measurement |
| JP2010500900A (en) * | 2006-08-17 | 2010-01-14 | カリディアンビーシーティー、インコーポレーテッド | Blood processing equipment with robust automatic process control |
| US9116129B2 (en) * | 2007-05-08 | 2015-08-25 | Idexx Laboratories, Inc. | Chemical analyzer |
| EP2443450A2 (en) * | 2009-06-16 | 2012-04-25 | Robert Aaron Levine | Harvesting target materials from centrifuged suspensions |
| AU2010282784C1 (en) * | 2009-08-13 | 2014-03-13 | Siemens Healthcare Diagnostics Inc. | Methods and apparatus for ascertaining interferents and physical dimensions in liquid samples and containers to be analyzed by a clinical analyzer |
| US20110226045A1 (en) | 2009-11-25 | 2011-09-22 | Mcquillan Adrian Charles | Liquid analysis system |
| EP2743704A3 (en) * | 2010-07-23 | 2014-06-25 | Beckman Coulter, Inc. | System or method of including analytical units |
| US9476825B2 (en) * | 2010-10-19 | 2016-10-25 | Baxter International Inc. | Optical imaging system with multiple imaging channel optical sensing |
| AR085087A1 (en) * | 2011-01-21 | 2013-09-11 | Theranos Inc | SYSTEMS AND METHODS TO MAXIMIZE THE USE OF SAMPLES |
| JP5414707B2 (en) * | 2011-01-31 | 2014-02-12 | 株式会社日立ハイテクノロジーズ | Analysis equipment |
| JP6143584B2 (en) * | 2013-07-04 | 2017-06-07 | 株式会社日立ハイテクノロジーズ | Detector and biological sample analyzer |
| WO2015159620A1 (en) * | 2014-04-17 | 2015-10-22 | 株式会社日立ハイテクノロジーズ | Specimen inspection automation system, check module, and sample check method |
| US11009467B2 (en) * | 2015-02-17 | 2021-05-18 | Siemens Healthcare Diagnostics Inc. | Model-based methods and apparatus for classifying an interferent in specimens |
| JP6791972B2 (en) | 2016-01-28 | 2020-11-25 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． | Methods and Devices for Detecting Interferents in Samples |
-
2018
- 2018-11-08 US US16/184,494 patent/US11386551B2/en active Active
-
2019
- 2019-10-23 AU AU2019375858A patent/AU2019375858A1/en active Pending
- 2019-10-23 WO PCT/US2019/057535 patent/WO2020096772A1/en unknown
- 2019-10-23 CA CA3118716A patent/CA3118716A1/en active Pending
- 2019-10-23 KR KR1020217017465A patent/KR102504240B1/en active IP Right Grant
- 2019-10-23 JP JP2021525333A patent/JP7250925B2/en active Active
- 2019-10-23 CN CN201980073984.7A patent/CN112997063A/en active Pending
- 2019-10-23 BR BR112021008799-0A patent/BR112021008799A2/en not_active Application Discontinuation
- 2019-10-23 EP EP19804917.3A patent/EP3877747A1/en active Pending
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