JPWO2020092448A5 - - Google Patents
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- Publication number
- JPWO2020092448A5 JPWO2020092448A5 JP2021548539A JP2021548539A JPWO2020092448A5 JP WO2020092448 A5 JPWO2020092448 A5 JP WO2020092448A5 JP 2021548539 A JP2021548539 A JP 2021548539A JP 2021548539 A JP2021548539 A JP 2021548539A JP WO2020092448 A5 JPWO2020092448 A5 JP WO2020092448A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- mutations
- recombinant protein
- antitrypsin
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024103143A JP2024123234A (ja) | 2018-10-29 | 2024-06-26 | アルファ－１－アンチトリプシン欠乏症のための組成物及び方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862752182P | 2018-10-29 | 2018-10-29 | |
| US62/752,182 | 2018-10-29 | ||
| PCT/US2019/058673 WO2020092448A1 (en) | 2018-10-29 | 2019-10-29 | Compositions and methods for alpha-1-antitrypsin disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024103143A Division JP2024123234A (ja) | 2018-10-29 | 2024-06-26 | アルファ－１－アンチトリプシン欠乏症のための組成物及び方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022509517A JP2022509517A (ja) | 2022-01-20 |
| JPWO2020092448A5 true JPWO2020092448A5 (https=) | 2022-11-08 |
| JP2022509517A5 JP2022509517A5 (https=) | 2022-11-08 |
| JP7731288B2 JP7731288B2 (ja) | 2025-08-29 |
Family
ID=68771752
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021548539A Active JP7731288B2 (ja) | 2018-10-29 | 2019-10-29 | アルファ－１－アンチトリプシン欠乏症のための組成物及び方法 |
| JP2024103143A Pending JP2024123234A (ja) | 2018-10-29 | 2024-06-26 | アルファ－１－アンチトリプシン欠乏症のための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024103143A Pending JP2024123234A (ja) | 2018-10-29 | 2024-06-26 | アルファ－１－アンチトリプシン欠乏症のための組成物及び方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12497441B2 (https=) |
| EP (1) | EP3873926A1 (https=) |
| JP (2) | JP7731288B2 (https=) |
| KR (1) | KR20210111245A (https=) |
| CN (1) | CN113286816B (https=) |
| AU (1) | AU2019369403B2 (https=) |
| BR (1) | BR112021008200A2 (https=) |
| CA (1) | CA3117961A1 (https=) |
| WO (1) | WO2020092448A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3914261A4 (en) | 2019-01-22 | 2023-06-28 | Korro Bio, Inc. | Rna-editing oligonucleotides and uses thereof |
| KR20210129646A (ko) | 2019-01-22 | 2021-10-28 | 코로 바이오, 인크. | Rna-편집 올리고뉴클레오타이드 및 그의 용도 |
| TW202043469A (zh) | 2019-01-22 | 2020-12-01 | 美商科羅生物公司 | Ｒｎａ編輯之寡核苷酸及其用途 |
| AU2021279027A1 (en) * | 2020-05-28 | 2022-12-08 | Korro Bio, Inc. | Methods and compositions for the ADAR-mediated editing of SERPINA1 |
| EP4240323A1 (en) * | 2020-11-06 | 2023-09-13 | AATEC Medical GmbH | A composition comprising extra-cellular vesicles from mesenchymal stem cells and alpha-1 antitrypsin for the treatment of viral infections |
| IL303712A (en) * | 2020-12-18 | 2023-08-01 | Cullinan Amber Corp | Bi-functional linear fusion collagen-localized immunomodulatory molecules and methods thereofלטו |
| CN117942275A (zh) * | 2022-10-31 | 2024-04-30 | 康码（上海）生物科技有限公司 | 一种基于病毒阻断剂的洗手液及其应用 |
| EP4705336A1 (en) * | 2023-05-05 | 2026-03-11 | Paul Thomas King | Novel therapeutic polypeptide |
| EP4730999A1 (en) * | 2023-06-22 | 2026-04-29 | AATEC Medical GmbH | Recombinant aat from yeast to treat transplants |
| EP4480493A1 (en) | 2023-06-22 | 2024-12-25 | AATEC Medical GmbH | A recombinant human alpha-1 antitrypsin glycoprotein for treating non-viral inflammatory diseases of the lung |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE122007000007I1 (de) | 1986-04-09 | 2007-05-16 | Genzyme Corp | Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| GB8909916D0 (en) * | 1989-04-29 | 1989-06-14 | Delta Biotechnology Ltd | Polypeptides |
| GB9404270D0 (en) | 1994-03-05 | 1994-04-20 | Delta Biotechnology Ltd | Yeast strains and modified albumins |
| CA2386180C (en) | 1999-10-13 | 2010-03-09 | Immunex Corporation | Vectors and methods for recombinant protein expression |
| EP2206720A1 (en) * | 2000-04-12 | 2010-07-14 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| AU2003244515A1 (en) | 2002-02-07 | 2003-09-02 | Novozymes Delta Limited | Albumin-fused anti-angiogenesis peptides |
| CA2534352A1 (en) | 2003-08-08 | 2005-02-17 | Arriva Pharmaceuticals, Inc. | Methods of protein production in yeast |
| US20070269442A1 (en) | 2006-05-19 | 2007-11-22 | Robert J. Webber | Chimeric monoclonal antibody recognizing iNOS |
| CN101646689A (zh) | 2006-09-08 | 2010-02-10 | 埃博灵克斯股份有限公司 | 具有长半衰期的血清清蛋白结合蛋白 |
| US20100048680A1 (en) | 2007-01-11 | 2010-02-25 | University Of Florida Research Foundation Inc. | Alpha-1-Antitrypsin Variants and Uses Thereof |
| KR100992526B1 (ko) | 2007-11-21 | 2010-11-05 | 한국과학기술연구원 | 이황화결합을 이용한 내열성의 알파-1-안티트립신 뮤테인및 그의 제조방법 |
| US8341615B2 (en) | 2008-07-11 | 2012-12-25 | International Business Machines Corporation | Single instruction multiple data (SIMD) code generation for parallel loops using versioning and scheduling |
| WO2010123290A2 (ko) | 2009-04-22 | 2010-10-28 | (주)알테오젠 | 체내 지속성을 유지함으로 체내 반감기가 증가된 단백질 또는 펩티드 융합체, 및 이를 이용하여 체내 반감기를 증가시키는 방법 |
| CN110551223A (zh) | 2011-06-28 | 2019-12-10 | 英伊布里克斯有限合伙公司 | 丝氨酸蛋白酶抑制蛋白融合多肽及其使用方法 |
| US10400029B2 (en) * | 2011-06-28 | 2019-09-03 | Inhibrx, Lp | Serpin fusion polypeptides and methods of use thereof |
| AU2012275295B2 (en) * | 2011-06-28 | 2016-11-10 | Inhibrx, Lp | WAP domain fusion polypeptides and methods of use thereof |
| AU2013202648B2 (en) | 2012-01-10 | 2016-05-19 | Konkuk University | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| GB201322091D0 (en) * | 2013-12-13 | 2014-01-29 | Cambridge Entpr Ltd | Modified serpins for the treatment of bleeding disorders |
| SG11201703390SA (en) | 2014-10-27 | 2017-05-30 | Inhibrx Lp | Serpin fusion polypeptides and methods of use thereof |
| WO2018183705A1 (en) | 2017-03-29 | 2018-10-04 | Cornell University | Oxidation-resistant aat gene therapy |
| CN110092828B (zh) | 2018-01-31 | 2021-08-24 | 北京大学 | 重组突变体α1-抗胰蛋白酶及其制备和应用 |
-
2019
- 2019-10-29 CA CA3117961A patent/CA3117961A1/en active Pending
- 2019-10-29 CN CN201980084112.0A patent/CN113286816B/zh active Active
- 2019-10-29 WO PCT/US2019/058673 patent/WO2020092448A1/en not_active Ceased
- 2019-10-29 JP JP2021548539A patent/JP7731288B2/ja active Active
- 2019-10-29 KR KR1020217016440A patent/KR20210111245A/ko not_active Ceased
- 2019-10-29 EP EP19813978.4A patent/EP3873926A1/en active Pending
- 2019-10-29 BR BR112021008200A patent/BR112021008200A2/pt unknown
- 2019-10-29 US US17/289,136 patent/US12497441B2/en active Active
- 2019-10-29 AU AU2019369403A patent/AU2019369403B2/en active Active
-
2024
- 2024-06-26 JP JP2024103143A patent/JP2024123234A/ja active Pending
-
2025
- 2025-11-13 US US19/388,528 patent/US20260092099A1/en active Pending
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