JPWO2020034941A5 - - Google Patents

Info

Publication number

JPWO2020034941A5

JPWO2020034941A5 JP2021507628A JP2021507628A JPWO2020034941A5 JP WO2020034941 A5 JPWO2020034941 A5 JP WO2020034941A5 JP 2021507628 A JP2021507628 A JP 2021507628A JP 2021507628 A JP2021507628 A JP 2021507628A JP WO2020034941 A5 JPWO2020034941 A5 JP WO2020034941A5

Authority

JP

Japan

Prior art keywords

antibody

seq

antigen

variable region

set forth

Prior art date

2022-08-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000012634 fragment Substances 0.000 claims 32
• 239000000427 antigen Substances 0.000 claims 28
• 102000036639 antigens Human genes 0.000 claims 28
• 108091007433 antigens Proteins 0.000 claims 28
• 125000003275 alpha amino acid group Chemical group 0.000 claims 23
• 239000000611 antibody drug conjugate Substances 0.000 claims 18
• 229940049595 antibody-drug conjugate Drugs 0.000 claims 18
• 208000022993 cryopyrin-associated periodic syndrome Diseases 0.000 claims 18
• 201000005569 Gout Diseases 0.000 claims 12
• 206010018634 Gouty Arthritis Diseases 0.000 claims 12
• 206010072221 mevalonate kinase deficiency Diseases 0.000 claims 12
• 102000004169 proteins and genes Human genes 0.000 claims 11
• 108090000623 proteins and genes Proteins 0.000 claims 11
• 101001033249 Homo sapiens Interleukin-1 beta Proteins 0.000 claims 9
• 238000000034 method Methods 0.000 claims 9
• 206010028980 Neoplasm Diseases 0.000 claims 7
• 208000023275 Autoimmune disease Diseases 0.000 claims 6
• 208000024172 Cardiovascular disease Diseases 0.000 claims 6
• 206010016207 Familial Mediterranean fever Diseases 0.000 claims 6
• 208000035690 Familial cold urticaria Diseases 0.000 claims 6
• 101001076418 Homo sapiens Interleukin-1 receptor type 1 Proteins 0.000 claims 6
• 101001076422 Homo sapiens Interleukin-1 receptor type 2 Proteins 0.000 claims 6
• 206010072010 Hyper IgD syndrome Diseases 0.000 claims 6
• 208000018208 Hyperimmunoglobulinemia D with periodic fever Diseases 0.000 claims 6
• 206010072219 Mevalonic aciduria Diseases 0.000 claims 6
• 208000026106 cerebrovascular disease Diseases 0.000 claims 6
• 230000001684 chronic effect Effects 0.000 claims 6
• 230000002526 effect on cardiovascular system Effects 0.000 claims 6
• 208000025487 periodic fever syndrome Diseases 0.000 claims 6
• 208000011580 syndromic disease Diseases 0.000 claims 6
• 102000055281 human IL1R2 Human genes 0.000 claims 5
• 108020004707 nucleic acids Proteins 0.000 claims 5
• 102000039446 nucleic acids Human genes 0.000 claims 5
• 150000007523 nucleic acids Chemical class 0.000 claims 5
• 239000002773 nucleotide Substances 0.000 claims 5
• 125000003729 nucleotide group Chemical group 0.000 claims 5
• 229940126586 small molecule drug Drugs 0.000 claims 5
• 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 3
• 206010003178 Arterial thrombosis Diseases 0.000 claims 3
• 201000001320 Atherosclerosis Diseases 0.000 claims 3
• 201000003274 CINCA syndrome Diseases 0.000 claims 3
• 208000003456 Juvenile Arthritis Diseases 0.000 claims 3
• 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 3
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
• 201000002795 Muckle-Wells syndrome Diseases 0.000 claims 3
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 3
• 208000006011 Stroke Diseases 0.000 claims 3
• 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 3
• 230000004913 activation Effects 0.000 claims 3
• 230000001154 acute effect Effects 0.000 claims 3
• 239000003795 chemical substances by application Substances 0.000 claims 3
• 230000007783 downstream signaling Effects 0.000 claims 3
• 230000000694 effects Effects 0.000 claims 3
• 206010064570 familial cold autoinflammatory syndrome Diseases 0.000 claims 3
• 206010073071 hepatocellular carcinoma Diseases 0.000 claims 3
• 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 3
• 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 3
• 201000005202 lung cancer Diseases 0.000 claims 3
• 208000020816 lung neoplasm Diseases 0.000 claims 3
• 230000001404 mediated effect Effects 0.000 claims 3
• 201000006417 multiple sclerosis Diseases 0.000 claims 3
• 208000010125 myocardial infarction Diseases 0.000 claims 3
• 230000000926 neurological effect Effects 0.000 claims 3
• 230000000737 periodic effect Effects 0.000 claims 3
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
• 230000009885 systemic effect Effects 0.000 claims 3
• 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 3
• 230000000903 blocking effect Effects 0.000 claims 2
• 230000002222 downregulating effect Effects 0.000 claims 2
• 230000004927 fusion Effects 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 1
• 101000961149 Homo sapiens Immunoglobulin heavy constant gamma 4 Proteins 0.000 claims 1
• 101000840257 Homo sapiens Immunoglobulin kappa constant Proteins 0.000 claims 1
• 101710138871 Ig gamma-1 chain C region Proteins 0.000 claims 1
• 102100039345 Immunoglobulin heavy constant gamma 1 Human genes 0.000 claims 1
• 102100039347 Immunoglobulin heavy constant gamma 4 Human genes 0.000 claims 1
• 102100029572 Immunoglobulin kappa constant Human genes 0.000 claims 1
• 102000013691 Interleukin-17 Human genes 0.000 claims 1
• 108050003558 Interleukin-17 Proteins 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 238000004113 cell culture Methods 0.000 claims 1
• 229940044683 chemotherapy drug Drugs 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 239000002254 cytotoxic agent Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 230000004001 molecular interaction Effects 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 150000003384 small molecules Chemical class 0.000 claims 1
• 241000894007 species Species 0.000 claims 1
• 230000008685 targeting Effects 0.000 claims 1