JPWO2020026647A1 - Automatic blood pressure measuring device - Google Patents

Automatic blood pressure measuring device Download PDF

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JPWO2020026647A1
JPWO2020026647A1 JP2020534109A JP2020534109A JPWO2020026647A1 JP WO2020026647 A1 JPWO2020026647 A1 JP WO2020026647A1 JP 2020534109 A JP2020534109 A JP 2020534109A JP 2020534109 A JP2020534109 A JP 2020534109A JP WO2020026647 A1 JPWO2020026647 A1 JP WO2020026647A1
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blood pressure
heartbeat
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哲二 深水
哲二 深水
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Parama Tech Co Ltd
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    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
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Abstract

血圧を測定するとともに、別途心電を取得するために電極を設けずに、血圧測定時の自律神経状態を検査することが可能な自律神経解析機能付きの自動血圧測定装置の提供。血圧測定時の血圧判定が完了するまでカフの圧を減圧するとともに、血圧測定終了後一定期間減圧を停止することにより、血圧測定中と血圧測定終了後一定時間減圧を停止した間との心拍同期波を得る心拍同期波取得手段31と、心拍同期波取得手段31により得られる心拍同期波より心拍周期関連値の揺らぎを検出する心拍周期関連値検出手段32と、心拍周期関連値検出手段32により検出された心拍周期関連値の揺らぎを周波数解析して低周波成分と高周波成分の周波数成分比を算出する周波数解析手段33と、算出された周波数成分比により被検者の緊張度を判定する緊張度判定手段34とを有する。Provided is an automatic blood pressure measuring device with an autonomic nerve analysis function that can measure the blood pressure and inspect the autonomic nervous state at the time of blood pressure measurement without providing a separate electrode to acquire an electrocardiogram. By reducing the pressure of the cuff until the blood pressure judgment at the time of blood pressure measurement is completed and stopping the pressure reduction for a certain period after the blood pressure measurement is completed, the heartbeat is synchronized between the time when the blood pressure measurement is completed and the time when the pressure reduction is stopped for a certain period after the blood pressure measurement is completed. By the heartbeat synchronization wave acquisition means 31 for obtaining a wave, the heartbeat cycle related value detecting means 32 for detecting the fluctuation of the heartbeat cycle related value from the heartbeat synchronization wave obtained by the heartbeat synchronization wave acquiring means 31, and the heartbeat cycle related value detecting means 32. The frequency analysis means 33 that calculates the frequency component ratio of the low frequency component and the high frequency component by frequency analysis of the fluctuation of the detected heart rate cycle-related value, and the tension that determines the degree of tension of the subject based on the calculated frequency component ratio. It has a degree determination means 34.

Description

本発明は、カフを用いて被検者の生体の一部を圧迫したときに得られる心拍同期波に基づいて被検者の血圧値を測定する自動血圧測定装置に係り、より詳しくは、血圧測定に加えて血圧測定時の自律神経状態を検査する自律神経解析機能付き自動血圧測定装置に関する。 The present invention relates to an automatic blood pressure measuring device that measures a blood pressure value of a subject based on a heartbeat-synchronized wave obtained when a part of the body of the subject is pressed with a cuff. More specifically, the present invention relates to a blood pressure measuring device. The present invention relates to an automatic blood pressure measuring device with an autonomic nerve analysis function that inspects the autonomic nerve state at the time of blood pressure measurement in addition to the measurement.

自律神経解析の一般的手法として、心拍変動の揺らぎを周波数解析する方法が知られている。心拍変動の揺らぎは、心電波形、あるいは脈波のR−R間隔を計測することで得ることができる。 As a general method of autonomic nerve analysis, a method of frequency analysis of fluctuations in heart rate variability is known. Fluctuations in heart rate variability can be obtained by measuring the RR interval of an electrocardiographic waveform or a pulse wave.

心臓の収縮の周期は必ずしも一定ではなく図9に示す如く微妙な揺らぎが有るのが普通である。この心臓の収縮の揺らぎは自律神経に支配されていると言われおり、この心臓の収縮のゆらぎを解析することにより自律神経の活動状態が分かるとされている。具体的には、被検者に心電計を装着し、心電のR波発生の間隔を周波数解析すると、図10に示すように2か所にピークが検出される。 The cycle of cardiac contraction is not always constant, and there are usually subtle fluctuations as shown in FIG. It is said that the fluctuation of the contraction of the heart is controlled by the autonomic nerve, and it is said that the activity state of the autonomic nerve can be understood by analyzing the fluctuation of the contraction of the heart. Specifically, when an electrocardiograph is attached to the subject and the interval of R wave generation of the electrocardiogram is frequency-analyzed, peaks are detected at two locations as shown in FIG.

このピークの低い方、つまりLF(Low frequency)は0.05〜0.20Hzであり、高い方HF(High frequency)は0.20〜0.35Hzである。LFは緊張や興奮を支配する交感神経の活動を表し、HFは逆に緊張や興奮を抑制する作用の副交感神経の活動を表している。
従ってこの両成分の比率を知ることにより、被検者の緊張状態やリラックス状態の推測が可能になる。
The lower peak, that is, LF (Low frequency) is 0.05 to 0.20 Hz, and the higher HF (High frequency) is 0.25 to 0.35 Hz. LF represents the activity of the sympathetic nerve that controls tension and excitement, and HF represents the activity of the parasympathetic nerve that suppresses tension and excitement.
Therefore, by knowing the ratio of these two components, it is possible to estimate the tense state and relaxed state of the subject.

図11は従来の自律神経評価機能付き自動血圧測定装置の全体的な構成を説明する斜視図である(特許文献1参照。)。この自動血圧測定装置110は、生体の一部たとえば上腕部に巻回されるカフ112と、ECG電極114a,114bを含む複数のECG電極と、本体116の上面に設けられた複数のキーを有する入力キーボード118と、本体116の前面に設けられた画像表示器120と、本体116の側面に設けられた出力プリンタ122とを備えている。 FIG. 11 is a perspective view illustrating the overall configuration of a conventional automatic blood pressure measuring device with an autonomic nerve evaluation function (see Patent Document 1). The automatic blood pressure measuring device 110 has a cuff 112 wound around a part of the living body, for example, the upper arm, a plurality of ECG electrodes including ECG electrodes 114a and 114b, and a plurality of keys provided on the upper surface of the main body 116. It includes an input keyboard 118, an image display 120 provided on the front surface of the main body 116, and an output printer 122 provided on the side surface of the main body 116.

特許第5584111号公報Japanese Patent No. 5584111

上記従来の自律神経解析機能付き自動血圧測定装置110では、被検者が腕にカフ112を装着するとともに、心電を取得するための複数のECG電極114a,114bを被検者に貼り付ける必要があり煩雑である。また、心電を検出するための心電検出装置も準備する必要がある。 In the conventional automatic blood pressure measuring device 110 with an autonomic nerve analysis function, it is necessary for the subject to wear a cuff 112 on his arm and to attach a plurality of ECG electrodes 114a and 114b to the subject to acquire an electrocardiogram. It is complicated. It is also necessary to prepare an electrocardiographic detection device for detecting the electrocardiogram.

本発明は、このような従来の構成が有していた問題を解決しようとするものであり、血圧を測定するとともに、別途心電を取得するために電極を設けずに、血圧測定時の自律神経状態を検査することが可能な自律神経解析機能付きの自動血圧測定装置を提供することを目的とする。 The present invention is intended to solve the problem of such a conventional configuration, and is autonomous at the time of blood pressure measurement without providing an electrode for measuring blood pressure and separately acquiring an electrocardiogram. It is an object of the present invention to provide an automatic blood pressure measuring device having an autonomic nerve analysis function capable of examining a nervous state.

本発明の自動血圧測定装置は、カフを用いて被検者の生体の一部を圧迫したときに得られる心臓の拍動に同期した脈波信号である心拍同期波に基づいて被検者の血圧値を測定する自動血圧測定装置であって、血圧測定時の血圧判定が完了するまでカフの圧を減圧するとともに、血圧測定終了後一定期間減圧を停止することにより、血圧測定中と血圧測定終了後一定時間減圧を停止した間との心拍同期波を得る心拍同期波取得手段と、心拍同期波取得手段により得られる心拍同期波より心拍周期関連値の揺らぎを検出する心拍周期関連値検出手段と、心拍周期関連値検出手段により検出された心拍周期関連値の揺らぎを周波数解析して低周波成分と高周波成分の周波数成分比を算出する周波数解析手段と、算出された周波数成分比により被検者の緊張度を判定する緊張度判定手段とを有するものである。 The automatic blood pressure measuring device of the present invention is based on a heartbeat-synchronized wave, which is a pulse wave signal synchronized with the heartbeat obtained when a part of the subject's body is pressed with a cuff. It is an automatic blood rate measuring device that measures the blood pressure value. It reduces the pressure of the cuff until the blood pressure judgment at the time of blood pressure measurement is completed, and stops the pressure reduction for a certain period after the blood rate measurement is completed. A heartbeat synchronization wave acquisition means for obtaining a heartbeat synchronization wave while decompression is stopped for a certain period of time after the end, and a heartbeat cycle related value detection means for detecting fluctuations in heartbeat cycle related values from the heartbeat synchronization wave obtained by the heartbeat synchronization wave acquisition means. And, the frequency analysis means for calculating the frequency component ratio of the low frequency component and the high frequency component by frequency analysis of the fluctuation of the heart rate cycle related value detected by the heart rate cycle related value detecting means, and the calculated frequency component ratio are used for the test. It has a tension determination means for determining a person's tension.

本発明によれば、心拍同期波間隔の時間を心拍周期関連値としてサンプリング処理を行うことで、心電のR波ではなく血圧測定中に検出される心臓の収縮により末梢に伝達される脈波、すなわち心拍同期波の発生間隔から心臓の収縮の揺らぎを検出し、それを周波数解析することにより自律神経の活動状態を推測することができる。 According to the present invention, by performing sampling processing using the time of the heartbeat synchronization wave interval as a heartbeat cycle-related value, a pulse wave transmitted to the periphery by the contraction of the heart detected during blood pressure measurement instead of the R wave of the electrocardiogram. That is, the fluctuation of the contraction of the heart can be detected from the generation interval of the heartbeat synchronous wave, and the activity state of the autonomic nerve can be estimated by frequency analysis of the fluctuation.

また、本発明の自動血圧測定装置は、緊張度判定手段により判定される被検者の緊張度が所定の基準値を超えるときに、一定期間被検者に安静を維持し、一定期間後再度測定を行うよう指示するか、もしくは緊張のために血圧が上昇している可能性に対する注意喚起を行う通知手段を有することが望ましい。 Further, the automatic blood pressure measuring device of the present invention maintains the subject at rest for a certain period of time when the degree of tension of the subject determined by the tension degree determining means exceeds a predetermined reference value, and again after a certain period of time. It is desirable to have a means of notification that either directs the measurement or alerts the patient to possible elevated blood pressure due to tension.

これにより、緊張度判定手段により判定される被検者の緊張度が所定の基準値を超えるときに、一定期間被検者に安静を維持し、一定期間後再度測定を行うよう指示するか、もしくは緊張のために血圧が上昇している可能性に対する注意喚起が行われる。 As a result, when the tension of the subject determined by the tension determination means exceeds a predetermined reference value, the subject is instructed to maintain rest for a certain period of time and to perform the measurement again after a certain period of time. Alternatively, a warning is given that blood pressure may be elevated due to tension.

(1)血圧測定時の血圧判定が完了するまでカフの圧を減圧するとともに、血圧測定終了後一定期間減圧を停止することにより、血圧測定中と血圧測定終了後一定時間減圧を停止した間との心拍同期波を得る心拍同期波取得手段と、心拍同期波取得手段により得られる心拍同期波より心拍周期関連値の揺らぎを検出する心拍周期関連値検出手段と、心拍周期関連値検出手段により検出された心拍周期関連値の揺らぎを周波数解析して低周波成分と高周波成分の周波数成分比を算出する周波数解析手段と、算出された周波数成分比により被検者の緊張度を判定する緊張度判定手段とを有する構成により、一つの自動血圧測定装置で、血圧測定と自律神経の状態を示す心拍周期関連値の周波数解析を同時に行うことができ、血圧測定時の自律神経状態を検査することが可能となる。 (1) By reducing the pressure of the cuff until the blood pressure determination at the time of blood pressure measurement is completed and stopping the pressure reduction for a certain period after the completion of the blood pressure measurement, during the blood pressure measurement and during the period when the pressure reduction is stopped for a certain period after the completion of the blood pressure measurement. Detected by the heartbeat synchronization wave acquisition means for obtaining the heartbeat synchronization wave, the heartbeat cycle related value detecting means for detecting the fluctuation of the heartbeat cycle related value from the heartbeat synchronization wave obtained by the heartbeat synchronization wave acquisition means, and the heartbeat cycle related value detecting means. A frequency analysis means that calculates the frequency component ratio of the low frequency component and the high frequency component by frequency analysis of the fluctuation of the heart rate cycle-related value, and the tension determination that determines the tension level of the subject based on the calculated frequency component ratio. With a configuration having means, one automatic blood pressure measuring device can simultaneously perform heart rate measurement and frequency analysis of heart rate cycle-related values indicating the state of the autonomic nerve, and can inspect the autonomic nerve state at the time of blood pressure measurement. It will be possible.

(2)緊張度判定手段により判定される被検者の緊張度が所定の基準値を超えるときに、一定期間被検者に安静を維持するよう指示し、一定期間後再度測定を行うか、もしくは緊張のために血圧が上昇している可能性に対する注意喚起を行う通知手段を有する構成により、血圧測定時の被検者の緊張度が所定の基準値を超えるときに、一定期間被検者に安静を維持し、一定期間後再度測定を行うよう指示することで、正確な血圧測定を行うことが可能となり、また、緊張のために正確な血圧測定結果ではない可能性があることを注意喚起することが可能となる。 (2) When the tension of the subject determined by the tension determination means exceeds a predetermined reference value, the subject is instructed to maintain rest for a certain period of time, and the measurement is performed again after a certain period of time. Alternatively, due to a configuration having a notification means for alerting the possibility that the blood pressure is rising due to tension, the subject for a certain period of time when the degree of tension of the subject at the time of blood pressure measurement exceeds a predetermined reference value. Note that it is possible to make an accurate blood pressure measurement by keeping the patient at rest and instructing the patient to take the measurement again after a certain period of time, and that the blood pressure measurement result may not be accurate due to tension. It becomes possible to arouse.

本発明の実施の形態における自律神経解析機能付き自動血圧測定装置の斜視図である。It is a perspective view of the automatic blood pressure measuring apparatus with an autonomic nerve analysis function in embodiment of this invention. 本発明の実施の形態における自律神経解析機能付き自動血圧測定装置のブロック図である。It is a block diagram of the automatic blood pressure measuring apparatus with an autonomic nerve analysis function in embodiment of this invention. 図2のマイクロコンピュータ回路の機能ブロック図である。It is a functional block diagram of the microcomputer circuit of FIG. 本発明の実施の形態における自律神経解析機能付き自動血圧測定装置の脈波図と脈波ピーク位置図である。It is a pulse wave diagram and the pulse wave peak position diagram of the automatic blood pressure measuring apparatus with an autonomic nerve analysis function in the embodiment of the present invention. 本発明の実施の形態における自律神経解析機能付き自動血圧測定装置の脈波間隔グラフ図である。It is a pulse wave interval graph figure of the automatic blood pressure measuring apparatus with an autonomic nerve analysis function in embodiment of this invention. 本発明の実施の形態における自律神経解析機能付き自動血圧測定装置の脈波間隔の等時間間隔変換図である。It is an equal time interval conversion figure of the pulse wave interval of the automatic blood pressure measuring apparatus with an autonomic nerve analysis function in embodiment of this invention. 本発明の実施の形態における自律神経解析機能付き自動血圧測定装置の自律神経解析結果表示画面である。It is an autonomic nerve analysis result display screen of the automatic blood pressure measuring apparatus with an autonomic nerve analysis function in embodiment of this invention. 本発明の実施の形態における自律神経解析機能付き自動血圧測定装置のソフトウエアプログラムの処理内容を示すフローチャートである。It is a flowchart which shows the processing content of the software program of the automatic blood pressure measuring apparatus with an autonomic nerve analysis function in embodiment of this invention. 心拍同期波の揺らぎの例を示す図である。It is a figure which shows the example of the fluctuation of the heartbeat synchronization wave. 心拍同期波の揺らぎの周波数解析の例を示す図である。It is a figure which shows the example of the frequency analysis of the fluctuation of a heartbeat synchronization wave. 従来の自律神経評価機能付の自動血圧測定装置の全体的な構成を説明する斜視図である。It is a perspective view explaining the overall structure of the conventional automatic blood pressure measuring apparatus with an autonomic nerve evaluation function.

1 自律神経解析機能付き自動血圧測定装置
2 腕挿入部
3 腕
4 腕載置台
5 カフ
6 手のひら
7 表示部
8 プリンタ
9 送気ポンプ
10 排気弁
11 カフ固定手段
12 圧力検出回路
13 脈波検出回路
14 マイクロコンピュータ回路
15 外部メモリ
16 送気ポンプ駆動回路
17 排気弁駆動回路
18 カフ駆動手段
19 LCD表示器
20 記録計
21 スピーカー
31 心拍同期波取得手段
32 心拍周期関連値検出手段
33 周波数解析手段
34 緊張度判定手段
35 通知手段
1 Automatic blood pressure measuring device with autonomic nerve analysis function 2 Arm insertion part 3 Arm 4 Arm mount 5 Cuff 6 Palm 7 Display 8 Printer 9 Air supply pump 10 Exhaust valve 11 Cuff fixing means 12 Pressure detection circuit 13 Pulse wave detection circuit 14 Microcomputer circuit 15 External memory 16 Insufflation pump drive circuit 17 Exhaust valve drive circuit 18 Cuff drive means 19 LCD display 20 Recorder 21 Speaker 31 Heart rate synchronization wave acquisition means 32 Heart rate cycle related value detection means 33 Frequency analysis means 34 Tension Judgment means 35 Notification means

図1は本発明の実施の形態における自律神経解析機能付き自動血圧測定装置の斜視図である。 FIG. 1 is a perspective view of an automatic blood pressure measuring device with an autonomic nerve analysis function according to an embodiment of the present invention.

図1において、本発明の実施の形態における自律神経解析機能付き自動血圧測定装置1は、被検者の生体の一部である腕3を挿入する腕挿入部2と、腕3を載置する腕載置台4とを備える。腕挿入部2には、血圧測定のときに腕を締めて阻血するカフ5を備える。 In FIG. 1, the automatic blood pressure measuring device 1 with an autonomic nerve analysis function according to the embodiment of the present invention mounts an arm insertion portion 2 into which an arm 3 which is a part of a living body of a subject is inserted and an arm 3. It is provided with an arm mounting table 4. The arm insertion portion 2 is provided with a cuff 5 that tightens the arm to prevent blood pressure when measuring blood pressure.

また、自律神経解析機能付き自動血圧測定装置1は、血圧測定結果や自律神経解析結果等を示す表示部7を備える。表示部7の表面はタッチパネルであり、各種入力処理を行うことができる。さらに、自律神経解析機能付き自動血圧測定装置1は、血圧測定結果や自律神経解析結果等をプリントするプリンタ8を備える。 Further, the automatic blood pressure measuring device 1 with an autonomic nerve analysis function includes a display unit 7 showing a blood pressure measurement result, an autonomic nerve analysis result, and the like. The surface of the display unit 7 is a touch panel, and various input processes can be performed. Further, the automatic blood pressure measuring device 1 with an autonomic nerve analysis function includes a printer 8 that prints a blood pressure measurement result, an autonomic nerve analysis result, and the like.

図2は図1の自律神経解析機能付き自動血圧測定装置1の内部ブロック図である。図2において、送気ポンプ9はカフ5に送気するポンプである。送気ポンプ9は、後述するマイクロコンピュータ回路14により制御される送気ポンプ駆動回路16によって駆動される。送気ポンプ9および送気ポンプ駆動回路16はカフ5の圧を加圧する加圧手段を構成する。 FIG. 2 is an internal block diagram of the automatic blood pressure measuring device 1 with an autonomic nerve analysis function of FIG. In FIG. 2, the air supply pump 9 is a pump that supplies air to the cuff 5. The air supply pump 9 is driven by an air supply pump drive circuit 16 controlled by a microcomputer circuit 14 described later. The air supply pump 9 and the air supply pump drive circuit 16 constitute a pressurizing means for pressurizing the pressure of the cuff 5.

排気弁10はカフ5の内部の空気を排気する弁である。排気弁10は、後述するマイクロコンピュータ回路14により制御される排気弁駆動回路17によって駆動される。排気弁10は、カフ5の内部の空気を外部へ排出することにより血圧測定中の排気調整や緊急時の排気等を行うためのものである。排気弁10および排気弁駆動回路17はカフ5の圧を減圧する減圧手段を構成する。 The exhaust valve 10 is a valve that exhausts the air inside the cuff 5. The exhaust valve 10 is driven by an exhaust valve drive circuit 17 controlled by a microcomputer circuit 14 described later. The exhaust valve 10 is for exhausting the air inside the cuff 5 to the outside to adjust the exhaust during blood pressure measurement, exhaust in an emergency, and the like. The exhaust valve 10 and the exhaust valve drive circuit 17 constitute a pressure reducing means for reducing the pressure of the cuff 5.

カフ固定手段11は、被検者の腕3に巻かれたカフ5を締め付けるギヤードモーターと、ギヤードモーターをロックするブレーキソレノイドとにより構成される。カフ固定手段11は、後述するマイクロコンピュータ回路14により制御されるカフ駆動手段18により駆動される。カフ駆動手段18は、ギヤードモーターを駆動するベルト駆動制御回路と、ブレーキソレノイドを制御するブレーキ制御回路とから構成される。 The cuff fixing means 11 includes a geared motor that tightens the cuff 5 wound around the subject's arm 3 and a brake solenoid that locks the geared motor. The cuff fixing means 11 is driven by a cuff driving means 18 controlled by a microcomputer circuit 14 described later. The cuff drive means 18 includes a belt drive control circuit for driving a geared motor and a brake control circuit for controlling a brake solenoid.

被検者の腕3を、手のひら6を上に向けてカフ5に挿入し、表示部7のタッチパネルにて被検者のIDの入力を行い、図示しない測定釦にて測定を開始すると、ギヤードモーターが駆動され、カフ5が被検者の腕3へ締め付けられ、ブレーキソレノイドに通電が行われ、カフ5が被検者の腕に固定される。 When the subject's arm 3 is inserted into the cuff 5 with the palm 6 facing upward, the subject's ID is input on the touch panel of the display unit 7, and measurement is started with a measurement button (not shown), the geared. The motor is driven, the cuff 5 is tightened to the subject's arm 3, the brake solenoid is energized, and the cuff 5 is fixed to the subject's arm.

圧力検出回路12は、半導体圧力センサと電気回路で構成されている。血圧測定時には、送気ポンプ9からカフ5に空気が送気され、挿入された腕3が規定圧まで締め付けられる。圧力検出回路12では、この測定時には、カフ圧力値に比例した電気出力が得られる。この電気出力には脈波の変化分が重畳されている。 The pressure detection circuit 12 includes a semiconductor pressure sensor and an electric circuit. At the time of blood pressure measurement, air is supplied from the air supply pump 9 to the cuff 5, and the inserted arm 3 is tightened to a specified pressure. At the time of this measurement, the pressure detection circuit 12 obtains an electric output proportional to the cuff pressure value. The change in pulse wave is superimposed on this electrical output.

脈波検出回路13は、圧力検出回路12から得られる電気出力にフィルタ処理を行い、脈波の変化分のみを出力するものである。 The pulse wave detection circuit 13 filters the electric output obtained from the pressure detection circuit 12 and outputs only the change in the pulse wave.

マイクロコンピュータ回路14は送気ポンプ駆動回路16(送気ポンプ9)、排気弁駆動回路17(排気弁10)、カフ駆動手段18、圧力検出回路(半導体圧力センサ)12、脈波検出回路13に接続するCPUである。図3はマイクロコンピュータ回路14の機能ブロック図である。マイクロコンピュータ回路14は、後述の図8のフローチャートに示すプログラムを実行することによりこれらの各要素の動作を制御することで、図3に示す各手段31〜35として機能する。 The microcomputer circuit 14 includes an air supply pump drive circuit 16 (air supply pump 9), an exhaust valve drive circuit 17 (exhaust valve 10), a cuff drive means 18, a pressure detection circuit (semiconductor pressure sensor) 12, and a pulse wave detection circuit 13. It is a CPU to be connected. FIG. 3 is a functional block diagram of the microcomputer circuit 14. The microcomputer circuit 14 functions as each means 31 to 35 shown in FIG. 3 by controlling the operation of each of these elements by executing the program shown in the flowchart of FIG. 8 to be described later.

図3において、心拍同期波取得手段31は、圧力検出回路12および脈波検出回路13からの入力に基づいて排気弁駆動回路17を制御することにより排気弁10を駆動して、血圧測定時の血圧判定が完了するまでカフ5の圧を減圧するとともに、血圧測定終了後一定期間減圧を停止することにより、血圧測定中と血圧測定終了後一定時間減圧を停止した間との心拍同期波を得る手段である。 In FIG. 3, the heartbeat synchronous wave acquisition means 31 drives the exhaust valve 10 by controlling the exhaust valve drive circuit 17 based on the inputs from the pressure detection circuit 12 and the pulse wave detection circuit 13, and at the time of blood pressure measurement. By depressurizing the pressure of the cuff 5 until the blood pressure determination is completed and stopping the depressurization for a certain period after the blood pressure measurement is completed, a heartbeat synchronous wave is obtained between the blood pressure measurement and the time when the depressurization is stopped for a certain period of time after the blood pressure measurement is completed. It is a means.

通常の血圧測定時、被検者の腕3に巻き付けられたカフ5内の空気圧が動脈の血流に反応して変動する。脈波検出回路13では、圧力検出回路12により得られたこの圧力(空気圧)の変動部分を抽出することにより、心臓の拍動に同期した脈波信号である心拍同期波(脈波データ)を得る。 During normal blood pressure measurement, the air pressure in the cuff 5 wrapped around the subject's arm 3 fluctuates in response to the blood flow in the artery. In the pulse wave detection circuit 13, the heartbeat synchronization wave (pulse wave data), which is a pulse wave signal synchronized with the heartbeat, is extracted by extracting the fluctuating portion of the pressure (air pressure) obtained by the pressure detection circuit 12. obtain.

心拍同期波取得手段31は、通常の血圧測定時には、送気ポンプ駆動回路16を制御して送気ポンプ9を駆動することにより最高血圧より高い圧でカフ5を締め付け、排気弁駆動回路17を制御して排気弁10を駆動することにより徐々に一定圧のスピードで最低血圧以下まで減圧し、血圧判定を行う。このとき、心拍同期波取得手段31は、この通常の血圧測定時の血圧判定が完了するまで、すなわち発生脈波レベルが基準以下のある一定値になるまでカフ5の減圧を続け、その後減圧を停止することにより、血圧測定中と血圧測定終了後一定時間減圧を停止した間との心拍同期波を得る。 At the time of normal blood pressure measurement, the heartbeat synchronous wave acquisition means 31 controls the air supply pump drive circuit 16 to drive the air supply pump 9 to tighten the cuff 5 at a pressure higher than the systolic blood pressure and press the exhaust valve drive circuit 17. By controlling and driving the exhaust valve 10, the blood pressure is gradually reduced to below the minimum blood pressure at a constant pressure speed, and the blood pressure is determined. At this time, the heartbeat synchronous wave acquisition means 31 continues to reduce the pressure of the cuff 5 until the blood pressure determination at the time of normal blood pressure measurement is completed, that is, until the generated pulse wave level reaches a certain constant value below the reference value, and then the pressure is reduced. By stopping, a heartbeat-synchronized wave is obtained between the time when the blood pressure is being measured and the time when the depressurization is stopped for a certain period of time after the blood pressure measurement is completed.

図4は、脈波検出回路13よりサンプリング処理された脈波データをグラフ化したものである。図4は脈波の周波数帯域のバンドパスフィルタ(0.7Hz〜3.0Hz)を通して脈波データを抽出した後、脈波毎のピークの位置と値を求めて描いた図である。 FIG. 4 is a graph of pulse wave data sampled by the pulse wave detection circuit 13. FIG. 4 is a diagram in which pulse wave data is extracted through a bandpass filter (0.7 Hz to 3.0 Hz) in the frequency band of the pulse wave, and then the position and value of the peak for each pulse wave are obtained.

心拍周期関連値検出手段32は、心拍同期波取得手段31により得られる心拍同期波より心拍周期関連値の揺らぎを検出する手段である。心拍周期間関連値とは、心臓の拍動に合わせて周期的に発生する心拍同期波の拍動ごとのインターバル(間隔の時間)を示す値である。心拍周期関連値検出手段32は、この心拍同期波間隔の時間を心拍周期関連値としてサンプリング処理を行うことで、心電のR波ではなく血圧測定中に検出される心臓の収縮により末梢に伝達される脈波、すなわち心拍同期波の発生間隔から心臓の収縮の揺らぎを検出する。 The heartbeat cycle-related value detecting means 32 is a means for detecting fluctuations in the heartbeat cycle-related value from the heartbeat-synchronized wave obtained by the heartbeat-synchronized wave acquiring means 31. The inter-heartbeat-cycle-related value is a value indicating an interval (interval time) for each beat of a heartbeat-synchronized wave that is periodically generated in accordance with the heartbeat. The heartbeat cycle-related value detecting means 32 performs sampling processing using the time of this heartbeat synchronization wave interval as a heartbeat cycle-related value, and transmits it to the periphery by the contraction of the heart detected during blood pressure measurement instead of the R wave of the electrocardiogram. The fluctuation of the contraction of the heart is detected from the generation interval of the pulse wave, that is, the heartbeat synchronization wave.

図5は、図4の脈波データのピーク間隔を縦軸にとり、脈波の発生時刻を横軸にとり、発生した脈波のピーク間隔の揺らぎを描いた図である。 FIG. 5 is a diagram depicting fluctuations in the peak interval of the generated pulse wave, with the peak interval of the pulse wave data of FIG. 4 on the vertical axis and the time of occurrence of the pulse wave on the horizontal axis.

図6は、図5の発生した脈波のピーク間隔をもとに、脈波データを等間隔データ(500msec)に置き換えた(ラグランジェ補完処理)ものである。 FIG. 6 shows the pulse wave data replaced with evenly spaced data (500 msec) based on the peak intervals of the generated pulse waves in FIG. 5 (Lagrange complementation process).

周波数解析手段33は、心拍周期関連値検出手段32により検出された心拍周期関連値の揺らぎをフーリエ変換等により周波数解析して低周波成分と高周波成分の周波数成分比を算出する手段である。算出された周波数成分比は、マイクロコンピュータ回路14の記憶部に記憶されるとともに、LCD表示器19、記録計20や外部メモリ15等の出力手段に出力される。外部メモリ15は、測定結果データを被検者別に時系列データとして記憶する記憶手段である。 The frequency analysis means 33 is a means for calculating the frequency component ratio of the low frequency component and the high frequency component by frequency analyzing the fluctuation of the heart rate cycle related value detected by the heart rate cycle related value detecting means 32 by Fourier transform or the like. The calculated frequency component ratio is stored in the storage unit of the microcomputer circuit 14, and is output to output means such as the LCD display 19, the recorder 20, and the external memory 15. The external memory 15 is a storage means for storing measurement result data as time-series data for each subject.

図7は、本発明の実施の形態における自律神経解析機能付き自動血圧装置の自律神経解析結果の表示画面である。パワースペクトル密度は、心拍変動の揺らぎを周波数解析し、そのパワースペクトル強度をグラフ化したものである。この図の場合、0.04〜0.15Hzまでのパワーの面積は脈波のピーク間隔のゆらぎを周波数解析した低周波成分であり、0.15〜0.40Hzまでのパワーの面積は前記周波数解析した高周波成分である。また、LF(低周波成分)、HF(高周波成分)は、周波数解析した結果を数値で表現したものであり、周波数成分比LF/HFは前記低周波成分と前記高周波成分の成分比である。 FIG. 7 is a display screen of the autonomic nerve analysis result of the automatic blood pressure device with the autonomic nerve analysis function according to the embodiment of the present invention. The power spectral density is a graph of the power spectral intensity obtained by frequency-analyzing the fluctuation of heart rate variability. In the case of this figure, the area of power from 0.04 to 0.15 Hz is a low frequency component obtained by frequency-analyzing the fluctuation of the peak interval of the pulse wave, and the area of power from 0.1 to 0.40 Hz is the frequency. It is the analyzed high frequency component. Further, LF (low frequency component) and HF (high frequency component) represent the result of frequency analysis numerically, and the frequency component ratio LF / HF is the component ratio of the low frequency component and the high frequency component.

緊張度判定手段34は、周波数解析手段33により算出された周波数成分比により被検者の緊張度を判定する手段である。より詳しくは、緊張度判定手段34は、算出された周波数成分比LF/HFが所定の基準範囲内にあるか否かによって被検者の緊張度を判定し、自律神経の活動状態を推測する。 The tension determination means 34 is a means for determining the tension of the subject based on the frequency component ratio calculated by the frequency analysis means 33. More specifically, the tension determination means 34 determines the tension of the subject based on whether or not the calculated frequency component ratio LF / HF is within a predetermined reference range, and estimates the activity state of the autonomic nerve. ..

通知手段35は、緊張度判定手段34により判定される被検者の緊張度が所定の基準値を超えるときに、一定期間被検者に安静を維持し、一定期間後再度測定を行うよう指示するか、もしくは緊張のために血圧が上昇している可能性に対する注意喚起を行う手段である。通知手段35による指示または注意喚起は、LCD表示器19やスピーカー21によるアナウンスや、記録計20によるメッセージ印字等により行われる。 When the tension of the subject determined by the tension determination means 34 exceeds a predetermined reference value, the notification means 35 instructs the subject to maintain rest for a certain period of time and to perform measurement again after a certain period of time. It is a means of alerting you to the possibility that your blood pressure may be rising due to tension. The instruction or alert by the notification means 35 is given by an announcement by the LCD display 19 or the speaker 21, a message printing by the recorder 20, or the like.

図8は本発明の実施の形態における自律神経解析機能付き自動血圧測定装置に使用されるマイクロコンピュータ回路14に記憶されたソフトウエアプログラムの処理内容を示すフローチャートである。 FIG. 8 is a flowchart showing the processing contents of the software program stored in the microcomputer circuit 14 used in the automatic blood pressure measuring device with the autonomic nerve analysis function according to the embodiment of the present invention.

S1においてIDと一致する被検者を選択し、測定開始を行うと、心拍同期波取得手段31は、S2において被検者の腕に巻かれたカフ5を加圧する初期加圧値を190mmHgとする。 When a subject matching the ID is selected in S1 and measurement is started, the heartbeat synchronization wave acquisition means 31 sets the initial pressurization value of pressurizing the cuff 5 wrapped around the subject's arm in S2 to 190 mmHg. do.

心拍同期波取得手段31は、S3において、送気ポンプ駆動回路16を制御して送気ポンプ9を駆動してカフ5の送気口より送気を開始し、S4、S5においてカフ5内の圧力値が190mmHgに達すると送気を停止する。 The heartbeat synchronization wave acquisition means 31 controls the air supply pump drive circuit 16 in S3 to drive the air supply pump 9 to start air supply from the air supply port of the cuff 5, and in S4 and S5, the air supply in the cuff 5 is started. When the pressure value reaches 190 mmHg, the air supply is stopped.

心拍同期波取得手段31は、S5において送気を停止すると、S6において減圧速度を計算し、排気弁駆動回路17により排気弁10を操作してカフ5の圧を一定速度で徐々に減圧する。また、心拍同期波取得手段31は、S7においてカフ5の圧力のデータおよび脈波データを一定周期で連続的にマイクロコンピュータ回路14の記憶部(メモリ)に取り込む。この取り込んだ圧力データと脈派データにて、オシロメトリック法にて血圧を判定する。 When the heartbeat synchronous wave acquisition means 31 stops the air supply in S5, the decompression speed is calculated in S6, and the exhaust valve 10 is operated by the exhaust valve drive circuit 17 to gradually reduce the pressure of the cuff 5 at a constant speed. Further, the heartbeat synchronization wave acquisition means 31 continuously takes in the pressure data and the pulse wave data of the cuff 5 into the storage unit (memory) of the microcomputer circuit 14 at a fixed cycle in S7. Blood pressure is determined by the oscillometric method from the captured pressure data and pulse data.

心拍同期波取得手段31は、S8に示すように、血圧値が正常に判定された後は、自律神経解析のために、脈派データの取り込みを、S11に示すように、最高血圧判定時刻から所定時間、ここでは30秒間、経過するまで継続する。 After the blood pressure value is normally determined, as shown in S8, the heartbeat synchronization wave acquisition means 31 takes in pulse data for autonomic nerve analysis from the systolic blood pressure determination time as shown in S11. It continues for a predetermined time, here for 30 seconds, until it elapses.

S9において、減圧を進めると検出される脈派レベルは、徐々に小さくなるので、検出される脈派レベルが、最大脈派レベルの1/2以下になった時点で、心拍同期波取得手段31は、排気弁駆動回路17により排気弁10を閉じて減圧を停止する。 In S9, the pulse level detected as the decompression is advanced gradually decreases. Therefore, when the detected pulse level becomes 1/2 or less of the maximum pulse level, the heartbeat synchronization wave acquisition means 31 Closes the exhaust valve 10 by the exhaust valve drive circuit 17 to stop the depressurization.

心拍同期波取得手段31は、S12において、最高血圧判定時刻から所定時間、ここでは30秒間、経過するまで脈波データを取り込んだ後、排気弁駆動回路17により排気弁10を開放し、自律神経解析処理へ移行する。 In S12, the heartbeat synchronization wave acquisition means 31 captures pulse wave data for a predetermined time from the systolic blood pressure determination time, here for 30 seconds, and then opens the exhaust valve 10 by the exhaust valve drive circuit 17 to open the autonomic nerve. Move to analysis processing.

自律神経解析データ処理では、心拍周期関連値検出手段32は、S13において、サンプリングされた脈派の各々のピーク位置を検出し、ピーク位置データを算出する。また、心拍周期関連値検出手段32は、各々の脈波間のR−R間隔を全脈波の平均R−Rと比較し、規定水準以上もしくは規定水準以下の場合は、平均R−Rと置換し補正を加える。 In the autonomic nerve analysis data processing, the heart rate cycle-related value detecting means 32 detects the peak position of each sampled pulse group in S13 and calculates the peak position data. Further, the heart rate cycle-related value detecting means 32 compares the RR interval between each pulse wave with the average RR of all pulse waves, and if it is above or below the specified level, replaces it with the average RR. And add correction.

心拍周期関連値検出手段32は、S14において、ピーク位置データより、等時間間隔データへ変換を行い、脈波のピーク間の時間を計算し、時間間隔データに変換する。ピーク位置データから、各ピーク位置における脈波ピーク間隔値を得ることができるが、周波数解析を行うためには、時系列データ(一定周期のデータ)が必要となる。このため、ピーク位置データから得られる各ピーク位置における脈波ピーク間隔値(実データ)を使用して、実データの存在しない時点のデータを補間する必要がある。補間はラグランジュ補間を使用して行う。 In S14, the heart rate cycle-related value detecting means 32 converts the peak position data into equal time interval data, calculates the time between peaks of the pulse wave, and converts it into the time interval data. The pulse wave peak interval value at each peak position can be obtained from the peak position data, but time series data (data with a fixed period) is required for frequency analysis. Therefore, it is necessary to interpolate the data at the time when the actual data does not exist by using the pulse wave peak interval value (actual data) at each peak position obtained from the peak position data. Interpolation is performed using Lagrange interpolation.

周波数解析手段33は、S15において、S14で得られた等時間間隔データ(500msec、1024点)のフーリエ変換を行い、パワースペクトルを算出する。指標値のLFは0.04Hz〜0.15Hzのパワースペクトル面積、HFは0.15Hz〜0.40Hzのパワースペクトル面積である。 The frequency analysis means 33 performs a Fourier transform of the equi-time interval data (500 msec, 1024 points) obtained in S14 in S15, and calculates a power spectrum. The index value LF is a power spectrum area of 0.04 Hz to 0.15 Hz, and HF is a power spectrum area of 0.15 Hz to 0.40 Hz.

周波数解析手段33は、S16において、指標値LF、HFとその時点の血圧値をIDと一致する被検者のデータとして、外部メモリ15に時系列に記録する。 In S16, the frequency analysis means 33 records the index values LF and HF and the blood pressure value at that time as data of the subject matching the ID in the external memory 15 in time series.

緊張度判定手段34は、S17において、測定された血圧値が適正値の範囲内であるかどうかを判定する。心拍周期関連値の揺らぎを周波数解析して得られるLF/HFが基準範囲内の場合、通知手段35はS18に示すように血圧が正常であると正常結果表示を行う。 The tension determination means 34 determines in S17 whether or not the measured blood pressure value is within an appropriate range. When the LF / HF obtained by frequency analysis of the fluctuation of the heart rate cycle-related value is within the reference range, the notification means 35 displays the normal result when the blood pressure is normal as shown in S18.

一方、通知手段35は、LF/HFが基準範囲外の場合はS19に示すように不適正結果表示を行う。より具体的には、通知手段35は、緊張度判定手段34により判定される被検者の緊張度が所定の基準値を超えるときに、一定期間被検者に安静を維持し、一定期間後再度測定を行うよう指示するか、もしくは緊張のために血圧が上昇している可能性に対する注意喚起を行い、マイクロコンピュータ回路14は再測定処理を行う。 On the other hand, when the LF / HF is out of the reference range, the notification means 35 displays an inappropriate result as shown in S19. More specifically, the notification means 35 keeps the subject at rest for a certain period of time when the tension of the subject determined by the tension determination means 34 exceeds a predetermined reference value, and after a certain period of time. The microcomputer circuit 14 performs the remeasurement process by instructing the measurement to be performed again or calling attention to the possibility that the blood pressure is elevated due to tension.

このように、本実施形態における自律神経解析機能付き自動血圧測定装置1では、心拍同期波間隔の時間を心拍周期関連値としてサンプリング処理を行うことで、心電のR波ではなく血圧測定中に検出される心臓の収縮により末梢に伝達される脈波、すなわち心拍同期波の発生間隔から心臓の収縮の揺らぎを検出し、それを周波数解析することにより自律神経の活動状態を推測することができ、一つの自動血圧測定装置1で、血圧測定と自律神経の状態を示す心拍周期関連値の周波数解析を同時に行うことができ、血圧測定時の自律神経状態を検査することができる。 As described above, in the automatic blood pressure measuring device 1 with the autonomic nerve analysis function in the present embodiment, the time of the heartbeat synchronization wave interval is used as the heartbeat cycle-related value for sampling processing, so that the blood pressure is measured instead of the R wave of the electrocardiogram. It is possible to estimate the activity state of the autonomic nerves by detecting the fluctuation of the contraction of the heart from the pulse wave transmitted to the periphery by the detected contraction of the heart, that is, the generation interval of the heartbeat synchronous wave, and analyzing the frequency. With one automatic blood pressure measuring device 1, the blood pressure measurement and the frequency analysis of the heart rate cycle-related value indicating the state of the autonomic nerve can be performed at the same time, and the autonomic nerve state at the time of measuring the autonomic nerve can be inspected.

また、本実施形態における自律神経解析機能付き自動血圧測定装置1では、血圧測定時の被検者の緊張度が所定の基準値を超えるときに、一定期間被検者に安静を維持し、一定期間後再度測定を行うよう指示することで、正確な血圧測定を行うことが可能となり、また、緊張のために正確な血圧測定結果ではない可能性があることを注意喚起することができる。 Further, in the automatic blood pressure measuring device 1 with an autonomic nerve analysis function in the present embodiment, when the degree of tension of the subject at the time of blood pressure measurement exceeds a predetermined reference value, the subject is maintained at rest for a certain period of time and is constant. By instructing the measurement to be performed again after the period, it is possible to perform an accurate blood pressure measurement, and it is possible to warn that the blood pressure measurement result may not be accurate due to tension.

さらに、本実施形態における自律神経解析機能付き自動血圧測定装置1では、外部メモリ15に被検者ごとに記録された過去の血圧値および緊張度の履歴データより、平常時の血圧値を推測することもできる。 Further, in the automatic blood pressure measuring device 1 with an autonomic nerve analysis function in the present embodiment, the blood pressure value in normal times is estimated from the past blood pressure value and the history data of the tension degree recorded in the external memory 15 for each subject. You can also do it.

本発明の自動血圧測定装置は、血圧測定に加えて血圧測定時の自律神経状態を検査する自律神経解析機能付き自動血圧測定装置として有用である。 The automatic blood pressure measuring device of the present invention is useful as an automatic blood pressure measuring device with an autonomic nerve analysis function that examines the autonomic nervous state at the time of blood pressure measurement in addition to blood pressure measurement.

Claims (2)

カフを用いて被検者の生体の一部を圧迫したときに得られる心臓の拍動に同期した脈波信号である心拍同期波に基づいて前記被検者の血圧値を測定する自動血圧測定装置であって、
血圧測定時の血圧判定が完了するまでカフの圧を減圧するとともに、血圧測定終了後一定期間減圧を停止することにより、血圧測定中と血圧測定終了後一定時間減圧を停止した間との心拍同期波を得る心拍同期波取得手段と、
前記心拍同期波取得手段により得られる心拍同期波より心拍周期関連値の揺らぎを検出する心拍周期関連値検出手段と、
前記心拍周期関連値検出手段により検出された心拍周期関連値の揺らぎを周波数解析して低周波成分と高周波成分の周波数成分比を算出する周波数解析手段と、
前記算出された周波数成分比により前記被検者の緊張度を判定する緊張度判定手段と
を有する自動血圧測定装置。
Automatic blood pressure measurement that measures the blood pressure value of the subject based on the heartbeat-synchronized wave, which is a pulse wave signal synchronized with the heartbeat obtained when a part of the subject's body is pressed with a cuff. It ’s a device,
By reducing the pressure of the cuff until the blood pressure judgment at the time of blood pressure measurement is completed and stopping the depressurization for a certain period after the end of the blood pressure measurement, the heartbeat is synchronized between the time during the blood pressure measurement and the time when the decompression is stopped for a certain period after the end of the blood pressure measurement. Blood pressure synchronization wave acquisition means to obtain waves,
A heartbeat cycle-related value detecting means that detects fluctuations in the heartbeat cycle-related value from the heartbeat synchronization wave obtained by the heartbeat synchronization wave acquisition means, and a heartbeat cycle-related value detecting means.
A frequency analysis means for calculating the frequency component ratio of the low frequency component and the high frequency component by frequency analyzing the fluctuation of the heart rate cycle related value detected by the heart rate cycle related value detecting means.
An automatic blood pressure measuring device including a tension degree determining means for determining the tension degree of the subject based on the calculated frequency component ratio.
前記緊張度判定手段により判定される前記被検者の緊張度が所定の基準値を超えるときに、一定期間被検者に安静を維持し、一定期間後再度測定を行うよう指示するか、もしくは緊張のために血圧が上昇している可能性に対する注意喚起を行う通知手段を有する請求項1の自動血圧測定装置。 When the tension of the subject, which is determined by the tension determination means, exceeds a predetermined reference value, the subject is instructed to maintain rest for a certain period of time and perform measurement again after a certain period of time. The automatic blood pressure measuring device according to claim 1, which has a notification means for alerting the possibility that the blood pressure is rising due to tension.
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JP2003265420A (en) * 2002-03-15 2003-09-24 Terumo Corp Hemodynamometer with arterial pressure pulse wave analyzing function using brachium pressurizing method
JP2008279126A (en) * 2007-05-11 2008-11-20 Terumo Corp Pulsation fluctuation measuring apparatus and its information processing method
CN101366627A (en) * 2008-09-26 2009-02-18 鲁东大学 Electrosphygmomanometer capable of prompting confidence level of blood pressure result of measurement
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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002034933A (en) * 2000-07-26 2002-02-05 Nippon Colin Co Ltd Postoperative recovery state evaluating device
JP2003265420A (en) * 2002-03-15 2003-09-24 Terumo Corp Hemodynamometer with arterial pressure pulse wave analyzing function using brachium pressurizing method
JP2008279126A (en) * 2007-05-11 2008-11-20 Terumo Corp Pulsation fluctuation measuring apparatus and its information processing method
CN101366627A (en) * 2008-09-26 2009-02-18 鲁东大学 Electrosphygmomanometer capable of prompting confidence level of blood pressure result of measurement
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