JPWO2019235598A1 - Needleless syringe - Google Patents

Abstract

The disclosure of the present application is a needleless syringe that injects the injection target substance into the injection target area by injecting the injection target substance while pressing the injection target area without using an injection needle. And a pressing portion, and a predetermined gap is formed between the nozzle portion and the pressing portion. The pressing portion is formed so that the width of the tip portion thereof is narrower than the width of the tip portion of the nozzle portion, and when the injection target region is pressed by the pressing portion, a predetermined gap is formed in one of the injection target regions. Accommodates the department. With this configuration, a desired contact state can be suitably formed and maintained between the injection target region and the nozzle portion.

Description

The present invention relates to a needleless syringe that injects an injection target substance into an injection target area without using a needle.

A needleless syringe that injects an injection solution without passing through an injection needle and injects an object is widely known. For example, in the needleless syringe described in Patent Document 1, a cylindrical skirt is formed on the tip end side thereof, and an injection tube is arranged in a separable chamber defined by the skirt. Then, in the needleless syringe, the air in the compartment is sucked by the suction pump with the open end of the skirt pressed against the patient's skin. It is disclosed that the patient's skin is then sucked into the compartment and the skin near the tip of the injection tube is kept stable.

U.S. Pat. No. 6,406,456

The needleless syringe is provided with a nozzle portion in which an injection port for injecting a substance to be injected is formed. In such a needleless syringe, in order to accurately deliver the injection target substance ejected from the injection port to the target site of the injection target region, an appropriate contact state is formed between the injection target region and the nozzle portion. The condition must be maintained during the injection of the injection target substance into the target site. In this way, the contact state between the injection target area and the nozzle portion, which enables accurate delivery of the injection target substance to the target site of the injection target area, may be hereinafter referred to as a “desired contact state”. is there.

However, the contact state between the injection target area and the nozzle portion may change due to a difference in the user's procedure or the like. Therefore, it may be difficult to form a desired contact state by simply pressing the nozzle portion against the surface of the injection target area by the user. Further, even if a desired contact state is formed when the nozzle portion is first brought into contact with the surface of the injection target area, for example, if skidding occurs in the process of performing the injection operation, the injection is performed. The contact state between the target area and the nozzle portion changes. That is, it may be difficult to maintain the desired contact state by simply pressing the nozzle portion against the surface of the injection target area by the user.

Here, according to the needleless syringe described in Patent Document 1, the pressure in the compartment is reduced and the skin of the patient is sucked into the compartment. Therefore, according to the technique, it seems that the desired contact state can be formed and maintained relatively easily. However, without a configuration for depressurizing the compartment, the desired contact state between the injection target area and the nozzle portion cannot be formed and maintained.

In view of the above problems, an object of the present invention is to provide a needleless syringe capable of suitably forming and maintaining a desired contact state between an injection target region and a nozzle portion.

The needleless syringe of the present invention includes a nozzle portion and a pressing portion, and a predetermined gap is formed between the nozzle portion and the pressing portion. Then, in order to solve the above problem, the pressing portion is formed so that the width of the tip portion thereof is narrower than the width of the tip portion of the nozzle portion, and when the injection target area is pressed by the pressing portion, a predetermined value is obtained. The gap accommodates a portion of the injection target area. With such a configuration, a desired contact state can be suitably formed and maintained between the injection target region and the nozzle portion.

Specifically, the needleless injector of the present invention injects the injection target substance into the injection target area by injecting the injection target substance while pressing the injection target area without using an injection needle. A needle injector for injecting an injection target substance provided in the housing of the needleless injector and a storage portion provided in the housing for containing the injection target substance. A drive unit for generating injection energy and a nozzle unit provided so as to project from a predetermined end portion of the housing on the side of the accommodating portion, and the injection energy generated by the drive unit is applied. An injection port for injecting the injection target substance toward the injection target area is formed, and when the injection target substance is injected from the injection port, the tip portion is configured to come into contact with the injection target area. A pressing portion that protrudes from the predetermined end portion so as to surround the nozzle portion and form a predetermined gap between the nozzle portion and the injection port. It includes a pressing portion configured so that the tip portion comes into contact with the injection target region when the injection target substance is injected. Then, in the needleless syringe of the present invention, the width of the portion of the tip of the pressing portion that contacts the injection target region is narrower than the width of the portion of the tip of the nozzle that contacts the injection target region. When the injection target area is pressed by the pressing portion, the predetermined gap accommodates a part of the injection target area.

In the needleless syringe of the present invention, when the injection target area is pressed by the pressing portion, the portion of the injection target area surrounded by the pressing portion tends to rise toward the syringe. However, in the above-mentioned needleless syringe, the nozzle portion is provided so as to protrude from a predetermined end portion of the housing and be surrounded by a pressing portion that presses the injection target area. Therefore, a part of the region surrounded by the pressing portion in the injection target region is pressed by the tip portion of the nozzle portion. In addition, another portion of the area penetrates the predetermined gap so as to bulge towards the syringe as described above. Then, when the injection target region and the nozzle portion are brought into contact with each other in this way, a desired contact state between the injection target region and the nozzle portion can be easily formed and maintained.

However, when the injection target area is pressed by the pressing portion, if the tip of the pressing portion and the surface of the injection target area are not in good contact with each other, the injection target area may not be sufficiently pressed. As a result, when the injection target substance is injected into the injection target area, if the desired contact state between the injection target area and the nozzle portion is not formed and maintained, the injection target substance is accurately injected. There is a risk that it will not be possible to reach the target part of the target area.

Therefore, in the needleless syringe according to the present invention, the width of the portion in contact with the injection target region at the tip of the pressing portion is narrower than the width of the portion in contact with the injection target region at the tip of the nozzle portion. A pressing portion is formed. The widths of the pressing portion and the nozzle portion are the respective widths when the syringe is viewed in the vertical cross section of the housing, and are the widths at the respective tip portions in contact with the injection target area. Then, the adhesion between the tip of the pressing portion and the surface of the injection target area is improved as compared with the case where the pressing portion is formed so that the width of the pressing portion is wider than the width of the nozzle portion. .. As a result, the injection target area can be sufficiently pressed by the pressing portion, and thus a desired contact state can be formed between the injection target region and the nozzle portion. That is, by narrowing the width of the tip portion of the pressing portion, the load applied to the injection target region can be concentrated, and the capacity (invasion amount) of the injection target region into the predetermined gap can be increased. As a result, the injection target area can be positioned around the tip portion of the pressing portion and the nozzle portion, and thus the pressing portion and the nozzle portion can be easily held. Further, when the capacity (invasion amount) of the injection target area into the predetermined gap is increased, the portion of the injection target area surrounded by the pressing portion tends to rise higher toward the syringe, and thus becomes the injection target area. It becomes easy to adhere to the nozzle part. Further, if the adhesion between the tip of the pressing portion and the surface of the injection target region is improved, the pressing state of the pressing portion with respect to the injection target region can be easily maintained. Therefore, the injection target deformed as described above by being pressed. The region can be well fixed in its post-deformed mode. As a result, a desired contact state between the injection target area and the nozzle portion can be stably formed and maintained. Therefore, as long as such an effect can be obtained, the shape and specifications of the pressing portion may be limited, and the pressing portion may be, for example, an annular shape that continuously covers the periphery of the nozzle portion, or a plurality of pressing portions. The portions may be arranged in the circumferential direction with a space between them.

According to the needleless syringe described above, a desired contact state can be suitably formed and maintained between the injection target area and the nozzle portion, and the injection target substance can be administered to the target site in the injection target area. It is possible to perform accurately, stably, and with good reproduction.

Here, even if the pressing portion is formed in a cylindrical shape and has a tapered shape in which the distance between the inner peripheral surface and the outer peripheral surface thereof gradually decreases toward the tip side along the axial direction. Good. As a result, the adhesion between the tip of the pressing portion and the surface of the injection target region can be improved.

Further, the pressing portion may be formed so that the area of the end surface of the tip portion thereof is larger than the area of the end surface of the tip portion of the nozzle portion. The end faces of the pressing portion and the nozzle portion are the tip surfaces of the pressing portion and the nozzle portion extending along the axial direction of the housing. In this way, when the area of the tip surface of the pressing portion is made larger than the area of the tip surface of the nozzle portion, when the injection target area is pressed by the pressing portion, the injection target area and the end surface of the tip portion of the pressing portion The contact area with is increased, and the pressed state is easily maintained stably. According to this, for example, it is possible to suppress as much as possible a situation in which the syringe slips or tilts in the process of performing the injection operation. Therefore, a desired contact state between the injection target region and the nozzle portion can be stably formed and maintained.

Alternatively, when the pressing portion has the tapered shape described above, the pressing portion may be formed so that the area of the end surface of the tip portion thereof is smaller than the area of the end surface of the tip portion of the nozzle portion. According to such a configuration, the tip portion of the pressing portion can be made as thin as possible while ensuring the mechanical strength of the pressing portion. By making the tip of the pressing portion as thin as possible in this way, when the injection target region is pressed by the pressing portion, the pressed state can be easily maintained in a stable manner. According to this, for example, even if the syringe is tilted in the process of performing the injection operation, the surface of the injection target area is pressed relatively strongly by the tip surface of the pressing portion, so that the injection is pressed. As a result, the injection target region deformed as described above can be satisfactorily fixed in the deformed mode. In addition, it is possible to suppress as much as possible a situation in which the syringe slips or the like in the process of performing the injection operation. Therefore, a desired contact state between the injection target region and the nozzle portion can be stably formed and maintained.

In the needleless syringe described above, the nozzle portion may be formed so that its width gradually decreases toward the tip side. The width is the width of the nozzle portion when the syringe is viewed in the vertical cross section of the housing. According to such a configuration, when the injection target region is pressed by the pressing portion and the injection target region is deformed as described above, the deformed injection target region and the tip portion of the nozzle portion are more easily brought into close contact with each other. Then, the injection target area surrounds the tip portion of the nozzle portion and is in close contact with the tip portion, and the nozzle portion is easily fixed by the injection target region. As a result, it becomes easy to maintain a desired contact state between the injection target area and the nozzle portion.

According to the present invention, a desired contact state can be suitably formed and maintained between the injection target region and the nozzle portion.

It is the first figure which shows the schematic structure of the syringe which concerns on Example 1 of this invention. It is a figure for demonstrating the contact state between the injection target area and the tip end part of the nozzle part when an injection liquid is injected into the injection target area of an object. It is a figure showing the contact state between the skin of a living body and the tip of a nozzle part when the skin of a living body is pressed by a rim, and the case where a desired contact state is not formed between the skin and the nozzle part. It is a figure which shows. It is a figure showing the contact state between the skin of a living body and the tip portion of a nozzle part when the skin of a living body is pressed by a rim, and a desired contact state is formed between the skin and the nozzle part. It is a figure which shows. It is a second figure which shows the schematic structure of the syringe which concerns on Example 1 of this invention. It is a figure which shows the schematic structure of the syringe which concerns on the modification 1 of Example 1 of this invention. It is a figure which shows the contact state between the skin of a living body and the tip part of a nozzle part at the time of pressing the skin of a living body by a rim in the modification 1 of Example 1. FIG. It is a figure which shows the schematic structure of the syringe which concerns on the modification 2 of Example 1 of this invention. It is a figure which shows the contact state between the skin of a living body and the tip part of a nozzle part when the skin of a living body is pressed by a rim in the modification 2 of Example 1. FIG.

Hereinafter, as a syringe according to the embodiment of the present invention with reference to the drawings, a needleless syringe 1 (hereinafter, simply referred to as “syringe 1”) will be described as an example. The configurations of the following embodiments are examples, and the present invention is not limited to the configurations of these embodiments.

<Example 1>
1 (a) is a cross-sectional view of the syringe 1, and FIGS. 1 (b) and 1 (c) are views of the syringe 1 as viewed from the tip side. In the following description of the present application, the injection target substance to be injected into the injection target area of the object by the syringe 1 is collectively referred to as "injection solution". However, this is not intended to limit the content or form of the substance to be injected. In the injection target substance, the component to be delivered to the skin structure may or may not be dissolved, and the injection target substance can also be injected into the skin structure from the injection port by pressurizing. If there is, the specific form does not matter, and various forms such as liquid, gel, and powder can be adopted.

Here, the syringe 1 has a housing 2 including a distal end side housing 3, a proximal end side housing 4, and a syringe portion 5, and the syringe portion 5 is between the distal end side housing 3 and the proximal end side housing 4. Have been placed. Then, these are fixed with screws and integrated to form the housing 2. However, the distal end side housing 3, the proximal end side housing 4, and the syringe portion 5 can be connected by a known method other than screws. Here, a hole 40, which is an internal space extending in the axial direction thereof, is formed inside the base end side housing 4.

The syringe unit 5 has an internal storage chamber (accommodation unit) 50 for accommodating the injection solution ML. The syringe portion 5 is screwed and attached to the proximal housing 4, and in the attached state, the hole 40 in the proximal housing 4 and the accommodation chamber 50 in the syringe 5 are continuous spaces. It becomes. In the attached state, the injection liquid ML is liquid-tightly housed in the storage chamber 50 by the plunger 7, and the plunger 7 is exposed to the hole 40 side. Here, the plunger 7 is slidably arranged in the storage chamber 50, and further slides to pressurize the injection liquid ML, so that the injection liquid is ejected from the injection port. Further, the plunger 7 is formed of a rubber member whose surface is thinly coated with silicone oil so that the plunger 7 can smoothly slide in the accommodation chamber 50. In order to improve the slidability of the plunger 7, for example, the surface of the plunger 7 may be treated with fluorine.

A metal piston 6 is arranged in the hole 40 in the base end side housing 4, and the piston 6 is slidably held in the hole 40. The piston 6 is formed in a substantially axial shape extending along the axial direction of the hole 40, and has a first end portion 6a that contacts the plunger 7 arranged in the syringe portion 5 and a side opposite to the first end portion 6a. It has a second end portion 6b provided in the above and defining a combustion chamber 41 described later. Further, around the piston 6 on the second end portion 6b side, a combustion product produced by combustion of an ignition charge, which will be described later, is sealed in the combustion chamber 41, and the piston 6 can smoothly slide in the hole 40. An O-ring 6c configured so as to be is arranged.

Further, in the base end side housing 4, the initiator 20 is arranged on the side opposite to the side to which the syringe portion 5 is attached. As shown in FIG. 1A, the initiator 20 is provided at an end portion of the housing 2 on the proximal end side. Then, the combustion chamber 41 formed at one end of the hole 40 is closed by the initiator 20. Here, the space defined by the initiator 20 and the second end portion 6b of the piston 6 in the hole 40 is the combustion chamber 41. Then, when a voltage is applied to the initiator 20, the ignition charge contained in the initiator 20 burns. Then, the combustion product generated by the combustion of the ignition charge flows into the combustion chamber 41, and the pressure in the combustion chamber 41 rises. In this way, injection energy for injecting the injection liquid ML stored in the storage chamber 50 is generated. The initiator 20 serves as a driving unit for generating this injection energy.

Here, as the igniter used in the injector 1, preferably, an explosive containing zirconium and potassium perchlorate (ZPP), an explosive containing titanium hydride and potassium perchlorate (THPP), and titanium and potassium perchlorate are used. Explosives containing (TiPP), explosives containing aluminum and potassium perchlorate (APP), explosives containing aluminum and bismuth oxide (ABO), explosives containing aluminum and molybdenum oxide (AMO), explosives containing aluminum and copper oxide (ACO) ), Explosives containing aluminum and iron oxide (AFO), or explosives consisting of a plurality of combinations of these explosives. These explosives generate high-temperature and high-pressure plasma during combustion immediately after ignition, but when they reach room temperature and condense combustible organisms, they do not contain gas components, so the generated pressure drops sharply. In addition, explosives other than these may be used as ignition agents.

Further, although nothing is arranged in the combustion chamber 41 shown in FIG. 1, a gas generator that burns by the combustion product generated by the combustion of the ignition charge to generate gas is arranged in the combustion chamber 41. You may. If a gas generating agent is arranged in the combustion chamber 41, an example thereof is a single-based smokeless powder composed of 98% by mass of nitrocellulose, 0.8% by mass of diphenylamine, and 1.2% by mass of potassium sulfate. It is also possible to use various gas generators used in gas generators for airbags and gas generators for seatbelt pretensioners. In the combined use of such a gas generating agent, unlike the case where only the igniting agent is used, the predetermined gas generated at the time of combustion contains a gas component even at room temperature, so that the rate of decrease in the generated pressure is small. Further, although the combustion completion time of the gas generating agent at the time of combustion is extremely longer than that of the igniting agent, the dimensions, size, and shape of the gas generating agent when arranged in the combustion chamber 41, particularly the surface shape, are It is possible to change the combustion completion time of the gas generating agent by adjusting. By adjusting the amount, shape, and arrangement of the gas generating agent in this way, the generated pressure in the combustion chamber 41 can be appropriately adjusted.

In the syringe 1 configured as described above, the distal end side housing 3 is further screwed and attached to the syringe portion 5 with respect to the syringe portion 5. The tip-side housing 3 is attached to the syringe portion 5 with the gasket 3a interposed therebetween. A nozzle portion 8 and a rim 9 are integrally formed with the front end side housing 3 in the front end side housing 3. Here, the nozzle portion 8 and the rim 9 are provided so as to project from a predetermined end portion 2a, which is a predetermined end portion on the tip end side (accommodation chamber 50 side) of the housing 2. The nozzle portion 8 and the rim 9 may be provided as separate parts from the front end side housing 3 so as to project from the predetermined end portion 2a.

Here, the nozzle portion 8 has a main body 8a having a diameter smaller than that of the syringe portion 5 side of the tip side housing 3. The main body 8a has a base end portion 82a whose diameter gradually decreases from the predetermined end portion 2a toward the tip end side in the axial direction, and a tip end portion 81a formed on the tip end side of the base end portion 82a. including. Then, in the nozzle portion 8, an injection port 8b is formed at the tip portion 81a of the main body 8a. The injection liquid ML pressurized by the plunger 7 flows through the flow path formed in the distal end side housing 3 and is ejected from the injection port 8b. Specifically, when the pressure in the combustion chamber 41 rises due to the combustion of the igniter of the initiator 20, the piston 6 slides toward the tip end side of the syringe 1. Then, as the piston 6 slides, the plunger 7 presses the injection liquid ML stored in the storage chamber 50. As a result, the injection solution ML flows through the flow path formed in the distal end side housing 3 and is ejected from the injection port 8b toward the injection target region.

A plurality of injection ports 8b may be formed at the tip end portion 81a of the main body 8a, or one may be formed. When a plurality of injection ports are formed, a flow path corresponding to each injection port is formed in the main body 8a of the nozzle portion 8 so that the injection liquid ML is delivered to each injection port as evenly as possible. Will be done. Further, when a plurality of ejection ports are formed, it is preferable that the ejection ports are arranged at equal intervals around the central axis of the syringe 1 as shown in FIG. 1 (c).

A rim 9 is formed around the nozzle portion 8 in the tip-side housing 3. The rim 9 is formed in a cylindrical shape so as to project from a predetermined end portion 2a, and in this embodiment, the distance (width) between the inner peripheral surface and the outer peripheral surface of the rim 9 does not change along the axial direction and is constant. ..

Then, a predetermined gap 10 is formed between the rim 9 and the nozzle portion 8. In the syringe 1 according to the present invention, a gap 10 is provided between the rim 9 and the nozzle portion 8 in this way, and when the injection solution ML is injected into the injection target area of the object, the injection target area is injected by the rim 9. At this time, a part of the injection target area invades the gap 10. In other words, the gap 10 will accommodate a portion of the injection target area. The rim 9 serves as a pressing portion for pressing the injection target area. This will be described in detail below.

FIG. 2 is a diagram for explaining a contact state between the injection target area and the tip end portion 81a of the nozzle portion 8 when the injection solution ML is injected into the injection target region of the target object. In the present invention, the injection solution ML is injected while the injection target area is pressed by the rim 9. Here, FIG. 2A shows a state in which the surface of the injection target region and the tip end portion of the rim 9 are in contact with each other, and FIG. 2B shows a state represented by FIG. 2A. Further, it represents a state in which the injection target area is pressed by the rim 9. Further, FIG. 2 (c) shows a state in which the initiator 20 is operated in the state represented by FIG. 2 (b) and the injection of the injection solution ML is completed.

As shown in FIG. 2B, when the injection target area is pressed by the rim 9, a part of the injection target area invades the gap 10. Here, if the nozzle portion 8 is not arranged inside the rim 9 of the tubular body, the injection target area tends to bulge in an arch shape inside the rim 9. On the other hand, in the syringe 1 of the present invention in which the nozzle portion 8 is arranged inside the rim 9, the injection target region that tends to rise in an arch shape toward the syringe 1 is the tip of the nozzle portion 8 inside the rim 9. While being pressed against the portion 81a, the injection target area existing inside the rim 9 invades the gap 10. In the syringe 1 of the present invention, the injection target area and the nozzle portion 8 are brought into contact with each other in this way. In the state represented by FIG. 2B, the injection target area is sufficiently pressed by the rim 9, and a desired contact state described later is formed between the injection target area and the nozzle portion 8. To do.

Then, when a voltage is applied to the initiator 20 in the state shown in FIG. 2B, the combustion product generated by the combustion of the igniter flows into the combustion chamber 41, and the pressure in the combustion chamber 41 rises. Then, the injection liquid ML is pressed by the plunger 7, and the injection liquid ML is ejected from the injection port 8b toward the injection target area. As a result, the syringe 1 reaches the state shown by FIG. 2 (c).

As described above, in the syringe 1, when the injection solution ML is injected into the injection target area of the object, the injection solution ML is in contact with the injection target area and the tip portion 81a of the nozzle portion 8 from the injection port 8b. Is injected. Then, at this time, if an appropriate contact state is formed between the injection target area and the nozzle portion 8 and the appropriate contact state is not maintained during the injection of the injection solution ML, the injection solution ML is accurately injected. It may not be possible to reach the target part of the area.

Therefore, in the syringe 1 according to the present invention, the width of the portion of the tip of the rim 9 that contacts the injection target region is narrower than the width of the portion of the nozzle portion 8 that contacts the injection target region 81a. , The rim 9 is formed. As a result, when injecting the injection solution ML into the injection target area of the object, the contact between the injection target area and the nozzle portion 8 enables accurate delivery of the injection solution ML to the target site of the injection target area. It is possible to perform injection in a state in which a state (hereinafter, may be referred to as a "desired contact state") is preferably formed and maintained. This will be described with reference to FIGS. 3A and 3B.

In the examples shown by FIGS. 3A and 3B, the contact state between the skin of the living body and the tip end portion 81a of the nozzle portion 8 when the skin of the living body is pressed by the rim 9 is shown. Here, when the injection target region is a living body, the skin on the surface thereof has irregularities due to pores (body hair), keratin, and the like. Therefore, due to this unevenness, the contact state between the tip surface of the rim 9 and the skin may change. Then, even if the pressing pressure is the same, the pressing state of the rim 9 against the skin may change, and thus the contact state between the skin of the living body and the tip portion 81a of the nozzle portion 8 changes. There is a risk.

Here, FIG. 3A illustrates a case where a desired contact state is not formed between the skin and the nozzle portion 8 due to the unevenness existing in the skin of the living body. In this case, unlike the syringe 1 according to the present invention, the width of the portion of the tip of the rim 9 that contacts the injection target region is larger than the width of the portion of the nozzle portion 8 that contacts the injection target region 81a. The rim 9 is formed so as to be thicker. The width at the tip of the rim 9 is the distance between the inner peripheral surface and the outer peripheral surface at the tip surface of the rim 9, and is represented by the width D21 in FIG. 3A showing the vertical cross section of the syringe 1. .. The width of the tip portion 81a of the nozzle portion 8 is the diameter of the tip portion 81a, and is represented by the width D1 in FIG. 3A showing the vertical cross section of the syringe 1. That is, in FIG. 3A, the rim 9 is formed so that the width D21 of the tip portion of the rim 9 is thicker than the width D1 of the tip portion 81a of the nozzle portion 8. Then, as shown in FIG. 3A, the unevenness of the skin reduces the adhesion between the tip of the rim 9 and the skin. That is, since the pressing load is dispersed on the tip surface of the rim 9, as a result, the stress is not concentrated on the skin, and the skin cannot be sufficiently pressed by the rim 9. Therefore, the swelling of the skin does not easily appear in the gap 10, and the desired contact state between the skin and the nozzle portion 8 is not formed. In this way, even if the syringe 1 is provided with the rim 9 and the gap 10, the rim 9 is provided so that the width at the tip of the rim 9 is wider than the width at the tip 81a of the nozzle 8. When is formed, a desired contact state cannot be suitably formed and maintained between the injection target region and the nozzle portion 8.

On the other hand, as shown in FIG. 3B, the width D22 of the portion of the tip of the rim 9 in contact with the injection target region is larger than the width D1 of the portion of the tip 81a of the nozzle portion 8 in contact with the injection target region. When the rim 9 is formed so as to be thin, the adhesion between the tip of the rim 9 and the skin is improved as compared with the case shown in FIG. 3A. As a result, the skin of the living body can be sufficiently pressed by the rim 9, and a desired contact state can be formed between the skin and the nozzle portion 8.

Further, according to the syringe 1 according to the present invention, such a desired contact state can be stably formed and maintained. This is because when the adhesion between the tip of the rim 9 and the skin is improved, the pressed state of the rim 9 against the injection target area is easily maintained. Therefore, the injection target area deformed as described above is formed inside the rim 9. This is because it can be satisfactorily fixed in the deformed mode. Further, at this time, the deformation mode of the injection target region fixed inside the rim 9 is dominated by the influence of the geometric shape of the rim 9 and the main body 8a of the nozzle portion 8, and is therefore caused by the difference in the user's procedure. Therefore, the situation in which the contact state between the injection target area and the nozzle portion 8 changes is less likely to occur.

Further, the injection target region that has entered the gap 10 presses the outer peripheral surface of the tip portion 81a so as to surround the tip portion 81a of the nozzle portion 8. Then, since the nozzle portion 8 is fixed by such an injection target region, the desired contact state can be easily maintained.

According to the syringe 1 described above, a desired contact state can be suitably formed and maintained between the injection target region and the nozzle portion 8. As a result, it becomes possible to accurately, stably and reproducibly administer the injection solution ML to the target site in the injection target area.

Further, as shown in FIGS. 1 (b) and 1 (c), in the syringe 1 in this embodiment, the rim 9 has the area of the tip surface thereof (this is defined as the area A2 in FIGS. 1 (b) and 1 (c)). (Represented) is formed so as to be larger than the area of the tip surface of the nozzle portion 8 (which is represented as the area A1 in FIGS. 1B and 1C). When the area of the tip surface of the rim 9 is made larger than the area of the tip surface of the nozzle portion 8 in this way, when the injection target area is pressed by the rim 9, the pressed state is likely to be stably maintained. Become. According to this, for example, it is possible to suppress as much as possible a situation in which the syringe 1 is tilted or the like in the process of performing the injection operation. Therefore, a desired contact state can be stably formed and maintained between the injection target region and the nozzle portion 8, and thus the injection solution ML can be stably administered.

However, the present invention is not limited to the syringe 1 provided with the rim 9 formed so that the area of the tip surface thereof is larger than the area of the tip surface of the nozzle portion 8, and the area of the tip surface of the rim 9 is. It may be smaller than the area of the tip surface of the nozzle portion 8. Such an embodiment is exemplified by the syringe 1 shown in FIG. In the syringe 1 illustrated in FIG. 4, a rim 9 that protrudes from a predetermined end portion 2a and is formed in a cylindrical shape is formed intermittently around the nozzle portion 8 instead of the entire circumference. As a result, the area of the tip surface of the rim 9 (which is represented as area A3 in FIGS. 4 (b) and 4 (c)) is the area of the tip surface of the nozzle portion 8 (which is represented by FIG. 4 (b)). ) And (c) are expressed as the area A1). In such a syringe 1, the pressure applied to the injection target area by the tip surface of the rim 9 increases, so that the situation where the syringe skids or the like occurs in the process of performing the injection operation is suppressed as much as possible. Will be done.

<Modification 1 of Example 1>
Next, a modification 1 of the above-mentioned Example 1 will be described with reference to FIGS. 5 and 6. In this modified example, the detailed description of the configuration substantially the same as that of the first embodiment described above will be omitted. 5 (a) is a cross-sectional view of the syringe 1 according to the present modification, and FIGS. 5 (b) and 5 (c) are views of the syringe 1 according to the present modification as viewed from the tip side.

As shown in FIG. 5A, in the syringe 1 according to this modification, the rim 9 has a tapered portion 9a. Specifically, a tapered portion 9a is formed on the inner peripheral surface of the cylindrical rim 9, and the distance between the inner peripheral surface and the outer peripheral surface of the rim 9 is increased toward the tip side along the axial direction by the tapered portion 9a. It is gradually reduced. A tapered portion may be formed on the outer peripheral surface of the cylindrical rim 9 so that the distance between the inner peripheral surface and the outer peripheral surface of the rim 9 gradually decreases toward the tip side along the axial direction. ..

Further, as shown in FIGS. 5 (b) and 5 (c), in the syringe 1 in this modified example, the rim 9 has the area of the tip surface thereof (this is defined as the area A4 in FIGS. 5 (b) and 5 (c). (Represented) is formed to be smaller than the area of the tip surface of the nozzle portion 8 (which is represented as the area A1 in FIGS. 5B and 5C). As described above, when the syringe 1 is configured so that the area of the tip surface of the rim 9 is smaller than the area of the tip surface of the nozzle portion 8, the distance between the inner peripheral surface and the outer peripheral surface of the rim 9 is assumed to be the axis. If it does not change along the direction, the rim 9 becomes thin over the entire length, so that it becomes difficult to secure the mechanical strength of the rim 9. On the other hand, as shown in FIG. 5, when the tapered portion 9a is formed on the rim 9 and the area of the tip surface of the rim 9 is smaller than the area of the tip surface of the nozzle portion 8. The tip of the rim 9 can be made as thin as possible while ensuring the mechanical strength of the rim 9.

Then, even with such a syringe 1, a desired contact state can be suitably formed and maintained between the injection target region and the nozzle portion 8. This will be described with reference to FIG.

In the example shown by FIG. 6, similarly to FIG. 3B, the contact state between the skin of the living body and the tip portion 81a of the nozzle portion 8 when the skin of the living body is pressed by the rim 9 is shown. As shown in FIG. 6, the distance between the inner peripheral surface and the outer peripheral surface of the rim 9 (width of the rim 9) is from D22 to D23 as the distance from the predetermined end portion 2a toward the tip end side along the axial direction. It is gradually reduced. Then, according to the syringe 1 according to the present modification, as shown in FIG. 6, the rim 9 bites into the skin relatively deeply. This is because, when the pressing force is the same, the thinner the tip of the rim 9 (the smaller the area of the tip surface of the rim 9), the more the load applied to the skin surface by the tip surface of the rim 9 is concentrated. Then, even when the skin is pressed in this way, the injection target area is deformed inside the rim 9 as in Example 1 described above, and a desired contact state is formed between the skin and the nozzle portion 8. Will be done.

Then, according to such a syringe 1, a desired contact state can be stably formed and maintained between the injection target region and the nozzle portion 8. This is because the rim 9 bites into the injection target area relatively deeply, so that the pressed state of the rim 9 against the injection target area can be easily maintained in a stable manner. According to this, for example, even if the syringe 1 is tilted in the process of performing the injection operation, the injection target area deformed as described above inside the rim 9 is good in the deformed mode. Can be fixed to. In addition, it is possible to suppress as much as possible a situation in which the syringe 1 skids or the like occurs in the process of performing the injection operation.

That is, a desired contact state is suitably formed and maintained between the injection target region and the nozzle portion 8, and thus the administration of the injection solution ML to the target site of the injection target region can be accurately and stably reproduced. It will be possible to do well.

<Modification 2 of Example 1>
Next, the modification 2 of the first embodiment described above will be described with reference to FIGS. 7 and 8. In this modified example, the detailed description of the configuration substantially the same as that of the first embodiment described above will be omitted. FIG. 7 (a) is a cross-sectional view of the syringe 1 according to the present modification, and FIGS. 7 (b) and 7 (c) are views of the syringe 1 according to the present modification as viewed from the tip side.

In the syringe 1 described in the description of the first embodiment, the main body 8a of the nozzle portion 8 has a proximal end portion 82a and a proximal end portion 82a whose diameter gradually decreases from the predetermined end portion 2a toward the distal end side along the axial direction. Includes a tip portion 81a formed on the tip side of the portion 82a and whose diameter does not change over the entire length. On the other hand, in the syringe 1 according to the present modification, the main body 8a of the nozzle portion 8 is formed at the same proximal end portion 82a as the syringe 1 according to the first embodiment and on the distal end side of the proximal end portion 82a. It includes a tip portion 811a whose diameter gradually decreases toward the tip side along the axial direction.

Then, even with such a syringe 1, a desired contact state can be suitably formed and maintained between the injection target region and the nozzle portion 8. This will be described with reference to FIG.

In the example shown by FIG. 8, similarly to FIG. 3B, the contact state between the skin of the living body and the tip portion 81a of the nozzle portion 8 when the skin of the living body is pressed by the rim 9 is shown. As shown in FIG. 8, the diameter of the tip portion 811a (width of the tip portion 811a) is gradually reduced from D1 to D11 toward the tip side along the axial direction. Further, the rim 9 is formed so that the width D22 of the tip portion of the rim 9 is narrower than the width D11 of the tip surface of the nozzle portion 8. Then, according to the syringe 1 according to the present modification, as shown in FIG. 8, the tip portion 811a of the nozzle portion 8 easily bites into the skin. Then, the nozzle portion 8 is easily fixed by the injection target region surrounding the outer peripheral surface of the tip portion 811a, and a desired contact state is easily maintained between the injection target region and the nozzle portion 8.

That is, a desired contact state is suitably formed and maintained between the injection target region and the nozzle portion 8, and thus the administration of the injection solution ML to the target site of the injection target region can be accurately and stably reproduced. It will be possible to do well.

<Other Examples>
According to the injector 1 according to the present invention, for example, in the field of regenerative medicine for humans, as shown in Japanese Patent Application Laid-Open No. 2008-206477, a person skilled in the art appropriately determines the site to be transplanted and the purpose of recellularization. Possible cells, such as endothelial cells, endothelial precursor cells, bone marrow cells, anterior osteoblasts, cartilage cells, fibroblasts, skin cells, muscle cells, liver cells, kidney cells, intestinal cells, stem cells, and other fields of regenerative medicine. Any cell considered in the above can be injected with the injector 1. More specifically, a liquid containing the above cells (cell suspension) is housed in a storage chamber 50, and by pressurizing the liquid (cell suspension), predetermined cells are injected and transplanted into the site to be transplanted.

Furthermore, the syringe 1 according to the present invention can also be used for delivery of DNA and the like as described in JP-A-2007-525192. In this case, it can be said that it is more preferable to use the syringe 1 according to the present invention because the influence on cells, scaffold tissue, scaffold, etc. can be suppressed as compared with the case of delivery using a needle.

Furthermore, the injector 1 according to the present invention is also preferably used when delivering various genes, tumor suppressor cells, lipid envelopes, etc., or when administering an antigen gene in order to enhance immunity against a pathogen. In addition, in the fields of various disease treatments (fields described in JP-A-2008-508881, JP-A-2010-503616, etc.), immunomedical fields (fields described in JP-A-2005-523679, etc.), etc. , The syringe 1 can be used, and its usable field is not intentionally limited.

1 ... Syringe 2 ... Housing 3 ... Tip side housing 4 ... Base end side housing 5 ... Syringe part 6 ... Piston 7 ... Plunger 8 ...・ ・ ・ Nozzle part 8a ・ ・ ・ Main body 81a ・ ・ Tip part 8b ・ ・ ・ Injection port 9 ・ ・ ・ ・ Rim 10 ・ ・ ・ ・ Gap 20 ・ ・ ・ ・ Initiator

Claims (5)

A needleless syringe that injects the target substance for injection into the target area for injection by injecting the target substance for injection while pressing the target area for injection without using an injection needle.
An accommodating portion for accommodating the substance to be injected, which is provided in the housing of the needleless syringe.
A drive unit provided in the housing and generating injection energy for injecting the injection target substance contained in the storage unit.
The injection target substance, which is a nozzle portion provided so as to project from a predetermined end portion of the housing on the side of the accommodating portion and to which the injection energy generated by the driving portion is applied, is injected. An injection port for ejecting toward the target area is formed, and when the injection target substance is injected from the injection port, a nozzle portion configured so that the tip portion comes into contact with the injection target area, and a nozzle portion.
A pressing portion provided so as to surround the nozzle portion and to form a predetermined gap between the nozzle portion and the nozzle portion, and the injection target substance is injected from the injection port. When the tip is in contact with the injection target area,
With
The width of the portion of the tip of the pressing portion that contacts the injection target region is formed to be narrower than the width of the portion of the tip of the nozzle that contacts the injection target region.
When the injection target area is pressed by the pressing portion, the predetermined gap is configured to accommodate a part of the injection target area.
Needleless syringe. The pressing portion is formed in a cylindrical shape, and has a tapered shape in which the distance between the inner peripheral surface and the outer peripheral surface thereof gradually decreases toward the tip end side along the axial direction.
The needleless syringe according to claim 1. The pressing portion is formed so that the area of the end surface of the tip portion thereof is larger than the area of the end surface of the tip portion of the nozzle portion.
The needleless syringe according to claim 1 or 2. The pressing portion is formed so that the area of the end surface of the tip portion thereof is smaller than the area of the end surface of the tip portion of the nozzle portion.
The needleless syringe according to claim 2. The nozzle portion is formed so that its width gradually decreases toward the tip side.
The needleless syringe according to any one of claims 1 to 4.

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