JPWO2019234187A5 - - Google Patents
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- Publication number
- JPWO2019234187A5 JPWO2019234187A5 JP2020567523A JP2020567523A JPWO2019234187A5 JP WO2019234187 A5 JPWO2019234187 A5 JP WO2019234187A5 JP 2020567523 A JP2020567523 A JP 2020567523A JP 2020567523 A JP2020567523 A JP 2020567523A JP WO2019234187 A5 JPWO2019234187 A5 JP WO2019234187A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide complex
- cancer
- trimer
- complex according
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 34
- 229920001184 polypeptide Polymers 0.000 claims 33
- 102000004196 processed proteins & peptides Human genes 0.000 claims 33
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 239000013638 trimer Substances 0.000 claims 17
- 239000000427 antigen Substances 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 8
- 239000000556 agonist Substances 0.000 claims 8
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 6
- 108091008034 costimulatory receptors Proteins 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 102000012406 Carcinoembryonic Antigen Human genes 0.000 claims 3
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 claims 3
- 102000001301 EGF receptor Human genes 0.000 claims 3
- 108060006698 EGF receptor Proteins 0.000 claims 3
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- 102000009027 Albumins Human genes 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 2
- 230000002494 anti-cea effect Effects 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 102000047200 Collagen Type XVIII Human genes 0.000 claims 1
- 108010001463 Collagen Type XVIII Proteins 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 102000004140 Oncostatin M Human genes 0.000 claims 1
- 108090000630 Oncostatin M Proteins 0.000 claims 1
- 108700026244 Open Reading Frames Proteins 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 201000010255 female reproductive organ cancer Diseases 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 230000002489 hematologic effect Effects 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 230000000926 neurological effect Effects 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 210000001635 urinary tract Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18382401.0 | 2018-06-06 | ||
| EP18382401 | 2018-06-06 | ||
| PCT/EP2019/064864 WO2019234187A1 (en) | 2018-06-06 | 2019-06-06 | Trimeric polypeptide complexes and uses thereof |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021525537A JP2021525537A (ja) | 2021-09-27 |
| JPWO2019234187A5 true JPWO2019234187A5 (https=) | 2022-06-14 |
| JP2021525537A5 JP2021525537A5 (https=) | 2022-06-14 |
| JP7557377B2 JP7557377B2 (ja) | 2024-09-27 |
Family
ID=62716010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020567523A Active JP7557377B2 (ja) | 2018-06-06 | 2019-06-06 | 三量体ポリペプチド複合体およびその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US12454577B2 (https=) |
| EP (1) | EP3802601A1 (https=) |
| JP (1) | JP7557377B2 (https=) |
| CN (1) | CN112566939A (https=) |
| WO (1) | WO2019234187A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2021285201A1 (en) * | 2020-06-05 | 2022-11-24 | Pieris Pharmaceuticals Gmbh | Multimeric immunomodulator targeting 4-1BB |
| WO2021249010A1 (en) * | 2020-06-10 | 2021-12-16 | Sichuan Clover Biopharmaceuticals, Inc. | Coronavirus diagnostic compositions, methods, and uses thereof |
| US20230303664A1 (en) * | 2020-07-29 | 2023-09-28 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Therapeutic and diagnostic vhh antibodies against sars-cov-2 and methods for their enhancement |
| EP3944877A1 (en) * | 2020-07-29 | 2022-02-02 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Nanobodies sars-cov2 |
| EP3957650A1 (en) | 2020-08-17 | 2022-02-23 | Themis Bioscience GmbH | Co-stimulatory 4-1bbl ectodomain polypeptides for immunomodulation |
| WO2022184937A1 (en) * | 2021-03-05 | 2022-09-09 | Leadartis, S.L. | Trimeric polypeptides and uses thereof in the treatment of cancer |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
| CA2155335C (en) | 1993-02-04 | 2001-06-05 | HANS CHRISTIAN THõGERSEN | Improved method for the refolding of proteins |
| ES2701445T3 (es) * | 2010-10-15 | 2019-02-22 | Leadartis S L | Generación de complejos polipeptídicos multifuncionales y multivalentes mediante el dominio de trimerización del colágeno XVIII |
| CN118440206A (zh) | 2014-04-07 | 2024-08-06 | 中外制药株式会社 | 免疫活化抗原结合分子 |
| EP3387014B1 (en) | 2015-12-11 | 2022-01-19 | Leadartis, S.L. | Single chain fusionconstructs comprising multimeric antibody fragments fused to collagen trimerization domains |
| AU2017252233A1 (en) | 2016-04-22 | 2018-11-15 | Alligator Bioscience Ab | Novel bispecific polypeptides against CD137 |
-
2019
- 2019-06-06 CN CN201980052447.4A patent/CN112566939A/zh active Pending
- 2019-06-06 US US16/972,654 patent/US12454577B2/en active Active
- 2019-06-06 JP JP2020567523A patent/JP7557377B2/ja active Active
- 2019-06-06 WO PCT/EP2019/064864 patent/WO2019234187A1/en not_active Ceased
- 2019-06-06 EP EP19731177.2A patent/EP3802601A1/en active Pending
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