JPWO2019218022A5 - - Google Patents

Claims (12)

Binds or binds to a group A streptococcus M protein fragment, or a variant thereof, or derivative thereof for use in passive immunization, treatment, or prevention of invasive group A streptococcal disease (iGAS) in mammals. An antibody or antibody fragment thereof, wherein the M protein fragment is a storage region for or contains the M protein . The antibody or antibody fragment according to claim 1, wherein the invasive group A streptococcal disease (iGAS) is streptococcal toxic shock syndrome (STSS). The antibody or antibody fragment according to claim 1 or 2, further comprising an antibody or antibody fragment produced or bound to a group A streptococcal superantigen protein, a fragment, a variety, or a derivative thereof . The antibody or antibody fragment according to claim 3 , wherein the superantigen is streptococcal exotoxin (Spe) A or SpeC. The antibody or antibody fragment according to any one of claims 1 to 4, wherein the M protein fragment is a p145 peptide, contains it, or is contained therein. The antibody or antibody fragment according to any one of claims 1 to 4, wherein the M protein fragment is a J8 peptide, a fragment thereof, a manifold, or a derivative thereof, or contains or is contained therein. The antibody or antibody fragment according to any one of claims 1 to 4, wherein the M protein fragment is a p17 peptide, a fragment thereof, a manifold, or a derivative thereof, or contains or contains the p17 peptide. The antibody or antibody fragment according to any one of claims 1 to 4, wherein the M protein fragment contains or contains an amino acid sequence selected from the group consisting of SEQ ID NOs: 1 to 10 and 13 to 29. The antibody or antibody fragment according to any one of claims 1 to 8 , wherein the antibody or antibody fragment is a monoclonal antibody or antibody fragment. The antibody or antibody fragment according to claim 9, wherein the antibody or antibody fragment is a humanized monoclonal antibody or antibody fragment. The antibody or antibody fragment according to any one of claims 1 to 10, wherein the mammal is a human. A pharmaceutical composition comprising the antibody or antibody fragment according to any one of claims 1 to 11.