JPWO2019203255A1 - 再構成癌組織を用いた薬剤評価方法 - Google Patents
再構成癌組織を用いた薬剤評価方法 Download PDFInfo
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- JPWO2019203255A1 JPWO2019203255A1 JP2020514407A JP2020514407A JPWO2019203255A1 JP WO2019203255 A1 JPWO2019203255 A1 JP WO2019203255A1 JP 2020514407 A JP2020514407 A JP 2020514407A JP 2020514407 A JP2020514407 A JP 2020514407A JP WO2019203255 A1 JPWO2019203255 A1 JP WO2019203255A1
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018080585 | 2018-04-19 | ||
| JP2018080585 | 2018-04-19 | ||
| PCT/JP2019/016421 WO2019203255A1 (ja) | 2018-04-19 | 2019-04-17 | 再構成癌組織を用いた薬剤評価方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2019203255A1 true JPWO2019203255A1 (ja) | 2021-06-10 |
| JPWO2019203255A5 JPWO2019203255A5 (https=) | 2022-03-02 |
Family
ID=68238962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020514407A Pending JPWO2019203255A1 (ja) | 2018-04-19 | 2019-04-17 | 再構成癌組織を用いた薬剤評価方法 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPWO2019203255A1 (https=) |
| WO (1) | WO2019203255A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7702110B2 (ja) * | 2020-04-28 | 2025-07-03 | 国立大学法人高知大学 | ヒト膵癌オルガノイドを用いたマウスモデルの樹立 |
| US20220276225A1 (en) * | 2020-06-25 | 2022-09-01 | Next & Bio Inc. | Method for providing information necessary for diagnosing cancer patient's resistance to anti-cancer agent and/or radiation |
| EP4253516A3 (en) | 2020-06-25 | 2023-12-06 | Next & Bio Inc. | Method for mass proliferation of stem cells without using hydrogel |
| US12606783B2 (en) | 2020-06-25 | 2026-04-21 | Next & Bio Inc. | Well plate and 3D culture plate comprising the same |
| KR102746473B1 (ko) | 2021-07-09 | 2024-12-26 | 주식회사 넥스트앤바이오 | 가상 오가노이드를 이용한 촬영 이미지 데이터 생성 방법 |
| KR102746470B1 (ko) | 2021-07-09 | 2024-12-26 | 주식회사 넥스트앤바이오 | 가상 오가노이드 생성 방법 |
| WO2023238939A1 (ja) * | 2022-06-09 | 2023-12-14 | 慶應義塾 | 癌の再燃若しくは再発の予防剤又は治療剤及びそのスクリーニング方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015153997A2 (en) * | 2014-04-04 | 2015-10-08 | Oncomed Pharmaceuticals, Inc. | Notch3 antibodies and uses thereof |
| WO2016089208A2 (en) * | 2014-12-04 | 2016-06-09 | Stichting Maastricht Radiation Oncology "Maastro-Clinic" | Sulfonamide, sulfamate and sulfamide derivatives of anti-cancer agents |
| JP2016520289A (ja) * | 2013-03-15 | 2016-07-14 | オンコメッド ファーマシューティカルズ インコーポレイテッド | 膵臓癌の治療方法 |
-
2019
- 2019-04-17 WO PCT/JP2019/016421 patent/WO2019203255A1/ja not_active Ceased
- 2019-04-17 JP JP2020514407A patent/JPWO2019203255A1/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016520289A (ja) * | 2013-03-15 | 2016-07-14 | オンコメッド ファーマシューティカルズ インコーポレイテッド | 膵臓癌の治療方法 |
| WO2015153997A2 (en) * | 2014-04-04 | 2015-10-08 | Oncomed Pharmaceuticals, Inc. | Notch3 antibodies and uses thereof |
| WO2016089208A2 (en) * | 2014-12-04 | 2016-06-09 | Stichting Maastricht Radiation Oncology "Maastro-Clinic" | Sulfonamide, sulfamate and sulfamide derivatives of anti-cancer agents |
Non-Patent Citations (10)
| Title |
|---|
| BRITISH JOURNAL OF CANCER, vol. 108, JPN6019021353, 14 March 2013 (2013-03-14), pages 1488 - 1494, ISSN: 0005115713 * |
| CANCER RESEARCH, vol. 69, JPN6019021354, 10 March 2009 (2009-03-10), pages 2400 - 2407, ISSN: 0005115714 * |
| CANCER TREATMENT REVIEWS, vol. 55, JPN6019021352, 2017, pages 36 - 45, ISSN: 0004973777 * |
| MEDICAL ONCOLOGY, vol. 27, JPN6019021356, 9 October 2009 (2009-10-09), pages 1017 - 1022, ISSN: 0004973779 * |
| NATURE, vol. 499, JPN6020022734, 3 July 2013 (2013-07-03), pages 481 - 484, ISSN: 0004973782 * |
| ONCOTARGETS AND THERAPY, vol. 6, JPN6019021355, 2013, pages 1249 - 1259, ISSN: 0004973778 * |
| 公益財団法人日本膵臓病研究財団 第23回研究報告書 (2015年度), vol. 23, JPN6020022732, 20 December 2016 (2016-12-20), pages 131 - 135, ISSN: 0004973780 * |
| 奥田諒 ほか: "[2P-0879] 腫瘍微小環境を有する患者由来ヒト膵癌オルガノイドの創出", 2017年度生命科学系学会合同年次大会 [ONLINE], JPN6020022730, 15 November 2017 (2017-11-15), ISSN: 0005115711 * |
| 奥田諒 ほか: "[3AS13-7(3P-0750)] 腫瘍微小環境を模倣するヒト膵癌オルガノイドの創出", 第39回日本分子生物学会年会 [ONLINE], JPN6020022731, 16 November 2016 (2016-11-16), ISSN: 0005115712 * |
| 濱中香織 ほか: "P-1236 ヒト膵癌オルガノイドを用いた新規薬剤評価系の構築", 第74回日本癌学会学術総会 [ONLINE], JPN6020022733, 2015, ISSN: 0004973781 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019203255A1 (ja) | 2019-10-24 |
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