JPWO2019203255A1 - 再構成癌組織を用いた薬剤評価方法 - Google Patents

再構成癌組織を用いた薬剤評価方法 Download PDF

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JPWO2019203255A1
JPWO2019203255A1 JP2020514407A JP2020514407A JPWO2019203255A1 JP WO2019203255 A1 JPWO2019203255 A1 JP WO2019203255A1 JP 2020514407 A JP2020514407 A JP 2020514407A JP 2020514407 A JP2020514407 A JP 2020514407A JP WO2019203255 A1 JPWO2019203255 A1 JP WO2019203255A1
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cancer
cells
emt
administration
anticancer drug
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JPWO2019203255A5 (https=
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英樹 谷口
英樹 谷口
圭輔 関根
圭輔 関根
康晴 上野
康晴 上野
諒 奥田
諒 奥田
聡一郎 森永
聡一郎 森永
洋平 宮城
洋平 宮城
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Kanagawa Prefectural Hospital Organization
Yokohama City University
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Kanagawa Prefectural Hospital Organization
Yokohama City University
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    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

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JP2020514407A 2018-04-19 2019-04-17 再構成癌組織を用いた薬剤評価方法 Pending JPWO2019203255A1 (ja)

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JP2018080585 2018-04-19
JP2018080585 2018-04-19
PCT/JP2019/016421 WO2019203255A1 (ja) 2018-04-19 2019-04-17 再構成癌組織を用いた薬剤評価方法

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JPWO2019203255A5 JPWO2019203255A5 (https=) 2022-03-02

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Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
JP7702110B2 (ja) * 2020-04-28 2025-07-03 国立大学法人高知大学 ヒト膵癌オルガノイドを用いたマウスモデルの樹立
US20220276225A1 (en) * 2020-06-25 2022-09-01 Next & Bio Inc. Method for providing information necessary for diagnosing cancer patient's resistance to anti-cancer agent and/or radiation
EP4253516A3 (en) 2020-06-25 2023-12-06 Next & Bio Inc. Method for mass proliferation of stem cells without using hydrogel
US12606783B2 (en) 2020-06-25 2026-04-21 Next & Bio Inc. Well plate and 3D culture plate comprising the same
KR102746473B1 (ko) 2021-07-09 2024-12-26 주식회사 넥스트앤바이오 가상 오가노이드를 이용한 촬영 이미지 데이터 생성 방법
KR102746470B1 (ko) 2021-07-09 2024-12-26 주식회사 넥스트앤바이오 가상 오가노이드 생성 방법
WO2023238939A1 (ja) * 2022-06-09 2023-12-14 慶應義塾 癌の再燃若しくは再発の予防剤又は治療剤及びそのスクリーニング方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015153997A2 (en) * 2014-04-04 2015-10-08 Oncomed Pharmaceuticals, Inc. Notch3 antibodies and uses thereof
WO2016089208A2 (en) * 2014-12-04 2016-06-09 Stichting Maastricht Radiation Oncology "Maastro-Clinic" Sulfonamide, sulfamate and sulfamide derivatives of anti-cancer agents
JP2016520289A (ja) * 2013-03-15 2016-07-14 オンコメッド ファーマシューティカルズ インコーポレイテッド 膵臓癌の治療方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016520289A (ja) * 2013-03-15 2016-07-14 オンコメッド ファーマシューティカルズ インコーポレイテッド 膵臓癌の治療方法
WO2015153997A2 (en) * 2014-04-04 2015-10-08 Oncomed Pharmaceuticals, Inc. Notch3 antibodies and uses thereof
WO2016089208A2 (en) * 2014-12-04 2016-06-09 Stichting Maastricht Radiation Oncology "Maastro-Clinic" Sulfonamide, sulfamate and sulfamide derivatives of anti-cancer agents

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BRITISH JOURNAL OF CANCER, vol. 108, JPN6019021353, 14 March 2013 (2013-03-14), pages 1488 - 1494, ISSN: 0005115713 *
CANCER RESEARCH, vol. 69, JPN6019021354, 10 March 2009 (2009-03-10), pages 2400 - 2407, ISSN: 0005115714 *
CANCER TREATMENT REVIEWS, vol. 55, JPN6019021352, 2017, pages 36 - 45, ISSN: 0004973777 *
MEDICAL ONCOLOGY, vol. 27, JPN6019021356, 9 October 2009 (2009-10-09), pages 1017 - 1022, ISSN: 0004973779 *
NATURE, vol. 499, JPN6020022734, 3 July 2013 (2013-07-03), pages 481 - 484, ISSN: 0004973782 *
ONCOTARGETS AND THERAPY, vol. 6, JPN6019021355, 2013, pages 1249 - 1259, ISSN: 0004973778 *
公益財団法人日本膵臓病研究財団 第23回研究報告書 (2015年度), vol. 23, JPN6020022732, 20 December 2016 (2016-12-20), pages 131 - 135, ISSN: 0004973780 *
奥田諒 ほか: "[2P-0879] 腫瘍微小環境を有する患者由来ヒト膵癌オルガノイドの創出", 2017年度生命科学系学会合同年次大会 [ONLINE], JPN6020022730, 15 November 2017 (2017-11-15), ISSN: 0005115711 *
奥田諒 ほか: "[3AS13-7(3P-0750)] 腫瘍微小環境を模倣するヒト膵癌オルガノイドの創出", 第39回日本分子生物学会年会 [ONLINE], JPN6020022731, 16 November 2016 (2016-11-16), ISSN: 0005115712 *
濱中香織 ほか: "P-1236 ヒト膵癌オルガノイドを用いた新規薬剤評価系の構築", 第74回日本癌学会学術総会 [ONLINE], JPN6020022733, 2015, ISSN: 0004973781 *

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