JPWO2019201710A5 - - Google Patents
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- Publication number
- JPWO2019201710A5 JPWO2019201710A5 JP2020556795A JP2020556795A JPWO2019201710A5 JP WO2019201710 A5 JPWO2019201710 A5 JP WO2019201710A5 JP 2020556795 A JP2020556795 A JP 2020556795A JP 2020556795 A JP2020556795 A JP 2020556795A JP WO2019201710 A5 JPWO2019201710 A5 JP WO2019201710A5
- Authority
- JP
- Japan
- Prior art keywords
- organically
- inorganic
- derived
- microparticles
- inositol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 12
- 239000011859 microparticle Substances 0.000 claims description 12
- 229920000388 Polyphosphate Polymers 0.000 claims description 5
- 239000001205 polyphosphate Substances 0.000 claims description 5
- 235000011176 polyphosphates Nutrition 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 7
- 239000010419 fine particle Substances 0.000 claims 5
- 239000001506 calcium phosphate Substances 0.000 claims 4
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 4
- 235000011010 calcium phosphates Nutrition 0.000 claims 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 4
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims 3
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims 3
- 229960000367 inositol Drugs 0.000 claims 3
- 229920000137 polyphosphoric acid Polymers 0.000 claims 3
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims 3
- CTPQAXVNYGZUAJ-UHFFFAOYSA-N Inositol pentaphosphate Natural products OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O CTPQAXVNYGZUAJ-UHFFFAOYSA-N 0.000 claims 2
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims 2
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 claims 2
- MMWCIQZXVOZEGG-HOZKJCLWSA-N [(1S,2R,3S,4S,5R,6S)-2,3,5-trihydroxy-4,6-diphosphonooxycyclohexyl] dihydrogen phosphate Chemical compound O[C@H]1[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](O)[C@H]1OP(O)(O)=O MMWCIQZXVOZEGG-HOZKJCLWSA-N 0.000 claims 2
- CTPQAXVNYGZUAJ-UYSNGIAKSA-N [(1s,2r,4s,5r)-3-hydroxy-2,4,5,6-tetraphosphonooxycyclohexyl] dihydrogen phosphate Chemical compound OC1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)C(OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O CTPQAXVNYGZUAJ-UYSNGIAKSA-N 0.000 claims 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 2
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 2
- 239000007795 chemical reaction product Substances 0.000 claims 2
- 229940068041 phytic acid Drugs 0.000 claims 2
- 239000007858 starting material Substances 0.000 claims 2
- 238000003756 stirring Methods 0.000 claims 2
- 239000012646 vaccine adjuvant Substances 0.000 claims 2
- 229940124931 vaccine adjuvant Drugs 0.000 claims 2
- INAPMGSXUVUWAF-UHFFFAOYSA-L (2,3,4,5,6-pentahydroxycyclohexyl) phosphate Chemical compound OC1C(O)C(O)C(OP([O-])([O-])=O)C(O)C1O INAPMGSXUVUWAF-UHFFFAOYSA-L 0.000 claims 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
- YDHWWBZFRZWVHO-UHFFFAOYSA-H [oxido-[oxido(phosphonatooxy)phosphoryl]oxyphosphoryl] phosphate Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O YDHWWBZFRZWVHO-UHFFFAOYSA-H 0.000 claims 1
- 229960005305 adenosine Drugs 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- 229940047712 aluminum hydroxyphosphate Drugs 0.000 claims 1
- 238000010261 blood fractionation Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000001177 diphosphate Substances 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 239000012153 distilled water Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- MPNNOLHYOHFJKL-UHFFFAOYSA-N peroxyphosphoric acid Chemical compound OOP(O)(O)=O MPNNOLHYOHFJKL-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000001179 sorption measurement Methods 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000001069 Raman spectroscopy Methods 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 238000010884 ion-beam technique Methods 0.000 description 1
- 150000002500 ions Chemical group 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 238000001320 near-infrared absorption spectroscopy Methods 0.000 description 1
- 238000001004 secondary ion mass spectrometry Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18167434.2A EP3556728A1 (en) | 2018-04-16 | 2018-04-16 | Organically modified mineral micro-particles, methods of preparing the same and uses thereof |
| EP18167434.2 | 2018-04-16 | ||
| PCT/EP2019/059118 WO2019201710A1 (en) | 2018-04-16 | 2019-04-10 | Organically modified mineral micro-particles, methods of preparing the same and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021521089A JP2021521089A (ja) | 2021-08-26 |
| JPWO2019201710A5 true JPWO2019201710A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2023-05-16 |
| JP7352567B2 JP7352567B2 (ja) | 2023-09-28 |
Family
ID=62110845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020556795A Active JP7352567B2 (ja) | 2018-04-16 | 2019-04-10 | 有機的に修飾される無機物微粒子、同様のものを調製する及びそれらを使用する方法 |
Country Status (9)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210052389A (ko) | 2018-08-27 | 2021-05-10 | 리제너론 파마슈티칼스 인코포레이티드 | 다운스트림 정제에서의 라만 분광법의 사용 |
| CN111943157B (zh) * | 2020-08-14 | 2021-12-21 | 山东大学 | 一种基于肌醇分子制备α-磷酸三钙的方法及其应用 |
| WO2024102801A2 (en) * | 2022-11-09 | 2024-05-16 | Wisconsin Alumni Research Foundation | Mineral-coated iron oxide microparticles and use of same including use for immunomodulation |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6623762B2 (en) * | 2001-02-16 | 2003-09-23 | Cambridge Biostability Ltd. | Composition and method for controlled release injections |
| DE102004009400A1 (de) * | 2004-02-24 | 2005-09-08 | Zlb Behring Gmbh | Fibrinogen Reinigung |
| US20090142303A1 (en) * | 2005-08-11 | 2009-06-04 | David Edwards | Methods and compositions for dried cellular forms |
| JP5234536B2 (ja) * | 2007-01-25 | 2013-07-10 | 学校法人明治大学 | セメント用材料及びセメント |
| WO2008093195A2 (en) * | 2007-01-29 | 2008-08-07 | Medipol Sa | Chitosan-based colloidal particles for rna delivery |
| CN102188701A (zh) * | 2010-03-12 | 2011-09-21 | 上海泽润生物科技有限公司 | 一种磷酸铝佐剂及其制备方法 |
| CN107080838A (zh) * | 2010-06-04 | 2017-08-22 | 惠氏有限责任公司 | 疫苗制剂 |
| ES2729111T3 (es) * | 2011-11-23 | 2019-10-30 | Merck Sharp & Dohme | Método para la preparación de adyuvante de hidroxifosfato de aluminio |
| ES2495666B1 (es) * | 2013-03-15 | 2015-08-10 | Laboratoris Sanifit, S.L. | Uso de derivados con enlaces c-o-p en pacientes con fallo renal |
| EP3556398A1 (en) * | 2018-04-16 | 2019-10-23 | Croda Denmark A/S | Phytates for use as a biomolecules delivery or adsorption system |
-
2018
- 2018-04-16 EP EP18167434.2A patent/EP3556728A1/en not_active Withdrawn
-
2019
- 2019-04-10 BR BR112020021238-5A patent/BR112020021238A2/pt unknown
- 2019-04-10 JP JP2020556795A patent/JP7352567B2/ja active Active
- 2019-04-10 WO PCT/EP2019/059118 patent/WO2019201710A1/en not_active Ceased
- 2019-04-10 US US17/044,769 patent/US20210106681A1/en active Pending
- 2019-04-10 AU AU2019256582A patent/AU2019256582B2/en active Active
- 2019-04-10 EP EP19715524.5A patent/EP3781517A1/en active Pending
- 2019-04-10 CN CN201980033400.3A patent/CN112135791B/zh active Active
- 2019-04-10 CA CA3096479A patent/CA3096479A1/en active Pending
-
2020
- 2020-10-15 CL CL2020002668A patent/CL2020002668A1/es unknown
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