JPWO2019087620A1 - Laser-printed supports, laser-printed patches and their manufacturing methods - Google Patents

Abstract

There is no risk of ink or the like seeping into the drug-containing layer, it is possible to prevent the characters or the like from becoming unreadable due to the dissolution of the ink or the like, and the laser is printed with easily identifiable characters or the like on its surface. It is an object of the present invention to provide a method for producing a laser-printed support or a patch, which can easily and easily produce a printed support and a patch and a laser-printed patch. A support 1 containing a discoloration-induced oxide and composed of fibers, the support 1 is a laser-printed support in which a part of the surface thereof is discolored by the discoloration-induced oxide, and a discoloration-induced support. A support 1 containing an oxide and composed of fibers, an adhesive layer arranged on one surface of the support 1, and a release liner covering one surface of the adhesive layer are laminated to form a surface of the support 1. A laser-printed patch that is partially discolored by the discoloration-induced oxide.

Description

The present invention relates to a laser-printed support, a laser-printed patch, and a method for producing them.

Conventionally, tape agents, poultices and the like have been widely used as patches. Since these patches have almost the same form and their outer shapes and colors are similar to each other, it is difficult to distinguish the components contained in the patches once they are taken out from the packaging bag. .. In addition, various regulations may require that the drug name of the patch taken out from the packaging bag be recognizable.
On the other hand, a method of embossing a non-woven fabric as a support (for example, Patent Document 1), a method of directly printing on a support by laser irradiation (for example, Patent Document 2), and the like have been proposed. Further, a method of directly printing characters on the non-woven fabric which is the support of the patch with ink or the like and identifying them can be considered.

Japanese Unexamined Patent Publication No. 2001-231812 Japanese Unexamined Patent Publication No. 2003-102773

However, embossing and laser printing are difficult to identify, and a large amount of energy is applied to facilitate the identification, which causes deterioration of the support and is concerned about the influence on the drug. Further, in printing with ink, there is a problem that the ink may seep into the drug-containing layer, and the characters and the like cannot be read due to the dissolution of the ink.

The present invention has been made in view of the above problems, and the support is not altered, there is no risk of ink or the like oozing out into the drug-containing layer, and characters or the like become unreadable due to dissolution of the ink or the like. Laser-printed, which can easily and easily produce a laser-printed support and a patch on which easily identifiable characters and the like are printed on the surface thereof, and a laser-printed patch. It is an object of the present invention to provide a method for producing a support or a patch.

The present application includes the following inventions.
(1) A support containing a discoloration-induced oxide and composed of fibers.
The support is a laser-printed support characterized in that a part of the surface is discolored by the discoloration-induced oxide.
(2) The laser-printed support according to the above, wherein the discoloration-induced oxide is uniformly contained in the support.
(3) The laser-printed support according to the above, wherein the discoloration-induced oxide is titanium oxide.
(4) A support containing a discoloration-induced oxide and composed of fibers.
An adhesive layer arranged on one surface of the support,
A release liner covering one surface of the pressure-sensitive adhesive layer is laminated.
The support is a laser-printed patch characterized in that a part of the surface thereof is discolored by the discoloration-induced oxide.
(5) The laser-printed patch according to the above, wherein a drug is contained in the pressure-sensitive adhesive layer.
(6) Laser printing including irradiating a support containing a discoloration-induced oxide and composed of fibers with laser light to discolor a part of the surface of the support with the discoloration-induced oxide. A method for manufacturing a support or a patch.

The laser-printed support and patch of the present application do not deteriorate the support, there is no risk of ink or the like seeping into the drug-containing layer, and the characters or the like become unreadable due to the dissolution of the ink or the like. It is possible to maintain the printing of easily identifiable characters and the like on the surface thereof.
Further, according to the method for producing a laser-printed support or patch of the present application, it is possible to easily and easily manufacture a patch with printed characters or the like that can be easily identified by laser printing.

It is a photograph which shows one Embodiment of the laser-printed support of this application. It is sectional drawing which shows typically the discoloration form of the laser-printed support of this application. It is a photograph which shows another embodiment of the laser-printed support of this application.

[Laser-printed support]
In the laser-printed support of the present application, a part of the surface thereof is discolored by the discoloration-induced oxide, so that arbitrary characters, shapes, etc. are arranged in appropriate places. As a result, bleeding of characters and the like caused by printing with ink can be avoided, and fine or small characters, lines, figures and the like can be clearly displayed. Further, since the ink usually contains an organic substance, discoloration or the like may occur due to deterioration with respect to a high temperature or the like, but in laser printing, discoloration or discoloration due to a high temperature can be avoided. Further, since the printing form in which the constituent material of the support itself is deteriorated is not adopted, the deterioration and deterioration of the support can be avoided, and the surface form of the support can be maintained before and after printing.

The laser-printed support of the present application may be any one used as a support for a patch in the art, and may contain fibers. The form of the support includes various forms such as a woven fabric, a knitted fabric or a non-woven fabric, a combination thereof, or a laminated body. Further, the support may include a polymer film or the like. In this case, the polymer film preferably has at least one surface covered with a woven fabric, a knitted fabric, or a non-woven fabric. Among them, the support preferably has elasticity, and a knitted fabric having elasticity in one or two directions is preferable.

The fiber material of the support may be, for example, a natural fiber alone, a thermoplastic fiber alone, a non-thermoplastic fiber alone, or a blend of two or more of these.
Examples of natural fibers include plant fibers such as cotton and hemp, animal fibers such as wool and silk, and mineral fibers such as asbestos.
Examples of the thermoplastic fiber include materials made of a thermoplastic resin such as polyurethane, polyester, polypropylene, acrylic and nylon, for example, polyester fiber, polyethylene fiber, polypropylene fiber, polyamide fiber and polyvinyl chloride fiber.
Examples of the non-thermoplastic fiber include rayon and cupra.
Nonwoven fabrics using these fibers can be produced by known methods such as a water jet and a needle punching method.
In terms of condition, a knitted fabric having a uniform thickness containing 70% or more of polyester fiber, polyethylene fiber, polypropylene fiber, polyamide fiber, rayon fiber and the like is preferable.

Such a support is usually used as a support for an external patch, and the thickness thereof is, for example, 0.1 mm to 3 mm, preferably 0.2 mm to 2 mm, preferably 400 to 800 μm. More preferred.

The discoloration-induced oxide contained in the support means an oxide that induces discoloration by being irradiated with laser light. Examples of the discoloration-induced oxide include one or more oxides selected from the group consisting of titanium oxide, yellow iron sesquioxide, iron sesquioxide and the like. Of these, titanium oxide is preferable.

It is preferable that the discoloration-induced oxide is uniformly contained in the support, that is, in the plane and in the thickness direction before the discoloration-induced oxide is discolored. With such inclusion, it is possible to discolor arbitrary characters, shapes, etc. so as to be arranged in an appropriate place.

In order to uniformly contain the discoloration-induced oxide in the support, for example, a method of immersing the support in a solution or a dispersion containing the discoloration-induced oxide after preparing the support, fibers constituting the support. A method of immersing, coating, or spraying fibers in a solution or dispersion containing a discoloration-induced oxide, melting or dissolving the fiber material constituting the support, and discoloring the melt or solution. Examples thereof include a method in which an induced oxide is added and uniformly mixed.
In consideration of uniformity in such a support and handleability, the discolored organic oxide is preferably, for example, granular or powdery.

The discoloration-induced oxide can be used, for example, at a ratio of 0.05 parts by mass to 30 parts by mass (0.05% by mass to 30% by mass) with respect to 100 parts by mass of all fibers constituting the support. 0.1 part by mass to 10 parts by mass (0.1% by mass to 10% by mass) is preferable, and 0.2 parts by mass to 5 parts by mass (0.2% by mass to 5% by mass) is more preferable. Alternatively, from another perspective, discoloration induced oxide may be a 1g / m ² ~200g / m ² as a weight per unit area of the support is preferably set to ^{5g / m 2 ~150g / m 2} .

In order to discolor the discoloration-induced oxide in the support and arrange arbitrary characters, shapes, etc. in appropriate places, a method of irradiating the discoloration-induced oxide with laser light can be mentioned.
The type, wavelength, output, etc. of the laser light here can be appropriately adjusted in order to induce the intended discoloration. For example, the laser light is preferably an ultraviolet laser light, and the light source thereof includes ArF (wavelength 193 nm), KrCl (wavelength 222 nm), KrF (wavelength 248 nm), XeCl (wavelength 308 nm), XeF (wavelength 350 nm) and the like. Examples thereof include an excima laser having photon energy in the near-ultraviolet region to the far-ultraviolet region, and may be a harmonic laser such as a copper steam laser or a YAG laser.

Energy of the irradiated laser light, for ^{example, 50mJ / cm 2 ~21000mJ / cm} 2, 100mJ / cm 2 ~18000mJ / cm 2 is preferred. 300mJ / cm ² ~10000mJ / cm ² is more preferable. By setting it in such a range, it is possible to avoid thermal damage to the support and the like. The laser light irradiation may be performed at room temperature, at a lower temperature or a higher temperature than that, in any atmosphere such as air, nitrogen gas, or vacuum. The frequency of the laser light is, for example, 10000 Hz to 60,000 Hz, preferably 20000 Hz to 30000 Hz.

The surface of the support of the laser beam is irradiated directly, a method of irradiating through a glass plate or the like that transmits the laser beam, a method of irradiating a focused or magnified light using a lens, a laser beam and a support. Examples thereof include a method of irradiating the entire surface with a laser beam through a mask between the body surface and the body surface. Usually, a method of irradiating a laser beam after applying the necessary masking to the support, or a method of narrowing the beam diameter of the laser beam and irradiating the required marking portion by laser scanning is used.

When the discoloration-induced oxide is irradiated with laser light, the oxygen atom in the discoloration-induced oxide is desorbed, and the desorption of the oxygen atom causes the oxygen atom and the non-oxygen atom in the discoloration-induced oxide to be desorbed. The ratio changes, and the discoloration is visually recognized. For example, in the case of titanium oxide, the ratio of oxygen atom to titanium atom 2: 1 changes by irradiation with laser light, and a discoloration from white to gray is visually observed. Since such desorption of oxygen atoms is performed only on the surface of the support irradiated with the laser beam, the discoloration-induced oxide is other than the discolored portion in the thickness direction of the support under the surface. It is uniformly dispersed at the same concentration as in the support of. As will be described later, this can be confirmed, for example, by visual inspection or microscopic observation of the cross section of the portion discolored by irradiation with laser light when the support is cut.

[Laser-printed patch]
The patch in the present application is a preparation applied to the skin, etc. according to the 17th revised Japanese Pharmacopoeia, and mainly, the above-mentioned support, adhesive layer, and release liner are laminated in this order, for example, a tape agent and a poultice. Means what is called.
By providing the above-mentioned support with the patch, it is possible to avoid contamination of the drug and indecipherability of characters and the like due to printing using ink and the like. Further, since the printing form that deteriorates the constituent material of the support itself is not adopted, drug contamination does not occur. Further, since characters and the like corresponding to printing without using ink can be imparted by discoloration by the color-induced oxide, it is possible to surely recognize the drug name and the like of the patch taken out from the bag.

The pressure-sensitive adhesive layer is laminated on the non-discolored surface of the support described above and usually contains a drug. Drugs include, for example, acetaminophenone, phenacetin, mephenamic acid, diclofenac sodium, flufenamic acid, aspirin, sodium salicylate, methyl salicylate, glycol salicylate, aminopyrine, alcrophenac, ibprofen, naproxene, flurubiprofen, ketoprofen, amphenacone , Mepyrilol, indomethacin, pyroxicum, loxoprofen, thiaprofen, acemetacin, fervinac, slindac, etdrac, tolmethin, ampyroxicam, azapropazone, valdecoxib, lofecoxib and other anti-inflammatory analgesics, hydrocortisone, triamsinolone Local anesthetics such as ethyl aminobenzoate, lidocaine, lidocaine hydrochloride, tetracaine hydrochloride, brocaine hydrochloride, dibucaine hydrochloride, oxybuprocaine hydrochloride, propitocaine hydrochloride, diphenhydramine hydrochloride, chlorpheniramine maleate, promethazine, cipropheptazine hydrochloride, diphenylpyraline hydrochloride Anti-histamines such as, salicylic acid, cyclopyroxolamine, agents for parasitic skin diseases such as coroconazole hydrochloride, skin softeners such as urea, calcitriol, thiamine hydrochloride, sodium riboflamin phosphate, pyridoxin hydrochloride, nicotinic acid amide, bread Examples thereof include vitamin preparations such as tenol and ascorbic acid.

The pressure-sensitive adhesive is known in the art and is preferably composed of the above-mentioned components that do not affect the drug. For example, rubber-based pressure-sensitive adhesives, acrylic-based pressure-sensitive adhesives, water-soluble pressure-sensitive adhesives, and the like can be mentioned.

Examples of the rubber component of the rubber-based pressure-sensitive adhesive include natural rubber, styrene-butadiene rubber, styrene-isoprene-styrene block copolymer, and butyl rubber.
Examples of the acrylic pressure-sensitive adhesive include an acrylic acid / acrylic acid octyl ester copolymer, a 2-ethylhexyl acrylic acid / vinylpyrrolidone copolymer solution, and an acrylic acid ester / vinyl acetate copolymer.
Water-soluble pressure-sensitive adhesives include gelatin, pectin, agarose, alginate, xanthan gum, dextrin, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycol, maleic anhydride copolymer, polyacrylic acid and Examples thereof include natural polymers such as the salt or a crosslinked product thereof, and modified products thereof.
These components can be used alone or in combination of two or more.
The pressure-sensitive adhesive may contain additives used in the art in addition to the above-mentioned components.

The drug can be contained, for example, in an amount of 0.1% by mass to 80% by mass, preferably 0.5 to 10% by mass, based on the total mass constituting the pressure-sensitive adhesive.
The pressure-sensitive adhesive layer can have a thickness of, for example, 10 μm to 3 mm, preferably 10 μm to 1 mm, and more preferably 30 to 300 μm.

A release liner is laminated on the surface of the pressure-sensitive adhesive layer opposite to the support in order to protect the pressure-sensitive surface of the pressure-sensitive adhesive layer until the use of the patch. As the peeling liner, it suffices to ensure sufficiently light peelability. For example, films such as polyester, polyvinyl chloride, polyvinylidene chloride, polyethylene terephthalate, high-quality paper, glassin paper, etc., which have been peeled by applying silicone resin, fluororesin, etc. to the surface in contact with the adhesive layer. Examples thereof include a laminated film of polyolefin paper, high-quality paper, glassin paper, and the like.

[Manufacturing method of laser-printed support or patch]
In the method for producing a laser-printed support or patch, as described above, a support containing a discoloration-induced oxide and made of fibers is prepared, and the support is irradiated with laser light to irradiate the surface of the support with laser light. Including discoloring a part of the above with a discoloration-induced oxide. By this discoloration, any character or figure can be printed.
Irradiation of the support with laser light is as described above, but especially in the case of manufacturing a patch, after preparing the support, before and after forming the pressure-sensitive adhesive layer on the support, on the release liner. The support can be irradiated with laser light at any time, such as before and after transferring the adhesive layer formed on the support.
By such a manufacturing method, it is possible to print easily and freely, and even after applying the drug to the support, the drug can be printed quickly without deteriorating or deteriorating.

Example 1
I prepared a polyester knit. This knit is usually used as a tape agent and contains 0.3% titanium oxide with respect to the total mass of the knit. This knit is formed by mixing and stirring titanium oxide powder with a polyester melt and spinning it into a fibrous form.
One side of the prepared knit was laser-printed with a UV laser marking device (model: LIS-250D (manufactured by Qualicaps Co., Ltd.)) under the conditions of pulse energy of 48% and 20 kHz.

As a result of Example 1, as shown in FIG. 1, gray printing that can be clearly discriminated by visual inspection was recognized. The printed surface was flat with no deterioration, no unevenness, no burning, etc., before the irradiation with the laser beam.
Further, when the support of the printed portion was cut and the cross section thereof was visually observed, as shown in FIG. 2, about 1/2 of the surface of the support 1 in the thickness direction was the same as the surface. A gray discolored portion 2 was observed, and no discoloration was observed at about 1/2 of the thickness on the back surface side opposite to the front surface of the support 1.

Example 2
As a condition for laser printing, the number of drawing lines of the design data (CAD) used for drawing is doubled as in Example 1, and the same as in Example 1 except that the gap between lines is eliminated. Laser printing was performed under the conditions of.

As a result of Example 2, as shown in FIG. 3, gray printing that can be clearly discriminated by visual inspection was recognized, and a darker printing than that of Example 1 was obtained.

Example 3
The polyester knit used in Example 1 was prepared. Further, an adhesive layer having a coating thickness of 100 μm was formed on the release liner. An adhesive layer was attached to one surface of the knit to form an adhesive.
The surface of the obtained patch on which the pressure-sensitive adhesive layer was not laminated was irradiated with laser light in the same manner as in Example 1 to print.
As a result, the same result as in Example 1 was obtained.
No alteration of the drug was observed in the pressure-sensitive adhesive layer adjacent to the support.

1 Support 2 Discolored part

Claims (6)

A support composed of fibers containing a discoloration-induced oxide.
The support is a laser-printed support characterized in that a part of the surface is discolored by the discoloration-induced oxide. The laser-printed support according to claim 1, wherein the discoloration-induced oxide is uniformly contained in the support. The laser-printed support according to claim 1 or 2, wherein the discoloration-induced oxide is titanium oxide. A support composed of fibers containing a tarnish-induced oxide,
An adhesive layer arranged on one surface of the support,
A release liner covering one surface of the pressure-sensitive adhesive layer is laminated.
The support is a laser-printed patch characterized in that a part of the surface thereof is discolored by the discoloration-induced oxide. The laser-printed patch according to claim 4, wherein the pressure-sensitive adhesive layer contains a drug. A laser-printed support containing a discoloration-induced oxide and comprising irradiating a support composed of fibers with laser light to discolor a part of the surface of the support with the discoloration-induced oxide. Manufacturing method of patch.