JPWO2018074261A1 - Manufacturing method and manufacturing apparatus for sealed container - Google Patents

Abstract

In producing a product by sealing the opening of a cup containing contents with a lid, in order to provide a suitable method for reliably joining the cup and the lid, in the method for producing an enclosed container according to the present invention, A lid that covers the cup from a sheet that is a lid material for sealing the opening of the cup containing the contents and has an adhesive layer on the side that is in close contact with the outer surface of the peripheral wall of the cup. And the inner surface of the peripheral wall of the lid is bonded to the outer surface of the peripheral wall of the cup.

Description

  The present invention relates to a manufacturing method and a manufacturing apparatus for an enclosure that encloses contents.

  One of the methods used in the manufacture of pharmaceutical preparations for oral administration is to compress powders that have been homogenized by adding additives such as excipients, binders, and disintegrants to the active ingredients, and then using light. Some tablets are coated with a film coating in consideration of quality deterioration or patient use. However, depending on the type of active ingredient, it may be difficult to compress a tablet having sufficient hardness necessary for distribution, formulation, and administration in the market, and the physical properties during film coating may be difficult. The quality of the tablet may be impaired because a part of the molded body is damaged by the impact. In addition, the solvent used for film coating may affect the stability of the active ingredient.

  Examples of preparations other than tablets include capsules. Capsules are produced, for example, by filling pre-formed capsules with active ingredient powder and sealing them (see Patent Document 1 below). However, capsules, in principle, have only a standard and uniform shape and a standardized size, and it is difficult to obtain a characteristic appearance like a tablet. Furthermore, some capsules can be easily opened, and the contents of the capsules can be replaced.

  On the other hand, there exists a thing of the aspect manufactured by compressing the powder with which the cup shape | molded with the thermoplastic film was compressed with a scissors (refer following patent document 2).

  Alternatively, there is also an embodiment in which a tablet containing an active ingredient is inserted between two gelatin sheets, and then the two sheets are bonded together and then punched into the shape of a preparation using a mold (the following patent document) 3). In order to manufacture this formulation, it is necessary to manufacture a tablet beforehand using another apparatus. Gelatin is an animal protein although it is widely used in capsules. In recent years, hypromellose has been used as an alternative from the viewpoint of BSE infection.

JP-A-10-192370 Japanese Patent No. 4417246 JP 2009-196958 A

  After the active ingredient and other contents are contained in a cup, when the product is manufactured by sealing the opening of the cup with a lid, it is dissolved or dispersed in a solvent in order to securely join the cup and the lid. It can be considered that the applied adhesive is applied to the joining surface immediately before joining the cup and the lid.

  However, when such a method is adopted, there is a concern that a solvent such as ethanol or water used for the adhesive may impair the stability of the contents stored in the cup or cause the growth of bacteria.

  The present invention intends to provide a suitable method or manufacturing apparatus capable of reliably joining a cup and a lid when a product is manufactured by sealing an opening of a cup containing contents with a lid.

  The method for manufacturing a sealed container according to the present invention is a material for a lid for sealing an opening of a cup in which contents are stored, and an adhesive layer is previously provided on the side that is in close contact with the outer surface of the peripheral wall of the cup. A lid covering the cup is molded from the provided sheet, and the inner surface of the peripheral wall of the lid is bonded to the outer surface of the peripheral wall of the cup.

  According to the present invention, it is possible to reliably join the lid to the cup containing the contents. In addition, it is not necessary to apply adhesive at the time of joining the lid to the cup, avoiding the problem that the solvent used in the adhesive will alter the contents stored in the cup and cause bacteria to propagate it can.

  In forming the lid, for example, the cup is a male mold, the sheet is moved relative to the cup with the opening portion facing the sheet side, and the sheet is pressed against the cup. As a result, the lid can be molded, and at the same time, the cup and the lid are joined.

  In order to bond the lid to the cup more firmly, it is preferable to perform a step of pressing the inner surface of the peripheral wall of the lid against the outer surface of the peripheral wall of the cup after the lid is formed.

  The adhesive layer is made of, for example, copolyvidone, methacrylic acid copolymer LD, ethyl acrylate / methyl methacrylate copolymer, polyvinyl pyrrolidone, or aminoalkyl methacrylate copolymer E.

  The sheet is, for example, a film made of a thermoplastic polymer material. In this case, prior to molding of the lid, copolyvidone, methacrylic acid copolymer LD, ethyl acrylate / methyl methacrylate copolymer E, or aminoalkyl methacrylate copolymer E is dissolved in ethanol or water and then applied to the film and dried. Thus, the adhesive layer can be configured.

  The preparation production apparatus according to the present invention is a lid material for sealing the opening of the cup containing the contents, and an adhesive layer is provided in advance on the side that is in close contact with the outer surface of the peripheral wall of the cup. A lid forming unit for forming a lid for covering the cup from the formed sheet is provided.

  The lid molding unit, for example, makes the cup a male mold, moves the sheet relative to the cup with the opening facing the sheet side, and presses the sheet against the cup so that the lid is Mold.

  ADVANTAGE OF THE INVENTION According to this invention, when manufacturing the product by sealing the opening part of the cup which stored the content with a lid | cover, the suitable method or manufacturing apparatus which can join a cup and a lid | cover reliably is realizable.

The schematic diagram which shows the outline | summary of the manufacturing method of the enclosure container and formulation of one Embodiment of this invention. The schematic diagram which shows the outline | summary of the manufacturing method of the embodiment. The perspective view which shows the whole view of the enclosure and the manufacturing apparatus of the embodiment. The perspective view which shows the cup formation unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the cup shaping | molding unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the cup shaping | molding unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the cup shaping | molding unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the cup shaping | molding unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the cup shaping | molding unit of the manufacturing apparatus of the embodiment. The perspective view which shows the powder compression unit and insertion unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the powder compression unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the powder compression unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the insertion unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the insertion unit of the manufacturing apparatus of the embodiment. The perspective view which shows the cup processing unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the cup processing unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the cup processing unit of the manufacturing apparatus of the embodiment. The perspective view which shows the lid | cover molding unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the lid | cover molding unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the lid | cover molding unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the lid | cover molding unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the lid | cover molding unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the lid processing unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the lid processing unit of the manufacturing apparatus of the embodiment. The perspective view which shows the crimping | compression-bonding unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the crimping | compression-bonding unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the crimping | compression-bonding unit of the manufacturing apparatus of the embodiment. The perspective view which shows the 2nd insertion unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the 2nd insertion unit of the manufacturing apparatus of the embodiment. The sectional side view which shows the 2nd insertion unit of the manufacturing apparatus of the embodiment.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings.

  <Outline> First, an outline of the manufacturing methods of the enclosures 1 and 2 and the preparation in this embodiment will be described. In this embodiment, the molded product 3 in which the powder 30 is compressed is wrapped with the wrapping base sheets 10 and 20 as the enclosures 1 and 2 to produce a wrapping tablet. The wrapping tablet is a lid 2 in which the contents, for example, a molded product 3 obtained by compressing the powder 30 is inserted into a cup 1 having a volume molded from the sheet 10 and then the opening of the cup 1 is molded from the sheet 20. It is a formulation formed by sealing with. The powder refers to an aggregate of minute individuals, and is a concept that includes an aggregate of particles such as so-called granules and an aggregate of powders having a shape smaller than the particles. As shown in FIG.1 and FIG.2, the manufacturing method of the enclosure containers 1 and 2 and a formulation of this embodiment are the cup formation process which shape | molds the cup 1 for accommodating the molded article 3 from the sheet | seat 10, and powder The powder compression step of compressing the body 30 to form the molded product 3 that is the contents of the wrapping tablet, the insertion step of inserting the molded product 3 into the cup 1, and the cup 10 from the cup 1 into which the molded product 3 is inserted. A cup processing step of cutting off the remaining portion 13 and a sealing step of sealing the opening of the cup 1 into which the molded product 3 is inserted with the sheet 20 are provided.

  In the cup forming step, as shown in FIG. 1I, the sheet 10 that is the material of the cup 1 is moved relative to the male mold 507, and the sheet 10 is pressed against the male mold 507, thereby the sheet. The cup 1 having a volume protrudes from 10. Thereby, the cup 1 having a shape including the bottom wall 12 and the peripheral wall 11 standing along the outer peripheral edge of the bottom wall 12 is formed.

  The sheet 10 serving as the material of the cup 1 is a thin film using a thermoplastic polymer material. When the preparation to be manufactured is a medicine to be administered orally, a film made of a material that can be used for the medicine, such as piperomellose or polyvinyl alcohol, is adopted as the sheet 10. In addition, when manufacturing the thin film-like sheet | seat 10, you may mix | blend a plasticizer with the material of the said sheet | seat 10. FIG. Moreover, you may mix | blend titanium oxide with the material of the sheet | seat 10 as a light-shielding agent for suppressing that the content of the wrapping tablet is exposed to light, for example.

  Thereafter, as shown in FIG. 1 (II), an unnecessary portion of the unnecessary sheet 10 connected to the cup 1 is roughly cut off by laser processing for irradiating the sheet with the laser light L, for example. At this stage, the remaining portion 13 of the bowl-shaped sheet 10 extending outward from the opening of the cup 1, in other words, the edge of the peripheral wall 11, remains, and the cup 1 has a shape like a hat. The wavelength of the laser beam L used for cutting the sheet 10 needs to be a wavelength that allows the sheet 10 to absorb the energy of the laser beam L. When the transparency of the sheet 10 is high, a laser having a relatively long wavelength, for example, a carbon dioxide gas laser having a wavelength of 10.6 μm or 9.4 μm is used.

  In the powder compression step, the tip (upper end) of the lower punch 603 is inserted from below into a mortar hole 601 provided on the mortar table 602 that passes vertically, and the active ingredient (when the preparation is a pharmaceutical) is inserted into the mortar hole 601 Is filled with the powder 30 containing the main agent), and then the tip (lower end) of the upper punch 604 is inserted into the mortar hole 601 from above, and the powder in the mortar hole 601 is inserted by the upper punch 604 and the lower punch 603. The molded body 3 is obtained by compressing the body 30 (see FIGS. 10 to 12). The powder 30 to be compression-molded comprises an active ingredient and components other than the active ingredient (excipients, binders, disintegrants, lubricants, stabilizers, preservatives, etc. if the tablet is a medicine) May be a mixture of In addition, the molded product 3 manufactured in the powder compression process does not necessarily have a necessary and sufficient hardness as a tablet that can be distributed on the market. As long as the shape retaining property can be maintained, the shape can be maintained. That is, in the powder compression step, the powder 30 may be compressed so strongly that the molded product 3 has sufficient hardness as a tablet, and the powder 30 is pressed at such a pressure that the molded product 3 does not easily break or collapse. May be compressed.

  In the insertion step, as shown in FIG. 1 (III), the molded product 3 obtained through the powder compression step is inserted into the cup 1 from above with the opening of the cup 1 facing upward.

  In the cup processing step, as shown in FIG. 1 (IV), the hook-shaped remaining portion 13 extending outward from the opening of the cup 1 is cut off. At that time, while rotating the sheet 10 including the cup 1 around the axis α, the laser beam L whose optical axis is directed in a direction intersecting (particularly orthogonal) with respect to the direction in which the rotation axis α extends is applied to the sheet. Laser processing is performed to irradiate a portion near the edge of the peripheral wall 11 of the cup 1 protruding from the remaining portion 13 from the outside. By such processing, the remaining portion 13 of the sheet 10 is surely cut from the cup 1 without leaving an unnecessary piece of the sheet 10 at the opening edge of the cup 1, and the cup 1 having only the bottom wall 12 and the peripheral wall 11 is completed. Can be made. The laser L used for cutting the remaining portion 13 of the sheet 10 is, for example, a carbon dioxide gas laser having a wavelength of 10.6 μm or 9.4 μm.

  The sealing step includes a lid molding step for molding the lid 2 for sealing the opening of the cup 1 from the sheet 20, a lid processing step for cutting off the remaining portion 23 of the sheet 20 from the molded lid 2, and the peripheral wall of the lid 2 And a pressure-bonding step in which pressure is applied to 21 and pressure-bonded to the peripheral wall 11 of the cup 1. In the lid forming step, as shown in FIG. 2 (V), the cup 1 into which the molded product 3 is inserted is a male mold, the sheet 20 that is the material of the lid 2 is moved relative to the cup 1, and the sheet 20 Is pressed against the cup 1 so that the lid 2 having a shape that wraps the cup 1 from the sheet 20 is projected. Thereby, the lid 2 having a shape including the top wall 22 and the peripheral wall 21 hanging along the outer peripheral edge of the top wall 22 is formed. At the same time, the inner surface of the peripheral wall 21 of the lid 2 is in close contact with the outer surface of the peripheral wall 11 of the cup 1, and the top wall 22 of the lid 2 closes the opening of the cup 1.

  The sheet 20 as the material of the lid 2 is also a thin film using a thermoplastic polymer material, like the sheet as the material of the cup 1. When the preparation to be produced is a medicine to be administered orally, a film made of a material that dissolves in the body of the person who took it, for example, piperomellose or polyvinyl alcohol, is adopted as the sheet 20. In addition, when manufacturing the thin film-like sheet | seat 20, you may mix | blend a plasticizer with the material of the said sheet | seat 20. FIG. Moreover, you may mix | blend a titanium oxide with the material of the sheet | seat 20 as a light-shielding agent for suppressing that the content of a wrapping tablet is exposed to light, for example.

  The sheet 20 that is the material of the lid 2 may be provided with an adhesive layer 24 in advance on the side that becomes the inner surface in close contact with the outer surface of the peripheral wall 11 of the cup 1 (see FIGS. 19 and 20). The adhesive layer 24 is made of, for example, copolyvidone, methacrylic acid copolymer LD, ethyl acrylate / methyl methacrylate copolymer, polyvinyl pyrrolidone, or aminoalkyl methacrylate copolymer E. More specifically, the adhesive layer 24 is prepared by dissolving copolyvidone or the like as an adhesive in ethanol or water together with a plasticizer, and applying the solution to a piperomellose film or polyvinyl alcohol film as the sheet 20 and drying. Configure. When applying the adhesive to the sheet 20, a plate made of punching metal or the like may be used, and the adhesive may be applied in innumerable dots. Alternatively, instead of dispersing the adhesive in a solvent and applying it, a thin film made of the adhesive is produced, and the film is bonded to the piperomellose film as the sheet 20 while applying heat and pressure. By doing so, it is conceivable to form the adhesive layer 24. The adhesive layer 24 is not necessarily provided on the entire surface of the sheet 20, and at least the peripheral wall 21 (the inner surface thereof adheres to the outer surface of the peripheral wall 11 of the cup 1) and the top wall 22 (the lower surface is the upper surface of the molded product 3). It is only necessary to be provided at a site that is to be adhered to.

  In the process of molding the lid 2 in the lid molding process, the inner surface of the peripheral wall 21 of the lid 2 is joined to the outer surface of the peripheral wall 11 of the cup 1. In the case where the adhesive layer 24 is provided on the sheet 20 of the material of the lid 2, due to the heat applied to the sheet 20 at this time, the adhesive layer 24 is separated from the inner surface of the peripheral wall 21 of the lid 2 and the outer surface of the peripheral wall 11 of the cup 1. Glue.

  After that, as shown in FIG. 2 (VI), an unnecessary portion of the unnecessary sheet 20 connected to the lid 2 is roughly cut off by laser processing for irradiating the sheet 20 with laser light L, for example. At this stage, the opening 23 of the lid 2, in other words, the remaining portion 23 of the bowl-shaped sheet 20 extending outward from the edge of the peripheral wall 21 remains, and the lid 2 has a shape like a hat. As already described, the laser L used for cutting the sheet 20 is, for example, a carbon dioxide gas laser having a wavelength of 10.6 μm or 9.4 μm.

  Next, in the lid processing step, as shown in FIG. 2 (VII), the hook-like remaining portion 23 extending outward from the opening of the lid 2 is cut off. At that time, the sheet 20 including the lid 2 is rotated around the various axes α of the cup 1, and the laser beam L having the optical axis directed in a direction intersecting (particularly orthogonal) to the direction in which the rotation axis α extends. Is applied to the portion near the edge of the peripheral wall 21 of the lid 2 protruding from the remaining portion 23 of the sheet 20 from outside. At that time, the peripheral wall 11 of the cup 1 is cut or otherwise damaged by the laser light L by focusing the laser light L on the peripheral wall 21 of the lid 2 and / or adjusting the output of the laser light L. Do not. By such processing, the remaining portion 23 of the sheet 20 is surely cut off from the lid 2 without leaving an unnecessary small piece of the sheet 20 at the opening edge of the lid 2, and the lid 2 having only the top wall 22 and the peripheral wall 21 is completed. Can be made. Since the peripheral wall 11 of the cup 1 and the peripheral wall 21 of the lid are overlapped to complete the peripheral wall of the lapping tablet, the side surface of the wrapped molded product 3 is not exposed. As already described, the laser L used for cutting the sheet 20 is, for example, a carbon dioxide gas laser having a wavelength of 10.6 μm or 9.4 μm.

  Further, in the crimping step, the peripheral wall 21 of the lid 2 is pressed from the outer side toward the inner side, and the inner surface of the peripheral wall 21 of the lid 2 is crimped to the outer surface of the peripheral wall 11 of the cup 1. However, it is not essential to perform the crimping process. When the lid 2 is molded from the sheet in the lid molding process, if the inner surface of the peripheral wall 21 of the lid 2 adheres sufficiently firmly to the outer surface of the peripheral wall 11 of the cup 1, such crimping may not be performed. .

  Through the above steps, a wrapping tablet as shown in FIG. 2 (VIII), that is, a preparation in which a molded product 3 obtained by compressing powder 30 is wrapped with a wrapping capsule including a cup 1 and a lid 2 is completed.

  As shown in FIG. 3, the manufacturing apparatus used for carrying out the manufacturing method of the preparation of the present embodiment includes a wrapping capsule forming machine 500 that forms a cup 1 and a lid 2 from a sheet, and a molded product 3 from a powder 30. Is a set with a powder compression molding machine 600. Hereinafter, the manufacturing apparatus of this embodiment will be described in detail.

  <Cup Molding Unit> The cup molding unit A is in the wrapping capsule molding machine 500 and performs a cup molding process for molding the cup 1 having a volume from the sheet 10. As shown in FIGS. 4 to 9, in the cup forming unit A, first, a circular sheet 10 having a predetermined size is cut out from the tape 502 of the sheet 10 that is the material of the cup 1 at the sheet cutting position 501. The cutting of the sheet 10 is performed by irradiating the laser beam L along the outline of the cut sheet 10, for example. Then, the cut sheet 10 is held by the holding mechanism 504 at the forming position 503. The retaining mechanism 504 sandwiches the sheet 10 from above and below by a pair of annular hollow members 505 and 506 that are paired up and down. The lower member 506 of the retaining mechanism 504 can move between the sheet cutting position 501 and the forming position 503, receives the sheet 10 cut out at the sheet cutting position 501, and transports it to the forming position 503.

  At the molding position 503, a substantially cylindrical male mold 507 protruding upward is waiting below the retaining mechanism 504. Then, hot air is blown toward the sheet 10 from the duct 508 having a fan, which exists on the side opposite to the male mold 507 as viewed from the sheet 10, that is, above the sheet 10. Warm up. Then, the holding mechanism 504 that holds and holds the sheet 10 descends toward the male mold 507 and presses the sheet 10 against the front end surface (upper end face) of the male mold 507 (FIG. 5). At the same time, the pressure on the male mold 507 side is reduced more than that on the duct 508 side when viewed from the sheet 10, specifically, the atmosphere below the sheet 10 is sucked, whereby the sheet 10 is moved to the front end (upper end) of the male mold 507. (Fig. 6). As a result, the cup 1 having a volume corresponding to the outer shape of the tip of the male mold 507 is molded so as to protrude upward from the sheet 10. The cup 1 has a cylindrical peripheral wall 11 that follows the shape of the outer peripheral surface of the distal end portion of the male mold 507 and a bottom wall 12 that conforms to the shape of the distal end face of the male mold 507.

  After the cup 1 is protruded from the sheet 10 and molded, the retaining mechanism 504 is lifted away from the male mold 507 while holding the sheet 10. Next, the male mold 507 is largely retracted downward, and the cup reversing machine 509 enters from the side along the X-axis direction directly below the retaining mechanism 504. The cup reversing machine 509 has a suction arm 511 protruding from a horizontal support shaft 510 that can be rotated about a horizontal axis along a direction orthogonal thereto, and an opening of the cup 1 that faces downward. It plays a role of inverting the cup 1 so as to face upward. The tip of the suction arm 511 has the same outer shape as the tip of the male mold 507. A suction passage 512 for sucking the atmosphere is formed inside the cup reversing machine 509, and the suction passage 512 is opened at the front end surface of the suction arm 511. The cup reversing machine 509 is positioned immediately below the cup 1 with the suction arm 511 facing upward. Thereafter, the holding mechanism 504 holding the sheet 10 is lowered again, and the tip of the suction arm 511 is inserted into the cup 1. In this state, when the suction passage 512 is sucked to be negative pressure, the sheet 10 including the cup 1 is sucked to the tip surface of the suction arm 511.

  Then, the excess part of the unnecessary sheet | seat 10 which continues to the opening part of the cup 1 is irradiated with the laser beam L, and the said excess part is cut off (FIG. 7). At this time, the laser beam L is irradiated to a position that is slightly outward from the opening edge of the cup 1 along the Z-axis direction, ie, the vertical direction perpendicular to the surplus portion of the sheet 10 (from the top in the illustrated example). At the same time, scanning is performed to move the irradiation position of the laser light L so as to draw an arc along a circular outline β having a diameter larger than the opening edge of the cup 1. Thereby, the sheet | seat 10 is cut | disconnected along the locus | trajectory of the irradiation position of the laser beam L. FIG. The remaining portion 13 of the bowl-shaped sheet 10 bent from the peripheral wall 11 of the cup 1 and projecting outward is left in the opening of the cup 1 where the excess portion of the sheet 10 is cut off. The surplus portion of the sheet 10 separated from the cup 1 is removed by suction later.

  After cutting off the surplus portion of the sheet, the suction arm 511 that sucks the cup 1 and the horizontal support shaft 510 are rotated halfway and the suction arm 511 is turned downward to invert the cup 1, and the suction arm 511 and the horizontal The support shaft 510 is displaced laterally along the X-axis direction, and the cup 1 with the opening facing upward is transported to a position directly above the transfer mechanism 513. Then, the transfer body 514 of the transfer mechanism 513 is raised toward the suction arm 511. The transfer body 514 is formed with a shaft hole 515 opening on the upper surface thereof. The inner diameter of the shaft hole 515 is from the upper surface of the transfer body 514 to a depth substantially equal to the height dimension of the peripheral wall 11 of the cup 1 (for example, to a depth of about 5 mm from the upper surface of the transfer body 514). The outer diameter of the cup 1 is substantially smaller than the outer diameter of the peripheral wall of the cup 1. When the transfer body 514 rises, the tip end portion of the suction arm 511 facing downward and the cup 1 adsorbed thereto are accommodated in the shaft hole 515 of the transfer body 514 (FIG. 8). Therefore, the cup 1 can be transferred from the suction arm 511 to the transfer body 514 by stopping the suction of the suction passage 512 of the cup reversing machine 509. At this time, the flange 13 extending outward from the opening edge of the cup 1 engages with the peripheral edge of the opening of the shaft hole 515 on the upper surface of the transfer body 514. Thereafter, the transfer body 514 descends and separates from the suction arm 511, and the cup reversing machine 509 returns to the original position (FIG. 9). In addition, the male mold 507 rises toward the original position. The transfer mechanism 513 in which the cup 1 is accommodated in the shaft hole 515 of the transfer body 514 functions to transfer the cup 1 so as to circulate around the units B, C, E, F, G, and H at various places.

  <Powder Compression Unit> The powder compression unit B is in the powder compression molding machine 600 and performs a powder compression step for compressing the powder 30 and obtaining the molded product 3 to be loaded in the cup 1. As shown in FIGS. 10 to 12, in the powder compression unit B, first, the distal end portion (upper end) of the lower punch 603 is inserted into the mortar hole 601 of the mortar table 602 having the mortar hole 601 penetrating vertically. And the height of the lower punch 603 is adjusted to secure a volume for filling the required amount of the powder 30 in the mortar hole 601. At this time, the upper punch 604 facing the mortar hole 601 is raised to open the area around the mortar hole 601 on the mortar table 602. Then, the filling device (feed) 605 is moved along the upper surface of the die table 602 so as to cover the die hole 601 of the die table 602 from above, and the powder 30 is filled into the die hole 601 (FIG. 11). . After the filling of the powder 30, the filling device 605 retracts from the area around the die hole 601 on the die table 602.

  Next, the upper punch 604 is lowered and the tip (lower end) thereof is inserted into the mortar hole 601 from above, and the powder 30 in the mortar 601 is formed by the tip of the upper punch 604 and the tip of the lower punch 603. Are pressed and compressed to form the molded product 3 (FIG. 12).

  <Insertion Unit> The insertion unit C is in the powder compression molding machine 600 and shares the same components as the powder compression unit B, and inserts the molded product 3 obtained by compressing the powder 30 into the cup 1. Run the insertion process. As shown in FIGS. 10, 13, and 14, in the insertion unit C, after the compression of the powder 30 by the powder compression step is completed, the lower punch 603 is lowered and the tip surface (upper end surface) is formed. Pull away from the bottom surface of product 3. At this time, the molded product 3 formed by compressing the powder 30 remains in the mortar hole 601. Further, the upper punch 604 and the mortar table 602 are raised to secure a space opened laterally along the Y-axis direction below the mortar hole 601. Thereafter, the transfer body 514 of the transfer mechanism 513 that accommodates the cup 1 in the shaft hole 515 and supports the cup 1 enters the space from below along the Y-axis direction (FIG. 13). The axial hole 515 of the transfer body 514 that has entered the space and the central axis α of the cup 1 are coaxial with the central axis of the mortar hole 601 of the mortar table 602, that is, from the Z-axis direction in which both central axes are up and down. Look and agree.

  Next, while lifting the transfer body 514 slightly, the upper punch 604 is lowered, and the molded product 3 staying in the mortar hole 601 is pushed into the cup 1 from above (FIG. 14). As a result, the molded product 3 is inserted into the cup 1. Then, the upper punch 604 is raised again and the transfer body 514 is slightly lowered to retract the transfer body 514 from the space below the mortar table 602. When the transfer body 514 is retracted, the mortar table 602 is lowered to the original position, and the distal end portion of the upper punch 604 comes out of the mortar hole 601. In addition, the lower eyelid 603 is also raised, and the tip part thereof enters the mortar hole 601 again.

  <Cup Processing Unit> The cup processing unit E is in the wrapping capsule molding machine 500 and cuts off the remaining portion 13 of the bowl-shaped sheet 10 projecting outward from the opening of the cup 1 in which the molded product 3 is inserted. Operates the cup processing process. As shown in FIGS. 15 to 17, in the cup processing unit E, first, a turntable 522 for rotating the cup 1 to be processed around its central axis α is advanced toward the processing position 523 (FIG. 15). 16). The turntable 522 includes a shaft body 524 and a piston 525 that extend in the vertical direction and can rotate about a central axis thereof, that is, a vertical axis, and a motor 526 that serves as a drive source for rotationally driving the shaft body 524. Inside the shaft body 524, a negative pressure passage 527 extending along the vertical direction and a negative pressure generating space 528 located below the negative pressure passage 527 and communicating with the negative pressure passage 527 are formed. The negative pressure passage 527 opens at the tip end surface (upper end surface) of the shaft body 524. The piston 525 is inserted into the negative pressure generation space 528 from below. The shaft body 524 and the piston 525 are spline-coupled, for example, and the piston 525 can be displaced relative to the shaft body 524 along the vertical direction, while the shaft body 524 rotates around the central axis. The piston 525 and the shaft body 524 rotate together. The volume of the negative pressure generating space 528 expands and contracts as the piston 525 moves up and down relatively with respect to the shaft body 524. The piston 525 is directly connected to the output shaft of the motor 526.

  The transfer body 514 of the transfer mechanism 513 that supports the cup 1 in which the molded product 3 is inserted moves above the turntable 522. At this time, the center axis of the shaft body 524 is coaxial with the shaft hole 515 of the transfer body 514 and the center axis α of the cup 1. Thereafter, when the transfer body 514 is lowered, the tip end portion (upper end portion) of the shaft body 524 is accommodated in the shaft hole 515 of the transfer body 514, and the tip end surface is in contact with or in close proximity to the bottom wall 12 of the cup 1. . In this state, when the shaft body 524 is raised, the tip portion of the shaft body 524 protrudes upward from the upper surface of the transfer body 514, and the cup 13 and the remaining portion 13 of the sheet 10 are moved up so as to push up the bottom wall 12 of the cup 1. It floats from the upper surface of the transfer body 514. At the same time, the piston 525 connected to the motor 526 is displaced downward relative to the shaft body 524, and the volume of the negative pressure generating space 528 is expanded to generate a negative pressure. The bottom wall 12 of the cup 1 is adsorbed to the tip surface of the shaft body 524 through the passage 527.

  In the cup processing step, the laser beam L is emitted from the side along the X-axis direction to a portion near the edge (upper end) of the peripheral wall 11 of the cup 1 in order to cut off the bowl-shaped remaining portion 13 connected to the opening of the cup 1. Irradiate. For this purpose, a mirror (or a 45 ° right angle prism) 529 that reflects the laser beam L and directs its optical axis in the X-axis direction faces the peripheral wall 11 of the cup 1 levitated from the upper surface of the transfer body 514 from the X-axis direction. Place at height. Then, the motor 526 is activated to rotate the piston 525, the shaft body 524, and the cup 1 adsorbed to the piston 525 around the central axis α, and the laser light L is sent to the edge of the peripheral wall 11 of the cup 1 via the mirror 529. Irradiate the region near the end (FIG. 17). The irradiation with the laser light L continues until the irradiation position circulates a plurality of times (for example, two times) along the peripheral wall 11 of the cup 1. As a result, the remaining portion 13 of the bowl-shaped sheet 10 can be cut off from the opening of the cup 1. The remaining part 13 of the sheet 10 separated from the cup 1 is removed by suction later.

  After the remaining portion 13 of the sheet 10 is cut from the cup 1, the shaft body 524 is lowered and the transfer body 514 is raised. At this time, since the piston 525 is displaced relatively upward with respect to the shaft body 524, the negative pressure adsorbing the bottom wall 12 of the cup 1 on the tip surface of the shaft body 524 disappears. Note that the remaining portion 13 of the sheet 10 that has been engaged with the periphery of the opening of the shaft hole 515 on the upper surface of the transfer body 514 has already been separated from the cup 1, but as already described, the shaft hole 515 of the transfer body 514 The inner diameter of the lower portion is narrower than the outer shape of the peripheral wall 11 of the cup 1. For this reason, the cup 1 rises together with the transfer body 514 while being supported by the transfer body 514 without falling deeply into the shaft hole 515. After the shaft body 524 escapes downward from the shaft hole 515 of the transfer body 514, the turntable 522 is retracted from the processing position 523.

  <Sealing unit> The sealing unit is in the wrapping capsule molding machine 500 and performs a sealing step of sealing the opening of the cup 1 into which the molded product 3 is inserted with the sheet 20. In this embodiment, the sealing unit includes a lid forming unit F, a lid processing unit G, and a pressure bonding unit H described below.

  The lid molding unit F shares the same components as the cup molding unit A, and performs a lid molding process for molding the lid 2 for sealing the opening of the cup 1 from the sheet 20. As shown in FIGS. 18 to 22, in the lid forming unit F, the holding mechanism that lowers the transfer body 514 of the transfer mechanism 513 that supports the cup 1 from which the remaining portion 13 of the sheet 10 is cut off and is located at the forming position 503. Move to a position below 504. On the other hand, at the sheet cutting position 501, the circular sheet 20 having a predetermined size is cut out from the tape 530 of the sheet 20 that is the material of the lid 2, and the cut sheet 20 is held by the holding mechanism 504 at the molding position 503 (FIG. 19). ). At that time, the lower member 506 of the retaining mechanism 504 receives the sheet 20 cut out at the sheet cutting position 501 and transports it to the forming position 503. The cutting of the sheet 20 that is the material of the lid 2 is performed by the same laser treatment as the cutting of the sheet 10 that is the material of the cup 1. An adhesive layer 24 is provided in advance on the downward surface of the sheet 20 that is the material of the lid 2.

  Next, the support shaft 531 is inserted into the shaft hole 515 of the transfer body 514 from below the transfer body 514. The support shaft 531 plays a role of supporting the cup 1 into which the molded product 3 is inserted, which is a male mold when the lid 2 is molded from the sheet, from below. A suction passage 532 for sucking the atmosphere is formed inside the support shaft 531, and the suction passage 532 is open to the front end surface (upper end surface) of the support shaft 531. The support shaft 531 raises the bottom surface 12 of the cup 1 to a height substantially equal to the upper surface of the transfer body 514 by raising the tip surface of the support shaft 531 to a height substantially equal to the upper surface of the transfer body 514. It is exposed upward from the shaft hole 515. In this state, the suction passage 532 is sucked to be negative pressure, and the bottom wall 12 of the cup 1 is attracted to and fixed to the tip surface of the support shaft 531.

  Thus, the thermoplastic sheet 20 is heated by blowing warm air toward the sheet 20 from the duct 508 having a built-in fan on the opposite side of the cup 1 as viewed from the sheet 20, that is, above the sheet 20. To do. Thereafter, the holding mechanism 504 holding and holding the sheet 20 descends toward the male cup 1, and the sheet 20 is inserted into the opening edge (upper edge) of the cup 1 and the molded product 3 inserted into the cup 1. Press against the top surface (FIG. 20). At the same time, the cup 1 side is decompressed more than the duct 508 side as viewed from the sheet 20, more specifically, by sucking the atmosphere below the sheet 20, the sheet 20 is brought into the cup 1 (and the upper surface of the transfer body 514). (Fig. 21). As a result, the lid 2 having a volume corresponding to the outer shape of the outer surface of the peripheral wall 11 of the cup 1 and the upper surface of the molded product 3 is molded so as to protrude upward from the sheet 20. The lid 2 has a cylindrical peripheral wall 21 along the shape of the outer periphery of the peripheral wall 11 of the cup 1 and a top wall 22 along the shape of the upper surface of the molded product 3. When the lid 2 is molded, the inner surface of the peripheral wall 21 of the lid 2 is bonded to the outer surface of the peripheral wall 11 of the cup 1, and the lower surface of the top wall 22 is bonded to the upper surface of the molded product 3 inserted in the cup 1. In particular, when the adhesive layer 24 is provided in advance on the downward surface of the sheet 20 serving as the lid 2, that is, the surface facing the cup 1 and the molded product 3, the inner surface of the peripheral wall 21 is formed when the lid 2 is molded. The bottom surface of the top wall 22 having the adhesive layer 24 is adhered to the upper surface of the molded product 3 inserted in the cup 1.

  After forming the lid 2 so as to protrude from the sheet 20, the suction of the suction passage 532 of the support shaft 531 is stopped, and the suction of the bottom wall 12 of the cup 1 to the tip surface of the support shaft 531 is released. Then, the retaining mechanism 504 rises while sandwiching the sheet 20 on which the lid 2 is formed, and the transfer body 514 also rises following the retaining mechanism 504. At this time, the cup 1 and the lid 2 are joined, the sheet 20 integrated with the lid 2 is sandwiched between the retaining mechanisms 504, and the surplus portion of the sheet 20 is placed on the upper surface of the transfer body 514. Therefore, the cup 1 and the lid 2 are also lifted together with the holding mechanism 504 and the transfer body 514 while being exposed upward from the upper surface of the transfer body 514.

  Then, the excess part of the unnecessary sheet | seat 20 which continues to the opening part of the lid | cover 2 is irradiated with the laser beam L, and the said excess part is cut off (FIG. 22). At this time, the laser beam L is irradiated along the vertical direction perpendicular to the surplus portion of the sheet 20 to the position slightly outward from the opening edge of the lid 2, and the irradiation position of the laser beam L is also the lid 2. The scanning is performed so as to draw an arc along a circular outline β having a diameter larger than that of the opening edge. Thereby, the sheet | seat 20 is cut | disconnected along the locus | trajectory of the irradiation position of the laser beam L. FIG. The remaining portion 23 of the bowl-shaped sheet 20 that is bent from the peripheral wall 21 of the lid 2 and projects outward is left in the opening of the lid 2 where excess portions of the sheet 20 are cut off. The remaining portion 23 of the sheet 20 engages with the periphery of the opening of the shaft hole 515 on the upper surface of the transfer body 514, and keeps the cup 1 and the lid 2 protruding upward from the upper surface of the transfer body 514. The surplus part of the sheet 20 cut off from the lid 2 is removed by suction later.

  After the excess portion of the sheet 20 is cut off, the transfer body 514 supporting the cup 1 and the lid 2 is slightly lowered, and the support shaft 531 is largely retracted downward.

  The lid processing unit G shares the same components as the cup processing unit E, and a lid processing step of cutting off the remaining portion 23 of the bowl-shaped sheet 20 projecting outward from the opening of the lid 2 sealing the cup 1. Run. As shown in FIGS. 23 and 24, in the lid processing unit G, first, the transfer body 514 of the transfer mechanism 513 that supports the cup 1 and the lid 2 is moved toward the processing position 523 (FIG. 23). The transfer body 514 stands by at a position above the turntable 522. In addition, the turntable 522 is advanced toward the machining position 523. At the processing position 523, the central axis of the shaft body 524 of the turntable 522 and the central axis α of the shaft hole 515, the cup 1 and the lid 2 of the transfer body 514 are coaxial. Thereafter, when the transfer body 514 is lowered, the tip end portion of the shaft body 524 is accommodated in the shaft hole 515 of the transfer body 514, and the tip end surface thereof comes into contact with or very close to the bottom wall 12 of the cup 1. In this state, when the shaft body 524 is raised, the tip of the shaft body 524 protrudes upward from the upper surface of the transfer body 514 and pushes up the bottom wall 12 of the cup 1 so that the remaining portion of the cup 1, the lid 2 and the sheet. From the upper surface of the transfer body 514. At the same time, the piston 525 connected to the motor 526 is displaced downward relative to the shaft body 524, and the volume of the negative pressure generating space 528 is expanded to generate a negative pressure. The bottom wall 12 of the cup 1 is adsorbed to the tip surface of the shaft body 524 through the passage 527.

  In the lid processing step, the laser beam L is emitted from the side along the X-axis direction to a portion near the edge (lower end) of the peripheral wall 21 of the lid 2 in order to cut off the bowl-shaped remaining portion 23 connected to the opening of the lid 2. Irradiate. For this purpose, a mirror 529 that reflects the laser beam L and directs its optical axis in the X-axis direction is arranged at a height that faces the peripheral wall 21 of the lid 2 that floats from the upper surface of the transfer body 514 from the X-axis direction. Then, the motor 526 is activated to rotate the piston 525, the shaft body 524, and the cup 1 and the lid 2 adsorbed to the shaft body 524 around the central axis α, while the laser beam L is covered via the mirror 529. 2 is irradiated to the vicinity of the edge of the peripheral wall 21 (FIG. 24). The irradiation with the laser light L is continued until the irradiation position circulates a plurality of times (for example, two times) along the peripheral wall 21 of the lid 2. As a result, the remaining portion 23 of the bowl-shaped sheet 20 can be cut off from the opening of the lid 2. The remaining part 23 of the sheet 20 cut off from the lid 2 is removed by suction later.

  The crimping unit H presses the peripheral wall 21 of the lid 2 from the outer side toward the inner side, and crimps the inner surface of the peripheral wall 21 of the lid 2 to the outer surface of the peripheral wall 11 of the cup 1 following the above-described lid processing step. Performs the crimping process. As shown in FIGS. 25 to 27, in the crimping unit H, the crimping mechanism 533 for pressing the peripheral wall 21 of the lid 2 is attracted to the shaft body 524 of the turntable 522 from the side along the Y-axis direction. Moved to the vicinity of the cup 1 and the lid 2 (FIG. 26). The pressure-bonding mechanism 533 includes a plurality of (three in the illustrated example) pressure-bonding rollers 534 arranged so as to surround the cup 1 and the lid 2, heaters 535 incorporated in the pressure-bonding rollers 534, the pressure-bonding rollers 534, And a roller support 536 that supports the heater 535. Each of the pressure rollers 534 can rotate around the vertical axis. The heater 535 functions to increase the temperature of the outer peripheral surface of the pressure roller 534. The roller support 536 includes an air chuck that can horizontally move the pressure-bonding rollers 534 that are supported toward the center of the roller support 536 and horizontally move away from the center.

  In the crimping process, the crimping mechanism 533 is positioned so that the cup 1 and the lid 2 are located immediately below the center of the roller support 536, and the outer circumferential surface of each crimping roller 534 supported by the roller support 536 is the outer surface of the circumferential wall of the lid 2. Let us face you. Then, each pressure roller 534 is displaced toward the center of the roller support 536 by an air chuck provided in the roller support 536 (FIG. 27). That is, the outer peripheral surface of each pressure roller 534 is brought into contact with the outer surface of the peripheral wall 21 of the lid 2, and the peripheral wall 21 of the lid 2 is sandwiched from the outer side by the pressure roller 534. Thereafter, the shaft body 524 of the turntable 522 adsorbing the cup 1 and the lid 2 is driven to rotate, and the lid 2 and the cup 1 sandwiched between the pressure-bonding rollers 534 are rotated around the central axis α. Thereby, it is possible to press the peripheral wall 21 of the lid 2 toward the peripheral wall 11 of the cup 1 while heating the peripheral wall 21 of the lid 2 via the pressure roller 534.

  When the crimping of the peripheral wall 21 of the lid 2 to the peripheral wall 11 of the cup 1 is completed, and the wrapping lock that wraps the molded products 3 and 4 with the cup 1 and the lid 2 is completed, the air chuck is driven to support each pressure roller 534 as a roller. It is displaced in a direction away from the center of the body 536, and the cup 1 and the lid 2 are released from the pinching pressure by each pressure roller 534. Thereafter, the crimping mechanism 533 is retracted to the original position. Further, the shaft body 524 of the turntable 522 is lowered and the transfer body 514 is raised. At this time, since the piston 525 is displaced relatively upward with respect to the shaft body 524, the negative pressure adsorbing the bottom wall 12 of the cup 1 on the tip surface of the shaft body 524 disappears. The remaining portion 23 of the sheet 20 that has been engaged with the periphery of the opening of the shaft hole 515 on the upper surface of the transfer body 514 has already been separated from the lid 2, but the outer diameter of the peripheral wall 21 of the lid 2, that is, the completed wrapping tablet. Since the outer diameter of the wrapping tablet is slightly larger than the inner diameter of the shaft hole 515 of the transfer body 514, the completed wrapping tablet does not fall into the shaft hole 515, and is transferred while being supported above the upper surface of the transfer body 514. It will rise with the body 514.

  In the pressure bonding unit H, the heater 535 for heating the pressure roller 534 is not essential. If the peripheral wall 21 of the lid 2 can be bonded sufficiently firmly to the peripheral wall 11 of the cup 1 without heating the pressure roller 534, it is not necessary to incorporate the heater 535 in the pressure roller 534.

  Furthermore, the crimping unit H and the crimping process itself are not essential. In the lid forming process, when the lid 2 is molded from the sheet using the cup 1 with the molded products 3 and 4 inserted as a male mold, the inner surface of the peripheral wall 21 of the lid 2 is sufficiently strong to the outer surface of the peripheral wall 11 of the cup 1. If it adheres to, the crimping | compression-bonding process does not need to be implemented but the crimping | compression-bonding unit H containing the crimping | compression-bonding mechanism 533 can be abolished.

  Finally, the transfer body 514 of the transfer mechanism 513 transfers the completed wrapping tablet to the product collection position in the manufacturing apparatus (the wrapping capsule forming machine 500). Then, the completed wrapping tablet is dropped into a discharge port (chute) installed at the product collection position.

  In the molding process of the cup 1, the sheet 10 is moved relative to the male mold 507, and the sheet 10 is pressed against the male mold 507, thereby causing the cup 1 having a volume to protrude from the sheet 10. In the above embodiment, the male mold 507 is fixed and then the sheet 10 is moved (lowered) toward the male mold 507. However, the male mold 507 is moved toward the sheet 10 after the sheet 10 is fixed. Alternatively, both the sheet 10 and the male mold 507 may be moved in the direction of approaching each other.

  Further, in the lid 2 molding process, the sheet 20 is moved relative to the cup 1 into which the molded product 3 is inserted, and the sheet 20 is pressed against the cup 1 as a male mold. The lid 2 which is a cup is protruded. In the above embodiment, the cup 1 into which the molded product 3 to be a male mold is inserted is fixed and then the sheet 20 is moved (lowered) toward the cup 1, but the molding is performed after the sheet 20 is fixed. The cup 1 in which the product 3 is inserted may be moved toward the sheet 20, or both the sheet 20 and the cup 1 may be moved in a direction close to each other.

  In the manufacturing method of the enclosures 1 and 2 according to the present embodiment, the inner surface is a material of the lid 2 for sealing the opening of the cup 1 in which the contents 3 are stored and is in close contact with the outer surface of the peripheral wall 11 of the cup 1. The lid 2 that covers the cup 1 is formed from the sheet 20 on which the adhesive layer 24 is provided in advance on the side, and the inner surface of the peripheral wall 21 of the lid 2 is bonded to the outer surface of the peripheral wall 11 of the cup 1. . The manufacturing apparatus of the enclosures 1 and 2 in the present embodiment is an inner surface that is a material of the lid 2 for sealing the opening of the cup 1 in which the contents 3 are stored and is in close contact with the outer surface of the peripheral wall 11 of the cup 1. The lid forming unit F for forming the lid 2 covering the cup 1 from the sheet 20 on which the adhesive layer 24 is previously provided on the side to be provided.

  According to the present embodiment, the cup 1 and the lid 2 are securely bonded via the adhesive layer 24 provided in advance on the sheet 20 by heat generated in the lid forming step and / or the crimping step. Since it is not necessary to apply an adhesive again when the cup 1 and the lid 2 are joined, ethanol or water used as a solvent for the adhesive alters the contents 30 contained in the cup 1 or propagates bacteria. There is no invitation. The problem that the water-soluble cup 1 and the lid 2 are melted with the application of the adhesive can also be avoided.

  In the lid forming step, the cup 1 containing the contents 3 is a male mold, and the sheet 20 is moved relative to the cup 1 with the opening of the cup 1 facing the sheet 20 side. By pressing 20 against the cup 1, the lid 2 having a volume protrudes from the sheet 20. Thereby, the lid 2 can be joined to the cup 1 simultaneously with the molding of the lid 2. In addition, it is possible to promote the joining of the cup 1 and the lid 2 by using heat generated when the lid 2 is molded.

  Furthermore, if a crimping step for crimping the inner surface of the peripheral wall 21 of the lid 2 against the outer surface of the peripheral wall 11 of the cup 1 is performed in the crimping step after the lid 2 is molded, the lid is attached to the cup 1. 2 can be bonded more firmly.

  Each of the sheets 10 and 20 as the material of the cup 1 and the lid 2 is a film made of a thermoplastic polymer material, for example, a film made of piperomellose or polyvinyl alcohol. In the case of producing a pharmaceutical preparation, it is a film of a material that dissolves in the body of a person who has taken it.

  In the above embodiment, in the powder compression molding machine 600 that performs the powder compression step, the insertion step of inserting the molded product 3 as the contents into the cup 1 is also performed. However, it is conceivable to perform the insertion step outside the powder compression molding machine 600 instead of inside the powder compression molding machine 600.

  In that case, the insertion unit D which performs an insertion process is provided in the wrapping capsule molding machine 500, for example. As shown in FIGS. 28 to 30, in the insertion unit D, the molded product 3 molded in advance is stored in a magazine 516 that can hold a plurality of molded products 3 in series along the vertical direction. The molded product 3 may be a product obtained by compressing the powder 30 using a powder compression molding machine 600, or compressing the powder 30 using a powder compression molding machine different from the molding machine 600. It may be what you did. In any case, the step of compressing the powder 30 to form the molded product 3 corresponds to the powder compression step, and the powder compression molding machine used to perform the powder compression step is a powder compression unit. It corresponds to.

  After the cup forming process in the cup forming unit A, the transfer body 514 of the transfer mechanism 513 that accommodates and supports the cup 1 in the shaft hole 515 is inserted into the insertion unit C in the powder compression molding machine 600. Instead, it is transferred to the insertion unit D in the wrapping capsule forming machine 500. At this time, the transfer body 514 enters below the base 517 on which the magazine 516 is placed (FIG. 29). An insertion port 518 penetrating in the vertical direction is bored at a position on the base 517 near the magazine 516. The inner diameter of the inlet 518 is substantially equal to the outer diameter of the upper end portion of the base 517 that supports the cup 1. The shaft hole 515 of the transfer body 514 that has entered below the base 517 and the central axis α of the cup 1 are coaxial with the input port 518 of the base 517. Thereafter, the transfer body 514 is raised, and the upper end thereof is inserted into the charging port 518 of the base 517 from below. At this time, the height of the upper surface of the transfer body 514 is substantially flush with the height of the upper surface of the base 517.

  Next, the drive body 519 located at the bottom of the magazine 516 advances from the side along the X-axis direction to a position directly above the input port 518 and the transfer body 514. The driving body 519 is a flat member having a thickness of one molded product 3 to be inserted into the cup 1 or slightly smaller than that, and has a catching hole 520 penetrating in the vertical direction at an end thereof. The inner diameter of the capture hole 520 is substantially equal to the outer diameter of the molded product 3. When the catching hole 520 of the driving body 519 is located immediately below the plurality of molded products 3 held by the magazine 516, the lowest one of the plurality of molded products 3 is in the catching hole 520. It falls and is captured by the capture hole 520. Then, when the drive body 519 advances to a position immediately above the charging port 518 and the transfer body 514, the capture hole 520 and the central axis of the molded product 3 captured thereby, the shaft hole 515 of the transfer body 514, and the cup The central axis α of 1 is coaxial.

  In this state, the rod-shaped pusher 521 kept above the charging port 518 is lowered, and the molded product 3 in the catching hole 520 is pushed into the cup 1 from above at the tip (lower end) (FIG. 30). . As a result, the molded product 3 is inserted into the cup 1.

  After the pusher 521 that has pushed the molded product 4 into the cup 1 rises, the drive body 519 is retracted to the original position. At this time, the catching hole 520 of the driving body 519 returns to a position immediately below the plurality of molded products 3 held by the magazine 516 to receive a new molded product 3. The transfer body 514 supporting the cup 1 in which the molded product 3 is inserted descends, and its upper end portion escapes from the charging port 518. Thereafter, the transfer body 514 moves above the turntable 522 in the cup processing unit E.

  The present invention is not limited to the embodiment described in detail above. The production method and production method of the preparation according to the present invention are also useful for the production of a compounding agent for blending a plurality of types of powders and a layering agent for laminating a plurality of types of powders. For example, a compounding agent or a laminating agent in which two or more active ingredients are enclosed in the cup 1 can be easily produced by inserting a plurality of molded products into one cup 1. It is also conceivable to enclose a powder, a film, or the like that is not compression molded into the cup 1 together with one or a plurality of molded products.

  Instead of inserting a molded product obtained by compressing powder into the cup 1, it is filled with non-compressed powder, liquid, sol, gel, etc., and the cup 1 is sealed with a lid 2. It is also allowed to manufacture. In short, the contents of the wrapping capsule including the cup 1 and the lid 2 as elements are not limited to a molded product obtained by compressing powder.

  Although the molding machine constituting the powder compression unit B in the above embodiment is the vertical powder compression molding machine 600, a rotary powder compression molding machine may be adopted as the molding machine constituting the powder compression unit. Good.

  In the above embodiment, the laser device for cutting the sheet 10 that is the material of the cup 1 from the tape 502, the laser device for cutting the excess portion of the sheet 10, and the remaining portion 13 from the opening edge of the cup 1. A laser device for performing a cutting process, a laser device for performing a process of cutting out the sheet 20 that is a material of the lid 2 from the tape 530, a laser device for performing a process of cutting an excess portion of the sheet 20, and the lid 2 A laser apparatus for performing the process of cutting off the remaining portion 23 from the opening edge is common, and a mirror (or prism) 529 is used to change the direction of the optical axis of the laser light L when the remaining portions 13 and 23 are cut off. It was. However, it is not always necessary to perform these processes using the same laser device, and it goes without saying that a plurality of laser devices may be mounted to improve the production capacity.

  Moreover, the object manufactured by the manufacturing method or the manufacturing apparatus according to the present invention is not limited to medicine. You may utilize this invention for manufacture of formulations other than a pharmaceutical.

  In addition, the specific configuration of each unit and the specific processing procedure can be variously modified without departing from the spirit of the present invention.

DESCRIPTION OF SYMBOLS 1 ... Cup 10 ... Sheet 11 ... Perimeter wall 13 ... Remaining part of sheet 2 ... Lid 20 ... Sheet 21 ... Peripheral wall 23 ... Remaining part of sheet 24 ... Adhesive layer 3 ... Contents (molded article)
F ... Lid molding unit H ... Crimp unit

Claims (7)

A lid that covers the cup from a sheet that is a lid material for sealing the opening of the cup containing the contents and has an adhesive layer on the side that is in close contact with the outer surface of the peripheral wall of the cup. And manufacturing the sealed container in which the inner surface of the peripheral wall of the lid is bonded to the outer surface of the peripheral wall of the cup. The enclosure according to claim 1, wherein the cup is a male mold, the sheet is moved relative to the cup with the opening facing the sheet side, and the lid is formed by pressing the sheet against the cup. Container manufacturing method. The method for manufacturing a sealed container according to claim 1 or 2, wherein after molding the lid, the inner surface of the peripheral wall of the lid is pressure-bonded to the outer surface of the peripheral wall of the cup. The method for producing a sealed container according to claim 1, 2 or 3, wherein the adhesive layer is composed of copolyvidone, methacrylic acid copolymer LD, ethyl acrylate / methyl methacrylate copolymer, polyvinyl pyrrolidone, or aminoalkyl methacrylate copolymer E. . The sheet is a film made of a thermoplastic polymer material,
Prior to molding of the lid, the copolyvidone, methacrylic acid copolymer LD, ethyl acrylate / methyl methacrylate copolymer E, or aminoalkyl methacrylate copolymer E is dissolved in ethanol or water and then applied to the film and dried to form the adhesive. The manufacturing method of the enclosure container of Claim 4 which comprises a layer. A lid that covers the cup from a sheet that is a lid material for sealing the opening of the cup containing the contents and has an adhesive layer on the side that is in close contact with the outer surface of the peripheral wall of the cup. The manufacturing apparatus of the enclosure which comprises the lid forming unit which shape | molds. The lid molding unit molds the lid by making the cup a male mold, moving the sheet relative to the cup with the opening directed toward the sheet, and pressing the sheet against the cup. The sealed container manufacturing apparatus according to claim 6.