JPWO2018021435A1 - A composition containing hydrogen as an active ingredient to improve exercise endurance or reduce fatigue after exercise - Google Patents
A composition containing hydrogen as an active ingredient to improve exercise endurance or reduce fatigue after exercise Download PDFInfo
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 title claims abstract description 168
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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Abstract
本発明は運動持久力を向上させ、又は運動後の疲労感を軽減させる組成物の提供を目的とする。本発明は、水素を有効成分として含む運動持久力を向上させ、又は運動後の疲労感を軽減させる組成物である。The present invention aims to provide a composition that improves exercise endurance or reduces the feeling of fatigue after exercise. The present invention is a composition containing hydrogen as an active ingredient to improve exercise endurance or reduce fatigue after exercise.
Description
本発明は、運動持久力を向上させ、又は運動後の疲労感を軽減させる組成物に関する。 The present invention relates to a composition that improves exercise endurance or reduces the feeling of fatigue after exercise.
運動持久力は運動を長く続ける能力をいい、持久力の低い人は高い人よりも死亡率が高いことが報告されている。また、運動持久力は身体活動量と強い相関関係があり、身体活動量を高めておけば肥満等を予防し、生活習慣病の予防にも効果があると考えられる。 Exercise endurance refers to the ability to continue exercising for a long time, and it is reported that people with low endurance have higher mortality rates than people with high endurance. In addition, exercise endurance has a strong correlation with the amount of physical activity, and if the amount of physical activity is increased, obesity and the like are prevented and it is considered that it is also effective in the prevention of lifestyle-related diseases.
また、運動持久力が向上することにより、運動後の疲労感を軽減させることができる。 In addition, the improvement of exercise endurance can reduce the feeling of fatigue after exercise.
一方、水素は従来の抗酸化能に加えて最近、多種の作用を有することが明らかになり、加えて、その効果や安全性についてもすでに多くの報告がなされている（特許文献１を参照）。 On the other hand, hydrogen has recently been found to have various actions in addition to the conventional antioxidant ability, and in addition, many reports have already been made on its effect and safety (see Patent Document 1). .
本発明は、運動持久力を向上させ、又は運動後の疲労感を軽減させる組成物の提供を目的とする。 The present invention aims to provide a composition that improves exercise endurance or reduces the feeling of fatigue after exercise.
本発明者は、水素の運動持久力に対する効果、又は運動後の疲労感を軽減させる効果について鋭意検討を行った。具体的には、被験体に水素水を１回摂取させ、運動持久力がどのように変化するかを最大酸素摂取量の変化、又は自覚的運動強度指数の変化等を指標に確認した。 The present inventors diligently studied the effect of hydrogen on exercise endurance or the effect of reducing the feeling of fatigue after exercise. Specifically, the subject was allowed to ingest hydrogen water once, and the change in exercise endurance was confirmed using the change in maximum oxygen intake or the change in subjective exercise intensity index as an index.
その結果、水素を摂取させた被験体において運動持久力が向上し、運動後の疲労感を軽減させることを見出し、本発明を完成させるに至った。 As a result, it has been found that exercise endurance improves in a subject who ingests hydrogen and reduces fatigue after exercise, and the present invention has been completed.
すなわち、本発明は以下のとおりである。
[１] 水素を有効成分として含む運動持久力を向上させ、又は運動後の疲労感を軽減させる組成物。
[２] 組成物が水素を含む液体である、[１]の組成物。
[３] 水素分子が飽和状態で含まれる、[２]の組成物。
[４] 組成物が水素ガスである、[１]の組成物。
[５] 水素ガスを１〜４％（v/v）の濃度で含む、[４]の組成物。
[６] 組成物が水素を吸蔵し保持している金属又は金属合金の微粒子である、[１]の組成物。
[７] 医薬組成物である、[１]〜[６]のいずれかの組成物。
[８] 健康食品である、[１]〜[３]のいずれかの組成物。
[９] 健康食品が水素水である、[８]の組成物。
[１０] 運動後の疲労感をVAS (Visual Analogue Scale)検査により評価する、[１]〜[９]のいずれかの組成物。That is, the present invention is as follows.
[1] A composition for improving exercise endurance or reducing fatigue after exercise which contains hydrogen as an active ingredient.
[2] The composition of [1], wherein the composition is a liquid containing hydrogen.
[3] The composition of [2], wherein hydrogen molecules are contained in a saturated state.
[4] The composition of [1], wherein the composition is hydrogen gas.
[5] The composition of [4], which contains hydrogen gas at a concentration of 1 to 4% (v / v).
[6] The composition of [1], wherein the composition is a fine particle of a metal or metal alloy that absorbs and holds hydrogen.
[7] The composition of any one of [1] to [6], which is a pharmaceutical composition.
[8] The composition according to any one of [1] to [3], which is a health food.
[9] The composition of [8], wherein the health food is hydrogen water.
[10] The composition according to any one of [1] to [9], wherein the feeling of fatigue after exercise is evaluated by a VAS (Visual Analogue Scale) test.
本明細書は本願の優先権の基礎である日本国特許出願2016-147541号の明細書および／または図面に記載される内容を包含する。 The present specification includes the contents described in the specification and / or drawings of Japanese Patent Application No. 2016-147541 based on the priority of the present application.
本発明の水素を有効成分として含む組成物を投与又は摂取することにより、運動持久力を向上させ、又は運動後の疲労感を軽減させることができる。 Exercise endurance can be improved or fatigue after exercise can be reduced by administering or ingesting a composition containing hydrogen as an active ingredient of the present invention.
以下、本発明を詳細に説明する。 Hereinafter, the present invention will be described in detail.
本発明は水素を有効成分として含む運動持久力を向上させ、又は運動後の疲労感を軽減させる組成物である。 The present invention is a composition containing hydrogen as an active ingredient to improve exercise endurance or reduce fatigue after exercise.
本発明の水素を含む運動持久力を向上させ、又は運動後の疲労感を軽減させる組成物は、液体であっても気体であってもよい。 The composition for improving exercise endurance or reducing fatigue after exercise of the present invention may be liquid or gas.
運動持久力は運動を長く続ける能力をいう。運動持久力の向上により、運動後の疲労感を軽減させることができる。従って、運動後の疲労感軽減と運動持久力の向上は同じ現象を表す。 Exercise endurance refers to the ability to continue exercising for a long time. The improvement of exercise endurance can reduce the feeling of fatigue after exercise. Therefore, the feeling of fatigue after exercise and the improvement of exercise endurance show the same phenomenon.
運動持久力は、例えば、最大酸素摂取量により測定することができる。最大酸素摂取量とは、漸増運動で測定された個人が摂取可能な単位時間あたりの酸素摂取量（mL/kg/min）の最大値を表した値である。通常は、モーター付のトレッドミルで計測される。最大酸素摂取量は、持久力の指標として用いられる。 Exercise endurance can be measured, for example, by maximal oxygen uptake. The maximum oxygen uptake is a value representing the maximum value of oxygen uptake per unit time (mL / kg / min) which can be ingested by the individual measured in the incremental exercise. It is usually measured with a treadmill with a motor. Maximum oxygen uptake is used as an indicator of endurance.
また、運動持久力は本人が自覚する自覚的運動強度の指数で表すことができる。自覚的運動強度（主観的運動強度）とは、運動強度がどの程度きつく感じたかを運動実践者の主観により表す指標であり、ボルグの自覚的運動強度（ボルグ・スケール）（図１）で表すことができる。ボルグの自覚的運動強度は６から２０までの１５段階の指数で表される（図１では６は示していない）。カテゴリー１段階が心拍数10bpmに相当している。運動持久力が向上すればするほど、同じ強度の運動を行った場合でも、自覚的運動強度の指数は小さく判定される。
In addition, exercise endurance can be represented by an index of perceived exercise intensity that the person is aware of. Subjective exercise intensity (subjective exercise intensity) is an index that indicates how tight the exercise intensity is felt by the subjectivity of the exercise practitioner, and is represented by Borg's subjective exercise intensity (Borg scale) (FIG. 1) be able to. Borg's subjective exercise intensity is expressed by a 15-level index from 6 to 20 (6 is not shown in FIG. 1). A
さらに、抗疲労臨床評価ガイドライン（日本疲労学会 平成23年7月22日）では、疲労のVAS (Visual Analogue Scale)を用いることが推奨されている。この方法は、検査用紙に記されたいくつかの質問で、直線の左端の「疲れを全く感じていない最良の感覚」から右端の「何もできないほど疲れきった最悪の感覚」のあいだに自分で×を記入していき、判定する（http://hirougakkai.com/hyouka.pdf 抗疲労臨床評価ガイドライン）。 Furthermore, according to the Anti-Fatigue Clinical Evaluation Guidelines (Japan Fatigue Society, July 22, 2011), it is recommended to use VAS (Visual Analogue Scale) for fatigue. This method is a number of questions written on the test sheet, and it is between the "best feeling not feeling tired at all" at the left end of the straight line and the "worst feeling that can not do anything tired" at the right end. Fill in the x and decide (http://hirougakkai.com/hyouka.pdf Anti-Fatigue Clinical Evaluation Guidelines).
このVAS検査により、運動後の疲労感を評価し、疲労感軽減の程度を判定することができる。 By this VAS test, the feeling of fatigue after exercise can be evaluated, and the degree of relief of fatigue can be determined.
水素分子を含む液体は、水溶液からなることを特徴とする。本発明において、水素を含む液体を水素水と呼ぶことがある。この水溶液を形成する媒体としては、純水、イオン交換水、蒸留水、生理食塩水等を使用し得る。さらに、前記媒体として純水、イオン交換水あるいは蒸留水を使用し、得られた生体内の有害なフリーラジカル除去剤を一般的な水性飲料品、例えば、ミネラルウォーター、ジュース、コーヒー、お茶等に添加して飲用するようにしてもよい。ここで、飲料品は、飲料用の健康食品、機能性表示食品、特定保健用食品、栄養機能食品等を含む。ここで、特定保健用食品とは、食生活において特定の保健の目的で摂取をし、その摂取により当該保健の目的が期待できる旨の表示をする食品をいう。これらの飲料品には、例えば運動持久力を向上させるために用いられるものである旨、あるいは運動後の疲労感を軽減させる旨の表示が付されていてもよい。 The liquid containing hydrogen molecules is characterized by comprising an aqueous solution. In the present invention, a liquid containing hydrogen may be called hydrogen water. Pure water, ion exchange water, distilled water, physiological saline and the like can be used as a medium for forming this aqueous solution. Furthermore, pure water, ion-exchanged water or distilled water is used as the medium, and the resultant harmful free radical scavenger in the living body is used as a general aqueous beverage product such as mineral water, juice, coffee, tea and the like. It may be added for drinking. Here, the beverage includes a health food for beverage, a functional indication food, a food for specified health, a nutritional function food and the like. Here, the food for specific health refers to a food which is ingested for the purpose of a specific health in the diet and which indicates that the purpose of the health can be expected by the intake. These beverages may be labeled, for example, to indicate that they are used to improve exercise endurance or to reduce fatigue after exercise.
水素分子は飽和状態であっても水又は水溶液中にある程度の時間溶けていることができる。このような水素分子が飽和状態の水又は水溶液は、加圧下において水素ガスを水又は水溶液に溶解させた後に圧力を取り除くことにより簡単に製造し得る。例えば、水溶液を0.4MPa以上の水素ガス圧下に数時間、好ましくは１〜３時間おけばよい。あるいは大量に水素水を製造する装置で短時間で製造してもよい。水溶液形態の水素水は、飲用として用いることもでき、生理食塩水の形で静注用として用いることもできる。この場合、投与はカテーテルを用いた投与や注射による投与が可能である。注入後は生体内に摂取された水素は生体にほとんど吸収され、血液を介して全身に行き渡り、効果を発揮し、その後呼気と一緒に排出される。 Hydrogen molecules can be dissolved in water or an aqueous solution for some time even in a saturated state. Such water or an aqueous solution saturated with hydrogen molecules can be easily produced by dissolving hydrogen gas in water or an aqueous solution under pressure and then removing the pressure. For example, the aqueous solution may be placed under a hydrogen gas pressure of 0.4 MPa or more for several hours, preferably 1 to 3 hours. Or you may manufacture in a short time with the apparatus which manufactures a large amount of hydrogen water. Hydrogen water in the form of an aqueous solution can be used for drinking, and can also be used for intravenous injection in the form of physiological saline. In this case, administration can be by administration using a catheter or by injection. After injection, hydrogen ingested into the living body is almost absorbed by the living body, spreads throughout the body via blood, exerts an effect, and is then excreted together with exhalation.
水素１気圧、室温条件で水素は水１L当たり約17.5mL溶存し得る（約1.6ppm、約0.8 mM）。本発明の水素分子を含む液体組成物は、水溶液１L当たり、10mL以上、好ましくは15mL以上、特に好ましくは17.5mL以上の水素分子を含む。また、本発明の水素分子を含む液体組成物は、0.8ppm以上、好ましくは1ppm以上、さらに好ましくは1.1ppm以上、さらに好ましくは1.2ppm以上の水素分子を含む。また、本発明の水素分子を含む液体組成物は、0.1mM以上、好ましくは0.4mM以上、さらに好ましくは0.6mM、特に好ましくは0.8mM以上の水素を含む。 Hydrogen can be dissolved at about 17.5 mL per liter of water (about 1.6 ppm, about 0.8 mM) under one atmosphere of hydrogen and at room temperature. The liquid composition containing hydrogen molecules of the present invention contains 10 mL or more, preferably 15 mL or more, particularly preferably 17.5 mL or more of hydrogen molecules per liter of the aqueous solution. The liquid composition containing hydrogen molecules of the present invention contains 0.8 ppm or more, preferably 1 ppm or more, more preferably 1.1 ppm or more, and further preferably 1.2 ppm or more of hydrogen molecules. Further, the liquid composition containing hydrogen molecules of the present invention contains 0.1 mM or more, preferably 0.4 mM or more, more preferably 0.6 mM, particularly preferably 0.8 mM or more of hydrogen.
また、本発明の水素分子を含む液体組成物は、酸素分子を含んでいてもよい。水溶液中に水素分子と酸素分子とが共存することとなるが、水素分子と酸素分子とが混合状態であっても、ただちに反応することはなく、両者とも安定に共存し得る。ただし、水溶液が多量の酸素分子を含む場合においては安全性を確保するために水素含有量は全気体の４％（v/v)未満となるようにすることが好ましい。安全性に問題がない使用環境下においては、水素含有量は可能な限り高濃度であることが好ましい。酸素を含む液体組成物も、飲用又は生理食塩水の形で静注用として使用し得るが、注射による投与の場合には、酸素分子がない場合に比すると、生体内が局部的に酸素不足の状態となることがないため、生体組織に損傷を与えることが少なくなる。 Also, the liquid composition containing hydrogen molecules of the present invention may contain oxygen molecules. Although hydrogen molecules and oxygen molecules coexist in the aqueous solution, even if the hydrogen molecules and oxygen molecules are in a mixed state, they do not react immediately, and both can coexist stably. However, in the case where the aqueous solution contains a large amount of oxygen molecules, it is preferable that the hydrogen content be less than 4% (v / v) of the total gas in order to ensure safety. In a use environment where there is no safety problem, the hydrogen content is preferably as high as possible. A liquid composition containing oxygen may also be used for drinking or in the form of saline in the form of intravenous solution, but in the case of administration by injection, oxygen locally lacks oxygen in the living body as compared to in the absence of molecular oxygen. As a result, there is less damage to living tissue.
本発明の液体組成物は、好ましくはアルミニウム等の水素を透過できない素材でできた容器中に保存するのが好ましい。また、低温である程、より多くの水素が溶存するので、低温で保存するのが好ましい。 The liquid composition of the present invention is preferably stored in a container made of a material that is impermeable to hydrogen, such as aluminum. Also, the lower the temperature, the more hydrogen is dissolved, so storage at a lower temperature is preferable.
本発明の液体組成物は、100〜5000mL、好ましくは150〜2000mL、さらに好ましくは150〜1000mL、さらに好ましくは200〜750mLを摂取すればよい。１回から数回の摂取で運動持久力の向上効果又は運動後の疲労感軽減効果が得られる。また、１日当たり上記の量を、１日から数年、好ましくは数か月〜数年、さらに好ましくは６ヶ月〜２年、さらに好ましくは６ヶ月〜１年間の間摂取してもよい。 The liquid composition of the present invention may ingest 100 to 5000 mL, preferably 150 to 2000 mL, more preferably 150 to 1000 mL, more preferably 200 to 750 mL. The effect of improving exercise endurance or the effect of reducing fatigue after exercise can be obtained by taking one to several times. In addition, the above-mentioned amount per day may be taken from one day to several years, preferably from several months to several years, more preferably from six months to two years, still more preferably from six months to one year.
水素分子を含む気体組成物は水素ガスを含む。本発明の気体組成物に含まれる水素ガスの濃度は、１〜４％（v/v）、好ましくは2.5〜3.5％(v/v)、さらに好ましくは約３％である。水素ガス含有量は安全性確保のために約４％(v/v)未満であることが望ましいが、密閉条件下で静電気が発生しないように配慮された安全な条件下であれば水素ガス含有量をより高くすることもできる。本発明の水素ガスを有効成分として含む気体組成物は、さらに酸素ガス及び／又は他の不活性ガスを含んでいてもよい。酸素ガスを含む場合、水素ガスと酸素ガスの混合ガスからなる。酸素ガスは呼吸のために消費される。不活性ガスとしては、窒素ガス、ヘリウムガス、アルゴンガス等を使用し得るが、安価な窒素ガスが望ましい。この不活性ガスの含有量は、多すぎない範囲で当業者が任意に設定できるが、呼吸用の酸素ガス濃度を考慮すると80％（v/v）以下が好ましい。さらに、本発明の水素ガスを有効成分として含む組成物は、水素ガスと空気の混合ガスであってもよい。このような混合ガスは、空気に水素ガスを適宜混合することにより簡単に製造し得る。さらに、本発明の水素ガスを有効成分として含む気体組成物は、麻酔用ガスを含んでいてもよい。この場合、水素ガスを有効成分として含む気体組成物は、水素ガスと麻酔ガスの混合ガスからなる。麻酔ガスとしては、笑気ガス等が挙げられる。 The gas composition containing hydrogen molecules contains hydrogen gas. The concentration of hydrogen gas contained in the gas composition of the present invention is 1 to 4% (v / v), preferably 2.5 to 3.5% (v / v), more preferably about 3%. Although it is desirable that the hydrogen gas content be less than about 4% (v / v) to ensure safety, hydrogen gas is included under safe conditions where static electricity is not generated under closed conditions. The amount can also be higher. The gas composition containing hydrogen gas of the present invention as an active ingredient may further contain oxygen gas and / or other inert gas. When oxygen gas is contained, it consists of mixed gas of hydrogen gas and oxygen gas. Oxygen gas is consumed for breathing. As the inert gas, nitrogen gas, helium gas, argon gas or the like may be used, but inexpensive nitrogen gas is desirable. The content of the inert gas can be optionally set by the person skilled in the art without being too high, but preferably 80% (v / v) or less in consideration of the oxygen gas concentration for breathing. Furthermore, the composition containing the hydrogen gas of the present invention as an active ingredient may be a mixed gas of hydrogen gas and air. Such a mixed gas can be easily manufactured by appropriately mixing hydrogen gas with air. Furthermore, the gas composition containing hydrogen gas of the present invention as an active ingredient may contain an anesthetic gas. In this case, the gas composition containing hydrogen gas as an active ingredient is a mixed gas of hydrogen gas and an anesthetic gas. As an anesthetic gas, a laughing gas etc. are mentioned.
本発明の水素ガスを有効成分として含む気体組成物は、例えばガスボンベ等の耐圧性の容器中に入れられる。本発明は、水素ガスを有効成分として含む気体組成物を含む容器をも包含する。 The gas composition containing the hydrogen gas of the present invention as an active ingredient is placed, for example, in a pressure resistant container such as a gas cylinder. The present invention also encompasses a container containing a gas composition containing hydrogen gas as an active ingredient.
本発明の気体状の水素ガスを有効成分として含む気体組成物は、被験体に吸引させることができる。吸引は吸引手段を用いて行うことができ、水素ガスを有効成分として含む気体組成物を含む容器から配管を通して吸引手段を介して吸引させればよい。吸引手段は限定されないが、例えば、吸引マスクが挙げられ該マスクは好ましくは患者の口及び鼻を同時に覆うことができる。さらに、吸引手段として密閉された小密閉室がある、該小室は患者がその中に入り込める程度の大きさを有し、該小室に患者が入った状態で、小室内に本発明の水素ガスを有効成分として含む気体組成物を供給することにより、患者に吸引させることができる。このような小室の一例として、密閉されたベッドが挙げられる。患者はベッドに横臥した状態で本発明の水素ガスを有効成分として含む気体組成物を吸引することができる。 The gas composition containing the gaseous hydrogen gas of the present invention as an active ingredient can be drawn into a subject. Suction can be performed using a suction means, and may be sucked from a container containing a gas composition containing hydrogen gas as an active ingredient through piping through the suction means. The suction means is not limited, but includes, for example, a suction mask, which can preferably cover the patient's mouth and nose simultaneously. Furthermore, there is a small sealed chamber sealed as suction means, which has a size enough to allow the patient to enter therein, and with the patient entering the chamber, the hydrogen gas of the present invention is introduced into the chamber. The patient can be aspirated by supplying a gaseous composition containing as an active ingredient. An example of such a small room is a sealed bed. The patient can inhale the gas composition containing the hydrogen gas of the present invention as an active ingredient while lying on the bed.
さらに、本発明は水素ガスを有効成分として含む気体組成物を含む容器、ガス吸引用手段並びに前記容器中のガスを吸引用手段に供給する供給配管を備えている、水素ガスを有効成分として含む気体組成物を被験体に供給するための装置を包含する。容器は例えば、水素ガスボンベである。また、ガス吸引手段として前述のように、吸引マスク、密閉した小室が挙げられる。該装置は、さらに、酸素ガス、不活性ガス、空気及び麻酔ガスからなる群から選択される少なくとも１種のガスを含む容器を備えていてもよく、この場合、水素ガスを有効成分として含む気体組成物と酸素ガス、不活性ガス及び空気からなる群から選択される少なくとも１種のガスを別々に或いは混合した後にガス吸引用手段に供給すればよい。例えば、吸引マスクに水素ガスが含まれるガス吸引バックを直結し、このガス吸引バックに水素ガスを含むガスボンベから水素ガスを供給すればよい。図５に本発明の装置の概略図を示す。該図は、ガス吸引用手段１、水素ガスを有効成分として含む急性期脳梗塞の治療剤を含む容器２、酸素ガス、不活性ガス、空気及び麻酔ガスからなる群から選択される少なくとも１種のガスを含む容器３並びに配管４を備え、ガスが配管を通してガス吸引用手段に供給され、患者に投与される。
Furthermore, the present invention comprises a container containing a gas composition containing hydrogen gas as an active ingredient, a means for gas suction, and a supply pipe for supplying the gas in the container to the means for suction, containing hydrogen gas as an active ingredient It includes an apparatus for supplying a gaseous composition to a subject. The container is, for example, a hydrogen gas cylinder. Moreover, as mentioned above as a gas suction means, a suction mask and a closed chamber are mentioned. The apparatus may further include a container containing at least one gas selected from the group consisting of oxygen gas, inert gas, air and anesthetic gas, in which case a gas containing hydrogen gas as an active ingredient. The composition and at least one gas selected from the group consisting of oxygen gas, inert gas and air may be supplied to the gas suction means separately or after mixing. For example, a gas suction bag containing hydrogen gas may be directly connected to the suction mask, and the hydrogen gas may be supplied to the gas suction bag from a gas cylinder containing hydrogen gas. FIG. 5 shows a schematic view of the device of the present invention. The figure shows at least one selected from the group consisting of a
水素ガスを有効成分として含む気体組成物の投与は、１回0.1時間〜５時間、好ましくは0.5時間から２時間、さらに好ましくは１時間行えばよい。１回から数回の投与で運動持久力の向上の効果、又は運動後の疲労感軽減効果が得られる。また、上記の投与量で、１日当たり１〜５回、好ましくは１〜３回、さらに好ましくは２回を、数日から数年、好ましくは数か月〜数年、さらに好ましくは６ヶ月〜２年、さらに好ましくは６ヶ月〜１年投与してもよい。水素ガスを投与するときの吸引スピードは、例えば、１時間当たり数Ｌ、好ましくは約６Ｌである。 The administration of the gas composition containing hydrogen gas as an active ingredient may be performed once for 0.1 hour to 5 hours, preferably for 0.5 hours to 2 hours, more preferably for 1 hour. The effect of improving exercise endurance or the effect of reducing fatigue after exercise can be obtained by one to several administrations. In the above dose, 1 to 5 times, preferably 1 to 3 times, more preferably 2 times per day, several days to several years, preferably several months to several years, more preferably 6 months to It may be administered for 2 years, more preferably 6 months to 1 year. The suction speed when administering hydrogen gas is, for example, several liters per hour, preferably about 6 liters.
さらに、本発明の組成物は水素原子を吸蔵し保持している、あるいは水素を発生させる物質を有効成分として含む組成物も含む。水素原子を吸蔵し保持している、あるいは水素を発生させる物質として、水素を吸蔵し保持している、あるいは水素を発生させる金属又は金属合金の微粒子である。本発明において、水素という場合、原子状水素及び分子状水素を含む。 Furthermore, the composition of the present invention also includes a composition which occludes and holds a hydrogen atom, or contains a substance that generates hydrogen as an active ingredient. The substance which occludes and holds hydrogen atoms or generates hydrogen is fine particles of a metal or metal alloy which occludes and holds hydrogen or generates hydrogen. In the present invention, reference to hydrogen includes atomic hydrogen and molecular hydrogen.
水素吸蔵金属として、リチウム（Li）、マグネシウム(Mg)、カルシウム(Ca)、バナジウム(V)、ランタン（La）等が挙げられる。本発明において、水素吸蔵金属又は金属合金とは、水素と化合して水素化物となることにより、水素を吸蔵し得る上記金属及びその合金を含む。この中でも、マグネシウム又はその合金が望ましい。水素を吸蔵した金属化合物を水素化金属化合物といい、例えば、水素を吸蔵したマグネシウムを水素化マグネシウム（MgH2）という。Examples of hydrogen storage metals include lithium (Li), magnesium (Mg), calcium (Ca), vanadium (V), lanthanum (La) and the like. In the present invention, the hydrogen storage metal or metal alloy includes the above-mentioned metals capable of storing hydrogen by combining with hydrogen to be a hydride, and an alloy thereof. Among these, magnesium or its alloy is desirable. The metal compound which occluded hydrogen is called a hydrogenation metal compound, for example, the magnesium which occluded hydrogen is called magnesium hydride (MgH 2 ).
水素化マグネシウムの場合は、水分と反応し、分子状水素を発生し、残りはMg(OH)2となるので、安全である。In the case of magnesium hydride, it is safe because it reacts with water to generate molecular hydrogen and the rest is Mg (OH) 2 .
MgH2から発生した原子状水素は接触した酸化物質（例えば以下の化学式ではXで示す）を以下の式により還元する。
MgH2＋2X→Mg＋2H＋2X→Mg＋2XHThe atomic hydrogen generated from MgH 2 reduces the contacted oxidant (for example, indicated by X in the following chemical formula) according to the following formula.
MgH 2 + 2X → Mg + 2H + 2X → Mg + 2XH
残ったMgはH2Oと反応し、Mg(OH)2となる。The remaining Mg reacts with H 2 O to form Mg (OH) 2 .
本発明の水素吸蔵金属又は金属合金の微粒子のサイズは、平均粒径が0.5μm〜10μm、好ましくは１μm〜５μm、さらに好ましくは１μm〜３μmである。 The fine particles of the hydrogen storage metal or metal alloy of the present invention have an average particle diameter of 0.5 μm to 10 μm, preferably 1 μm to 5 μm, and more preferably 1 μm to 3 μm.
さらに、微粒子をより細粉化（ナノ化）し、ナノメートルサイズのナノ粒子として利用することもできる。ナノ粒子のサイズは、平均粒径５〜500nm、好ましくは10〜100nmである。 Furthermore, fine particles can be further pulverized (nanosized) and used as nanometer-sized nanoparticles. The size of the nanoparticles is 5 to 500 nm, preferably 10 to 100 nm, in average particle size.
目的によって異なる粒径をもつ微粒子を配合することによって、両者の効果を発揮させることが可能である。サイズが大きな微粒子の場合は、ゆっくりと水素を発生し、サイズが小さな微粒子は表面積が大きいので早く水素を発生する。従って、サイズの小さな微粒子とサイズの大きな微粒子を混合させると、速やかに水素を発生し、かつ長時間にわたって水素を発生し続けることが可能になる。 By blending fine particles having different particle sizes according to the purpose, it is possible to exhibit the effects of both. In the case of large size particles, hydrogen is generated slowly, and small size particles generate hydrogen quickly because of their large surface area. Therefore, mixing small-sized particles with large-sized particles makes it possible to generate hydrogen quickly and keep generating hydrogen for a long time.
水素吸蔵金属又は金属合金は、金属に水素を結合させることにより製造することができ、公知の方法により製造可能である。例えば、金属と水素の存在下で加圧すればよい。得られた水素吸蔵金属又は金属合金を粉末の衝突等により、細粉化すればよい。 A hydrogen storage metal or metal alloy can be produced by bonding hydrogen to a metal, and can be produced by a known method. For example, it may be pressurized in the presence of metal and hydrogen. The obtained hydrogen storage metal or metal alloy may be pulverized by collision of the powder or the like.
MgH2は金属Mgとは異なり短時間で空気中の酸素と反応することはないので、粒子間の衝突を繰り返すことによって、微粉化する。衝突速度と衝突頻度によって、特定の大きさの粒子を作製する。例えば、密閉容器内でMgH2微粒子を不活性な気体（例えば、窒素）をキャリアーガスとして、粒子同士の衝突や、壁面と衝突させる方式により、さらなる微粉化が可能である。この時、円周方向に向かうキャリアーガスの圧力、ガス流量及びMgH2粉体の投入量を制御することにより、目的とするサイズのMgH2微粒子が得られる。目的とする粒径以下になったMgH2微粒子はその見かけ比重による遠心力により、粒径が小さくなった物ほど中心部に集まる。そして、キャリアーガスに随伴されて、系外に排出される。つまり、粉砕対象物質をキャリアーガスで円周方向に運動するエネルギーを与えて、随所で乱流化させるガス流により目的物粒同士あるいは壁面や障害物に衝突させることにより水素吸蔵金属又は金属合金の微粒子をさらに細粉化することができる。Unlike metal Mg, MgH 2 does not react with oxygen in air in a short time, so it is pulverized by repeating collisions between particles. Particles of a specific size are produced according to impact velocity and impact frequency. For example, further pulverization is possible by a method of colliding particles with each other or colliding with a wall surface by using MgH 2 fine particles as a carrier gas in a closed vessel with an inert gas (eg, nitrogen) as a carrier gas. At this time, by controlling the pressure of the carrier gas in the circumferential direction, the gas flow rate, and the input amount of the MgH 2 powder, MgH 2 fine particles of the target size can be obtained. The particles of MgH 2 particles which have become smaller than the target particle diameter are concentrated in the center as the particles whose particle diameter is reduced due to the centrifugal force due to the apparent specific gravity. Then, it is entrained by the carrier gas and discharged out of the system. In other words, the energy to move in the circumferential direction with the carrier gas is given to the material to be crushed, and the object particles or the wall surface or obstacle collide with the object particles by the gas flow causing turbulent flow everywhere. Fine particles can be further pulverized.
水と反応させることによって以下の反応式にしたがって分子状水素を発生させることができる。
MgH2+2H2O→Mg(OH)2＋2H2 By reacting with water, molecular hydrogen can be generated according to the following reaction formula.
MgH 2 + 2H 2 O → Mg (OH) 2 + 2H 2
水素吸蔵金属又は金属合金の微粒子は樹脂中に含まれていてもよく、本発明は水素を吸蔵し保持している金属又は金属合金の微粒子を含む樹脂を有効成分として含む組成物も包含する。水素を吸蔵し保持している金属又は金属合金の微粒子を含む樹脂は、水素を発生し、外に放出することができる。また、本発明は水素を吸蔵し保持している金属又は金属合金の微粒子を含む樹脂を含む水素放出剤又は水素発生剤である。 Fine particles of a hydrogen storage metal or metal alloy may be contained in a resin, and the present invention also includes a composition containing a resin containing fine particles of a metal or metal alloy storing and holding hydrogen as an active ingredient. A resin containing fine particles of metal or metal alloy that occludes and holds hydrogen can generate hydrogen and release it to the outside. Further, the present invention is a hydrogen releasing agent or hydrogen generating agent containing a resin containing fine particles of metal or metal alloy storing and holding hydrogen.
Mg(OH)2自体は生体にとって有害な物質ではないが、飲料水や食品に混入することは好ましくないので、本発明の水素吸蔵合金を含む樹脂においては、水素を発生してできたMg(OH)2は樹脂中に封じ込められ樹脂の外に出ることはない。Mg (OH) 2 itself is not a harmful substance to the living body, but it is not preferable to mix it in drinking water and food, so in the resin containing the hydrogen storage alloy of the present invention OH) 2 is contained in the resin and does not go out of the resin.
水素吸蔵金属又は金属合金を含む樹脂として、ポリエチレン、ポリエチレンテレフタレート、ポリプロピレン、塩化ビニル、ポリスチレン、ポリカーボネート、ポリエステル、ポリメチルペンテン、スチロール、アクリル、ナイロン、フッ素樹脂等が挙げられる。用いる樹脂は、食品を入れる容器の材料になり、あるいは食品を包装するフィルムやシートの材料として用いることができる樹脂である。 Examples of the resin containing a hydrogen storage metal or metal alloy include polyethylene, polyethylene terephthalate, polypropylene, vinyl chloride, polystyrene, polycarbonate, polyester, polymethylpentene, styrene, acryl, nylon, fluorine resin and the like. The resin to be used is a resin which can be used as a material of a container for containing a food or as a material of a film or a sheet for packaging a food.
樹脂に水素吸蔵金属又は金属合金を含ませる方法として、例えば、樹脂をメタノール、エタノール、イソプロピルアルコール、シクロヘキサン、トリクロロエチレン、ジクロロメタン、ベンゼン、酢酸エチル、酢酸ブチル、アセトン、トルエン、キシレン等の有機溶媒や熱により溶解あるいは軟化させ、可塑性を有する状態とし、その状態で樹脂に水素吸蔵金属又は金属合金を練り込むことにより樹脂中に水素吸蔵金属又は金属合金を均一に含ませることができる。例えば、有機溶媒にMgH2等の水素吸蔵金属又は金属合金を入れ、そこにポリスチレンやポリエチレン等の樹脂を添加し、溶解させ、溶解樹脂中に水素吸蔵金属又は金属合金が懸濁した状態とし、次いで有機溶媒を蒸発させることにより、水素吸蔵金属又は金属合金を含んだ樹脂を製造することができる。このようにして水素吸蔵金属又は金属合金を含む樹脂は任意の形状に加工することができる。例えば、粒子状、顆粒状、シート状、フィルム状に加工することができる。As a method of containing a hydrogen storage metal or metal alloy in a resin, for example, an organic solvent such as methanol, ethanol, isopropyl alcohol, cyclohexane, trichloroethylene, dichloromethane, benzene, ethyl acetate, butyl acetate, acetone, toluene, xylene, etc. By dissolving or softening the resin so that it has plasticity and then kneading the hydrogen storage metal or metal alloy into the resin in that state, the hydrogen storage metal or metal alloy can be uniformly contained in the resin. For example, a hydrogen storage metal or metal alloy such as MgH 2 is added to an organic solvent, a resin such as polystyrene or polyethylene is added thereto and dissolved, and the hydrogen storage metal or metal alloy is suspended in the dissolved resin. Then, the organic solvent is evaporated to produce a resin containing a hydrogen storage metal or a metal alloy. Thus, the resin containing a hydrogen storage metal or a metal alloy can be processed into any shape. For example, it can be processed into particles, granules, sheets, films.
水素吸蔵金属又は金属合金を含む樹脂を水又は水溶液に入れるか、あるいは湿度が高い環境下に置くことにより、水が樹脂を透過浸入し水素吸蔵金属又は金属合金と接触し、水素が放出される。この際、Mg等の金属又は金属合金は樹脂中に保持されており、金属又は金属合金が樹脂から放出されることはない。この際、樹脂の水透過性及び樹脂に含ませる水素吸蔵金属又は金属合金の量を変動させることにより、樹脂からの水素放出期間を調節することができる。例えば、本発明の水素吸蔵金属又は金属合金を含む樹脂は１日以上、好ましくは３日以上、さらに好ましくは１週間以上、特に好ましくは２週間以上にわたって水素を放出し得る。 When a resin containing a hydrogen storage metal or metal alloy is placed in water or an aqueous solution or placed in a high humidity environment, water permeates through the resin and contacts the hydrogen storage metal or metal alloy to release hydrogen. . At this time, the metal or metal alloy such as Mg is held in the resin, and the metal or metal alloy is not released from the resin. At this time, by varying the water permeability of the resin and the amount of hydrogen storage metal or metal alloy contained in the resin, the hydrogen release period from the resin can be adjusted. For example, the resin containing the hydrogen storage metal or metal alloy of the present invention can release hydrogen for one day or more, preferably three days or more, more preferably one week or more, particularly preferably two weeks or more.
水素吸蔵金属又は金属合金は高温、例えば270℃以上で水素を放出し得るが、常温常圧化で湿度が低くコントロールされた状態では、水素を放出することはない。また、樹脂は水を透過しにくいので、水素吸蔵金属又は金属合金を常温常圧で保存した場合、１年以上、好ましくは３年以上、さらに好ましくは５年以上、特に好ましくは10年以上は水素が放出されてなくなることはない。 A hydrogen storage metal or metal alloy can release hydrogen at high temperature, for example, 270 ° C. or higher, but does not release hydrogen in a state where the humidity is controlled to be low at normal temperature and pressure. In addition, since the resin does not easily permeate water, when the hydrogen storage metal or metal alloy is stored at normal temperature and pressure, it is preferably 1 year or more, preferably 3 years or more, more preferably 5 years or more, particularly preferably 10 years or more. There is no loss of hydrogen release.
また、コップ等の容器に水を入れ、発明の水素吸蔵金属又は金属合金を含む樹脂を入れ水素を発生させて水素含有水を製造することができる。 In addition, water can be placed in a container such as a cup, the resin containing the hydrogen storage metal or metal alloy of the invention can be placed, and hydrogen can be generated to produce hydrogen-containing water.
水素原子を吸蔵し保持している物質を有効成分として含む組成物は水素を発生させ、水素ガス又は水素水の状態にしてから、被験体に投与すればよい。 A composition containing a substance which occludes and holds a hydrogen atom as an active ingredient may generate hydrogen and make it into a hydrogen gas or hydrogen water state, and then administered to a subject.
本発明の水素を有効成分として含む運動持久力を向上させる組成物は、運動持久力の低下を自覚していたり、運動持久力を向上させることを希望していたり、運動後の疲労感軽減を希望する被験体に投与し、あるいは摂取させてもよい。 The composition for improving exercise endurance containing hydrogen as an active ingredient according to the present invention is aware of a decrease in exercise endurance, wishes to improve exercise endurance, or reduces fatigue after exercise It may be administered to or taken from a desired subject.
本発明の水素を有効成分として含む運動持久力を向上させ、又は運動後の疲労感を軽減させる組成物により、運動持久力を向上させ、運動後の疲労感を軽減させることができる。 The composition for improving exercise endurance containing hydrogen as an active ingredient or reducing fatigue after exercise according to the present invention can improve exercise endurance and reduce fatigue after exercise.
本発明の水素を有効成分として含む運動持久力を向上させ、又は運動後の疲労感を軽減させる組成物が効果があったか否かは、例えば、水素を有効成分として含む運動持久力を向上させ、又は運動後の疲労感を軽減させる組成物の投与又は摂取の前後での最大酸素摂取量の変化、又は自覚的運動強度指数の変化により確認することができる。すなわち、水素を有効成分として含む運動持久力を向上させる組成物を投与又は摂取した後に、最大酸素摂取量は1.5 mL/kg/min以上、好ましくは2.0mL/kg/min以上、さらに好ましくは3.0mL/kg/min以上増加する。また、ボルグの自覚的運動強度（ボルグ・スケール）の指数は0.35以上、好ましくは0.5以上、さらに好ましくは0.6以上低下する。あるいは、運動後の疲労感の軽減効果を、疲労のVAS (Visual Analogue Scale)検査により疲労感を評価してもよい。 Whether the composition for improving exercise endurance containing hydrogen as an active ingredient or reducing the feeling of fatigue after exercise according to the present invention is effective, for example, improves exercise endurance containing hydrogen as an active ingredient, Alternatively, it can be confirmed by a change in maximal oxygen uptake before or after administration or intake of a composition that reduces the feeling of fatigue after exercise, or a change in subjective exercise intensity index. That is, after administration or intake of a composition for improving exercise endurance containing hydrogen as an active ingredient, the maximum oxygen intake is 1.5 mL / kg / min or more, preferably 2.0 mL / kg / min or more, more preferably 3.0 Increase by more than mL / kg / min. Also, the index of Borg's subjective exercise intensity (Borg scale) decreases by 0.35 or more, preferably 0.5 or more, more preferably 0.6 or more. Alternatively, the effect of reducing fatigue after exercise may be evaluated by the Visual Analogue Scale (VAS) test for fatigue.
本発明を以下の実施例によって具体的に説明するが、本発明はこれらの実施例によって限定されるものではない。 The present invention is specifically described by the following examples, but the present invention is not limited by these examples.
運動持久力の向上
水素分子には、抗酸化作用があることが明らかにされ、水素水を飲用することで、認知機能の低下抑制、パーキンソン病の抑制、抗炎症作用、動脈硬化の抑制、腎臓の安定的移植、抗アレルギー効果、抗がん剤の副作用軽減などの効果があることが動物実験で明らかにされている。Improving exercise endurance It has been revealed that hydrogen molecules have an antioxidative effect, and drinking hydrogen water suppresses cognitive function decline, Parkinson's disease inhibition, anti-inflammatory action, arteriosclerosis inhibition, kidney Animal experiments have shown that it has effects such as stable transplantation, antiallergic effect, and side effect reduction of anticancer drugs.
ここでは、水素水を飲んだ経験のないボランティア60人にあらかじめ500mLの水を飲ませ、その10分後に体力測定をした。１週間後に30人には500mLの水素水（水素濃度1.0 ppm）を飲んでもらい、10分後に1週間前と同じ体力測定をした（水素水群）。同時に30人には、容器が水素水と同一のプラセボ水（水道水）500mLを飲んでもらい、前回と同じ体力測定を行った（プラセボ群）。１回目と２回目の体力測定を比較することによって、水素水飲用の体力への影響を調べた。 Here, 60 volunteers who did not have hydrogen water drink 500 mL of water beforehand, and 10 minutes after that, their physical strength was measured. One week later, 30 people drank 500 mL of hydrogen water (hydrogen concentration: 1.0 ppm), and after 10 minutes, the same physical strength measurement as one week ago was performed (hydrogen water group). At the same time, 30 people received 500 mL of placebo water (tap water), the same container as hydrogen water, and performed the same physical strength measurement as before (placebo group). By comparing the first and second strength measurements, the influence of drinking hydrogen water on the strength was examined.
被験者
被験者は、実験の趣旨を十分説明して同意を得たボランティアから年齢、男女比を考慮して、協力を得た。Subject Subject fully explained the purpose of the experiment and obtained consent, taking into consideration the age and gender ratio from volunteers who obtained consent.
被験者の年齢は、20歳代12名、30歳代12名、40歳代12名、50歳代12名、60歳代12名で、男女比は30：30である。 The subjects were 12 in their 20's, 12 in their 30's, 12 in their 40's, 12 in their 50's, 12 in their 60's, and their male / female ratio was 30:30.
水素水群とプラセボ群は、年齢、男女比が同じになるようにアトランダムに分類した。 The hydrogen water group and the placebo group were classified at random so that the age and sex ratio would be the same.
水の飲用
ボランティアに水道水を500mL一気に飲んでもらい、10分後に体力測定を開始した。その一週間後に水素水群の人には、水素水（1.0 ppm）を500mL飲んでもらい、10分後に体力測定を行った。プラセボ群の人には、水素水の容器につめたプラセボ水（水道水）500mLを飲ませ、10分後に体力測定をおこなった。Drinking water A volunteer was asked to drink 500 mL of tap water at once, and after 10 minutes, the physical strength measurement was started. One week after that, people in the hydrogen water group were given 500 mL of hydrogen water (1.0 ppm), and after 10 minutes, their physical strength was measured. People in the placebo group were given 500 mL of placebo water (tap water) in a container of hydrogen water, and after 10 minutes, their physical strength measurements were taken.
最大酸素摂取量
最大酸素摂取量（さいだいさんそせっしゅりょう、英: VO2max, maximal oxygen consumption）とは、漸増運動で測定された酸素消費の最大量のことで、通常は、モーター付のトレッドミルで計測される。最大酸素摂取量は有酸素運動能力を反映し、長時間の最大限下の運動持久力を決める重要な要素である。Maximum Oxygen Uptake Maximum Oxygen Uptake (English: VO 2 max, maximal oxygen consumption) is the maximum amount of oxygen consumption measured during incremental exercise, usually with a motor. Measured on a treadmill. Maximal oxygen uptake reflects aerobic exercise capacity and is an important factor in determining exercise endurance under maximum duration for a long time.
筋肉の運動が続く間、酸素を身体にどんどん取り込んで運動のエネルギーを作り出していく。酸素摂取量は時間の経過とともに右肩上がりに増加していくわけであるが、この運動を持続していくと、運動の強度が上がっても酸素摂取量は増加せずに頭打ちとなる部分が出現する。これが酸素摂取量の最大値で、個人における生理的な限界を意味する。 While the muscle exercise continues, oxygen is taken in more and more into the body to create the energy of exercise. Although oxygen intake gradually increases with the passage of time, if this exercise is sustained, even if the intensity of exercise increases, there is a part where the oxygen uptake does not increase but the leveling up Appear. This is the maximum value of oxygen uptake, meaning the physiological limit in the individual.
一般的に「mL/kg/min/」の単位で表され、体重1kg当り1分間にどれだけの酸素を摂取（利用）できるのか評価する。 Generally expressed in units of "mL / kg / min /", it is evaluated how much oxygen can be ingested (utilized) per 1 kg of body weight per minute.
Senoh Cordless Bike V70iを用いて、常法にしたがって最大酸素消費量を測定した。原理は、一定速度で（60回転／分）でバイクをこぎ、脈拍を測定する。ステップ的に３段階に負荷を増加し、その時の脈拍数の増加によって、最大負荷時の脈拍を推定し、最大酸素消費量（VO2max）（mL/kg/min）とした。運動時間は11分である。The maximum oxygen consumption was measured according to a conventional method using Senoh Cordless Bike V70i. The principle is to measure the pulse by riding the bike at a constant speed (60 rev / min). The load was increased stepwise in three steps, and the pulse rate at the maximum load was estimated by increasing the pulse rate at that time, and the maximum oxygen consumption (VO 2 max) (mL / kg / min) was obtained. The exercise time is 11 minutes.
自覚運動強度
さらに、運動後に自覚運動強度を申告してもらった。ボルグが作成した運動強度の表示法のひとつ、自覚的に感じる運動の強さを、非常に楽であるから非常にきついまで15段階の表現として分け、これに6〜20の整数を対応させている。きついと感じる方が数値は高くなる。図１にボルグの自覚的運動強度（RPE)を示す（1976 小野寺・宮下より）。Subjective exercise intensity Furthermore, I was asked to declare the subjective exercise intensity after exercise. One of Borg's display methods of exercise intensity, the intensity of exercise felt subjectively, is divided into 15 levels from extremely easy to very tight, and this corresponds to an integer of 6 to 20 There is. If you feel tight, the numbers will be higher. Figure 1 shows Borg's subjective exercise intensity (RPE) (from 1976 Onodera and Miyashita).
運動後の疲労感軽減
一般社団法人日本生活習慣病予防協会によると、疲労の度合いを数値化する指針として、エルゴメーター（自転車こぎ）運動による身体能力テストがあげられている（http://www.seikatsusyukanbyo.com/calendar/2008/000407.php）。
「非侵襲的な運動強度の評価方法の一つにBorgが提唱したRPE（rating perceived exertion）スケールがある。RPE は主観的な疲労感などを利用した運動強度指標である」（文献：エルゴメーター運動による血中乳酸と唾液中アミラーゼの変化 阿部征次 日本経大論集40巻第1号119-127）であり、RorgのRPEは運動強度指標であるが、主観的な疲労感を利用したものであり、疲労感の指標でもある。Alleviation of fatigue after exercise According to the Japan Society for the Prevention of Lifestyle Diseases, a physical ability test using an ergometer exercise is cited as a guideline for quantifying the degree of fatigue (http: // www) .seikatsusyukanbyo.com / calendar / 2008 / 000407.php).
"One of the non-invasive evaluation methods of exercise intensity is the RPE (rating perceived exercise) scale proposed by Borg. RPE is an exercise intensity index using subjective fatigue etc." (literature: Ergometer Changes in blood lactic acid and salivary amylase due to exercise Seiji Abe Nihon Keizai Univ. Collection Vol. 40 No. 1 119-127), and Rorg's RPE is an exercise intensity index, but using subjective fatigue It is also an indicator of fatigue.
抗疲労臨床評価ガイドライン（日本疲労学会 平成23年7月22日）では、疲労のVAS (Visual Analogue Scale)を用いることが推奨されている。この方法は、検査用紙に記されたいくつかの質問で、直線の左端の「疲れを全く感じていない最良の感覚」から右端の「何もできないほど疲れきった最悪の感覚」のあいだに自分で×を記入していき、判定する（http://hirougakkai.com/hyouka.pdf 抗疲労臨床評価ガイドライン）。 The Anti-Fatigue Clinical Evaluation Guideline (Japan Fatigue Society, July 22, 2011) recommends the use of the Visual Analogue Scale (VAS) for fatigue. This method is a number of questions written on the test sheet, and it is between the "best feeling not feeling tired at all" at the left end of the straight line and the "worst feeling that can not do anything tired" at the right end. Fill in the x and decide (http://hirougakkai.com/hyouka.pdf Anti-Fatigue Clinical Evaluation Guidelines).
ランダムに被験者の半数（３０人、水素水群１５人、プラセボ群１５人）に対して、VAS検査を用いて疲労感を評価し、疲労感軽減効果を判定した。 We randomly evaluated the feeling of fatigue using a VAS test on half of the subjects (30 people, 15 people in the hydrogen water group, and 15 people in the placebo group), and the effect of reducing the feeling of fatigue was judged.
結果
最大酸素摂取量の変化は、１週間後の結果から１週間前の結果を差し引き集計した。水素水群では、体力の増加が見られた者は24名で６名はやや低下した。変化の平均±標準偏差値は、3.08±5.75mL/kg/minであった。一方、プラセボ群では、増加が見られた者は12名で、18名はやや低下した。変化の平均±標準偏差値は、-0.14±5.65であり、やや低下していた。この両者をt-検定で統計処理を行うとP＝0.0324で、有意な差が認められた（図２、左のグラフが水素水群）。Results The change in maximal oxygen intake was calculated by subtracting the results of 1 week before from the results of 1 week after. In the hydrogen water group, 24 persons showed an increase in physical strength, and 6 persons decreased slightly. The mean ± standard deviation of change was 3.08 ± 5.75 mL / kg / min. On the other hand, in the placebo group, 12 showed an increase and 18 showed a slight decrease. The mean ± standard deviation of the change was −0.14 ± 5.65, which was slightly lower. When both were statistically processed by t-test, a significant difference was observed at P = 0.0324 (FIG. 2, left graph: hydrogen water group).
自覚運動強度の変化においては、水素水群では、２度目は前に比べて、楽になったと感じた者21名、同じと感じた者5名、きつく感じた者4名であった。プラセボ群では、２度目は前に比べて、楽になったと感じた者3名、同じと感じた者16名、きつく感じた者11名であった。水素水群では、平均±標準偏差値では、-0.70±1.09（マイナスは楽に感じたことを意味し、グラフでは縦軸は+と-は逆に表示している）。プラセボ群では、変化の平均±標準偏差値は、+0.37±1.38であった。この２群をt-検定にて統計処理をおこなうと、P＝0.0015であり、有意であった（図３：左のグラフが水素水群）。 Regarding the change in the subjective exercise intensity, in the hydrogen water group, the second time was 21 people who felt easier than before, 5 people who felt the same, and 4 people who felt tight. In the placebo group, the second time was 3 people who felt easier, 16 people who felt the same, and 11 people who felt tight compared to before. In the hydrogen water group, the mean ± standard deviation value is -0.70 ± 1.09 (minus means comfortable feeling, and in the graph, the vertical axis is opposite of + and-). In the placebo group, the mean ± standard deviation of change was + 0.37 ± 1.38. When these two groups were statistically processed by t-test, P = 0.0015, which was significant (FIG. 3: left graph: hydrogen water group).
疲労のVAS (Visual Analogue Scale)を用いた判定では、水素水群では、-12.47±8.50であり、プラセボ群では-6.67±4,70であった（図４：左のグラフが水素水群）。この結果により、水素水を飲んだ群では、主観的な運動後の疲労感が軽減しており、水素水を飲んでから運動すると運動後の疲労感が少ないことが示唆された。 Judgment using fatigue VAS (Visual Analogue Scale) was -12.47 ± 8.50 in the hydrogen water group and -6.67 ± 4, 70 in the placebo group (Fig. 4: left graph shows hydrogen water group) . The results suggest that in the group who drank hydrogen water, subjective feeling of fatigue after exercise is reduced, and after drinking hydrogen water, there is less fatigue after exercise.
結論
水素水を飲む事によって、最大酸素摂取量が増大することが明らかになり、水素水による持久力を含む体力の増強が示唆された。Conclusions It was found that drinking hydrogen water increased maximal oxygen uptake, suggesting that hydrogen water enhances physical fitness including endurance.
また、疲労のVAS (Visual Analogue Scale)を用いた判定により水素水を飲むことによって、運動後疲労感が軽減することが示された。 In addition, it was shown that the feeling of fatigue after exercise was reduced by drinking hydrogen water according to the judgment using VAS (Visual Analogue Scale) of fatigue.
本明細書で引用した全ての刊行物、特許および特許出願をそのまま参考として本明細書にとり入れるものとする。 All publications, patents and patent applications cited herein are incorporated herein by reference in their entirety.
本発明の水素を有効成分として含む組成物は、運動持久力の向上や運動後の疲労感軽減に利用できる。 The composition containing hydrogen of the present invention as an active ingredient can be used to improve exercise endurance and reduce fatigue after exercise.
１ ガス吸引用手段
２ 水素ガスを含む容器
３ 酸素ガス、不活性ガス、空気及び麻酔ガスからなる群から選択される少なくとも１種のガスを含む容器
４ 配管1 Means for
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| JP2000354696A (en) * | 1999-06-15 | 2000-12-26 | Joho Kagaku Kenkyusho:Kk | Equipment for continuous supply of hydrogen saturated water in great quantity to washing water, bath water, etc. |
| JP2014028714A (en) * | 2012-07-31 | 2014-02-13 | Kracie Home Products Ltd | Composition for generating hydrogen |
| WO2014132982A1 (en) * | 2013-02-27 | 2014-09-04 | 株式会社明治 | Anti-stress agent |
| JP2014532561A (en) * | 2012-08-27 | 2014-12-08 | シームス バイオニックス インコーポレイテッド | Acid water electrolyzer and method of using the acid water |
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| JP2000354696A (en) * | 1999-06-15 | 2000-12-26 | Joho Kagaku Kenkyusho:Kk | Equipment for continuous supply of hydrogen saturated water in great quantity to washing water, bath water, etc. |
| JP2014028714A (en) * | 2012-07-31 | 2014-02-13 | Kracie Home Products Ltd | Composition for generating hydrogen |
| JP2014532561A (en) * | 2012-08-27 | 2014-12-08 | シームス バイオニックス インコーポレイテッド | Acid water electrolyzer and method of using the acid water |
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