JPWO2014061714A1 - ケイ素含有カルボン酸誘導体 - Google Patents
ケイ素含有カルボン酸誘導体 Download PDFInfo
- Publication number
- JPWO2014061714A1 JPWO2014061714A1 JP2014514942A JP2014514942A JPWO2014061714A1 JP WO2014061714 A1 JPWO2014061714 A1 JP WO2014061714A1 JP 2014514942 A JP2014514942 A JP 2014514942A JP 2014514942 A JP2014514942 A JP 2014514942A JP WO2014061714 A1 JPWO2014061714 A1 JP WO2014061714A1
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl group
- hydrogen atom
- atom
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
金属マグネシウム(2.19 g, 91.3 mgatom)のテトラヒドロフラン(THF, 60 ml)懸濁液にヨウ素(小片)をくわえ、アルゴン雰囲気下、時折氷冷しつつブロモシクロプロパン(7.3 ml, 91.7 mmol)を滴下した。マグネシウムの溶解後反応容器を氷冷し、クロロ(クロロメチル)ジメチルシラン(10.0 ml, 75.9 mmol)のTHF (15 ml)溶液を約10分間で滴下、さらにTHF (5 ml)にて滴下容器を洗浄した。氷冷下30分、さらに室温にて16時間撹拌を続けた後、反応液を塩化アンモニウム-氷にあけ、ジエチルエーテルにて抽出。有機層を飽和食塩水で洗浄後常圧蒸留に付し、表記クロロメチル(シクロプロピル)ジメチルシラン(7.69 g, 68%)を無色油状物として得た。
1H-NMR (CDCl3) δ: -0.34 (1H, dddd, J=9.5, 9.5, 7, 7 Hz), 0.03 (6H, s), 0.23-0.29 (2H, m), 0.57-0.66 (2H, s), 2.80 (2H, s).
1H-NMR (CDCl3) δ: -0.37 (1H, dddd, J=9.5, 9.5, 7, 7 Hz), 0.020 (3H, s), 0.023 (3H, s), 0.21-0.27 (2H, m), 0.57-0.68 (2H, m), 1.26 (1H, dd, J=14.5, 9 Hz), 1.32 (1H, dd, J=14.5, 7 Hz), 1.33 (3H, t, J=7 Hz), 3.55 (1H, dd, J=9, 7 Hz), 4.20-4.31 (2H, m).
1H-NMR (CDCl3) δ: -0.36 (1H, dddd, J=9.5, 9.5, 7, 7 Hz), 0.02 (6H, s), 0.18-0.29 (2H, m), 0.57-0.69 (2H, m), 0.90 (1H, dd, J=14.5, 5.5 Hz), 1.05 (1H, dd, J=14.5, 10.5 Hz), 1.29 (3H, t, J=7 Hz), 2.60 (1H, dd, J=16.5, 7 Hz), 2.75 (1H, dd, J=16.5, 7.5 Hz), 3.13 (1H, dddd, J=10.5, 7.5, 7, 5.5 Hz), 4.20 (2H, q, J=7 Hz).
1H-NMR (CD3OD) δ: -0.38 (1H, dddd, J=9.5, 9.5, 7, 7 Hz), -0.04 (6H, s), 0.20-0.27 (2H, m), 0.57-0.64 (2H, m), 0.66 (1H, dd, J=15, 6 Hz), 0.73 (1H, dd, J=15, 8 Hz), 2.18-2.30 (1H, m), 2.33 (1H, dd, J=15.5, 9 Hz), 2.54 (1H, dd, J=15.5, 3 Hz), 2.87 (1H, dd, J=12.5, 7.5 Hz), 2.98 (1H, dd, J=12.5, 3.5 Hz).
Claims (3)
- R1がシクロプロピル基であり、R2及びR3がメチル基であり、nが0又は1であり、R4がアミノ基、モノアルキルアミノ基、又はアシルアミノ基であり、R5が-(CH2)p-COOR6(pは0から3の整数を示し、R6は水素原子又はアルキル基である)である請求項1に記載の化合物又はその塩。
- R1がシクロプロピル基であり、R2及びR3がメチル基であり、nが1であり、R4がアミノ基であり、R5が-(CH2)p-COOR6(pは0から3の整数を示し、R6は水素原子又はアルキル基である)である請求項1に記載の化合物又はその塩。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261715399P | 2012-10-18 | 2012-10-18 | |
US61/715,399 | 2012-10-18 | ||
PCT/JP2013/078121 WO2014061714A1 (ja) | 2012-10-18 | 2013-10-17 | ケイ素含有カルボン酸誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP5572783B1 JP5572783B1 (ja) | 2014-08-13 |
JPWO2014061714A1 true JPWO2014061714A1 (ja) | 2016-09-05 |
Family
ID=50488274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014514942A Expired - Fee Related JP5572783B1 (ja) | 2012-10-18 | 2013-10-17 | ケイ素含有カルボン酸誘導体 |
Country Status (5)
Country | Link |
---|---|
US (1) | US9353134B2 (ja) |
EP (1) | EP2910560B1 (ja) |
JP (1) | JP5572783B1 (ja) |
CN (1) | CN104781264A (ja) |
WO (1) | WO2014061714A1 (ja) |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2628245A (en) * | 1950-12-07 | 1953-02-10 | Dow Corning | Trialkylsilyladipic acid |
US6197819B1 (en) * | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
US5616793A (en) | 1995-06-02 | 1997-04-01 | Warner-Lambert Company | Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
US5637767A (en) | 1995-06-07 | 1997-06-10 | Warner-Lambert Company | Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
WO2002100344A2 (en) | 2001-06-11 | 2002-12-19 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
GB0301143D0 (en) * | 2003-01-17 | 2003-02-19 | Amedis Pharm Ltd | Compounds and their use |
WO2010017498A1 (en) | 2008-08-07 | 2010-02-11 | Xenoport, Inc. | Methods of synthesizing n-hydroxysuccinimidyl carbonates |
US8895769B2 (en) * | 2011-04-20 | 2014-11-25 | Kemphys Ltd. | Silicon-containing carboxylic acid derivative |
-
2013
- 2013-10-17 JP JP2014514942A patent/JP5572783B1/ja not_active Expired - Fee Related
- 2013-10-17 WO PCT/JP2013/078121 patent/WO2014061714A1/ja active Application Filing
- 2013-10-17 US US14/435,621 patent/US9353134B2/en not_active Expired - Fee Related
- 2013-10-17 EP EP13847854.0A patent/EP2910560B1/en not_active Not-in-force
- 2013-10-17 CN CN201380054365.6A patent/CN104781264A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2910560A4 (en) | 2016-06-15 |
EP2910560A1 (en) | 2015-08-26 |
WO2014061714A1 (ja) | 2014-04-24 |
CN104781264A (zh) | 2015-07-15 |
EP2910560B1 (en) | 2017-09-06 |
US9353134B2 (en) | 2016-05-31 |
JP5572783B1 (ja) | 2014-08-13 |
US20150232487A1 (en) | 2015-08-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TW536534B (en) | Difluoroprostaglandin derivatives and pharmaceutical composition comprising them | |
RU2435756C2 (ru) | Избирательные андрогенные рецепторные модуляторы | |
JP6149975B2 (ja) | 二環式化合物およびその医薬用途 | |
DK1704141T3 (en) | Prostaglandin nitrooxyderivatives | |
TWI225864B (en) | Amino acids with affinity for the alpha2delta-protein | |
JP2011037861A (ja) | C16不飽和fp−選択的プロスタグランジン類縁体 | |
JP5835236B2 (ja) | 二環式化合物およびその医薬用途 | |
AU2011237072B2 (en) | Therapeutic agent or prophylactic agent for fibromyalgia | |
JP5230847B2 (ja) | ケイ素含有カルボン酸誘導体 | |
JPWO2009057199A1 (ja) | レチノイドプロドラッグ化合物 | |
JP5572783B1 (ja) | ケイ素含有カルボン酸誘導体 | |
JP5284574B2 (ja) | レチノイドプロドラッグ化合物 | |
JP2011136905A (ja) | ベンゼン化合物及びその医薬用途 | |
JP5284964B2 (ja) | 5員複素環化合物 | |
US20210332009A1 (en) | Benzene derivative | |
JP2015137253A (ja) | フッ素含有カルボン酸誘導体 | |
JP7384179B2 (ja) | ベンゼン誘導体を含有する医薬組成物 | |
RU2811803C2 (ru) | Производное бензола | |
JPWO2011129365A1 (ja) | 抗がん剤 | |
JP2953817B2 (ja) | 安息香酸誘導体 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20140514 |
|
TRDD | Decision of grant or rejection written | ||
A975 | Report on accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A971005 Effective date: 20140528 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20140514 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20140617 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140630 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5572783 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |