JPWO2005032792A1 - Manufacturing method of ophthalmic lens article, ophthalmic lens article obtained by the same, and mold for ophthalmic lens article - Google Patents

Abstract

To provide a novel method for producing an ophthalmic lens article having a surface excellent in biocompatibility, and to provide such an ophthalmic lens article excellent in biocompatibility, and such an ophthalmic lens article. It is an object to provide a mold for manufacturing, and the first mold 12 and the second mold 14 that form a mold cavity having a shape that gives a target ophthalmic lens article 44 by mold matching, Electrodes 28 and 38 made of a conductive material are respectively disposed on at least a part of a portion for providing a molding cavity, and a monomer mixed solution containing at least an ionic monomer is filled in the pair of electrodes 28 and 38 in the molding cavity. In this state, a DC voltage was applied between the pair of electrodes 28 and 38 while the monomer mixture was polymerized.

Description

  The present invention relates to a method for producing an ophthalmic lens article, an ophthalmic lens article obtained by the method, and a mold for producing the ophthalmic lens article, and more particularly, a method for advantageously producing an ophthalmic lens article having excellent biocompatibility. Further, the present invention relates to an ophthalmic lens article obtained by such a method, and further relates to a mold that can be suitably used when molding such an ophthalmic lens article. Here, it should be understood that the ophthalmic lens article includes not only ophthalmic lenses such as contact lenses and intraocular lenses but also semi-finished products of these ophthalmic lenses.

Conventionally, some medical devices represented by contact lenses have been required to have high oxygen permeability for the purpose of supplying sufficient oxygen to a living body part to be contacted. At present, silicon-containing components are the most effective and versatile as materials that can impart high oxygen permeability to devices.
In recent years, contact lenses made of polymers such as silicon-containing monomers have been put into practical use. However, oxygen-permeable contact lenses formed from such silicon-containing monomers have a high surface water repellency and poor water wettability, so that the tears and lens surface become familiar when worn on the eye. The tears are repelled on the lens surface. Therefore, the wearer may be given an uncomfortable feeling such as dryness or foreign material. In addition, since it is difficult to exchange the tear fluid existing between the lens and the cornea, the lipid component in the tear fluid is likely to adhere to the lens surface, thereby improving the optical characteristics of the contact lens. There is also a risk of damage, blurring of the field of view, blurring, and the like. Thus, poor water wettability on the lens surface leads to poor biocompatibility.
Therefore, conventionally, in order to solve the above-mentioned problems caused by the water repellency and hydrophobicity of the lens surface, and to improve the biocompatibility of ophthalmic lens articles such as contact lenses, the lens surface is made hydrophilic, Various techniques have been proposed to improve the wettability and improve the familiarity with tears, and hence the familiarity between the cornea and the lens surface. For example, to give a specific example, a method of molding a contact lens using a polypropylene mold that has been subjected to plasma treatment before polymerization, or plasma treatment is performed on the surface of a contact lens material to improve water wettability. A method (Japanese Patent Publication No. 63-40293) and a method of grafting a hydrophilic monomer onto the surface of an ophthalmic lens (Japanese Patent Laid-Open No. 6-49251) have been proposed.
However, in a method of polymerizing a monomer mixture in a mold using a polypropylene mold subjected to plasma treatment before polymerization and molding a contact lens, the lens material is placed in the mold. After polymerization, it is very difficult to remove the polymer lens from the mold. In some cases, the lens may be damaged, and the plasma treatment precisely controls the surface modification of the mold. It was technically difficult to do so, and the reproducibility of the surface wettability of the obtained lens surface was poor. Moreover, even if such a complicated treatment is performed, only a few hydrophilic groups are present in a large number of hydrophobic groups on the lens surface.
In addition, a method of improving the wettability by performing plasma treatment on the surface of the contact lens material and a method of graft polymerizing a hydrophilic monomer on the surface of the ophthalmic lens are formed so as to have a predetermined lens shape. Since this is a method of chemically modifying the surface, it is likely to cause deformation of the material, which may threaten the optical function of the ophthalmic lens material, and part of the chemical bond on the lens surface is broken by plasma irradiation, thereby There was a possibility that the resulting decomposition product may inhibit the hydrophilicity of the lens surface.
Furthermore, in any of the methods described above, it is impossible to impart sufficient hydrophilicity to the lens surface, and in spite of the short duration of the effect, complicated processing steps are required. There are inherent problems such as increased time and cost for manufacturing the lens and reduced productivity.
On the other hand, in order to increase the hydrophilicity of the lens material, it is also considered to increase the blending ratio of the hydrophilic monomer in the monomer mixture that gives the lens material, but the blending ratio of the hydrophilic monomer is increased. As a result, the proportion of the monomer that contributes to the improvement of oxygen permeability, such as a silicon-containing monomer, inevitably decreases. Therefore, it has been extremely difficult to ensure both oxygen permeability and hydrophilicity at a high level.

Here, the present invention has been made in the background of such circumstances, and the problem to be solved is a novel lens for producing an ophthalmic lens article having a surface excellent in biocompatibility. It is to provide a method. Another object of the present invention is to provide an ophthalmic lens article excellent in biocompatibility, and a mold for producing the lens article.
And, as a result of intensive studies in order to solve such problems, the present inventors have filled a monomer mixture liquid containing an ionic monomer as a lens raw material into a molding cavity of a mold. The inventors have found that when such a mold is energized and molded, the surface of the obtained ophthalmic lens article is advantageously made hydrophilic, and excellent biocompatibility can be imparted.
Accordingly, the present invention has been completed based on such knowledge, and the first aspect thereof is that the first mold and the second mold are matched to each other. In the meantime, using a molding die configured to form a molding cavity having a shape that gives a target ophthalmic lens article, the molding cavity is filled with a monomer mixture containing at least an ionic monomer. A method for producing an objective ophthalmic lens article by molding by polymerization, wherein at least a part of the first and second molds providing the molding cavity is electrically conductive. An electrode made of a conductive material is disposed, and the monomer mixture filled in the molding cavity is brought into contact with the pair of electrodes, and a DC voltage is applied between the pair of electrodes. By moving the ionic monomer to either one or both sides of the pair of electrodes and polymerizing the monomer mixture, at least one of the surfaces of the ophthalmic lens article is obtained. In the method for producing an ophthalmic lens article, a surface layer having excellent biocompatibility is formed of a polymer having a higher polymerization ratio of the ionic monomer.
Further, in the second aspect of the method for producing an ophthalmic lens article according to the present invention, by applying a direct current voltage between the pair of electrodes, the monomer mixture solution filled in the molding cavity After the ionic monomer is moved to one or both sides of the pair of electrodes, the monomer mixture is polymerized in the moved state.
Furthermore, in the third aspect of the method for producing an ophthalmic lens article according to the present invention, a metal material, a conductive inorganic material, or a conductive organic material is employed as the conductive material.
In addition, in the fourth aspect of the method for manufacturing an ophthalmic lens article according to the present invention, the molding is performed so that the thickness of the surface layer excellent in biocompatibility is 100 μm or less.
In the fifth aspect of the method for producing an ophthalmic lens article according to the present invention, a zwitterionic monomer is used as the ionic monomer.
In the sixth aspect of the method for producing an ophthalmic lens article according to the present invention, the monomer mixture solution further containing a silicon-containing monomer is employed.
By the way, the present invention is also directed to an ophthalmic lens article obtained by the method for producing an ophthalmic lens article as described above, and has a droplet contact angle of the surface layer excellent in biocompatibility ( The embodiment is an ophthalmic lens article having a contact angle by a droplet method of 70 ° or less.
Furthermore, the present invention is also directed to a mold for an ophthalmic lens article that can be advantageously used in the method for producing an ophthalmic lens article as described above, and includes a first mold and a second mold. Are formed so that a molding cavity having a shape that gives a target ophthalmic lens article is formed between the molds, and at least an ionic monomer is contained in the molding cavity. A molding die in which the objective ophthalmic lens article is molded by polymerizing a monomer mixture, wherein at least one of the first and second molds providing the molding cavity is provided. An electrode made of a conductive material is disposed on each of the portions, and the monomer mixed solution filled in the molding cavity is brought into contact with the pair of electrodes, and the pair of electrodes A predetermined DC voltage to mold ophthalmic lenses article being characterized in that the leg sweep member can be applied, and with its one aspect to.
Moreover, in another aspect of the mold for the ophthalmic lens article according to the present invention, the electrode disposed on the first mold among the pair of electrodes is molded on the first mold side to provide the mold cavity. While constituting the entire cavity surface, the electrode arranged on the second mold constitutes a part of the molding cavity surface on the second mold side for providing the molding cavity, and the second mold However, it has a light transmission part which can perform photopolymerization.
By the way, according to the first aspect described above in the method for manufacturing an ophthalmic lens article according to the present invention, the pair of electrodes made of a conductive material is formed into a mold so as to come into contact with the monomer mixture filled in the molding cavity. In the state where the monomer mixture liquid which is a lens raw material is filled in the molding cavity of the molding die, a direct current voltage is applied between the pair of electrodes. The ionic monomer contained in the liquid moves to the cathode side, the anode side, or both electrode sides of the pair of electrodes.
Therefore, when a DC voltage is applied between the pair of electrodes while the polymerization of the monomer mixture filled in the molding cavity is started, the monomer mixture in the state where the ionic monomer in the monomer mixture has moved to the electrode The polymerization of the liquid will proceed. That is, since the polymerization of the monomer mixture proceeds in a state where the ionic monomer in the monomer mixture is attracted to the electrodes constituting at least a part of the molding cavity surface and oriented, the weight obtained after the polymerization is increased. On the surface of the ophthalmic lens article made of coalescence, a surface layer made of a polymer with an increased polymerization ratio of the ionic monomer is formed on the surface in contact with the electrode. High hydrophilicity (water wettability) is imparted to the portion where the surface layer is formed, and excellent biocompatibility is exhibited.
Further, according to the second aspect of the method for producing an ophthalmic lens article according to the present invention, after the ionic monomer in the monomer mixture is moved to the vicinity of the electrode, the polymerization is performed while maintaining the state. Therefore, a surface layer excellent in biocompatibility is formed more reliably.
Furthermore, according to the 3rd and 4th aspect of the manufacturing method of the ophthalmic lens article according to this invention, the surface layer excellent in biocompatibility will be formed advantageously.
Moreover, according to the fifth aspect of the method for producing an ophthalmic lens article according to the present invention, a monomer that becomes zwitterion (zwitterionic monomer) in the liquid is employed as the ionic monomer. Such an ionic monomer can move to either of the anode and the cathode.
In addition, in the sixth aspect of the method for producing an ophthalmic lens article according to the present invention, since a silicon-containing monomer is further added to the monomer mixture, the biocompatibility and the oxygen permeability are excellent. Ophthalmic lens articles are advantageously manufactured.
Moreover, in the ophthalmic lens article according to the present invention, the droplet contact angle of the surface layer as described above is 70 ° or less. For this reason, when such an ophthalmic lens article is used as, for example, a contact lens, an excellent wearing feeling or a feeling of use can be obtained because it is excellent in water wettability.
Furthermore, according to the above-described aspect of the mold for the ophthalmic lens article according to the present invention, the surface made of a polymer having a high polymerization rate of the ionic monomer is provided on the ophthalmic lens article obtained using such a mold. A layer will advantageously be formed.
In addition, in the mold for the ophthalmic lens article according to the present invention, if the light transmitting portion is formed, the ophthalmic lens article is molded by photopolymerization that allows easy polymerization and polymerization in a short time. Thus, the productivity of the ophthalmic lens article can be advantageously improved.

FIG. 1 is a cross-sectional explanatory view showing an example of a mold used for producing an ophthalmic lens article according to the present invention.
FIG. 2 is a cross-sectional explanatory view of a male mold constituting the mold shown in FIG.
FIG. 3 is a cross-sectional explanatory view of a female mold constituting the mold shown in FIG.
FIG. 4 is an explanatory plan view of the female mold shown in FIG.
FIG. 5 is an explanatory view showing an example of a process for producing an ophthalmic lens article according to the method of the present invention, and shows a state in which a monomer mixed solution is accommodated in a female hemispherical part under a mold open state. ing.
FIG. 6 is an explanatory view showing an example of a process for producing an ophthalmic lens article according to the method of the present invention, and a monomer mixed solution filled in a molding cavity when a DC voltage is applied between electrodes. It is the image figure which showed the state which the ionic monomer in it moves to the vicinity of an electrode.
FIG. 7 is an explanatory view showing another example of a process for producing an ophthalmic lens article according to the method of the present invention, and is intended for use in a molding cavity formed between a male mold and a female mold. The state which carried out the mold polymerization of the ophthalmic lens article is shown.
FIG. 8 is an explanatory view showing another example of a process for producing an ophthalmic lens article according to the method of the present invention, and shows a state in which the mold is opened after molding.
FIG. 9 is a cross-sectional explanatory view showing three types of molds used in the examples. (A) shows an electrode (anode) made of an aluminum film and a point electrode (cathode) made of a brass needle. ) Is a cross-sectional explanatory view of the forming die A, and (b) is a forming in which an electrode (anode) made of an aluminum film and a flat plate electrode (cathode) made of a brass circular plate are arranged. It is sectional explanatory drawing of the type | mold B, Furthermore, (c) is sectional explanatory drawing of the shaping | molding die C made from the conventional polypropylene in which the electrode is not provided.
FIG. 10 is a graph showing the transition of the current value flowing between the pair of electrodes immediately after the start of energization in Test Example 1 of the example.
FIG. 11 is a graph showing the transition of the current value flowing between a pair of electrodes immediately after the start of energization in Test Example 4 of the example.
FIG. 12 is an explanatory view for showing a contact angle measurement site in a circular plate-shaped polymer sample formed in Test Example 4 of the Example, and (a) is an upper mold side of the polymer sample. FIG. 4B is a plan view of the surface facing the surface of the mold, and FIG. 5B is a cross-sectional view of the mold B before the polymer sample is demolded, and FIG. FIG. 2 shows a plan view of the side facing surface.
FIG. 13 is a graph showing the transition of the value of current flowing between a pair of electrodes immediately after the start of polymerization in Test Example 6 of the example.

なお、上記したモノマー混合液４２におけるイオン性モノマーの配合量は、特に制限されるものではないものの、余りにも少ないと、重合によって得られる眼用レンズ物品の表面における親水性が不充分となる一方、その配合量が多過ぎると、酸素透過性を向上せしめるためのモノマー成分等、他のモノマー成分を充分に配合することが出来なくなって、親水性以外に眼用レンズ物品に必要とされる他の特性を充分に確保することが出来なくなる恐れがあるところから、かかるイオン性モノマーは、好ましくは０．１〜２０重量％、より好ましくは０．５〜１０重量％の割合において、モノマー混合液中に配合せしめられることが望ましい。
また、かかるモノマー混合液４２には、上記したイオン性モノマー以外にも、従来より眼用レンズ物品の原料として用いられてきている疎水性のモノマー成分や親水性のモノマー成分、例えば、シリコン含有（メタ）アクリレートやシリコン含有スチレン誘導体、シリコン含有マクロモノマー等のケイ素含有モノマー；フッ素含有スチレン誘導体、フッ素含有アルキル（メタ）アクリレート等のフッ素含有モノマー；（メタ）アクリル酸エステル；架橋性モノマー等が、適宜に選択されて含有せしめられるのである。特に、眼用レンズ物品に対して、優れた酸素透過性を付与したり、また、成形性を良好に確保して、複雑な形状のものを容易に成形するためには、シロキサンマクロモノマーやシロキサンモノマー等のケイ素含有モノマーが含有せしめられることが望ましい。なお、かかるケイ素含有モノマーを用いる場合、その配合量としては、一般に、３０〜９０重量％、好ましくは５０〜８０重量％の割合が好適に採用される。また、上記「・・・（メタ）アクリレート」なる表記は、「・・・アクリレート」及び「・・・メタクリレート」を含む総称として用いられており、また、その他の（メタ）アクリル誘導体についても同様である。
更に、かかるモノマー混合液４２には、必要に応じて、従来から一般的に用いられている各種の添加剤、例えば、紫外線吸収剤や色素等が、従来と同様に、適量において、添加せしめられても何等差支えなく、更には、非重合性の溶媒が、重合の妨げにならない程度の量において添加されていてもよい。
加えて、そのようなモノマー混合液４２は、従来と同様に、熱及び／又は光による重合が有利に実現されるように、採用する重合手法に見合った重合開始剤等が添加された状態で、上述せるように、成形型１０の成形キャビティ１６内に充填されることとなるのである。
かくして、モノマー混合液４２が、成形キャビティ１６内に充填されると、そこに収容されたモノマー混合液４２が、成形型１０に配された一対の電極に接触することとなる。そして、電極とモノマー混合液４２が接触した状態で、かかる一対の電極間（陽極２８−陰極３８間）に、直流電源２４から直流電圧を印加して、通電を行なうのである。
この際、電極間に印加する電圧は、コンタクトレンズを構成する材料や原料、成形型１０の材質等に応じて、適宜に設定されるのであり、特に制限されるものではない。例えば、コンタクトレンズの前面と後面の両面を親水化したい場合には、一対の電極に正負の直流電圧を印加することが望ましく、また、コンタクトレンズの片面のみを親水化する場合には、正負の何れかの電圧を一方の電極に印加し、他方の電極を０電位（アース）とすることも出来る。但し、印加する電圧は、正の電圧であっても、或いは負の電圧であっても何等差支えないのであるが、コンタクトレンズを構成する材料や原料、成形型１０を構成する材料が電気分解しない電圧が、採用されることとなる。何故なら、通電によって材料の分解が惹起されると、気泡が発生する等して、眼用レンズ物品の表面の仕上がりが悪くなる等、悪影響が生じることとなるからである。
このように電圧を印加して、通電を実施すると、第６図に示されるように、モノマー混合液４２中のイオン性モノマー４３が、一対の電極の何れか一方の側、或いは両方の側に移動することとなる。これにより、通電前にはモノマー混合液４２中に均一に存在せしめられていたイオン性モノマー４３が、通電によって、電極付近に引き寄せられて偏って存在するようにより、電極付近におけるイオン性モノマー４３の濃度が効果的に高められるのである。
そして、かかる通電により、イオン性モノマーが電極の近傍に移動しつつある状態で、或いは、イオン性モノマーの電極近傍への移動が略完了して、イオン性モノマーの濃度が変化しなくなった状態（換言すれば、電極間を流れる電流が一定となった状態）で、モノマー混合液４２の重合操作を実施するのである。このように、モノマー混合液４２に含有せしめられたイオン性モノマーが、静電的な相互作用によって、電極の周辺、つまり成形キャビティ面側に引きつけられた状態において、モノマー混合液４２の重合が進行せしめられると、重合終了後に得られる重合体（眼用レンズ物品）の表面には、通電を実施しないで重合された眼用レンズ物品に比して、より多くのイオン性モノマーが配向して存在せしめられ得ることとなるのであり、特に、電極が配された部位に対応する表面には、イオン性モノマーの重合割合が高められた重合体からなる表面層が形成されることとなるのである。従って、眼用レンズ物品たるコンタクトレンズには、かかる表面層にて、優れた親水性、ひいては生体適合性が付与されることとなる。また、かかる表面層による親水化の効果は長期間に亘って持続するのである。ここにおいて、上記した「イオン性モノマーの重合割合が高められた重合体」とは、イオン性モノマーの濃度分布が均一な通電前のモノマー混合液をそのまま重合して得られる重合体よりも、イオン性モノマーユニットが多く含まれた重合体を意味している。
なお、モノマー混合液４２への通電操作とモノマー混合物４２の重合操作は、同時に開始しても、或いは、通電操作を開始して、所定時間の経過の後に、重合操作を開始するようにしても良いのであるが、有利には、イオン性モノマーの移動が見かけ上無くなって、濃度分布の変化が生じなくなる状態まで、通電を実施した後、重合が開始せしめられることが望ましく、これによって、イオン性モノマーがより一層有利に電極（成形キャビティ面）側に配向せしめられた状態で、モノマー混合液４２の重合が実施されることとなる。そして、得られる眼用レンズ物品にあっては、より一層優れた親水性が付与されるようになるのである。また、重合操作の開始に先立って、モノマー混合液４２への通電を実施する場合、かかる通電操作は、重合操作を開始する際に終了するようにしても、或いは重合操作の途中で終了するようにしても、或いは、重合操作の終了と共に終了するようにしても良い。要するに、モノマー混合液４２の重合速度や、イオン性モノマーの移動速度等を勘案して、イオン性モノマーの重合割合が、電極の近傍で高くなるように通電処理を施せば良いのである。
ところで、上記モノマー混合液４２の重合方法としては、特に限定されるものではなく、モノマー混合液４２を室温〜約１３０℃の温度範囲で徐々に或いは段階的に加熱して重合せしめる熱重合法や、マイクロ波、紫外線、放射線（γ線）等の電磁波を照射して重合を行なう光重合法等、従来から公知の重合方法を何れも採用することが出来る。また、重合は、塊状重合法によって行なわれても良いし、溶媒等を用いた溶液重合法によって行なわれても良く、またその他の方法によって行なわれても良い。
そして、本実施形態においては、第７図に示されるように、紫外光を、光透過性を有する透明な雌型１４を通じて、成形キャビティ１６内に導入しており、光重合法にてモノマー混合液４２の重合を行なっている。
かくして、モノマー混合液４２が重合せしめられることにより、生成する重合体にて目的とする眼用レンズ物品たるコンタクトレンズ４４がモールド成形されるのである。そして、形成されたコンタクトレンズ４４には、雄型１２の後面成形キャビティ面２０に対応したベースカーブ面と、雌型１４の前面成形キャビティ面３４に対応したフロントカーブ面が付与されることとなる。
その後、第８図に示されるように、雄型１２を雌型１４から取り外すことにより、型開きを行ない、そして、かかる型開きの後、従来と同様な離型操作で、コンタクトレンズ４４を脱型すれば、目的とする眼用レンズ物品たるコンタクトレンズ４４が得られるのである。
このようにして得られたコンタクトレンズ４４にあっては、電極に接触していた部分に、イオン性モノマーの重合割合が高められた重合体からなる表面層が形成されるのである。従って、かかる表面層にて、コンタクトレンズ４４には、優れた親水性、ひいては生体適合性が付与されているのである。特に、本実施形態に係るコンタクトレンズ４４は、雄型１２の後面成形キャビティ２０の全面が電極であるところから、ベースカーブ面の親水性が極めて効果的に向上せしめられる。これによって、角膜への適合性が向上して、装用感が顕著に高められるのである。
このように、モノマー混合液４２中のイオン性モノマーが、レンズ表面に移動した状態で重合が行なわれ、得られる重合体にてコンタクトレンズが形成されているところから、イオン性モノマーの配合量をむやみに増加せしめなくても、従来に比して、優れた親水性が実現されることとなる。それ故、眼用レンズ物品に必要とされる酸素透過性を高度に維持したまま、レンズ表面の親水性を有利に改善することが出来るのである。
しかも、上述せる如くして眼用レンズ物品を製造すれば、眼用レンズ物品のモールド成形と同時に、眼用レンズ物品表面の親水性化を実施することが出来ることから、従来、眼用レンズ物品のモールド成形後に行なっていた煩雑な親水化処理工程も不要となり、レンズ製造に費やす時間やコストを有利に低減することも可能となる。
なお、上述せる如きイオン性モノマーの重合割合が高められた重合体からなる、生体適合性に優れた表面層は、液滴法による水滴の接触角が、７０°以下、好ましくは、５０°以下とされることが望ましい。
また、このような親水性を有利に実現するためには、上記したイオン性モノマーの重合割合が高められた表面層が、レンズ表面から、０．１〜１００μｍ、より好ましくは０．１〜１０μｍの厚みとなるように、形成されることが望ましいのである。何故なら、０．１μｍ未満では、表面層が形成されても、有効な親水性が発現され得ず、所望とする生体適合性を確保することが出来なくなるからであり、また、１００μｍを超える場合には、眼用レンズ物品自体の基材特性を損なう恐れがあるからである。尤も、上述せる如き表面層を、所望とする厚みにするには、電極間に印加する電圧の大きさや、通電時間、イオン性モノマーの配合量等を適宜に設定すればよい。
以上、本発明の代表的な実施形態について詳述してきたが、それは、あくまでも例示に過ぎないものであって、本発明は、そのような実施形態に係る具体的な記述によって、何等限定的に解釈されるものではないことが、理解されるべきである。
例えば、上記の実施形態では、雄型１２全体が導電性材料にて形成されていたため、雄型１２の後面成形キャビティ面２０の全面が、一方の電極として作用していたが、かかる後面成形キャビティ面２０の全面を電極とする必要は必ずしもなく、雌型１４と同様に、後面成形キャビティ面２０の一部のみを、導電性材料にて形成して、これを、一方の電極とすることも可能である。また、雌型１４にあっても、前面成形キャビティ面３４の一部を導電性材料にて形成して点電極とする以外にも、前面成形キャビティ面３４の全面を、導電性材料にて形成し、これを、もう一方の電極とすることも可能である。要するに、親水性を付与したいレンズ部位に対応する成形キャビティ面の部位に、電極を配するようにすれば良いのである。但し、一対の電極は、モノマー混合液４２が成形キャビティ１６内に充填された状態下で電気が通じるように、つまり、電極同士が直接接触せず、モノマー混合液４２の非充填下では、絶縁されるように、配されることとなる。
また、雄型１２と雌型１４を共に金属等の導電性材料にて形成することも可能であるが、上例のように、何れか一方の型に光透過部が形成されるように構成することが、望ましい。何故なら、何れか一方の型に光透過性材料からなる透過部を設ければ、光重合法にて、モノマー混合液４２の重合を実施することが可能となるからである。
また、上記実施形態では、雄型１２全体が導電性材料にて形成されていたが、例えば、雄型を樹脂材料にて作製し、かかる樹脂製の雄型の下底部１８の凸面に、導電性材料をコーティングして、その導電性材料からなるコーティング層を電極としたり、或いは、樹脂製の雄型１２の所定の部位に、導電性材料を埋め込み、その部分を電極とすることも可能である。同様に、雌型１４についても、各種の形態において、適宜に電極が配されることとなる。
さらに、上例では、第一の型である雄型１２に配される電極が、直流電源のプラス端子に接続されて、陽極とされる一方、第二の型である雌型１４に配される電極が、直流電源のマイナス端子に接続されて、陰極とされていたが、何れの電極が陽極であっても、或いは陰極であっても良いのであり、レンズ表面の所望とする部位が親水性化され得るように、イオン性モノマーの種類等を勘案して、適宜に設定されることとなる。
加えて、前記実施形態では、コンタクトレンズを成形するための成形型及びその製造方法に対して本発明を適用したものの具体例を示したが、本発明は、そのようなコンタクトレンズの他、眼内レンズ等の眼用レンズ、或いは、それらの眼用レンズの半完成品（例えば、一方の面が完成されたレンズ面形状に成形されている一方、他方の面が、レンズ面としては未だ完成されていない、切削加工等の後加工を必要とする形状に成形された、該眼用レンズを与える眼用レンズ材料）等の、所謂眼用レンズ物品を成形するための成形型及びそれらの製造方法に対しても、有利に適用され得る。そして、特に、眼用レンズ物品が眼用レンズの半完成品の場合には、少なくとも目的とする眼用レンズのレンズ形状に完成された側の面に、親水性が付与されることとなる。
その他、一々列挙はしないが、本発明が、当業者の知識に基づいて、種々なる変更、修正、改良等を加えた態様において実施され得るものであり、また、そのような実施態様が、本発明の趣旨を逸脱しない限り、何れも、本発明の範囲内に含まれるものであることは、言うまでもないところである。Hereinafter, in order to clarify the present invention more specifically, the configuration of a mold for an ophthalmic lens article and a method for manufacturing an ophthalmic lens article according to the present invention will be described in detail with reference to the drawings. To do.
First, FIG. 1 shows a specific example of a mold polymerization mold for molding an ophthalmic lens article (here, a contact lens). The mold 10 of the present embodiment is shown as a cross-sectional view, and includes a male mold (upper mold) 12 as a first mold and a female mold (lower mold) 14 as a second mold. Have and be configured. Then, when the male mold 12 and the female mold 14 are matched with each other, a molding cavity 16 having a shape that gives a target contact lens is formed between the molds.
More specifically, the male mold 12 constituting the molding die 10 is entirely made of a conductive material, and as shown in FIG. 2, the bottomed cylinder has an open top as a whole. It has a shape. The lower bottom portion 18 located at the lower portion has a curved surface shape that protrudes outward, and the outer surface (convex surface) of the lower bottom portion 18 is accurate to the rear surface (base curve surface) of the target contact lens. The rear surface forming cavity surface 20 having a shape corresponding to the above is provided. Further, an outer flange portion 22 that protrudes radially outward is integrally formed on the outer peripheral portion on the upper opening side of the cylindrical wall portion 21. Further, as shown in FIG. 1, a lead wire 26 connecting the male mold 12 and the positive terminal of the DC power source 24 is provided at an appropriate portion of the male mold 12 (here, the outer flange portion 22). The male mold 12 as a whole constitutes one electrode (in this case, the anode 28) when energized. That is, the entire rear molding cavity surface 20 of the male mold 12 is the anode 28.
On the other hand, the female die 14 constituting the mold 10 is formed of a transparent material that allows light to pass except for a part of the center. As shown in FIG. It has a bottomed truncated cone shape. And the upper bottom part 30 located in the upper part is made into the shape which became depressed in the downward direction in the substantially hemispherical shape. Further, as shown in FIGS. 3 and 4, a cylindrical or rod-like conductor 32 made of a conductor material is provided at the center of the concave surface of the upper bottom portion 30, and the upper surface thereof is a concave surface of the upper bottom portion 30. So that they are flush with each other. More specifically, a cylindrical or rod-like conductor 32 having the same size as the through hole is provided in the through hole provided in the center of the concave surface of the upper bottom portion 30 in the vertical direction. The conductor 32 is integrally attached by being inserted so that the upper surface of 32 is flush with the concave surface of the upper bottom portion 30 and completely filling the through hole of the upper bottom portion 30. Then, the substantially entire surface of the upper surface of the conductor 32 and the concave surface of the upper bottom portion 30 (specifically, the portion below the contact portion 41 described later) is accurately on the front surface (front curve surface) of the target contact lens. The front molding cavity surface 34 corresponding to the above is provided.
Also, below the conductor 32, as shown in FIG. 1, a lead wire 36 that connects the conductor 32 and the negative terminal of the DC power source 24 is detachably attached. Sometimes, the conductor 32 forms one electrode (here, the cathode 38). That is, the front molding cavity surface 34 of the female die 14 is partly composed of a point electrode (cathode 38). The female die 14 is integrally formed with an outer flange portion 40 projecting radially outward at a lower portion of the side wall portion 39.
1, the male mold 12 and the female mold 14 are brought into contact so that the center of the rear molding cavity surface 20 of the male mold 12 and the center of the front molding cavity surface 34 of the female mold 14 coincide with each other. At least, by assembling them and matching the molds, a molding cavity 16 having a shape that gives a target contact lens is formed below the contact portion 41 in the space between the molds. ing. In other words, the molding cavity 16 is formed in the space between the rear molding cavity surface 20 of the male mold 12 and the front molding cavity surface 34 of the female mold 14.
In addition, the male mold 12 and the female mold 14 are matched with each other, so that a pair of electrodes (the anode 28 and the cathode 38) are opposed to each other with the molding cavity 16 therebetween. Will be placed. That is, the pair of electrodes are arranged so as to be exposed to the molding cavity 16 without being directly contacted and short-circuited. And if the monomer mixture which gives the polymer which comprises a contact lens is filled in this shaping | molding cavity 16, this monomer mixture will contact each electrode.
By the way, each of the pair of electrodes described above is formed of a predetermined conductive material. However, such a conductive material is not particularly limited, and may be a polymer that forms a contact lens. A conventionally known material having conductivity can be appropriately selected in consideration of affinity, affinity with a monomer mixed solution that gives the polymer, cost, moldability, and the like. Specific examples of such conductive materials include, for example, metals such as pure metals, iron-based alloys, and non-ferrous alloys; conductive inorganic materials such as conductive glass; conductive organic materials such as conductive polymers. I can do it. Among these, considering the workability and conductivity of the mold, a copper alloy or an aluminum alloy is particularly preferably employed.
Note that the degree of conductivity of the conductive material is not particularly limited, but if the conductivity is too low, it becomes difficult to energize, so the resistivity is 10 ⁻⁸ to 10 ^3. A material that is Ω · m, more preferably 10 ⁻⁸ to 10 ⁻¹ Ω · m, can be suitably employed.
Further, in the female mold 14 according to the present embodiment, parts other than the conductor 32 described above are formed of a light transmissive material. Even in this light transmissive material, considering the affinity, cost, and moldability with the polymer constituting the contact lens and the monomer mixture liquid that gives it, it is appropriately selected from the known light transmissive materials. Specific examples of the light transmissive material include, for example, resin materials such as polyolefins such as polyethylene and polypropylene, polyamides such as nylon 6, nylon 66, nylon 610, nylon 612, nylon 11 and nylon 12, and the like. Glass, quartz, fused quartz and the like. Among these, considering moldability and economic efficiency, resin materials such as polyolefin and polyamide are particularly preferably employed.
As described above, in the mold 10 according to the present embodiment, although a part of the center of the female mold 14 is a point electrode made of a conductive material, the other part is made of a light transmissive material. Since the light transmitting portion is used, the polymerization operation can be carried out sufficiently by photopolymerization. Needless to say, when carrying out photopolymerization, light is irradiated from the side of the female die 14 having the light transmitting portion.
Thus, when the mold 10 having the structure as described above is used to mold (polymerize) a contact lens, which is a target ophthalmic lens article, for example, the following method is used. Will be adopted.
That is, first, as shown in FIG. 5, a monomer that gives a polymer constituting a contact lens, which is a target ophthalmic lens article, from a predetermined supply device (not shown) in the recess of the upper bottom 30 of the female mold 14. The liquid mixture 42 is supplied in a predetermined amount.
Then, by assembling the male mold 12 and the female mold 14 so that the center of the rear molding cavity surface 20 of the male mold 12 and the center of the front molding cavity surface 34 of the female mold 14 coincide, A molding cavity 16 is formed between the male mold 12 and the female mold 14 (see FIG. 1), and the monomer mixture liquid 42 is filled into the molding cavity 16.
In addition, as the monomer mixed solution 42 used here, the type of contact lens (for example, hard, soft, non-hydrous, hydrous, etc.) and characteristics required for the contact lens (for example, oxygen permeation) Depending on the property, etc., a monomer mixture of various blending compositions, which is suitably blended with two or more conventionally known monomer components, will be used in the present invention. In the monomer mixed solution 42, a component having a charge such as a cation, an anion, or a zwitter ion (zwitter ion), in other words, at least one ionic monomer having an anionic group and / or a cationic group is contained. Need to be included. This is because the ionic monomer is a hydrophilic component having a strong affinity for water, and if it cannot be contained, even if a predetermined DC voltage is applied between a pair of electrodes as described later, the ionic monomer is ionic. This is because a surface layer made of a polymer having a high monomer polymerization rate is not formed, and an ophthalmic lens article excellent in biocompatibility (for example, hydrophilicity) cannot be produced.
Such an ionic monomer is not particularly limited, and examples thereof include unsaturated compounds having an anionic group or a cationic group such as a carboxyl group, an amino group, a substituted amino group, a sulfonic acid group, a sulfonyl group, and a phosphoryl group. More specifically, anionic monomers such as (meth) acrylic acid and 2- (meth) acryloyloxyethyl acid phosphoate, and cations such as 2-aminoethyl (meth) acrylate and dimethylaminoethyl (meth) acrylate Monomers, 2-acrylamido-2-methylpropanesulfonic acid (AMPS) represented by the following structural formula (I), 2-methacryloyloxyethyl phosphorylcholine (MPC) represented by the following structural formula (II), N- ( (Meth) acryloyloxyethyl-N, N, N-trimethyla Zwitterionic monomers (amphoteric monomers) such as monium chloride (METAC), N- (3-sulfopropyl) -N- (meth) acryloyloxyethyl-N, N-dimethylammonium betaine (SPE), etc. Known unsaturated compounds can be exemplified, and at least one or two or more of such ionic monomers can be appropriately selected and used, and among them, in particular, AMPS and MPC When the zwitterionic monomer such as is used, a surface layer excellent in biocompatibility is efficiently formed on the surface of the obtained ophthalmic lens article. It will be used suitably.

The amount of the ionic monomer in the monomer mixture 42 is not particularly limited, but if it is too small, the hydrophilicity on the surface of the ophthalmic lens article obtained by polymerization becomes insufficient. If the blending amount is too large, other monomer components such as a monomer component for improving oxygen permeability cannot be blended sufficiently. The ionic monomer is preferably 0.1 to 20% by weight, more preferably 0.5 to 10% by weight, because there is a possibility that the above characteristics cannot be sufficiently secured. It is desirable to be blended in.
In addition to the ionic monomers described above, the monomer mixed solution 42 includes a hydrophobic monomer component and a hydrophilic monomer component that have been conventionally used as raw materials for ophthalmic lens articles, such as silicon-containing ( Silicon-containing monomers such as (meth) acrylate, silicon-containing styrene derivatives, silicon-containing macromonomers; fluorine-containing monomers such as fluorine-containing styrene derivatives and fluorine-containing alkyl (meth) acrylates; (meth) acrylic acid esters; crosslinkable monomers, It is appropriately selected and contained. In particular, in order to impart excellent oxygen permeability to ophthalmic lens articles, and to ensure good moldability and easily mold complex shapes, siloxane macromonomer and siloxane It is desirable to include a silicon-containing monomer such as a monomer. In addition, when using this silicon-containing monomer, as a compounding quantity, generally the ratio of 30 to 90 weight%, Preferably 50 to 80 weight% is employ | adopted suitably. The notation "... (meth) acrylate" is used as a general term including "... acrylate" and "... methacrylate", and the same applies to other (meth) acryl derivatives. It is.
Further, in the monomer mixed solution 42, various additives conventionally used in general, for example, ultraviolet absorbers and dyes, etc., are added in appropriate amounts as in the conventional case, as necessary. However, the non-polymerizable solvent may be added in such an amount that does not interfere with the polymerization.
In addition, such a monomer mixed solution 42 is added with a polymerization initiator or the like suitable for the polymerization technique employed so that polymerization by heat and / or light can be advantageously realized as in the conventional case. As described above, the molding cavity 16 of the mold 10 is filled.
Thus, when the monomer mixed liquid 42 is filled in the molding cavity 16, the monomer mixed liquid 42 accommodated therein comes into contact with the pair of electrodes disposed in the mold 10. In a state where the electrode and the monomer mixed solution 42 are in contact with each other, a DC voltage is applied from the DC power source 24 between the pair of electrodes (between the anode 28 and the cathode 38) to conduct electricity.
At this time, the voltage applied between the electrodes is appropriately set according to the material and raw material constituting the contact lens, the material of the molding die 10 and the like, and is not particularly limited. For example, when it is desired to make both the front and back surfaces of a contact lens hydrophilic, it is desirable to apply a positive / negative DC voltage to a pair of electrodes, and when only one surface of a contact lens is made hydrophilic, positive / negative Either voltage can be applied to one electrode, and the other electrode can be set to zero potential (ground). However, the applied voltage may be a positive voltage or a negative voltage. However, the material and raw materials constituting the contact lens and the material constituting the mold 10 are not electrolyzed. A voltage will be employed. This is because when the material is decomposed by energization, bubbles are generated, and the surface finish of the ophthalmic lens article is deteriorated.
When the voltage is applied in this way and energization is performed, as shown in FIG. 6, the ionic monomer 43 in the monomer mixed solution 42 is applied to one or both sides of the pair of electrodes. Will move. As a result, the ionic monomer 43 that has been uniformly present in the monomer mixture 42 before energization is attracted to the vicinity of the electrode by energization and is biased. The concentration is effectively increased.
And by such energization, the state where the ionic monomer is moving to the vicinity of the electrode, or the movement of the ionic monomer to the vicinity of the electrode is almost completed, and the concentration of the ionic monomer is not changed ( In other words, the polymerization operation of the monomer mixture 42 is performed in a state where the current flowing between the electrodes is constant. In this way, the polymerization of the monomer mixture 42 proceeds in a state where the ionic monomer contained in the monomer mixture 42 is attracted to the periphery of the electrode, that is, the molding cavity surface side by electrostatic interaction. When it is allowed to stand, more ionic monomers are present on the surface of the polymer (ophthalmic lens article) obtained after the completion of the polymerization than in the ophthalmic lens article polymerized without conducting electricity. In particular, a surface layer made of a polymer in which the polymerization rate of the ionic monomer is increased is formed on the surface corresponding to the portion where the electrode is disposed. Accordingly, the contact lens as an ophthalmic lens article is imparted with excellent hydrophilicity and thus biocompatibility in the surface layer. Moreover, the effect of hydrophilization by such a surface layer lasts for a long time. Here, the above-mentioned “polymer with increased polymerization ratio of ionic monomer” means that the ionic monomer concentration distribution is more ionic than the polymer obtained by directly polymerizing the monomer mixture before energization. It means a polymer containing a large number of functional monomer units.
The energization operation to the monomer mixture 42 and the polymerization operation of the monomer mixture 42 may be started at the same time, or the energization operation may be started and the polymerization operation may be started after a predetermined time has elapsed. Advantageously, it is desirable that the polymerization be initiated after energization to a state where the migration of the ionic monomer is apparently absent and no change in concentration distribution occurs, thereby allowing the ionic The polymerization of the monomer mixed solution 42 is carried out in a state where the monomer is more advantageously oriented to the electrode (molding cavity surface) side. And in the obtained ophthalmic lens article, even better hydrophilicity is imparted. Further, when energizing the monomer mixed solution 42 prior to the start of the polymerization operation, the energization operation may be terminated when the polymerization operation is started or may be completed in the middle of the polymerization operation. Alternatively, it may be ended with the end of the polymerization operation. In short, in consideration of the polymerization rate of the monomer mixture 42, the transfer rate of the ionic monomer, and the like, the energization treatment may be performed so that the polymerization rate of the ionic monomer is high in the vicinity of the electrode.
By the way, the polymerization method of the monomer mixed solution 42 is not particularly limited, and a thermal polymerization method in which the monomer mixed solution 42 is polymerized by heating gradually or stepwise in a temperature range of room temperature to about 130 ° C. Any conventionally known polymerization method such as a photopolymerization method in which polymerization is performed by irradiation with electromagnetic waves such as microwaves, ultraviolet rays, and radiation (γ rays) can be employed. The polymerization may be performed by a bulk polymerization method, a solution polymerization method using a solvent or the like, or may be performed by other methods.
In this embodiment, as shown in FIG. 7, ultraviolet light is introduced into the molding cavity 16 through a transparent female mold 14 having light transmittance, and monomer mixing is performed by a photopolymerization method. Polymerization of the liquid 42 is performed.
Thus, when the monomer mixed solution 42 is polymerized, the contact lens 44 as a target ophthalmic lens article is molded by the polymer to be produced. The formed contact lens 44 is provided with a base curve surface corresponding to the rear molding cavity surface 20 of the male mold 12 and a front curve surface corresponding to the front molding cavity surface 34 of the female mold 14. .
Thereafter, as shown in FIG. 8, the male mold 12 is removed from the female mold 14 to open the mold, and after such mold opening, the contact lens 44 is removed by a conventional mold release operation. If the mold is formed, the contact lens 44 as a target ophthalmic lens article can be obtained.
In the contact lens 44 obtained in this manner, a surface layer made of a polymer having a high polymerization rate of the ionic monomer is formed in the portion that has been in contact with the electrode. Therefore, in such a surface layer, the contact lens 44 is imparted with excellent hydrophilicity and eventually biocompatibility. In particular, in the contact lens 44 according to the present embodiment, the hydrophilicity of the base curve surface is extremely effectively improved because the entire surface of the rear molding cavity 20 of the male mold 12 is an electrode. As a result, compatibility with the cornea is improved, and wearing comfort is remarkably enhanced.
As described above, the ionic monomer in the monomer mixed solution 42 is polymerized in a state where it moves to the lens surface, and the contact lens is formed from the resulting polymer. Even if it is not increased unnecessarily, superior hydrophilicity will be realized as compared with the prior art. Therefore, the hydrophilicity of the lens surface can be advantageously improved while maintaining the oxygen permeability required for the ophthalmic lens article at a high level.
Moreover, if the ophthalmic lens article is manufactured as described above, the ophthalmic lens article surface can be made hydrophilic simultaneously with the molding of the ophthalmic lens article. This eliminates the need for a complicated hydrophilization process that has been carried out after the molding of the lens, and it is possible to advantageously reduce the time and cost for manufacturing the lens.
In addition, the surface layer excellent in biocompatibility composed of a polymer with an increased polymerization ratio of the ionic monomer as described above has a water droplet contact angle of 70 ° or less, preferably 50 ° or less by a droplet method. It is desirable that
Further, in order to advantageously realize such hydrophilicity, the surface layer in which the polymerization rate of the ionic monomer is increased is 0.1 to 100 μm, more preferably 0.1 to 10 μm from the lens surface. It is desirable to form so that it may become thickness of this. This is because if it is less than 0.1 μm, effective hydrophilicity cannot be expressed even if a surface layer is formed, and the desired biocompatibility cannot be ensured, and if it exceeds 100 μm. This is because the substrate characteristics of the ophthalmic lens article itself may be impaired. However, in order to make the surface layer as described above have a desired thickness, the magnitude of the voltage applied between the electrodes, the energization time, the blending amount of the ionic monomer, and the like may be appropriately set.
The exemplary embodiments of the present invention have been described in detail above. However, the embodiments are merely examples, and the present invention is limited in any way by specific descriptions according to such embodiments. It should be understood that it is not interpreted.
For example, in the above embodiment, since the entire male mold 12 is formed of a conductive material, the entire rear molding cavity surface 20 of the male mold 12 acts as one electrode. It is not always necessary to use the entire surface 20 as an electrode. Like the female mold 14, only a part of the rear molding cavity surface 20 is formed of a conductive material, and this may be used as one electrode. Is possible. In addition, even in the female mold 14, the entire front molding cavity surface 34 is formed of a conductive material in addition to forming a part of the front molding cavity surface 34 of a conductive material to be a point electrode. However, this can be used as the other electrode. In short, it is only necessary to arrange the electrode at a part of the molding cavity surface corresponding to the lens part to which hydrophilicity is desired. However, the pair of electrodes are insulated so that electricity can be conducted in a state where the monomer mixed solution 42 is filled in the molding cavity 16, that is, the electrodes are not in direct contact with each other and are not filled with the monomer mixed solution 42. As will be done, it will be arranged.
It is also possible to form both the male mold 12 and the female mold 14 with a conductive material such as a metal, but as shown in the above example, the light transmitting portion is formed in either one of the molds. It is desirable to do. This is because if one of the molds is provided with a transmission part made of a light transmissive material, the monomer mixture 42 can be polymerized by a photopolymerization method.
In the above embodiment, the entire male mold 12 is formed of a conductive material. However, for example, a male mold is made of a resin material, and a conductive material is formed on the convex surface of the lower bottom portion 18 of the resin male mold. It is also possible to coat a conductive material and use the coating layer made of the conductive material as an electrode, or to embed a conductive material in a predetermined part of the male mold 12 made of resin and use that part as an electrode. is there. Similarly, with respect to the female die 14, electrodes are appropriately arranged in various forms.
Further, in the above example, the electrode disposed on the male mold 12 as the first mold is connected to the positive terminal of the DC power source to serve as the anode, while disposed on the female mold 14 as the second mold. The electrode is connected to the negative terminal of the DC power source to be a cathode, but any electrode may be an anode or a cathode, and the desired part of the lens surface is hydrophilic. In view of the nature of the ionic monomer, it is set appropriately.
In addition, in the said embodiment, although the specific example of what applied this invention with respect to the shaping | molding die for shape | molding a contact lens, and its manufacturing method was shown, this invention is an eye other than such a contact lens. Ophthalmic lenses such as inner lenses, or semi-finished products of these ophthalmic lenses (for example, one surface is molded into a completed lens surface shape, while the other surface is still completed as a lens surface. Molds for molding so-called ophthalmic lens articles, such as ophthalmic lens materials that give the ophthalmic lens, which have not yet been formed into a shape that requires post-processing such as cutting, and the manufacture thereof The method can also be advantageously applied. In particular, when the ophthalmic lens article is a semi-finished product of an ophthalmic lens, hydrophilicity is imparted to at least the surface of the target ophthalmic lens that has been completed into the lens shape.
In addition, although not listed one by one, the present invention can be implemented in a mode with various changes, modifications, improvements, and the like based on the knowledge of those skilled in the art. It goes without saying that all are included in the scope of the present invention without departing from the spirit of the invention.

そして、下記表２の配合割合となるように、上記で調製された溶液（Ａ）と、イオン性モノマーである２−メタクリロイルオキシメチルホスホリルコリン（ＭＰＣ）又は２−アクリルアミド−２−メチルスルホン酸（ＡＭＰＳ）とを、混合して、モノマー混合液１〜モノマー混合液４を調製した。なお、かかるモノマー混合液には、それぞれ、全モノマー成分の１００重量部に対して、０．２重量部の光重合開始剤：２−ヒドロキシ−２−メチルプロピオフェノン（シグマアルドリッチ社製）と、全モノマー成分の１００重量部に対して、２０重量部の重合溶媒：エタノール（和光純薬（株）製）を各々添加、混合した。

＜成形型の準備＞
円形プレート状の重合体試料を作製するために、第９図の（ａ）〜（ｃ）に示される如き構造の成形型Ａ〜Ｃの３種類の成形型を、それぞれ、必要な分だけ準備した。
なお、成形型Ａ〜Ｃは、何れも、０．５ｍｍ深さで直径２０ｍｍの円形状凹部４６，４８，５０が形成されたポリプロピレン製の下型５２，５４，５６と、かかる下型５２，５４，５６の円形状凹部４６，４８，５０の開口部を全て覆うことが出来る、ポリプロピレン製の平板状の上型５８，６０，６２とから、構成されており、かかる上型と下型の間に形成される空間にて、それぞれ、成形キャビティが形成されている。
かかる成形型Ａ〜Ｃのうち、成形型Ａにあっては、その下型５２の中心に、直径２ｍｍの真鍮製の針６４が差し込まれており、かかる針６４からなる点電極が、凹部４６内に収容されるモノマー混合液に接触するようになっている。一方、かかる成形型Ａの上型５８の下面には、アルミニウムフィルムからなる電極６６が、凹部４６の開口部を覆うように設置されている。
また、成形型Ｂにあっては、その下型５４の凹部４８の中央に位置する部位に、直径１０ｍｍの真鍮製の円形状平板６８が埋設されており、かかる円形状平板６８からなる電極が、凹部４８内に収容されるモノマー混合液に接触するようになっている。一方、かかる成形型Ｂの上型６０の下面には、成形型Ａと同様に、アルミニウムフィルムからなる電極７０が、凹部４８の開口部を覆うように設置されている。
一方、成形型Ｃにあっては、上型６２にも下型５６にも電極が形成されておらず、従来と同様な樹脂製のモールド成形型とされている。
＜試験例 １＞
上記で調製されたモノマー混合液１〜４を、それぞれ、上記成形型Ａの成形キャビティ内に充填した。そして、上型５８側の電極６６に、＋１．２Ｖ、下型５２側の電極（６４）に、−１．２Ｖの直流電圧を印加して、通電を行なった。そして、１０分間通電を行なった後、ピーク波長が３６０ｎｍである紫外線を、放射照度が１０ｍＷ／ｃｍ^２となるように、下型５２の下方側から３０分間照射することにより、モノマー混合液の重合を行なった。なお、かかる重合中も、一対の電極間に、電圧を印加し続けた。そして、重合反応終了後、アルミニウムフィルムに付着した円形プレート状重合体試料を、２−プロパノール中に浸漬した。次いで、アルミニウムフィルムから剥離した重合体試料を、生理食塩水中に移して置換した。
また、モノマー混合液１を用いた際において、通電開始時から、一対の電極間を流れる電流値を測定し、得られた電流値の推移を、第１０図に示した。かかる第１０図より、通電開始後５〜１０分で、電流値が安定することが確認された。
さらに、上述せる如くして得られた各円形プレート状重合体試料の表面（第９図中、電極６６に接する側の表面中央部）の接触角（液滴法）を測定し、その結果を下記表３に示した。なお、かかる接触角の測定は、重合体試料の表面上に、マイクロシリンジにて約２μｌの液滴（蒸留水）を付け、かかる重合体試料表面と液滴との接する角度を、ゴニオメーター式接触角測定装置Ｇ−１（エルマ光学株式会社製）を用いて測定することによって、行なった。
＜試験例 ２＞
上記で調製されたモノマー混合液１〜４を、それぞれ、非導電性の上記成形型Ｃの成形キャビティ内に充填した。そして、１０分経過後、ピーク波長が３６０ｎｍである紫外線を、放射照度が１０ｍＷ／ｃｍ^２となるように、下型５６の下方側から３０分間照射することにより、モノマー混合液の重合を行なった。その後、上記試験例１と同様に、２−プロパノール及び生理食塩水への浸漬処理を行なうことにより、円形プレート状重合体試料を得た。また、そのようにして得られた各重合体試料の表面（第９図中、上型６２に接する側の表面中央部）の接触角（液滴法）を測定し、その結果を下記表３に示した。
＜試験例 ３＞
上記で調製されたモノマー混合液１〜４を、それぞれ、上記成形型Ａの成形キャビティ内に充填した。そして、電圧を印加することなく、１０分経過の後、ピーク波長が３６０ｎｍである紫外線を、放射照度が１０ｍＷ／ｃｍ^２となるように、下型５２の下方側から３０分間照射することにより、モノマー混合液の重合を行なった。その後、上記試験例１と同様に、２−プロパノール及び生理食塩水への浸漬処理を行なうことにより、円形プレート状重合体試料を得た。また、そのようにして得られた各重合体試料の表面（第９図中、電極６６に接する側の表面中央部）の接触角（液滴法）を測定し、その結果を下記表３に示した。

かかる表３の結果から明らかなように、従来よりモールディング製法において一般的に用いられているポリプロピレン製の成形型Ｃを用いて、電圧を印加することなく、モールド成形を行なって得られた試験例２に係る重合体試料と比較すると、一対の電極が配された成形型Ａを用いて、直流電圧を印加した状態で、モールド成形を行なって得られた試験例１に係る重合体試料は、何れも、接触角が著しく低下しており、水濡れ性が高められていることが、認められる。
また、成形型Ａを用いて、電圧を印加することなく、アルミニウム製の成形面に接した状態でモールド成形が行なわれた試験例３に係る重合体試料は、何れも、ポリプロピレン製の成形面と接して得られた試験例２に係る重合体試料よりも接触角の値が小さくなっているものの、上記試験例１に係る重合体試料の接触角と比べると、接触角の値が大きなものとなっていることが分かる。
さらに、双性イオン性モノマー不含のモノマー混合液４からなる重合体にあっては、通電を実施しても、接触角があまり低下しないのに対して、双性イオン性モノマーを含むモノマー混合液１〜３からなる重合体にあっては、通電によって、接触角が著しく低下しており、イオン性モノマーが含まれていない系では、通電を行なっても、親水化を有利に実施することが出来ないことが認められる。
＜試験例 ４＞
上記で調製されたモノマー混合液１を、上記成形型Ｂの成形キャビティ内に充填した。そして、上型６０側の電極７０に、＋１．２Ｖ、下型５４側の電極（６８）に、−１．２Ｖの直流電圧を印加して、通電を行なった。そして、１０分間通電を行なった後、ピーク波長が３６０ｎｍである紫外線を、放射照度が１０ｍＷ／ｃｍ^２となるように、下型５４の下方側から３０分間照射することにより、モノマー混合液の重合を行なった。なお、かかる重合中も、一対の電極間に、電圧を印加し続けた。そして、重合反応終了後、アルミニウムフィルムに付着した円形プレート状重合体試料を、２−プロパノール中に浸漬した。次いで、アルミニウムフィルムから剥離した重合体試料を、生理食塩水中に移して、置換した。
この際、通電開始時から、一対の電極間を流れる電流値を測定し、得られた電流値の推移を、第１１図に示した。また、上述せる如くして得られた円形プレート状重合体試料の表面の接触角（液滴法）を測定し、その結果を下記表４に示した。なお、接触角の測定は、第１２図に示されるように、円形プレート状重合体試料７２の、電極７０側の上面中央部（ｉ）、上面周辺部（ｉｉ）、円形状平板６８側の下面中央部（ｉｉｉ）、下面周辺部（ｉｖ）の４箇所で行なった。また、下記表４には、比較のために、上記試験例１〜３において、モノマー混合液１を重合して得られた重合体試料の接触角を併せて示した。

かかる表４からも明らかなように、一対の電極が配された成形型Ｂを用いて、直流電圧を印加した状態で、モールド成形を行なって得られた試験例４に係る重合体試料は、ポリプロピレン製の成形型Ｃを用いて、電圧を印加することなく、モールド成形を行なって得られた試験例２に係る重合体試料や、成形型Ａを用いて、電圧を印加することなく、アルミニウム製の成形面に接した状態でモールド成形が行なわれた試験例３に係る重合体試料に比べて、接触角の値が低くなっている。
また、陰極が平板状電極とされた成形型Ｂを用いて得られた試験例４に係る重合体試料は、陰極が点電極とされた成形型Ａを用いて得られた試験例１に係る重合体試料よりも、接触角が大きく低下することが、認められた。
さらに、重合体試料の表面の中でも、とりわけ、陽極や陰極に接して形成された部位（第１２図中、ｉ，ｉｉｉ）の接触角が一様に低いものとなった。これは、電極の近傍に、双性イオン性モノマーである２−メタクリロイルオキシメチルホスホリルコリンが凝集したためであると、考えられる。
＜試験例 ５＞
直流電圧を印加した際におけるチャージの影響を確認するために、上記試験例１と試験例４において、モノマー混合液１を重合して得られた重合体試料の接触角（液滴法）を、下記表５に纏めた。

かかる表５からも明らかなように、陽極側表面にあっても、陰極側表面にあっても、親水化が有利に図られていることが分かる。これは、双性イオン性モノマー（ＭＰＣ）が、通電によって、両側の電極に移動するためであると、考えられる。
＜試験例 ６＞
通電操作と重合操作を実施するタイミングによる影響をみるために、上記表２に示される配合組成のモノマー混合液１と、前記成形型Ｂを用いて、（１）通電開始から１０分を経過した後に重合を開始して、或いは、（２）通電と重合を同時に開始して、円形プレート状重合体試料を作製した。なお、使用した成形型や通電操作と重合操作を実施するタイミング以外は、上記試験例１と同様にして、重合体試料を作製した。
また、重合開始直後から、それぞれの電極間を流れる電流値を測定し、得られた電流値の推移を、第１３図に示した。かかる第１３図より、重合に先立って電圧を印加した方が、電流値が大きくなっていることが、認められる。
さらに、上述せる如くして得られた各円形プレート状重合体試料の表面（第９図中、電極７０に接する側の表面中央部）の接触角（液滴法）を測定し、その結果を下記表６に示した。

かかる表６から明らかなように、（１）重合に先立って通電を開始した場合の重合体試料の方が、（２）通電と重合を同時に開始した場合の重合体試料より、接触角が有利に低下せしめられていることが、分かる。これは、第１３図に示される電流値の推移等を勘案すると、上記（２）では、電荷を有するイオン性モノマーが、電極近傍の表面付近に充分に凝集される前に、重合が開始されたことが原因ではないかと考えられる。また、上記（１）では、電極近傍に電荷を有する成分が充分に凝集されて、電流値が安定した状態で、重合を開始しているところから、表面の親水性がより一層有利に高められていると、考えられる。
本実施例では、ケイ素含有モノマーの中でも、疎水性を高め易いシロキサンユニットを含むケイ素含有モノマーが７０重量％以上といった高い割合で用いられているところから、通常であれば、接触角が極めて高くなるはずである。しかし、以上の結果から明らかなように、本発明に従って眼用レンズ物品を製造した場合には、その表面の接触角が、７０°以下となるのである。因みに、これまで、シロキサンユニットを含むケイ素含有モノマーを用いて、表面の接触角を低下せしめるには、かかるケイ素含有モノマーと同量以上の親水性成分を共重合させる必要があったのであり、この親水性成分の割合の増加によって、酸素透過性が抑制されていたのである。
また、以上の結果より、本実施例において確認された接触角の低下は、電荷を有する成分が、表面側に凝集したことに起因して生じた可能性が高いと推察される。つまり、通電によって、電荷を有する成分の帯電部が、効果的に表面に凝集され、重合によって、バルクとは異なる親水性に優れた表面層を形成するものと考えられる。Hereinafter, representative examples of the present invention will be shown to clarify the present invention more specifically, but the present invention is not limited by the description of such examples. It goes without saying.
<Preparation of monomer mixture>
First, as shown in Table 1 below, 79% by weight of silicon-containing monomer composed of tris (trimethylsiloxy) silylpropyl acrylate and dimethylsiloxane macromonomer, and hydrophilic property composed of 2-hydroxyethyl methacrylate and 2-hydroxyethyl acrylate A solution (A) was prepared by mixing 20% by weight of the monomer and 1% by weight of ethyl dimethacrylate as a crosslinkable monomer.

And so that it may become the mixture ratio of following Table 2, the solution (A) prepared above, 2-methacryloyloxymethyl phosphorylcholine (MPC) which is an ionic monomer, or 2-acrylamido-2-methylsulfonic acid (AMPS) ) Were mixed to prepare monomer mixture 1 to monomer mixture 4. In this monomer mixture, 0.2 parts by weight of photopolymerization initiator: 2-hydroxy-2-methylpropiophenone (manufactured by Sigma-Aldrich) and 100 parts by weight of all monomer components, respectively. Then, 20 parts by weight of polymerization solvent: ethanol (manufactured by Wako Pure Chemical Industries, Ltd.) was added to and mixed with 100 parts by weight of all monomer components.

<Preparation of mold>
In order to produce a circular plate-shaped polymer sample, three types of molds A to C having a structure as shown in FIGS. 9A to 9C are prepared as necessary. did.
Each of the molds A to C includes a lower mold 52, 54, 56 made of polypropylene in which circular recesses 46, 48, 50 having a diameter of 0.5 mm and a diameter of 20 mm are formed, and the lower mold 52, It is composed of a flat plate-shaped upper mold 58, 60, 62 made of polypropylene that can cover all the openings of the circular recesses 46, 48, 50 of 54, 56. Molding cavities are respectively formed in the spaces formed therebetween.
Among the molds A to C, in the mold A, a brass needle 64 having a diameter of 2 mm is inserted into the center of the lower mold 52, and the point electrode made of the needle 64 is formed in the recess 46. It comes into contact with the monomer mixture contained therein. On the other hand, an electrode 66 made of an aluminum film is installed on the lower surface of the upper mold 58 of the mold A so as to cover the opening of the recess 46.
In the mold B, a circular flat plate 68 made of brass having a diameter of 10 mm is embedded in a portion located in the center of the concave portion 48 of the lower mold 54, and an electrode made of the circular flat plate 68 is provided. The monomer mixture is accommodated in the recess 48. On the other hand, on the lower surface of the upper mold 60 of the mold B, as in the mold A, an electrode 70 made of an aluminum film is installed so as to cover the opening of the recess 48.
On the other hand, in the molding die C, neither the upper die 62 nor the lower die 56 is formed with an electrode, and is a resin molding die similar to the conventional one.
<Test Example 1>
The monomer mixed liquids 1 to 4 prepared above were filled in the molding cavities of the mold A, respectively. Then, a DC voltage of +1.2 V was applied to the electrode 66 on the upper mold 58 side, and a DC voltage of -1.2 V was applied to the electrode (64) on the lower mold 52 side to conduct electricity. Then, after energizing for 10 minutes, ultraviolet rays having a peak wavelength of 360 nm are irradiated from the lower side of the lower mold 52 for 30 minutes so that the irradiance is 10 mW / cm ² , thereby polymerizing the monomer mixture. Was done. During the polymerization, a voltage was continuously applied between the pair of electrodes. And after completion | finish of polymerization reaction, the circular plate-shaped polymer sample adhering to the aluminum film was immersed in 2-propanol. Subsequently, the polymer sample peeled from the aluminum film was transferred to physiological saline for replacement.
Further, when the monomer mixed solution 1 was used, the value of the current flowing between the pair of electrodes was measured from the start of energization, and the transition of the obtained current value is shown in FIG. From FIG. 10, it was confirmed that the current value was stabilized 5 to 10 minutes after the start of energization.
Further, the contact angle (droplet method) of the surface of each circular plate-shaped polymer sample obtained as described above (the center portion of the surface on the side in contact with the electrode 66 in FIG. 9) was measured. The results are shown in Table 3 below. The contact angle is measured by applying a droplet (distilled water) of about 2 μl with a microsyringe on the surface of the polymer sample, and determining the angle between the surface of the polymer sample and the droplet as a goniometer type. The measurement was performed by using a contact angle measuring device G-1 (manufactured by Elma Optical Co., Ltd.).
<Test Example 2>
The monomer mixed liquids 1 to 4 prepared as described above were filled into the molding cavities of the non-conductive molding die C, respectively. After 10 minutes, the monomer mixture was polymerized by irradiating ultraviolet rays having a peak wavelength of 360 nm from the lower side of the lower mold 56 for 30 minutes so that the irradiance was 10 mW / cm ² . . Thereafter, in the same manner as in Test Example 1, a circular plate polymer sample was obtained by immersing in 2-propanol and physiological saline. Further, the contact angle (droplet method) of the surface of each polymer sample thus obtained (in FIG. 9, the surface central portion on the side in contact with the upper mold 62) was measured, and the results are shown in Table 3 below. It was shown to.
<Test Example 3>
The monomer mixed liquids 1 to 4 prepared above were filled in the molding cavities of the mold A, respectively. And after applying for 10 minutes without applying voltage, by irradiating ultraviolet rays having a peak wavelength of 360 nm from the lower side of the lower mold 52 for 30 minutes so that the irradiance becomes 10 mW / cm ² , Polymerization of the monomer mixture was performed. Thereafter, in the same manner as in Test Example 1, a circular plate polymer sample was obtained by immersing in 2-propanol and physiological saline. Further, the contact angle (droplet method) of the surface of each polymer sample thus obtained (in FIG. 9, the central portion of the surface in contact with the electrode 66) was measured, and the results are shown in Table 3 below. Indicated.

As is apparent from the results in Table 3, a test example obtained by molding without applying voltage using a polypropylene mold C that has been conventionally used in the molding process. As compared with the polymer sample according to 2, the polymer sample according to Test Example 1 obtained by performing molding with a DC voltage applied using the molding die A provided with a pair of electrodes, In any case, it is recognized that the contact angle is remarkably lowered and the water wettability is enhanced.
In addition, the polymer samples according to Test Example 3 in which the molding was performed in a state in which the molding die A was in contact with the aluminum molding surface without applying a voltage were all molded surfaces made of polypropylene. Although the contact angle value is smaller than that of the polymer sample according to Test Example 2 obtained in contact with the sample, the contact angle value is larger than that of the polymer sample according to Test Example 1 above. It turns out that it is.
Furthermore, in the polymer comprising the monomer mixture 4 containing no zwitterionic monomer, the contact angle does not decrease much even when energized, whereas the monomer mixture containing the zwitterionic monomer In the polymer consisting of liquids 1 to 3, the contact angle is remarkably lowered by energization. In a system that does not contain an ionic monomer, hydrophilization is advantageously performed even when energization is performed. It is recognized that cannot be done.
<Test Example 4>
The monomer mixture 1 prepared as described above was filled into the molding cavity of the mold B. Then, a DC voltage of +1.2 V was applied to the electrode 70 on the upper mold 60 side, and a DC voltage of -1.2 V was applied to the electrode (68) on the lower mold 54 side to conduct electricity. Then, after energizing for 10 minutes, ultraviolet rays having a peak wavelength of 360 nm are irradiated from the lower side of the lower mold 54 for 30 minutes so that the irradiance is 10 mW / cm ² , thereby polymerizing the monomer mixture. Was done. During the polymerization, a voltage was continuously applied between the pair of electrodes. And after completion | finish of polymerization reaction, the circular plate-shaped polymer sample adhering to the aluminum film was immersed in 2-propanol. Next, the polymer sample peeled from the aluminum film was transferred into physiological saline and replaced.
At this time, the current value flowing between the pair of electrodes was measured from the start of energization, and the transition of the obtained current value is shown in FIG. Further, the contact angle (droplet method) of the surface of the circular plate polymer sample obtained as described above was measured, and the results are shown in Table 4 below. As shown in FIG. 12, the measurement of the contact angle is performed on the circular plate-shaped polymer sample 72 on the upper surface center portion (i), upper surface peripheral portion (ii) on the electrode 70 side, and on the circular flat plate 68 side. The measurement was performed at four locations, the lower surface central portion (iii) and the lower surface peripheral portion (iv). Further, in Table 4 below, for comparison, the contact angles of the polymer samples obtained by polymerizing the monomer mixture 1 in Test Examples 1 to 3 are also shown.

As is clear from Table 4, the polymer sample according to Test Example 4 obtained by performing molding with a DC voltage applied using a molding die B in which a pair of electrodes is arranged, A polymer sample according to Test Example 2 obtained by performing molding without applying a voltage using a molding die C made of polypropylene, and aluminum without applying a voltage using a molding die A The value of the contact angle is lower than that of the polymer sample according to Test Example 3 in which molding was performed in contact with the molded surface.
In addition, the polymer sample according to Test Example 4 obtained using the mold B in which the cathode is a flat electrode is related to Test Example 1 obtained using the mold A in which the cathode is a point electrode. It was observed that the contact angle was much lower than the polymer sample.
Further, among the surfaces of the polymer samples, the contact angles of the portions (i, iii in FIG. 12) formed in contact with the anode and the cathode were particularly low. This is considered to be because 2-methacryloyloxymethyl phosphorylcholine which is a zwitterionic monomer aggregated in the vicinity of the electrode.
<Test Example 5>
In order to confirm the influence of the charge when a DC voltage is applied, the contact angle (droplet method) of the polymer sample obtained by polymerizing the monomer mixture 1 in Test Example 1 and Test Example 4 above, The results are summarized in Table 5 below.

As is apparent from Table 5, it can be seen that hydrophilicity is advantageously achieved both on the anode side surface and on the cathode side surface. This is considered to be because the zwitterionic monomer (MPC) moves to the electrodes on both sides by energization.
<Test Example 6>
In order to see the influence by the timing of conducting the energization operation and the polymerization operation, (1) 10 minutes have elapsed since the start of energization, using the monomer mixture 1 having the composition shown in Table 2 above and the molding die B. Polymerization was started later, or (2) energization and polymerization were started simultaneously to produce a circular plate polymer sample. A polymer sample was prepared in the same manner as in Test Example 1 except for the used mold and the timing of conducting the energization operation and the polymerization operation.
Further, immediately after the start of polymerization, the value of current flowing between the respective electrodes was measured, and the transition of the obtained current value is shown in FIG. From FIG. 13, it is recognized that the current value is larger when the voltage is applied prior to the polymerization.
Further, the contact angle (droplet method) of the surface of each circular plate-shaped polymer sample obtained as described above (the center of the surface on the side in contact with the electrode 70 in FIG. 9) was measured. The results are shown in Table 6 below.

As is apparent from Table 6, the contact angle is more advantageous for the polymer sample when the energization is started prior to the polymerization than for the polymer sample when the energization and the polymerization are simultaneously started (2). It can be seen that it has been lowered. In consideration of the transition of the current value shown in FIG. 13 and the like, in (2) above, the polymerization is started before the charged ionic monomer is sufficiently aggregated near the surface near the electrode. It is thought that this was the cause. Further, in the above (1), the hydrophilicity of the surface is further advantageously increased from the point where polymerization is started in a state where the charged component is sufficiently aggregated in the vicinity of the electrode and the current value is stable. It is thought that.
In this example, among the silicon-containing monomers, the silicon-containing monomer containing a siloxane unit that easily improves the hydrophobicity is used at a high ratio of 70% by weight or more, so that the contact angle is usually extremely high. It should be. However, as is apparent from the above results, when the ophthalmic lens article is manufactured according to the present invention, the contact angle of the surface is 70 ° or less. Incidentally, in the past, in order to reduce the contact angle of the surface using a silicon-containing monomer containing a siloxane unit, it was necessary to copolymerize a hydrophilic component equal to or more than the silicon-containing monomer. Oxygen permeability was suppressed by the increase in the ratio of the hydrophilic component.
In addition, from the above results, it is surmised that the decrease in the contact angle confirmed in this example is likely to have occurred due to the aggregation of the charged components on the surface side. That is, it is considered that charged portions of charged components are effectively aggregated on the surface by energization, and a surface layer having excellent hydrophilicity different from the bulk is formed by polymerization.

  As is apparent from the above description, according to the present invention, an ophthalmic lens article having a surface excellent in biocompatibility, particularly water wettability, can be advantageously obtained while maintaining high oxygen permeability. It can be done. The present invention can also be applied to the manufacture of medical devices that require biocompatibility in addition to ophthalmic lens articles.

Claims (9)

By using a molding die configured such that a molding cavity having a shape that gives a target ophthalmic lens article is formed between the first die and the second die by matching the die. In the molding cavity, a monomer mixed solution containing at least an ionic monomer is filled and polymerized to perform molding, thereby producing the target ophthalmic lens article,
The monomer mixture liquid in which electrodes made of a conductive material are arranged at least in a part of the first and second molds to give the molding cavity, and the pair of electrodes are filled in the molding cavity. The ionic monomer is moved to one or both sides of the pair of electrodes by applying a DC voltage between the pair of electrodes, while the monomer mixture is mixed. By performing polymerization of the liquid, a surface layer excellent in biocompatibility composed of a polymer having a high polymerization ratio of the ionic monomer is formed on at least a part of the surface of the ophthalmic lens article. A method for manufacturing an ophthalmic lens article. By applying a DC voltage between the pair of electrodes, the ionic monomer in the monomer mixed solution filled in the molding cavity is made to be near one or both sides of the pair of electrodes. The method for producing an ophthalmic lens article according to claim 1, wherein the monomer mixture solution is polymerized in the moved state after being moved to. The method for producing an ophthalmic lens article according to claim 1 or 2, wherein the conductive material is a metal material family, a conductive inorganic material, or a conductive organic material. The method for producing an ophthalmic lens article according to any one of claims 1 to 3, wherein the surface layer having excellent biocompatibility has a thickness of 100 µm or less. The method for producing an ophthalmic lens article according to any one of claims 1 to 4, wherein the ionic monomer is a zwitterionic monomer. The method for producing an ophthalmic lens article according to any one of claims 1 to 5, wherein the monomer mixture further contains a silicon-containing monomer. An ophthalmic lens article obtained by the method for producing an ophthalmic lens article according to any one of claims 1 to 6, wherein a droplet contact angle of the surface layer excellent in biocompatibility is An ophthalmic lens article having an angle of 70 ° or less. By combining the first mold and the second mold, a molding cavity having a shape that gives a target ophthalmic lens article is formed between the molds. In the mold, the objective ophthalmic lens article is molded by polymerizing a monomer mixed solution containing at least an ionic monomer,
The monomer mixture liquid in which electrodes made of a conductive material are arranged at least in a part of the first and second molds to give the molding cavity, and the pair of electrodes are filled in the molding cavity. A mold for an ophthalmic lens article, wherein a predetermined DC voltage can be applied between the pair of electrodes. Of the pair of electrodes, the electrode disposed on the first mold constitutes the entire surface of the molding cavity on the first mold side that provides the molding cavity, and is disposed on the second mold. The electrode constitutes a part of the molding cavity surface on the second mold side that provides the molding cavity, and the second mold has a light transmission part capable of performing photopolymerization. A mold for an ophthalmic lens article according to claim 8.

Images