CN104924508B - For the manufacture method of the mould of contact lenses, method for sorting and contact lenses - Google Patents
For the manufacture method of the mould of contact lenses, method for sorting and contact lenses Download PDFInfo
- Publication number
- CN104924508B CN104924508B CN201510262811.3A CN201510262811A CN104924508B CN 104924508 B CN104924508 B CN 104924508B CN 201510262811 A CN201510262811 A CN 201510262811A CN 104924508 B CN104924508 B CN 104924508B
- Authority
- CN
- China
- Prior art keywords
- mould
- hydrophilic
- high mol
- contact lenses
- hydrophilic high
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Eyeglasses (AREA)
Abstract
The invention discloses a kind of mould for contact lenses, the inner surface of described mould scribbles hydrophilic polymeric layer.Invention additionally discloses a kind of method for sorting of the mould for contact lenses, the method for sorting is comprised the following steps：Step 11）Configuration hydrophilic high mol solution, and hydrophilic high mol solution stirring is heated；Step 12）By hydrophilic high mol solution spraying in the inner surface of mould；Step 13）The mould for scribbling hydrophilic high mol solution is dried.The invention also discloses the manufacture method of contact lenses.The manufacture method of mould, method for sorting and contact lenses that this is used for contact lenses, using the Mold Making contact lenses, surface hydrophilic process is carried out to mould, the mould is recycled to be polymerized, the good contact lenses of surface hydrophilicity can be just directly obtained, without post processing being carried out to contact lenses.
Description
Technical field
The present invention relates to a kind of manufacture method of the mould, method for sorting and contact lenses for contact lenses.
Background technology
Cornea silicone hydrogel contact lenses are commonly called as contact lenss, be it is a kind of can both correct defects of vision, again can be with the doctor of beauty
Treat material；As compared to common spectacles, it not only can correct defects of vision, and the attractive in appearance of human body is not affected, so extensively being disappeared
Expense person's likes.It is hard that cornea silicone hydrogel contact lenses can be divided into the rigid silicone hydrogel contact lenses of air impermeability, breathability
Property silicone hydrogel contact lenses, common soft silicone hydrogel contact lenses and the soft silicone hydrogel contact lenses of high oxygen flow.With
The exploitation to material, and people are more and more stronger to the protective awareness of eyes, the soft cornea silicone hydrogel contact of high oxygen flow
Lens increasingly will be favored by market and consumer.
At present, on market, most common contact lens products are common soft silicone hydrogel contact lenses.From the fifties
Czechoslovakia high-molecular scholars Otto Wichterle et al. polymethylacrylic acid beta-hydroxy ethyl esters (HEMA) are made soft
Property cornea silicone hydrogel contact lenses since, a series of hydrophilic ventilative, soft and resilient new cornea silicone hydrogel contact is saturating
Mirror is developed in succession.The material is that HEMA monomers are polymerized the polymer of the crosslinking side chain to be formed, and water content is 38%.This
Kind material is soft, and mechanical strength is also higher, with certain elasticity.Subsequently people study again and are added thereto to other lists
The material copolymerization such as body such as polyvinyl alcohol (PVA), NVP and MMA obtain new contact lenss.But, this kind of contact lenss it is saturating
Gas performance is not ideal, is unfavorable for people's long periods of wear.In order to improve the oxygen permeability of contact lenss, add siliceous in raw material
The monomer of oxygen alkane becomes a new breakthrough mouth for improving contact lenss oxygen permeability.Because the polymer of silicone-containing is usual
There is higher oxygen permeability than common polymer.
But, as the mould for preparing contact lenss at present is prepared by some nonpolar resins (such as polypropylene)
, and the silicon monomer in silicone-containing monomer has stronger hydrophobicity, so from containing that these nonpolar moulds are obtained
The contact lenss of siloxanes just have hydrophobic surface, and this means that the surface wettability of this contact lenss is poor.And so
Contact lenss may will increase lipid precipitation, protein precipitation, be unfavorable for that long term consumer is worn.So improving containing silica
The surface hydrophilicity of the contact lenss of alkane is a focus of current research.
In the method for improving the surface hydrophilicity of contact lenss of silicone-containing, mainly used to containing silica at present
The silicone hydrogel contact lenses of alkane carry out a post processing in itself.Connect including surface chemistry is carried out to silicone hydrogel contact lenses
Branch, carry out radiating using plasma, using methods such as polymeric wetting agent IPN.But the means of these post processings all give making hidden
The technique and contact lenss of shape glasses brings more complicated problem in itself.Therefore need one kind need not be to contact lenss
The method for carrying out post processing, improves the poor problem of the contact lens surface hydrophilicity of silicone-containing.
The content of the invention
Technical problem：The embodiment of the present invention provides a kind of mould for contact lenses, method for sorting and contact lenses
Manufacture method, using the Mold Making contact lenses, carries out surface hydrophilic process to mould, recycles the mould to be polymerized,
The good contact lenses of surface hydrophilicity can be just directly obtained, without post processing being carried out to contact lenses.
Technical scheme：To solve above-mentioned technical problem, in a first aspect, the present embodiment provides a kind of mould for contact lenses
Tool, the inner surface of described mould scribble hydrophilic polymeric layer.
Used as a kind of embodiment, described mould is made up of mold and lower mould, and mold and lower mould are engaged,
Cavity between mold and lower mould is used to make contact lenses.
Second aspect, the present embodiment provide a kind of method for sorting of the mould for contact lenses, and the method for sorting includes
Following steps：
Step 11) configuration hydrophilic high mol solution, and hydrophilic high mol solution stirring is heated；
Step 12) by hydrophilic high mol solution spraying in the inner surface of mould；
Step 13) mould for scribbling hydrophilic high mol solution is dried.
As a kind of embodiment, described step 11) in, hydrophilic high mol solution is by hydrophilic high mol material and solvent group
Into, wherein, it is 10%～20% that hydrophilic high mol material accounts for the weight fraction of hydrophilic high mol solution, and solvent accounts for hydrophilic high mol
The weight fraction of solution is 80%～90%.
Used as a kind of embodiment, described hydrophilic high mol material is poly N-vinyl pyrrolidone, Polyethylene Glycol
(PEG), one kind or combination in any in polyvinyl alcohol.
Used as a kind of embodiment, described solvent is ethanol, hexanol, the one or any combination in capryl alcohol.
As a kind of embodiment, described step 12) in, by hydrophilic high mol solution spraying in the side of the inner surface of mould
Method is sprayed using pipette tips or spin coating instrument spin coating.
As a kind of embodiment, described step 13) in, the mould for scribbling hydrophilic high mol solution is placed in into forced air drying
In case, and it is to dry at 60～100 DEG C in temperature.
The third aspect, the present embodiment provide a kind of manufacture method of contact lenses, and the manufacture method is comprised the following steps：It is first
The material mixing stirring of contact lenses will be made first, form uniform mixture；Then the mixture for stirring is put into into mould
In tool, under initiation conditions, mixture solidification forms contact lenses；Then the lens after solidification are carried out into the demoulding, finally will be saturating
Mirror is placed in PBS and is hydrated, until lens hydration is complete；The inner surface of described mould scribbles hydrophilic polymeric layer.
Used as a kind of embodiment, the inner surface of described mould scribbles the process of hydrophilic polymeric layer to be included：
Step 11) configuration hydrophilic high mol solution, and hydrophilic high mol solution stirring is heated；
Step 12) macromolecular solution is sprayed at the inner surface of mould；
Step 13) mould for scribbling hydrophilic high mol solution is dried.
Beneficial effect：Compared with prior art, contact lens surfaces obtained in the embodiment of the present invention have high hydrophilic
Property.First, surface hydrophilic process will be carried out with super hydrophilic macromolecular solution for the mould for preparing contact lenses, then with process
Mould afterwards prepares contact lenses, and obtained contact lens surfaces can directly be coated with the hydrophilic polymeric layer.Meanwhile, this connects
Hydrophilic polymeric layer obtained by tactile lens is stable, will not come off easily, during cured lens, by hydrophilic high score
Sublayer is tightly sequestered in lens surface.So, resulting contact lens surfaces will have high hydrophilic.By this
Obtained in the mode of kind, the hydrophilic group of contact lens surfaces will not come off easily, so that this kind of silicone hydrogel contact lenses are not
Easily adhere to other pollutant, be suitable to long-time and wear.By the preparation method using the present embodiment, to obtained contact lenses not
Need to carry out post processing, preparation process is simpler.In addition, the raw material of the hydrophilic high mol material utilized in the present embodiment and solvent
Price is low, be readily available.
Specific embodiment
Below the embodiment of the present invention is described in detail.
The present embodiment provides a kind of mould for contact lenses, and the inner surface of mould scribbles hydrophilic polymeric layer.
The existing mould for making contact lenses, its inner surface do not have any hydrophilic polymeric layer.The embodiment of the present invention is carried
For the inner surface of mould scribble hydrophilic polymeric layer, during solidification contact lenses, the hydrophilic polymeric layer can be shifted
To lens surface, so as to get lens surface there is excellent hydrophilicity.The effect will be described in detail later.Preferred mould
Have for PP moulds, POM moulds, preferred mould is EVOH mold.
The mould for making contact lenses is made up of mold and lower mould, and mold and lower mould are engaged, mold
And the cavity between lower mould is used to make contact lenses.The wall of cavity scribbles hydrophilic polymeric layer.
Hydrophilic polymeric layer has various in the painting method of mould inner surface, the preferred below scheme of the present embodiment：It is a kind of to use
In the method for sorting of the mould of contact lenses, comprise the following steps：
Step 11) configuration hydrophilic high mol solution, and hydrophilic high mol solution stirring is heated.
In step 11) in, hydrophilic high mol solution is made up of hydrophilic high mol material and solvent, wherein, hydrophilic high mol
It is 10%～20% that material accounts for the weight fraction of hydrophilic high mol solution, and solvent accounts for the weight fraction of hydrophilic high mol solution and is
80%～90%.Used as a kind of preferred version, described hydrophilic high mol material is poly N-vinyl pyrrolidone, Polyethylene Glycol
(PEG), one kind or combination in any in polyvinyl alcohol.Preferably, hydrophilic high mol material is poly N-vinyl pyrrolidone.Parent
The mean molecule quantity of water polymer substance is 1000～200000.Preferably, the mean molecule quantity of poly N-vinyl pyrrolidone
For K30-K90, more preferably K88～90.Wherein, it is preferred that the weight fraction of hydrophilic high mol material be 10wt%～
15wt%.
Described solvent is ethanol, hexanol, the one or any combination in capryl alcohol.By dissolving hydrophilic high score with solvent
Son so that hydrophilic high mol solution can be evenly dispersed in die surface, then be placed in baking oven, make mould show to form one layer
Homogeneous hydrophilic high mol film.From solvent be non-polar solven because die surface is nonpolar, if selecting polarity
Solvent, then resulting hydrophilic high mol solution can not then be well dispersed in die surface, so solvent can not be selected
Water.Preferably, the weight fraction of solvent is 80wt%～90wt%, more preferably 85wt%～90wt%.
Step 12) by hydrophilic high mol solution in the inner surface of mould.
Preferably, by hydrophilic high mol solution spraying in the inner surface of mould method using pipette tips spray or
Spin coating instrument spin coating.Certainly hydrophilic high mol solution can also be sprayed using additive method, as long as can be molten by hydrophilic high mol
Inner surface of the liquid even application in mould.
Step 13) mould for scribbling hydrophilic high mol solution is dried.
Preferably the mould for scribbling hydrophilic high mol solution is placed in air dry oven as a kind of, and is 60 in temperature
Dry at～100 DEG C, more preferably 70～90 DEG C, most preferably 80 DEG C.Certainly, in other drying devices, can will be hydrophilic
Macromolecular solution is dried in mould inner surface.
In addition, also providing an embodiment, a kind of manufacture method of contact lenses is comprised the following steps：First making is connect
The material mixing stirring of tactile lens, forms uniform mixture；Then the mixture for stirring is put in mould, is being caused
Under the conditions of, mixture solidification forms contact lenses；Then the lens after solidification are carried out into the demoulding, lens is placed in into PBS finally and is delayed
Rush in liquid and be hydrated, until lens hydration is complete；The inner surface of described mould scribbles hydrophilic polymeric layer.
In the present embodiment, according to the mass ratio of the monomer of composition contact lenses, the mixing of various monomers is taken, such as with light-initiated,
Then need to be stirred under the conditions of lucifuge 24 hours；Thermal initiation is such as used, is then stirred 24 hours under the conditions of not lucifuge,
So as to make monomer mixture.
In the present embodiment, mould inner surface scribbles the process of hydrophilic polymeric layer to be included：
Step 11) configuration hydrophilic high mol solution, and hydrophilic high mol solution stirring is heated.
In step 11) in, hydrophilic high mol solution is made up of hydrophilic high mol material and solvent, wherein, hydrophilic high mol
It is 10%～20% that material accounts for the weight fraction of hydrophilic high mol solution, and solvent accounts for the weight fraction of hydrophilic high mol solution and is
80%～90%.Used as a kind of preferred version, described hydrophilic high mol material is poly N-vinyl pyrrolidone, Polyethylene Glycol
(PEG), one kind or combination in any in polyvinyl alcohol.Described solvent is ethanol, hexanol, one or any group in capryl alcohol
Close.
Step 12) by hydrophilic high mol solution in the inner surface of mould.
Preferably, by hydrophilic high mol solution spraying in the inner surface of mould method using pipette tips spray or
Spin coating instrument spin coating.Certainly hydrophilic high mol solution can also be sprayed using additive method, as long as can be molten by hydrophilic high mol
Inner surface of the liquid even application in mould.
Step 13) mould for scribbling hydrophilic high mol solution is dried.
Preferably the mould for scribbling hydrophilic high mol solution is placed in air dry oven as a kind of, and is 60 in temperature
Dry at～100 DEG C.Certainly, in other drying devices, hydrophilic high mol solution can be dried in mould inner surface.
In above-mentioned all embodiments, the inner surface of mould scribbles hydrophilic polymeric layer.Hydrophilic high mol solution is in mould
Middle film-forming, injects mould the monomer mixture for preparing contact lenses, and during initiation, monomer can produce freedom
Base, partly the monomer with free radical will penetrate into inside hydrophilic polymeric layer.These are entered into inside hydrophilic polymeric layer
Free radical, mutually reacts, and reacts with the free radical for being introduced into hydrophilic polymeric layer, so as to by hydrophilic high score
Sublayer is chelated.Hydrophilic polymeric layer be physical attachment in mould inner surface, so in the contact lenses demoulding, hydrophilic high score
Sublayer will be attached to contact lens surfaces, and will not come off easily.The surface hydrophilic of eyeglass can thus be greatly improved
Property, so as to the silicone hydrogel contact lenses for being suitable to long periods of wear are obtained.For example, when hydrophilic high mol material is poly N-ethylene
During base ketopyrrolidine, in contact lenses, monomer radical part is deep in poly N-vinyl pyrrolidone layer, poly N-ethylene
Base ketopyrrolidine is chelated.
The contact lenses referred in the embodiment of the present invention can be silicone-hydrogel, and the HEMA classes that can also be not siliceous are soft
Hydrogel, or the lens that other any classes are obtained by radical polymerization.
The compositing monomer of silicone-hydrogel is prior art.For example：A kind of silicone-hydrogel, according to percentage by weight, by following
Component is constituted：
(A) account for the silicon-containing monomer of gross weight 30wt%～50wt%；
(B) account for the hydrophilic monomer of gross weight 40wt%～60wt%；
(C) account for the radical initiator of gross weight 0.1wt%～2wt%；
(D) account for the cross-linking agent of gross weight 0.3wt%～5wt%；
(E) other monomers of gross weight 0.3wt%～4wt% are accounted for.
In above-mentioned silicone-hydrogel, silicon-containing monomer is preferably silicone-containing monomer.Silicone-containing monomer is methyl methacrylate
Double (trimethylsiloxane group) the silylpropyl glyceride of base, methacrylic acid double (trimethyl silicane alkoxyl) propyl ester, methyl
One kind or combination in any in acrylic acid pentamethyl disiloxane base ester.
Preferably, the percentage by weight of silicone-containing monomer is 40wt%, most preferably 50wt%.Because in compositionss
With sufficient silicone-containing monomer, can just make the lens of generation that there is higher oxygen permeability.
Hydrophilic monomer be HEMA, NVP, N, N- DMAAs, methyl
Acrylic acid, methacrylate, NIPA, Methacrylamide, sodium vinyl sulfonate, Sodium styrene sulfonate,
One kind or combination in any in N- vinyl pyrroles, 4- vinyl pyrroles.Wherein, the content of methacrylic acid is no more than
10wt%.Because methacrylic acid is ionic comonomer, ionic comonomer is present in contact lenss, may increase stealthy eye
Mirror surface it is proteins deposited.
Preferably, radical initiator is 2- hydroxy-2-methyl propiophenones, azodiisobutyronitrile, benzoyl peroxide, peroxide
One kind or combination in any in lauroyl.Preferably, the light trigger for adopting is 2- hydroxy-2-methyl propiophenones, thermal initiator
Using azodiisobutyronitrile.
Preferably, cross-linking agent is ethylene glycol dimethacrylate, allyl methacrylate, triethylene glycol dimethyl propylene
One kind in olefin(e) acid ester, pentaerythritol tetramethylacrylate, Aronix M 240, diallyl phthalate or
Combination in any.Ethylene glycol dimethacrylate is most preferably wherein.
Other monomers are one kind or the combination of soft section and coloring agent.Soft section, from polyethylene glycol dimethacrylate,
Once increase the elasticity and softness of contact lenss；Additionally include coloring agent, preferred phthalocyanine blue pigment.
The mould that the monomer composition of silicone hydrogel contact lenses was modified with this is solidified, super hydrophilic silicon is formed
Hydrogel contact lens.
The premium properties brought by above-described embodiment is verified below by experiment.
According to shown in table 1, the various monomers for making contact lenses are mixed according to corresponding mass ratio.According to table 2
Shown, the mould used to respective sample is processed accordingly.Detailed process is as follows：
Sample 1：Weigh 4g poly N-vinyl pyrrolidones (in text referred to as：PVP), 36g anhydrous alcohol solutions, magnetic force are added
90 DEG C are stirred and be warmed up to, after two hours of stirring, solution pipette tips is smoothened into the lower mould inner surface in PP moulds, drum is put into
80 DEG C of drying in wind drying baker so as to film-forming.The various monomers of composition contact lenses are mixed, under the conditions of lucifuge
It is stirred, the monomer mixture being stirred is injected in mould.
Wherein, contact lenses are according to percentage by weight, by 21% hydroxyethyl methylacrylate (HEMA), 9% N- second
Vinyl pyrrolidone (NVP), 7.9% N, N- DMAAs (DMA), the 50% double (front threes of methacrylic acid methyl
Radical siloxane base) silylpropyl glyceride (SiMA), 10% methacrylic acid (MAA), 0.1% 2- hydroxyl -2- first
Base propiophenone (D-1173), 0.35% Ethylene glycol dimethacrylate (EGDMA), 2% Polyethylene Glycol dimethyl allene
Acid esters (PEGDMA) is constituted.
Sample 2：Weigh 8g Polyethylene Glycol (in text referred to as：PEG), the dissolving of 32g anhydrous hexanols, magnetic agitation is added simultaneously to heat up
To 90 DEG C, after two hours of stirring, solution pipette tips are smoothened into the lower mould inner surface in PP moulds, is put in air dry oven
100 DEG C of drying so as to film-forming.The various monomers of composition contact lenses are mixed, is stirred in not lucifuge, is stirred
Mix 24 hours, the monomer mixture being stirred is injected in mould.
Wherein, contact lenses are according to percentage by weight, by 21% hydroxyethyl methylacrylate (HEMA), 9% N- second
Vinyl pyrrolidone (NVP), 7.9% N, N- DMAAs (DMA), the 50% double (front threes of methacrylic acid methyl
Radical siloxane base) silylpropyl glyceride (SiMA), 10% methacrylic acid (MAA), 0.1% azodiisobutyronitrile
(AIBN), 0.35% Ethylene glycol dimethacrylate (EGDMA), 2% polyethylene glycol dimethacrylate
(PEGDMA) constitute.
Sample 3：Weigh 6g polyvinyl alcohol (in text referred to as：PVA), the anhydrous capryl alcohol dissolvings of 34g, magnetic agitation is added simultaneously to heat up
To 90 DEG C, after two hours of stirring, solution pipette tips are smoothened into the lower mould inner surface in PP moulds, is put in air dry oven
60 DEG C of drying so as to film-forming.The various monomers of composition contact lenses are mixed, is stirred in not lucifuge, is stirred
Mix 24 hours, the monomer mixture being stirred is injected in mould.
Wherein, contact lenses are according to percentage by weight, by 21% hydroxyethyl methylacrylate (HEMA), 9% N- second
Vinyl pyrrolidone (NVP), 7.9% N, N- DMAAs (DMA), the 50% double (front threes of methacrylic acid methyl
Radical siloxane base) silylpropyl glyceride (SiMA), 10% methacrylic acid (MAA), 0.1% 2- hydroxyl -2- first
Base propiophenone (D-1173), 0.35% Ethylene glycol dimethacrylate (EGDMA), 2% Polyethylene Glycol dimethyl allene
Acid esters (PEGDMA) is constituted.
Sample 4：5g polyvinyl alcohol is weighed, adds 35g anhydrous alcohol solutions, magnetic agitation to be simultaneously warmed up to 90 DEG C, stirring two
After individual hour, solution pipette tips are smoothened into the lower mould inner surface in PP moulds, are put into 70 DEG C of drying in air dry oven so as to
Film-forming.The various monomers of composition contact lenses are mixed, is stirred in not lucifuge, stirred 24 hours, will stir
The monomer mixture mixed is injected in mould.
Wherein, contact lenses are according to percentage by weight, by 21% hydroxyethyl methylacrylate (HEMA), 9% N- second
Vinyl pyrrolidone (NVP), 7.9% N, N- DMAAs (DMA), the 50% double (front threes of methacrylic acid methyl
Radical siloxane base) silylpropyl glyceride (SiMA), 10% methacrylic acid (MAA), 0.1% azodiisobutyronitrile
(AIBN), 0.35% Ethylene glycol dimethacrylate (EGDMA), 2% polyethylene glycol dimethacrylate
(PEGDMA) constitute.
Contrast sample 1：The various monomers of composition contact lenses are mixed, is stirred under the conditions of lucifuge, will be stirred
The monomer mixture mixed is injected in mould.Wherein, contact lenses are according to percentage by weight, by 21% hydroxyethyl methacrylate
Ethyl ester (HEMA), 9% NVP (NVP), 7.9% N, N- DMAAs (DMA), 50% first
Double (trimethylsiloxane group) the silylpropyl glyceride (SiMA) of base propylene acid methyl, 10% methacrylic acid (MAA),
0.1% 2- hydroxy-2-methyl propiophenones (D-1173), 0.35% Ethylene glycol dimethacrylate (EGDMA), 2%
Polyethylene glycol dimethacrylate (PEGDMA) is constituted.
Contrast sample 2：The various monomers of composition contact lenses are mixed, is stirred in not lucifuge, is stirred 24
Hour, the monomer mixture being stirred is injected in mould.Wherein, contact lenses are according to percentage by weight, by 21% first
Base 2-(Acryloyloxy)ethanol (HEMA), 9% NVP (NVP), 7.9% N, N- DMAAs
(DMA), 50% methacrylic acid methyl double (trimethylsiloxane group) silylpropyl glyceride (SiMA), 10% first
Base acrylic acid (MAA), 0.1% azodiisobutyronitrile (AIBN), 0.35% Ethylene glycol dimethacrylate (EGDMA),
2% polyethylene glycol dimethacrylate (PEGDMA) composition.
Table 1
Table 2
Lens sample obtained in all samples is positioned in PBS and is hydrated, the eyeglass being hydrated is carried out
Water static contact angle is tested.Water static contact angle method of testing is carried out using the method for state label GB/T 11417.7, each sample
This test 4 times.Test result is as shown in table 3：
Table 3
| Sample 1 | Sample 2 | Sample 3 | Sample 4 | Contrast sample 1 | Contrast sample 2 | |
| Test for the first time | 28.9 | 21.2 | 27.6 | 20.5 | 102.1 | 95.6 |
| Test for second | 28.7 | 22.6 | 28.9 | 21.3 | 102.5 | 95.9 |
| Third time is tested | 29.3 | 21.9 | 29.2 | 19.7 | 103.4 | 96.1 |
| 4th test | 30.1 | 23.2 | 27.3 | 22.8 | 105.1 | 95.7 |
| Meansigma methodss | 29.25 | 22.23 | 28.25 | 21.075 | 103.28 | 95.83 |
| Standard deviation | 0.62 | 0.87 | 0.94 | 1.32 | 1.33 | 0.22 |
Numerical value in table 3 be contact angle, unit for °.Can be seen that from the data of table 3：Measured by sample 1 to sample 4
Lens surface contact angle it is all smaller, illustrate (one close i.e. in mould inner surface coating by the method for the die surface that is modified
Water macromolecule layer) lens surface that has significantly been modified hydrophilic.Contrast sample 1 is the matched group of sample 1 and sample 3, contrast
Sample 2 is the matched group of sample 2 and sample 4.From the data of table 3, it is apparent that：The modified mirror of non-modified mould
The contact angle on piece surface is all than larger.
The contact lenses for making to different materials below, are made using the method that above-described embodiment is provided, to its hydrophilic
Can be tested.
According to shown in table 4, various monomers are mixed according to corresponding mass ratio.According to shown in table 5, to corresponding enforcement
The mould used by example is processed accordingly.Detailed process is as follows：
Sample 5：(1300000) K88-K92, molecular weight, add 36g anhydrous alcohol solutions, magnetic agitation to weigh 4g PVP
And 90 DEG C are warmed up to, after one hour of stirring, solution pipette tips are smoothened into the lower mould inner surface in PP moulds, be put into air blast and do
60 DEG C of drying in dry case so as to film-forming.Various monomers are mixed according to corresponding mass ratio, is entered under the conditions of lucifuge
Row stirring 24 hours.The monomer mixture being stirred is injected in the mould handled well, is caused 2 hours under ultra-violet lamp.
Wherein, contact lenses are according to percentage by weight, by 25% hydroxyethyl methylacrylate (HEMA), 15% N- second
Vinyl pyrrolidone (NVP), 10% N, N- DMAAs (DMA), the 30% double (trimethyls of methacrylic acid methyl
Siloxy group) silylpropyl glyceride (SiMA), 10% methacrylic acid (MAA), 1% 2- hydroxy-2-methyl benzene
Acetone (D-1173), 5% Ethylene glycol dimethacrylate (EGDMA), 4% polyethylene glycol dimethacrylate
(PEGDMA) constitute.
Sample 6：4g PEG (Mn～700) are weighed, adds 36g anhydrous alcohol solutions, magnetic agitation to be simultaneously warmed up to 60 DEG C, stir
After mixing four hours, solution pipette tips are smoothened in lower mould inner surface, be put into 80 DEG C of drying in air dry oven so as to solidify
Film forming.Various monomers are mixed according to corresponding mass ratio, 24 hours are stirred under the conditions of lucifuge.By what is be stirred
Monomer mixture is injected in the mould handled well, is caused 2 hours under ultra-violet lamp.
Wherein, contact lenses are according to percentage by weight, by 22.7% hydroxyethyl methylacrylate (HEMA), 9.7%
NVP (NVP), 10% N, N- DMAAs (DMA), 45% methacrylic acid methyl double (three
Methyl siloxane-based) silylpropyl glyceride (SiMA), 10% methacrylic acid (MAA), 2% 2- hydroxyl -2- first
Base propiophenone (D-1173), 0.3% allyl methacrylate (AMA), 0.3% polyvinyl pyrrolidone (PVP) group
Into.
Sample 7：8g PVA are weighed, adds 32g anhydrous alcohol solutions, magnetic agitation to be simultaneously warmed up to 75 DEG C, stirring two is little
Shi Hou, solution pipette tips are smoothened in lower mould inner surface, are put into 100 DEG C of drying in air dry oven so as to film-forming.Will
Various monomers are mixed according to corresponding mass ratio, and 24 hours are stirred under the conditions of lucifuge.The monomer being stirred is mixed
Compound is injected in the mould handled well, is caused 2 hours under ultra-violet lamp.
Wherein, contact lenses are according to percentage by weight, by 18% hydroxyethyl methylacrylate (HEMA), 8% N- second
Vinyl pyrrolidone (NVP), 6% N, N- DMAAs (DMA), the 50% double (trimethyls of methacrylic acid methyl
Siloxy group) silylpropyl glyceride (SiMA), 8% methacrylic acid (MAA), 2% 2- hydroxy-2-methyl phenylpropyl alcohols
Ketone (D-1173), 4% methacrylic acid (MAA), 4% polyvinyl alcohol (PVA) composition.
Table 4
Table 5
| Sample | Whether mould is processed | PVP(g) | PEG(g) | PVA(g) | Ethanol (ml) |
| 5 | It is | 4 | 0 | 0 | 40 |
| 6 | It is | 0 | 4 | 0 | 36 |
| 7 | It is | 0 | 0 | 8 | 32 |
Lens sample obtained in sample 5-7 is positioned in PBS and is hydrated, the eyeglass being hydrated is carried out
Water static contact angle is tested.Water static contact angle method of testing is carried out using the method for state label GB/T 11417.7, each sample
This test 4 times.Test result is as shown in table 6：
Table 6
| Sample 5 | Sample 6 | Sample 7 | |
| Test for the first time | 31.5 | 30.9 | 29.2 |
| Test for second | 32.0 | 30.1 | 31.3 |
| Third time is tested | 31.7 | 29.3 | 30.5 |
| 4th test | 32.8 | 31.2 | 29.0 |
| Meansigma methodss | 32.00 | 30.38 | 30.00 |
| Standard deviation | 0.57 | 0.85 | 1.09 |
Numerical value in table 6 be contact angle, unit for °.As can be seen from Table 6：Lens surface measured by sample 5-7
Contact angle is all smaller, illustrates successfully to be modified the hydrophilic of lens surface by the method for the modified die surface of the present embodiment
Property.
The basic principles, principal features and advantages of the present invention have been shown and described above.Those skilled in the art should
Understand, the present invention do not limited by above-mentioned specific embodiment, the description in above-mentioned specific embodiment and description be intended merely to into
One step explanation the present invention principle, without departing from the spirit and scope of the present invention, the present invention also have various change and
Improve, these changes and improvements are both fallen within scope of the claimed invention.The scope of protection of present invention will by right
Ask book and its equivalent thereof.
Claims (8)
1. a kind of mould for contact lenses, it is characterised in that the inner surface of described mould scribbles hydrophilic polymeric layer；Institute
State hydrophilic polymeric layer and dried in mould inner surface by hydrophilic high mol solution and formed；Described hydrophilic high mol solution is by hydrophilic
Polymer substance and solvent composition, wherein, hydrophilic high mol material account for hydrophilic high mol solution weight fraction be 10%～
20%, it is 80%～90% that solvent accounts for the weight fraction of hydrophilic high mol solution；Described solvent is non-polar solven；Described
Die surface is apolar surfaces；
Described mould is made up of mold and lower mould, and mold and lower mould are engaged, between mold and lower mould
Cavity be used for make contact lenses.
2. a kind of method for sorting of the mould for contact lenses, it is characterised in that the method for sorting is comprised the following steps：
Step 11) configuration hydrophilic high mol solution, and hydrophilic high mol solution stirring is heated；Described hydrophilic high mol solution
It is made up of hydrophilic high mol material and solvent, wherein, hydrophilic high mol material accounts for the weight fraction of hydrophilic high mol solution and is
10%～20%, it is 80%～90% that solvent accounts for the weight fraction of hydrophilic high mol solution；Described solvent is non-polar solven；
Step 12) by hydrophilic high mol solution spraying in the inner surface of mould；The die surface is apolar surfaces；
Step 13) mould for scribbling hydrophilic high mol solution is dried.
3. according to the method for sorting of the mould described in claim 2, it is characterised in that described hydrophilic high mol material is poly- N-
One kind or combination in any in vinyl pyrrolidone, Polyethylene Glycol (PEG), polyvinyl alcohol.
4. according to the method for sorting of the mould described in Claims 2 or 3, it is characterised in that described solvent be ethanol, hexanol,
One or any combination in capryl alcohol.
5. according to the method for sorting of the mould described in claim 2, it is characterised in that described step 12) in, by hydrophilic high score
Sub- solution spraying is sprayed using pipette tips or spin coating instrument spin coating in the method for the inner surface of mould.
6. according to the method for sorting of the mould described in claim 2, it is characterised in that described step 13) in, will scribble hydrophilic
The mould of macromolecular solution is placed in air dry oven, and is to dry at 60～100 DEG C in temperature.
7. a kind of manufacture method of contact lenses, it is characterised in that the manufacture method is comprised the following steps：Contact will be made first
The material mixing stirring of lens, forms uniform monomer mixture；Then the monomer mixture for stirring is put in mould,
Under initiation conditions, monomer mixture solidification forms contact lenses；Then the lens after solidification are carried out into the demoulding, finally will be saturating
Mirror is placed in PBS and is hydrated, until lens hydration is complete, need not carry out post processing；The inner surface of described mould is scribbled
Hydrophilic polymeric layer；In elicitation procedure, monomer can produce free radical, and partly the monomer with free radical penetrates into hydrophilic high mol
Layer is internal；The free radical entered into inside hydrophilic polymeric layer, mutually reacts, and be introduced into hydrophilic polymeric layer
Free radical react, so as to hydrophilic polymeric layer is chelated.
8. according to the manufacture method of the contact lenses described in claim 7, it is characterised in that the inner surface of described mould is scribbled
The process of hydrophilic polymeric layer includes：
Step 11) configuration hydrophilic high mol solution, and hydrophilic high mol solution stirring is heated；
Step 12) macromolecular solution is sprayed at the inner surface of mould；
Step 13) mould for scribbling hydrophilic high mol solution is dried.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510262811.3A CN104924508B (en) | 2015-05-21 | 2015-05-21 | For the manufacture method of the mould of contact lenses, method for sorting and contact lenses |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510262811.3A CN104924508B (en) | 2015-05-21 | 2015-05-21 | For the manufacture method of the mould of contact lenses, method for sorting and contact lenses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104924508A CN104924508A (en) | 2015-09-23 |
| CN104924508B true CN104924508B (en) | 2017-04-05 |
Family
ID=54112080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510262811.3A Active CN104924508B (en) | 2015-05-21 | 2015-05-21 | For the manufacture method of the mould of contact lenses, method for sorting and contact lenses |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104924508B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116554719A (en) * | 2022-12-08 | 2023-08-08 | 华诺森（武汉）生物医药技术有限公司 | Coating process of hydrophilic silicon hydrogel cornea contact lens |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5010155A (en) * | 1988-09-28 | 1991-04-23 | Ciba-Geigy Corporation | Vinyl-urethane substituted hydroxyethyl cellulose |
| CN1164661A (en) * | 1996-03-19 | 1997-11-12 | 庄臣及庄臣视力产品有限公司 | Molded polymeric object with wettable surface made from latent-hydrophilic monomers |
| CN1214298A (en) * | 1997-10-09 | 1999-04-21 | 可乐丽股份有限公司 | Molded polymer article having hydrophilic surface and process for producing the same |
| CN1961223A (en) * | 2004-04-01 | 2007-05-09 | 诺瓦提斯公司 | Colored ink for pad transfer printing of silicone hydrogel lenses |
| CN103079787A (en) * | 2010-07-30 | 2013-05-01 | 库柏维景国际控股公司 | Ophthalmic device molds formed from vinyl alcohol copolymer, ophthalmic devices molded therein, and related methods |
-
2015
- 2015-05-21 CN CN201510262811.3A patent/CN104924508B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5010155A (en) * | 1988-09-28 | 1991-04-23 | Ciba-Geigy Corporation | Vinyl-urethane substituted hydroxyethyl cellulose |
| CN1164661A (en) * | 1996-03-19 | 1997-11-12 | 庄臣及庄臣视力产品有限公司 | Molded polymeric object with wettable surface made from latent-hydrophilic monomers |
| CN1214298A (en) * | 1997-10-09 | 1999-04-21 | 可乐丽股份有限公司 | Molded polymer article having hydrophilic surface and process for producing the same |
| CN1961223A (en) * | 2004-04-01 | 2007-05-09 | 诺瓦提斯公司 | Colored ink for pad transfer printing of silicone hydrogel lenses |
| CN103079787A (en) * | 2010-07-30 | 2013-05-01 | 库柏维景国际控股公司 | Ophthalmic device molds formed from vinyl alcohol copolymer, ophthalmic devices molded therein, and related methods |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104924508A (en) | 2015-09-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105418858B (en) | Silicone-hydrogel material, contact lens with high oxygen permeability and preparation method thereof | |
| CN106661224B (en) | Poly- (oxazoline -co- aziridine)-epichlorohydrin copolymer and application thereof | |
| TWI429713B (en) | Wettable silicone hydrogel contact lenses and related compositions and methods | |
| CN105399954B (en) | Hydrophilic siloxane oligomer, silicone-hydrogel, contact lens and preparation method | |
| TWI509312B (en) | Silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses | |
| AU2013210010B2 (en) | Silicone polymers comprising sulfonic acid groups | |
| KR101912572B1 (en) | Contact lens | |
| CA2456036C (en) | Method for coating articles by mold transfer | |
| CN106716233B (en) | Hydrogel contact lens and preparation method thereof with wettable surfaces | |
| CN103959140A (en) | Silicone hydrogel soft contact lens having wettable surface | |
| CN108369291A (en) | Method for the coating stablized to be applied to silicone hydrogel contact lens on piece | |
| CN107532038A (en) | For producing the method in the haptic lens thereon with durable lubricant coating | |
| CN102498431A (en) | Prepolymers suitable for making ultra-violet absorbing contact lenses | |
| JP2006507541A (en) | Contact lens extraction method | |
| CN106715101B (en) | Method for applying stable coating in silicone hydrogel contact lens on piece | |
| JPH02140718A (en) | Contact lens material and making thereof | |
| CN109212777A (en) | Contact lenses with surface modifications and methods of making the same | |
| EP3172041A1 (en) | Method of manufacturing wettable silicone hydrogel contact lenses | |
| CN109415474A (en) | Silicone hydrogels comprising high-content polyamide | |
| CN110028634A (en) | Eyeglass comprising low molecular polyamides and superpolyamide | |
| JP2005511289A (en) | Coated contact lens and method for manufacturing the same | |
| CN108690211A (en) | Ophthalmic lens and method for producing same | |
| CN108710221A (en) | Ophthalmic lens and method for producing same | |
| CN104924508B (en) | For the manufacture method of the mould of contact lenses, method for sorting and contact lenses | |
| KR102244359B1 (en) | Method of making coated contact lenses |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |