JPS6490190A - Novel cephalosporin derivative, salt and ester thereof - Google Patents

Novel cephalosporin derivative, salt and ester thereof

Info

Publication number
JPS6490190A
JPS6490190A JP24559087A JP24559087A JPS6490190A JP S6490190 A JPS6490190 A JP S6490190A JP 24559087 A JP24559087 A JP 24559087A JP 24559087 A JP24559087 A JP 24559087A JP S6490190 A JPS6490190 A JP S6490190A
Authority
JP
Japan
Prior art keywords
formula
expressed
compound
ester
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP24559087A
Other languages
Japanese (ja)
Inventor
Jiyooji Miketeitsushi Ronarudo
Hiroshi Matsumoto
Toshio Otani
Akio Hyodo
Naofumi Ishida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Priority to JP24559087A priority Critical patent/JPS6490190A/en
Publication of JPS6490190A publication Critical patent/JPS6490190A/en
Pending legal-status Critical Current

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  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound expressed by formula I (R<1> represents H or acyl; R<2> represents substitutive nitrogen-containing heterocyclic group; m is 0, 1 or 2; n is 1 or 2), salt and ester thereof. EXAMPLE:Benzhydryl 7beta-(2-thienyl) acetamide-3 [(5-methyl-1, 3, 4-thiadiazol-2-yl) sulfinylmethyl)]-3-cephem-1beta-oxide-4-carboxylate. USE:A chemotherapeutic agent for infectious diseases having improved toxicity. PREPARATION:A 7-aminocephalosporanic acid expressed by formula II is ini tially reacted with an acylating agent expressed by the formula R<1>X, then reacted with a heterocyclic thiol expressed by the formula R<2>SH to provide a compound expressed by formula III. Then the compound is esterified to form a compound expressed by formula IV and oxidized to afford the aimed com pound except when m is 0.
JP24559087A 1987-09-29 1987-09-29 Novel cephalosporin derivative, salt and ester thereof Pending JPS6490190A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP24559087A JPS6490190A (en) 1987-09-29 1987-09-29 Novel cephalosporin derivative, salt and ester thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP24559087A JPS6490190A (en) 1987-09-29 1987-09-29 Novel cephalosporin derivative, salt and ester thereof

Publications (1)

Publication Number Publication Date
JPS6490190A true JPS6490190A (en) 1989-04-06

Family

ID=17135991

Family Applications (1)

Application Number Title Priority Date Filing Date
JP24559087A Pending JPS6490190A (en) 1987-09-29 1987-09-29 Novel cephalosporin derivative, salt and ester thereof

Country Status (1)

Country Link
JP (1) JPS6490190A (en)

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