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Taiho Pharmaceutical Co Ltd
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Taiho Pharmaceutical Co Ltd
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Priority to JP24559087ApriorityCriticalpatent/JPS6490190A/en
Publication of JPS6490190ApublicationCriticalpatent/JPS6490190A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
NEW MATERIAL:A compound expressed by formula I (R<1> represents H or acyl; R<2> represents substitutive nitrogen-containing heterocyclic group; m is 0, 1 or 2; n is 1 or 2), salt and ester thereof. EXAMPLE:Benzhydryl 7beta-(2-thienyl) acetamide-3 [(5-methyl-1, 3, 4-thiadiazol-2-yl) sulfinylmethyl)]-3-cephem-1beta-oxide-4-carboxylate. USE:A chemotherapeutic agent for infectious diseases having improved toxicity. PREPARATION:A 7-aminocephalosporanic acid expressed by formula II is ini tially reacted with an acylating agent expressed by the formula R<1>X, then reacted with a heterocyclic thiol expressed by the formula R<2>SH to provide a compound expressed by formula III. Then the compound is esterified to form a compound expressed by formula IV and oxidized to afford the aimed com pound except when m is 0.
JP24559087A1987-09-291987-09-29Novel cephalosporin derivative, salt and ester thereof
PendingJPS6490190A
(en)
New oxime derivatives of'3-azidomethyl 7-amino thiazolyl acetamido cephalosporanic acid their process of preparationand pharamceutical compositions containing them
Crystalline salt of 7 beta -[2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-[(1-methyl-1H-tetrazol-5-yl)thiomethyl]ceph-3-em-4-carboxylic acid and HCl or HBr