JPS6483091A - Anthracycline derivative active to inhibit reverse transcriptase of human immunodeficiency virus - Google Patents

Anthracycline derivative active to inhibit reverse transcriptase of human immunodeficiency virus

Info

Publication number
JPS6483091A
JPS6483091A JP23897287A JP23897287A JPS6483091A JP S6483091 A JPS6483091 A JP S6483091A JP 23897287 A JP23897287 A JP 23897287A JP 23897287 A JP23897287 A JP 23897287A JP S6483091 A JPS6483091 A JP S6483091A
Authority
JP
Japan
Prior art keywords
salt
reverse transcriptase
immunodeficiency virus
human immunodeficiency
anthracycline derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP23897287A
Other languages
Japanese (ja)
Inventor
Tomio Takeuchi
Kazuo Umezawa
Sonoko Hirose
Shinichi Kondo
Daishiro Ikeda
Yoshiyuki Koyama
Keiichi Ajito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP23897287A priority Critical patent/JPS6483091A/en
Priority to DE88115741T priority patent/DE3886155T2/en
Priority to US07/248,417 priority patent/US5003055A/en
Priority to EP88115741A priority patent/EP0308977B1/en
Publication of JPS6483091A publication Critical patent/JPS6483091A/en
Pending legal-status Critical Current

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  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The compound of formula I [R<1> and R<2> are H, (substituted) 1-18C alkyl, aralkyl or aryl; R<1> and R<2> may together form 1-6C alkylene, alkylidene or cycloalkylidene] and its acid addition salt. USE:Agent for inhibiting the activity of reverse transcriptase of human immunodeficiency virus. PREPARATION:14-Bromodaunomycin hydrobromide or 14-chlorodaunomycin HCl salt is made to react with a metal salt (e.g. Na salt or K salt) of a benzoic acid derivative of formula II in an organic solvent at normal temperature or under heating and, as necessary, subjecting the reaction product to chromoatographic treatment.
JP23897287A 1987-09-25 1987-09-25 Anthracycline derivative active to inhibit reverse transcriptase of human immunodeficiency virus Pending JPS6483091A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP23897287A JPS6483091A (en) 1987-09-25 1987-09-25 Anthracycline derivative active to inhibit reverse transcriptase of human immunodeficiency virus
DE88115741T DE3886155T2 (en) 1987-09-25 1988-09-23 Anthracycline derivatives with inhibitory activity against the reverse transcriptase of the human immunodeficiency virus.
US07/248,417 US5003055A (en) 1987-09-25 1988-09-23 Anthracycline derivatives having inhibitory activity against reverse transcriptase of human immunodeficiency virus
EP88115741A EP0308977B1 (en) 1987-09-25 1988-09-23 Anthracycline derivatives having inhibitory activity against reverse transcriptase of human immunodeficiency virus

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP23897287A JPS6483091A (en) 1987-09-25 1987-09-25 Anthracycline derivative active to inhibit reverse transcriptase of human immunodeficiency virus

Publications (1)

Publication Number Publication Date
JPS6483091A true JPS6483091A (en) 1989-03-28

Family

ID=17038030

Family Applications (1)

Application Number Title Priority Date Filing Date
JP23897287A Pending JPS6483091A (en) 1987-09-25 1987-09-25 Anthracycline derivative active to inhibit reverse transcriptase of human immunodeficiency virus

Country Status (1)

Country Link
JP (1) JPS6483091A (en)

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