JPS6480300A - Production of cholecystokinin pancreozymine - Google Patents

Production of cholecystokinin pancreozymine

Info

Publication number
JPS6480300A
JPS6480300A JP23574287A JP23574287A JPS6480300A JP S6480300 A JPS6480300 A JP S6480300A JP 23574287 A JP23574287 A JP 23574287A JP 23574287 A JP23574287 A JP 23574287A JP S6480300 A JPS6480300 A JP S6480300A
Authority
JP
Japan
Prior art keywords
derivative
pancreozymine
cholecystokinin
sulfate
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP23574287A
Other languages
Japanese (ja)
Inventor
Masaharu Nakano
Koichi Wada
Masahide Amamiya
Masami Ohata
Miyuki Oki
Kyoichi Kobashi
Tadanori Morikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fuji Yakuhin Kogyo KK
Original Assignee
Fuji Yakuhin Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fuji Yakuhin Kogyo KK filed Critical Fuji Yakuhin Kogyo KK
Priority to JP23574287A priority Critical patent/JPS6480300A/en
Publication of JPS6480300A publication Critical patent/JPS6480300A/en
Pending legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE:To obtain the titled compound which is a gastrointestinal hormone having pancreatic digestive enzyme releasing action in high yield, by converting cholecystokinin pancreozymine nonsulfate derivative into sulfate derivative using allyl sulfotransferase. CONSTITUTION:p-Methylbenzhydrylamine polymer is reacted with amino acids having protected alpha-amino group in the presence of a condensing agent according to the amino acid sequence of a compound and the amino-protecting groups are then removed. The above-mentioned operations are repeated to synthesize a peptide chain, which is then treated with hydrogen fluoride to eliminate the peptide from the polymer and afford a cholecystokinin pancreozymine nonsulfate derivative, which is subsequently reacted with p-nitrophenyl sulfate in the presence of allyl sulfotransferase to provide a sulfate derivative. Thereby the aimed compound having the formula (X1 is Met or Val; X2 is Ile or Met; X3 is Val or Ile; X4 is Asn or Ser).
JP23574287A 1987-09-18 1987-09-18 Production of cholecystokinin pancreozymine Pending JPS6480300A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP23574287A JPS6480300A (en) 1987-09-18 1987-09-18 Production of cholecystokinin pancreozymine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP23574287A JPS6480300A (en) 1987-09-18 1987-09-18 Production of cholecystokinin pancreozymine

Publications (1)

Publication Number Publication Date
JPS6480300A true JPS6480300A (en) 1989-03-27

Family

ID=16990551

Family Applications (1)

Application Number Title Priority Date Filing Date
JP23574287A Pending JPS6480300A (en) 1987-09-18 1987-09-18 Production of cholecystokinin pancreozymine

Country Status (1)

Country Link
JP (1) JPS6480300A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60197699A (en) * 1984-03-19 1985-10-07 Fuji Yakuhin Kogyo Kk Preparation of cholecystoquinone pancreozymine c- terminated peptide and its analogue
JPS6248381A (en) * 1985-08-28 1987-03-03 Fuji Yakuhin Kogyo Kk Production of insoluble derivative of aryl sulfotransferase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60197699A (en) * 1984-03-19 1985-10-07 Fuji Yakuhin Kogyo Kk Preparation of cholecystoquinone pancreozymine c- terminated peptide and its analogue
JPS6248381A (en) * 1985-08-28 1987-03-03 Fuji Yakuhin Kogyo Kk Production of insoluble derivative of aryl sulfotransferase

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