JPS6479157A - Novel 2-pyrazolines and remedy for cerebrovascular disorder containing said compound as active component - Google Patents

Novel 2-pyrazolines and remedy for cerebrovascular disorder containing said compound as active component

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Publication number
JPS6479157A
JPS6479157A JP63146850A JP14685088A JPS6479157A JP S6479157 A JPS6479157 A JP S6479157A JP 63146850 A JP63146850 A JP 63146850A JP 14685088 A JP14685088 A JP 14685088A JP S6479157 A JPS6479157 A JP S6479157A
Authority
JP
Japan
Prior art keywords
formula
compound
pyrazoline
phenyl
pyrazolines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63146850A
Other languages
Japanese (ja)
Other versions
JPH062742B2 (en
Inventor
Hiroyuki Yamashita
Makoto Odate
Hajime Iizuka
Hiroshi Kawamo
Yoshio Shiga
Hiroshi Namekawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP63146850A priority Critical patent/JPH062742B2/en
Publication of JPS6479157A publication Critical patent/JPS6479157A/en
Publication of JPH062742B2 publication Critical patent/JPH062742B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The 2-pyrazoline derivative of formula I (R<1> is pyridyl, pyrazyl or alkoxy; R<2> is H, alkyl, pyridyl, furyl, phenyl or substituted phenyl). EXAMPLE:1-(3-Pyridylcarbonyl)-5-phenyl-2-pyrazoline. USE:It has activities to suppress cerebral edema, protect the ischemic focus and ameliorate nervous symptom and is useful as a drug. It is administered in the form of injection, suppository or oral drug. PREPARATION:The compound of formula I can be produced by reacting an alpha,beta-unsaturated aldehyde of formula II and hydrazine with acetic acid (preferably 0.5-2 equivalent based on hydrazine) in a solvent (e.g., water) and reacting the resultant 5-substituted-2-pyrazoline of formula III with an acid chloride of formula IV. The starting compound of formula II is obtained by using the compound of formula V and diethylphosphonoacetonitrile as starting raw materials.
JP63146850A 1987-06-17 1988-06-16 Novel 2-pyrazolines and cerebrovascular disorder therapeutic agents containing the same Expired - Fee Related JPH062742B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63146850A JPH062742B2 (en) 1987-06-17 1988-06-16 Novel 2-pyrazolines and cerebrovascular disorder therapeutic agents containing the same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP62-148919 1987-06-17
JP14891987 1987-06-17
JP63146850A JPH062742B2 (en) 1987-06-17 1988-06-16 Novel 2-pyrazolines and cerebrovascular disorder therapeutic agents containing the same

Publications (2)

Publication Number Publication Date
JPS6479157A true JPS6479157A (en) 1989-03-24
JPH062742B2 JPH062742B2 (en) 1994-01-12

Family

ID=26477559

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63146850A Expired - Fee Related JPH062742B2 (en) 1987-06-17 1988-06-16 Novel 2-pyrazolines and cerebrovascular disorder therapeutic agents containing the same

Country Status (1)

Country Link
JP (1) JPH062742B2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02157276A (en) * 1988-12-12 1990-06-18 Mitsui Toatsu Chem Inc New (-)2-pyrazoline compound and remedy for cerebral angiopathy containing the same as active ingredient
JP2013518080A (en) * 2010-01-29 2013-05-20 アボツト・ヘルスケア・プロダクツ・ベー・ブイ Synthesis of substituted pyrazoline carboxyamidine derivatives.
CN104030983A (en) * 2014-03-21 2014-09-10 上海大学 Fluorine-containing triphenylpyrazole derivative and preparation method thereof
JP2018515555A (en) * 2015-05-19 2018-06-14 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Heterocyclic amides as kinase inhibitors
JP2019535728A (en) * 2016-11-18 2019-12-12 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Heterocyclic amides as kinase inhibitors

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07308647A (en) * 1994-05-18 1995-11-28 Sansha Electric Mfg Co Ltd Tool for supporting article to be cleaned in cleaning apparatus

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS608211A (en) * 1983-06-28 1985-01-17 Showa Denko Kk Agricultural and horticultural fungicide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS608211A (en) * 1983-06-28 1985-01-17 Showa Denko Kk Agricultural and horticultural fungicide

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02157276A (en) * 1988-12-12 1990-06-18 Mitsui Toatsu Chem Inc New (-)2-pyrazoline compound and remedy for cerebral angiopathy containing the same as active ingredient
JP2013518080A (en) * 2010-01-29 2013-05-20 アボツト・ヘルスケア・プロダクツ・ベー・ブイ Synthesis of substituted pyrazoline carboxyamidine derivatives.
CN104030983A (en) * 2014-03-21 2014-09-10 上海大学 Fluorine-containing triphenylpyrazole derivative and preparation method thereof
JP2018515555A (en) * 2015-05-19 2018-06-14 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Heterocyclic amides as kinase inhibitors
US10590085B2 (en) 2015-05-19 2020-03-17 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as kinase inhibitors
JP2020143079A (en) * 2015-05-19 2020-09-10 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Heterocyclic amides as kinase inhibitors
US10899716B2 (en) 2015-05-19 2021-01-26 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as kinase inhibitors
US11485710B2 (en) 2015-05-19 2022-11-01 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as kinase inhibitors
JP2019535728A (en) * 2016-11-18 2019-12-12 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Heterocyclic amides as kinase inhibitors

Also Published As

Publication number Publication date
JPH062742B2 (en) 1994-01-12

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Legal Events

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