JPS6479157A - Novel 2-pyrazolines and remedy for cerebrovascular disorder containing said compound as active component - Google Patents
Novel 2-pyrazolines and remedy for cerebrovascular disorder containing said compound as active componentInfo
- Publication number
- JPS6479157A JPS6479157A JP63146850A JP14685088A JPS6479157A JP S6479157 A JPS6479157 A JP S6479157A JP 63146850 A JP63146850 A JP 63146850A JP 14685088 A JP14685088 A JP 14685088A JP S6479157 A JPS6479157 A JP S6479157A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- pyrazoline
- phenyl
- pyrazolines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The 2-pyrazoline derivative of formula I (R<1> is pyridyl, pyrazyl or alkoxy; R<2> is H, alkyl, pyridyl, furyl, phenyl or substituted phenyl). EXAMPLE:1-(3-Pyridylcarbonyl)-5-phenyl-2-pyrazoline. USE:It has activities to suppress cerebral edema, protect the ischemic focus and ameliorate nervous symptom and is useful as a drug. It is administered in the form of injection, suppository or oral drug. PREPARATION:The compound of formula I can be produced by reacting an alpha,beta-unsaturated aldehyde of formula II and hydrazine with acetic acid (preferably 0.5-2 equivalent based on hydrazine) in a solvent (e.g., water) and reacting the resultant 5-substituted-2-pyrazoline of formula III with an acid chloride of formula IV. The starting compound of formula II is obtained by using the compound of formula V and diethylphosphonoacetonitrile as starting raw materials.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63146850A JPH062742B2 (en) | 1987-06-17 | 1988-06-16 | Novel 2-pyrazolines and cerebrovascular disorder therapeutic agents containing the same |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62-148919 | 1987-06-17 | ||
JP14891987 | 1987-06-17 | ||
JP63146850A JPH062742B2 (en) | 1987-06-17 | 1988-06-16 | Novel 2-pyrazolines and cerebrovascular disorder therapeutic agents containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6479157A true JPS6479157A (en) | 1989-03-24 |
JPH062742B2 JPH062742B2 (en) | 1994-01-12 |
Family
ID=26477559
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63146850A Expired - Fee Related JPH062742B2 (en) | 1987-06-17 | 1988-06-16 | Novel 2-pyrazolines and cerebrovascular disorder therapeutic agents containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH062742B2 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02157276A (en) * | 1988-12-12 | 1990-06-18 | Mitsui Toatsu Chem Inc | New (-)2-pyrazoline compound and remedy for cerebral angiopathy containing the same as active ingredient |
JP2013518080A (en) * | 2010-01-29 | 2013-05-20 | アボツト・ヘルスケア・プロダクツ・ベー・ブイ | Synthesis of substituted pyrazoline carboxyamidine derivatives. |
CN104030983A (en) * | 2014-03-21 | 2014-09-10 | 上海大学 | Fluorine-containing triphenylpyrazole derivative and preparation method thereof |
JP2018515555A (en) * | 2015-05-19 | 2018-06-14 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
JP2019535728A (en) * | 2016-11-18 | 2019-12-12 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07308647A (en) * | 1994-05-18 | 1995-11-28 | Sansha Electric Mfg Co Ltd | Tool for supporting article to be cleaned in cleaning apparatus |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS608211A (en) * | 1983-06-28 | 1985-01-17 | Showa Denko Kk | Agricultural and horticultural fungicide |
-
1988
- 1988-06-16 JP JP63146850A patent/JPH062742B2/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS608211A (en) * | 1983-06-28 | 1985-01-17 | Showa Denko Kk | Agricultural and horticultural fungicide |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02157276A (en) * | 1988-12-12 | 1990-06-18 | Mitsui Toatsu Chem Inc | New (-)2-pyrazoline compound and remedy for cerebral angiopathy containing the same as active ingredient |
JP2013518080A (en) * | 2010-01-29 | 2013-05-20 | アボツト・ヘルスケア・プロダクツ・ベー・ブイ | Synthesis of substituted pyrazoline carboxyamidine derivatives. |
CN104030983A (en) * | 2014-03-21 | 2014-09-10 | 上海大学 | Fluorine-containing triphenylpyrazole derivative and preparation method thereof |
JP2018515555A (en) * | 2015-05-19 | 2018-06-14 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
US10590085B2 (en) | 2015-05-19 | 2020-03-17 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
JP2020143079A (en) * | 2015-05-19 | 2020-09-10 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
US10899716B2 (en) | 2015-05-19 | 2021-01-26 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
US11485710B2 (en) | 2015-05-19 | 2022-11-01 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
JP2019535728A (en) * | 2016-11-18 | 2019-12-12 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
Also Published As
Publication number | Publication date |
---|---|
JPH062742B2 (en) | 1994-01-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
LAPS | Cancellation because of no payment of annual fees |