JPS6463514A - Improvement in biologically using ability of drug - Google Patents
Improvement in biologically using ability of drugInfo
- Publication number
- JPS6463514A JPS6463514A JP62220267A JP22026787A JPS6463514A JP S6463514 A JPS6463514 A JP S6463514A JP 62220267 A JP62220267 A JP 62220267A JP 22026787 A JP22026787 A JP 22026787A JP S6463514 A JPS6463514 A JP S6463514A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- ability
- biologically
- group
- ester bonding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title abstract 11
- 229940079593 drug Drugs 0.000 title abstract 11
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- -1 cyclic anhydride Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 210000004185 liver Anatomy 0.000 abstract 2
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 abstract 1
- 150000003973 alkyl amines Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000001079 digestive effect Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 229940014800 succinic anhydride Drugs 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PURPOSE:To avoid initial passage effects of administered drug in the liver and to improve biologically using ability of the drug, by subjecting the drug to ester bonding with a cyclic anhydride of an aliphatic dicarboxylic acid. CONSTITUTION:In oral administration, a drug which reduces biologically using ability of the drug by receiving initial passage effect in the liver and contains replaceable hydrogen atom such as hydroxyl group, mercapto group, amino group or imino group as a free group is subjected to ester bonding with a cyclic anhydride of an aliphatic dicarboxylic acid (e.g. succinic anhydride or maleic anhydride) directly or in the presence of a solvent or the drug subjected to the ester bonding is further reacted with a halogenated alkyl or a lower alkylamine to improve biologically using ability of the drug. The prepared chemically modified drug is absorbed through a digestive tube, sent to the blood, returned to the original form of the drug, absorbed and shows characteristic pharmaceutical action of the drug.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62220267A JPS6463514A (en) | 1987-09-04 | 1987-09-04 | Improvement in biologically using ability of drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62220267A JPS6463514A (en) | 1987-09-04 | 1987-09-04 | Improvement in biologically using ability of drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6463514A true JPS6463514A (en) | 1989-03-09 |
Family
ID=16748504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62220267A Pending JPS6463514A (en) | 1987-09-04 | 1987-09-04 | Improvement in biologically using ability of drug |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6463514A (en) |
-
1987
- 1987-09-04 JP JP62220267A patent/JPS6463514A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| J.PHARMACEUTICAL SCI.=1978 * |
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