JPS646269A - Quinoline derivative - Google Patents
Quinoline derivativeInfo
- Publication number
- JPS646269A JPS646269A JP63050479A JP5047988A JPS646269A JP S646269 A JPS646269 A JP S646269A JP 63050479 A JP63050479 A JP 63050479A JP 5047988 A JP5047988 A JP 5047988A JP S646269 A JPS646269 A JP S646269A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- quinoline derivative
- bond
- compound
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- SJZKULRDWHPHGG-UHFFFAOYSA-N 1-benzylpiperidin-4-one Chemical compound C1CC(=O)CCN1CC1=CC=CC=C1 SJZKULRDWHPHGG-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 235000012054 meals Nutrition 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000000506 psychotropic effect Effects 0.000 abstract 1
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
NEW MATERIAL:A quinoline derivative of formula I [R is H, lower alkyl, aralkyl; R<1>-R<3> are H, lower alkyl; R<4>, R<5> each are H, or R<4> represents hydrox yl, while R<5> represents H or they connect to each other to form a C-C bond; Z is H, alkyl or formula II, formula III (m is 1-4; X is O, S; Ar is phenyl which may be substituted); the bond between 3- and 4-positions is single or double] and its acid adduct. EXAMPLE:1-( 2-Phenylethyl )-4-(7-methyl-2-oxo-1, 2, 3, 4-tetrahydroquinolin-6-yl)-4- piperidinol hydrochloride. USE:It is useful as a medicine such as a psychotropic, hypotensor, analgesic anti-inflammatory. PREPARATION:For example, the reaction product from a compound of formula IV (M is alkali meal atom) and N-benzyl-4-piperidone is hydrogenated to give the compound of formula I.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63050479A JPS646269A (en) | 1987-03-11 | 1988-03-02 | Quinoline derivative |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5626087 | 1987-03-11 | ||
| JP63050479A JPS646269A (en) | 1987-03-11 | 1988-03-02 | Quinoline derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS646269A true JPS646269A (en) | 1989-01-10 |
Family
ID=26390951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63050479A Pending JPS646269A (en) | 1987-03-11 | 1988-03-02 | Quinoline derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS646269A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6521630B1 (en) | 1999-08-31 | 2003-02-18 | Pfizer Inc. | Tetrahydroquinazoline-2,4-diones and therapeutic uses thereof |
-
1988
- 1988-03-02 JP JP63050479A patent/JPS646269A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6521630B1 (en) | 1999-08-31 | 2003-02-18 | Pfizer Inc. | Tetrahydroquinazoline-2,4-diones and therapeutic uses thereof |
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