JPS6461467A - 5-fluorouracil derivative - Google Patents

5-fluorouracil derivative

Info

Publication number
JPS6461467A
JPS6461467A JP62217158A JP21715887A JPS6461467A JP S6461467 A JPS6461467 A JP S6461467A JP 62217158 A JP62217158 A JP 62217158A JP 21715887 A JP21715887 A JP 21715887A JP S6461467 A JPS6461467 A JP S6461467A
Authority
JP
Japan
Prior art keywords
formula
compound expressed
fluorouracil
proper solvent
meth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62217158A
Other languages
Japanese (ja)
Other versions
JPH0730043B2 (en
Inventor
Shoichiro Ozaki
Toshio Nagase
Yasuyuki Watanabe
Junji Onishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeon Corp
Original Assignee
Nippon Zeon Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Zeon Co Ltd filed Critical Nippon Zeon Co Ltd
Priority to JP62217158A priority Critical patent/JPH0730043B2/en
Publication of JPS6461467A publication Critical patent/JPS6461467A/en
Publication of JPH0730043B2 publication Critical patent/JPH0730043B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound expressed by formula I (R is H or methyl). EXAMPLE:1-Acryloyloxymethyl-5-fluorouracil. USE:An antiulcer agent having excellent polymerization activity as well as exhibiting excellent antiulcer activity in case of itself or polymerized product, or intermediate therefor. PREPARATION:A compound expressed by formula II obtained by reacting 5- fluorouracil with formalin according to ordinary method is reacted with (meth) acrylic acid and thiophenol in a proper solvent to afford a compound expressed by formula III, which is condensed in a proper solvent in the presence of a condensing agent and base to give a compound expressed by formula IV, which is then converted into sulfoxide in a proper solvent using an oxidant and heated to provide the compound expressed by formula I. The compound expressed by formula I is also obtained by reacting (meth)acrylic acid halide with 1,3- dihydroxymethyl-5-fluorouracil according to ordinary method.
JP62217158A 1987-08-31 1987-08-31 5-fluorouracil derivative Expired - Lifetime JPH0730043B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62217158A JPH0730043B2 (en) 1987-08-31 1987-08-31 5-fluorouracil derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62217158A JPH0730043B2 (en) 1987-08-31 1987-08-31 5-fluorouracil derivative

Publications (2)

Publication Number Publication Date
JPS6461467A true JPS6461467A (en) 1989-03-08
JPH0730043B2 JPH0730043B2 (en) 1995-04-05

Family

ID=16699762

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62217158A Expired - Lifetime JPH0730043B2 (en) 1987-08-31 1987-08-31 5-fluorouracil derivative

Country Status (1)

Country Link
JP (1) JPH0730043B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10228365B2 (en) 2012-08-20 2019-03-12 Otsuka Pharmaceutical Co., Ltd. Method for measuring carbohydrate metabolism ability, and composition for use in said method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10228365B2 (en) 2012-08-20 2019-03-12 Otsuka Pharmaceutical Co., Ltd. Method for measuring carbohydrate metabolism ability, and composition for use in said method

Also Published As

Publication number Publication date
JPH0730043B2 (en) 1995-04-05

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