JPS6452790A - Platinum complex having antitumor activity - Google Patents

Platinum complex having antitumor activity

Info

Publication number
JPS6452790A
JPS6452790A JP63115541A JP11554188A JPS6452790A JP S6452790 A JPS6452790 A JP S6452790A JP 63115541 A JP63115541 A JP 63115541A JP 11554188 A JP11554188 A JP 11554188A JP S6452790 A JPS6452790 A JP S6452790A
Authority
JP
Japan
Prior art keywords
substituted
platinum complex
formula
expressed
alkoxycarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63115541A
Other languages
Japanese (ja)
Other versions
JP2543949B2 (en
Inventor
Masao Sugimura
Yukiko Kameyama
Kimio Iino
Tomoyuki Shibata
Shigeki Muramatsu
Tomoo Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP63115541A priority Critical patent/JP2543949B2/en
Publication of JPS6452790A publication Critical patent/JPS6452790A/en
Application granted granted Critical
Publication of JP2543949B2 publication Critical patent/JP2543949B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 4-coordinate and divalent platinum complex having a structure expressed by formula I [A and B represent NH3, primary or secondary alkylamine or aromatic amine or A and B link with each other to form diamine; R<1> represents H, (substituted)lower alkyl, nitrile or alkoxycarbonyl; R<2> represents H, (substituted)lower alkyl, (substituted)aryl, (substituted)heterocyclic group, acylamino, alkoxycarbonyl, etc.; X represents single bond, -C(CH3)H- or -C(CH3)2-]. EXAMPLE:cis-[trans-(1)-1,2-Diaminocyclohexane] platinum (II) (3S,4R)-3-[(R)-1-tert- butyl-dimethylsilyloxyethyl)-2-oxoazetidin-4-yl-acetate. USE:An antitumor agent. PREPARATION:An equivalent or excessive amount of an azetidinone derivative expressed by formula III and 2 equivalents alkali are added to an aqueous solution of a platinum complex expressed by formula II, etc., and reacted at 0-50 deg.C.
JP63115541A 1987-05-13 1988-05-12 Platinum complex with antitumor activity Expired - Lifetime JP2543949B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63115541A JP2543949B2 (en) 1987-05-13 1988-05-12 Platinum complex with antitumor activity

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11450087 1987-05-13
JP62-114500 1987-05-13
JP63115541A JP2543949B2 (en) 1987-05-13 1988-05-12 Platinum complex with antitumor activity

Publications (2)

Publication Number Publication Date
JPS6452790A true JPS6452790A (en) 1989-02-28
JP2543949B2 JP2543949B2 (en) 1996-10-16

Family

ID=26453228

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63115541A Expired - Lifetime JP2543949B2 (en) 1987-05-13 1988-05-12 Platinum complex with antitumor activity

Country Status (1)

Country Link
JP (1) JP2543949B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0623140A (en) * 1991-08-26 1994-02-01 Sayama Seimitsu Kogyo Kk Ball rental machine for pachinkoball
JP2002234289A (en) * 2001-02-09 2002-08-20 Pilot Ink Co Ltd Pen point for marking pen and manufacturing method thereof
JP2003011569A (en) * 2001-07-02 2003-01-15 Aubex Corp Method for manufacturing nib, and nib

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0623140A (en) * 1991-08-26 1994-02-01 Sayama Seimitsu Kogyo Kk Ball rental machine for pachinkoball
JP2002234289A (en) * 2001-02-09 2002-08-20 Pilot Ink Co Ltd Pen point for marking pen and manufacturing method thereof
JP2003011569A (en) * 2001-07-02 2003-01-15 Aubex Corp Method for manufacturing nib, and nib

Also Published As

Publication number Publication date
JP2543949B2 (en) 1996-10-16

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