JPS6452790A - Platinum complex having antitumor activity - Google Patents
Platinum complex having antitumor activityInfo
- Publication number
- JPS6452790A JPS6452790A JP63115541A JP11554188A JPS6452790A JP S6452790 A JPS6452790 A JP S6452790A JP 63115541 A JP63115541 A JP 63115541A JP 11554188 A JP11554188 A JP 11554188A JP S6452790 A JPS6452790 A JP S6452790A
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- platinum complex
- formula
- expressed
- alkoxycarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 4-coordinate and divalent platinum complex having a structure expressed by formula I [A and B represent NH3, primary or secondary alkylamine or aromatic amine or A and B link with each other to form diamine; R<1> represents H, (substituted)lower alkyl, nitrile or alkoxycarbonyl; R<2> represents H, (substituted)lower alkyl, (substituted)aryl, (substituted)heterocyclic group, acylamino, alkoxycarbonyl, etc.; X represents single bond, -C(CH3)H- or -C(CH3)2-]. EXAMPLE:cis-[trans-(1)-1,2-Diaminocyclohexane] platinum (II) (3S,4R)-3-[(R)-1-tert- butyl-dimethylsilyloxyethyl)-2-oxoazetidin-4-yl-acetate. USE:An antitumor agent. PREPARATION:An equivalent or excessive amount of an azetidinone derivative expressed by formula III and 2 equivalents alkali are added to an aqueous solution of a platinum complex expressed by formula II, etc., and reacted at 0-50 deg.C.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63115541A JP2543949B2 (en) | 1987-05-13 | 1988-05-12 | Platinum complex with antitumor activity |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11450087 | 1987-05-13 | ||
JP62-114500 | 1987-05-13 | ||
JP63115541A JP2543949B2 (en) | 1987-05-13 | 1988-05-12 | Platinum complex with antitumor activity |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6452790A true JPS6452790A (en) | 1989-02-28 |
JP2543949B2 JP2543949B2 (en) | 1996-10-16 |
Family
ID=26453228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63115541A Expired - Lifetime JP2543949B2 (en) | 1987-05-13 | 1988-05-12 | Platinum complex with antitumor activity |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2543949B2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0623140A (en) * | 1991-08-26 | 1994-02-01 | Sayama Seimitsu Kogyo Kk | Ball rental machine for pachinkoball |
JP2002234289A (en) * | 2001-02-09 | 2002-08-20 | Pilot Ink Co Ltd | Pen point for marking pen and manufacturing method thereof |
JP2003011569A (en) * | 2001-07-02 | 2003-01-15 | Aubex Corp | Method for manufacturing nib, and nib |
-
1988
- 1988-05-12 JP JP63115541A patent/JP2543949B2/en not_active Expired - Lifetime
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0623140A (en) * | 1991-08-26 | 1994-02-01 | Sayama Seimitsu Kogyo Kk | Ball rental machine for pachinkoball |
JP2002234289A (en) * | 2001-02-09 | 2002-08-20 | Pilot Ink Co Ltd | Pen point for marking pen and manufacturing method thereof |
JP2003011569A (en) * | 2001-07-02 | 2003-01-15 | Aubex Corp | Method for manufacturing nib, and nib |
Also Published As
Publication number | Publication date |
---|---|
JP2543949B2 (en) | 1996-10-16 |
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