JPS6452457A - Multiple unit admistration system - Google Patents

Multiple unit admistration system

Info

Publication number
JPS6452457A
JPS6452457A JP63156609A JP15660988A JPS6452457A JP S6452457 A JPS6452457 A JP S6452457A JP 63156609 A JP63156609 A JP 63156609A JP 15660988 A JP15660988 A JP 15660988A JP S6452457 A JPS6452457 A JP S6452457A
Authority
JP
Japan
Prior art keywords
solution
housing
medicine
liquid
osmotically effective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63156609A
Other languages
Japanese (ja)
Other versions
JP2732530B2 (en
Inventor
Esu Eru Uongu Patoritsuku
Teyuuuesu Fueritsukusu
Bii Etsukenhofu Jieemuzu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of JPS6452457A publication Critical patent/JPS6452457A/en
Application granted granted Critical
Publication of JP2732530B2 publication Critical patent/JP2732530B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To enable a medication system involving an effective agent to be released continuously while fixing time by designing a medicine dispenser so that a plurality of discontinuous individual medicine units aligned in the longitudinal direction are dosed by the linear expansion of a liquid activation drive element. CONSTITUTION: An osmotically effective solute is present in a solution 90 retained in a hard housing 92, and the hard housing 92 is constructed of an impermeable film that is permeable to the passage of an external liquid and impermeable to the passage of the osmotically effective solute contained in the solution 90. The solution 90 is separated from medicine units 94 by use of a flexible film 96. The ability of a drive element to exclude the medicine units 94 contained in the housing depends on osmotic pressure produced by the solution 90 of the osmotically effective solute limited to within the housing 92. The solution shows an osmotic pressure gradient to a liquid in an environment in which a dispenser is placed, and is preferably a saturated aqueous solution of a salt.
JP63156609A 1987-06-25 1988-06-24 Multiple unit dosage system Expired - Lifetime JP2732530B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6690587A 1987-06-25 1987-06-25
US066905 1987-06-25

Publications (2)

Publication Number Publication Date
JPS6452457A true JPS6452457A (en) 1989-02-28
JP2732530B2 JP2732530B2 (en) 1998-03-30

Family

ID=22072483

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63156609A Expired - Lifetime JP2732530B2 (en) 1987-06-25 1988-06-24 Multiple unit dosage system

Country Status (9)

Country Link
JP (1) JP2732530B2 (en)
AU (1) AU602221B2 (en)
CA (1) CA1301572C (en)
DE (1) DE3821424C2 (en)
ES (1) ES2009014A6 (en)
FR (1) FR2617045B1 (en)
GB (1) GB2206046B (en)
IT (1) IT1219401B (en)
NZ (1) NZ225058A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07194670A (en) * 1993-12-09 1995-08-01 Asta Medica Ag Medicinal article and its preparation
JP2008199988A (en) * 2007-02-22 2008-09-04 Fuji Kogyo Co Ltd Rod tip protecting cover of telescopic rod with guide
JP2008199987A (en) * 2007-02-22 2008-09-04 Fuji Kogyo Co Ltd Rod tip protecting cover of telescopic rod with guide
JP2012167106A (en) * 2000-10-30 2012-09-06 Euro-Celtique Sa Controlled-release hydrocodone formulation
JP2017189688A (en) * 2009-12-17 2017-10-19 タリス バイオメディカル エルエルシー Implanting type device having tolerance in urinary bladder

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6200600B1 (en) * 1989-02-16 2001-03-13 Btg International Limited Controlled delay release device
US5342624A (en) * 1989-02-16 1994-08-30 British Technology Group Ltd. Dispensing device
WO1990012567A1 (en) * 1989-04-21 1990-11-01 Moskovsky Avtomobilestroitelny Institut (Vtuz-Zil) Device for controlled dosing of active substances into an operative medium
GB9004702D0 (en) * 1990-03-02 1990-04-25 Polysystems Limited Dispensing device
US5474784A (en) * 1990-03-02 1995-12-12 British Technology Group Limited Dispensing device
US5017381A (en) * 1990-05-02 1991-05-21 Alza Corporation Multi-unit pulsatile delivery system
US5156850A (en) * 1990-08-31 1992-10-20 Alza Corporation Dosage form for time-varying patterns of drug delivery
US6440457B1 (en) 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
WO1995035131A1 (en) * 1994-06-22 1995-12-28 Unasco Pty. Ltd. Controlled release device and method
AU3909597A (en) * 1996-08-16 1998-03-06 Alza Corporation Dosage form for providing ascending dose of drug
US6919373B1 (en) 1996-11-12 2005-07-19 Alza Corporation Methods and devices for providing prolonged drug therapy
US20110104214A1 (en) 2004-04-15 2011-05-05 Purdue Pharma L.P. Once-a-day oxycodone formulations
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62283918A (en) * 1986-05-23 1987-12-09 メルク　エンド　カムパニ−　インコ−ポレ−テツド Pulse type drug releasing system

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350271A (en) * 1980-08-22 1982-09-21 Alza Corporation Water absorbing fluid dispenser
US4449983A (en) * 1982-03-22 1984-05-22 Alza Corporation Simultaneous delivery of two drugs from unit delivery device
US4576604A (en) * 1983-03-04 1986-03-18 Alza Corporation Osmotic system with instant drug availability
AU2815684A (en) * 1983-03-31 1984-10-25 English Glass Company Limited, The Multi-dose syringe and cannulae therefor
US4692336A (en) * 1984-03-19 1987-09-08 Alza Corporation Self controlled release device for administering beneficial agent to recipient
ES8800043A1 (en) * 1985-08-16 1987-10-16 Alza Corp Osmotic dispenser
US4675174A (en) * 1985-08-16 1987-06-23 Alza Corporation Veterinary dispenser delivering beneficial agent by gas power generated in situ
JPH0778017B2 (en) * 1985-12-28 1995-08-23 住友製薬株式会社 Pulsed and sustained release formulation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62283918A (en) * 1986-05-23 1987-12-09 メルク　エンド　カムパニ−　インコ−ポレ−テツド Pulse type drug releasing system

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07194670A (en) * 1993-12-09 1995-08-01 Asta Medica Ag Medicinal article and its preparation
JP2012167106A (en) * 2000-10-30 2012-09-06 Euro-Celtique Sa Controlled-release hydrocodone formulation
JP2015007112A (en) * 2000-10-30 2015-01-15 ユーロ−セルティーク エス．エイ． Controlled-release hydrocodone formulations
JP2016053074A (en) * 2000-10-30 2016-04-14 ユーロ−セルティーク エス．エイ． Controlled-release hydrocodone formulations
JP2008199988A (en) * 2007-02-22 2008-09-04 Fuji Kogyo Co Ltd Rod tip protecting cover of telescopic rod with guide
JP2008199987A (en) * 2007-02-22 2008-09-04 Fuji Kogyo Co Ltd Rod tip protecting cover of telescopic rod with guide
JP2017189688A (en) * 2009-12-17 2017-10-19 タリス バイオメディカル エルエルシー Implanting type device having tolerance in urinary bladder

Also Published As

Publication number Publication date
GB8814220D0 (en) 1988-07-20
GB2206046B (en) 1991-04-03
GB2206046A (en) 1988-12-29
IT8867602A0 (en) 1988-06-24
FR2617045B1 (en) 1991-09-13
FR2617045A1 (en) 1988-12-30
NZ225058A (en) 1990-11-27
ES2009014A6 (en) 1989-08-16
JP2732530B2 (en) 1998-03-30
AU602221B2 (en) 1990-10-04
CA1301572C (en) 1992-05-26
IT1219401B (en) 1990-05-11
AU1816988A (en) 1989-01-05
DE3821424C2 (en) 1997-02-20
DE3821424A1 (en) 1989-01-05

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