JPS6438068A - Production of 1,4-dihydropyridine derivative - Google Patents

Production of 1,4-dihydropyridine derivative

Info

Publication number
JPS6438068A
JPS6438068A JP62194063A JP19406387A JPS6438068A JP S6438068 A JPS6438068 A JP S6438068A JP 62194063 A JP62194063 A JP 62194063A JP 19406387 A JP19406387 A JP 19406387A JP S6438068 A JPS6438068 A JP S6438068A
Authority
JP
Japan
Prior art keywords
ester
nitratopropyl
dihydropyridine
reacting
nitrophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62194063A
Other languages
Japanese (ja)
Inventor
Yoshimoto Nakajima
Toshihisa Ogawa
Atsuo Nakazato
Kaoru Soda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Priority to JP62194063A priority Critical patent/JPS6438068A/en
Publication of JPS6438068A publication Critical patent/JPS6438068A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE:To obtain the titled compound useful as a hypotensor, etc., under mild condition in high yield, by reducing 3-(3-nitratopropyl) ester 5-acetylmethyl ester of 1,4-dihydropyridine dicarboxylic acid and reacting with acetyl nitrate. CONSTITUTION:2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-di carboxylic acid 3-(2-nitratopropyl) ester 5-(3-nitratopropyl) ester is produced by reacting 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(3- nitratopropyl) ester 5-acetylmethyl ester with a reducing agent such as sodium borohydride and reacting the resultant alcohol compound with acetyl nitrate. The produced compound is useful as a drug having long-acting hypotensive action and vasodilating action.
JP62194063A 1987-08-03 1987-08-03 Production of 1,4-dihydropyridine derivative Pending JPS6438068A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62194063A JPS6438068A (en) 1987-08-03 1987-08-03 Production of 1,4-dihydropyridine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62194063A JPS6438068A (en) 1987-08-03 1987-08-03 Production of 1,4-dihydropyridine derivative

Publications (1)

Publication Number Publication Date
JPS6438068A true JPS6438068A (en) 1989-02-08

Family

ID=16318335

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62194063A Pending JPS6438068A (en) 1987-08-03 1987-08-03 Production of 1,4-dihydropyridine derivative

Country Status (1)

Country Link
JP (1) JPS6438068A (en)

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