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Kissei Pharmaceutical Co Ltd
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Kissei Pharmaceutical Co Ltd
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Priority to JP19143487ApriorityCriticalpatent/JPH072744B2/en
Publication of JPS6434985ApublicationCriticalpatent/JPS6434985A/en
Publication of JPH072744B2publicationCriticalpatent/JPH072744B2/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
NEW MATERIAL:A compound shown by formula I (R is H, OH or acetoxy). EXAMPLE:6a,9a-trans-6,6a,7,8,9,9a-Hexahydro-4H-indolo[6,5,4-cd]indol-8 -one. USE:Having inhibitory action on prolactin secretion, useful as a remedy for hyperprolactinemia, an inhibitor against milk secretion and an intermediate for producing drugs having an indole skeleton. PREPARATION:Methyl 2-(4, 5-cis-4-nitro-1,3,4,5-tetrahydrobenz [cd] indol-5-yl) acetate shown by formula II is reduced and subjected to ring closure by using a proper reducing agent such as zinc amalgam to give a compound shown by formula I wherein group R is OH.
Process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions.