JPS57142988A - Improvement of absorption of cephalosporin derivative through intestinal tracts - Google Patents

Improvement of absorption of cephalosporin derivative through intestinal tracts

Info

Publication number
JPS57142988A
JPS57142988A JP56026743A JP2674381A JPS57142988A JP S57142988 A JPS57142988 A JP S57142988A JP 56026743 A JP56026743 A JP 56026743A JP 2674381 A JP2674381 A JP 2674381A JP S57142988 A JPS57142988 A JP S57142988A
Authority
JP
Japan
Prior art keywords
derivative
cephalosporin
absorption
intestinal tracts
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56026743A
Other languages
Japanese (ja)
Inventor
Joji Nishikido
Eiji Kodama
Mitsuru Shibukawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Priority to JP56026743A priority Critical patent/JPS57142988A/en
Priority to US06/351,613 priority patent/US4465668A/en
Priority to EP82101508A priority patent/EP0060422A3/en
Publication of JPS57142988A publication Critical patent/JPS57142988A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

PURPOSE: A specific oligopetptide is bonded to a cephalosporin derivative with antibacterial activity to improve the absorption of the cephalosporin derivative through intestinal tracts, thus enabling its oral administration.
CONSTITUTION: A peptide of formulaI[X is H, R3CO-(R3 is H, alkyl), protecting group, which can be readily removed by acidolysis, hydrogenolysis or with an enzyme in a living body; R1, R2 are side chain of aminoacid; n is 1W3]is bonded to a side chain in the 3-, 4- or 7-position in 7-ACA derivative with antibacterial activity. Thus, a cephalosporin, which is substantially not absorbed orally, becomes intestinally absorbable by this process, thus enabling oral administration. The typical examples of 7-ACA derivative is a group of compounds of formula II (R4 is group of formula III, IV; R5 is methyl, chlorine, H; R6 is H, alkali metal).
COPYRIGHT: (C)1982,JPO&Japio
JP56026743A 1981-02-27 1981-02-27 Improvement of absorption of cephalosporin derivative through intestinal tracts Pending JPS57142988A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP56026743A JPS57142988A (en) 1981-02-27 1981-02-27 Improvement of absorption of cephalosporin derivative through intestinal tracts
US06/351,613 US4465668A (en) 1981-02-27 1982-02-24 Method for improving intestinal absorption of cephalosporin derivatives
EP82101508A EP0060422A3 (en) 1981-02-27 1982-02-26 Method for improving intestinal absorption of cephalosporin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56026743A JPS57142988A (en) 1981-02-27 1981-02-27 Improvement of absorption of cephalosporin derivative through intestinal tracts

Publications (1)

Publication Number Publication Date
JPS57142988A true JPS57142988A (en) 1982-09-03

Family

ID=12201775

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56026743A Pending JPS57142988A (en) 1981-02-27 1981-02-27 Improvement of absorption of cephalosporin derivative through intestinal tracts

Country Status (1)

Country Link
JP (1) JPS57142988A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6034978A (en) * 1984-03-29 1985-02-22 Kyoto Yakuhin Kogyo Kk Cephalosporin derivative and its preparation
JPS6034975A (en) * 1984-03-29 1985-02-22 Kyoto Yakuhin Kogyo Kk Production of cephalosporin

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6034978A (en) * 1984-03-29 1985-02-22 Kyoto Yakuhin Kogyo Kk Cephalosporin derivative and its preparation
JPS6034975A (en) * 1984-03-29 1985-02-22 Kyoto Yakuhin Kogyo Kk Production of cephalosporin

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