JPS6427490A - Novel glycoprotein, its production and immuno-suppressing agent containing said compound as active component - Google Patents
Novel glycoprotein, its production and immuno-suppressing agent containing said compound as active componentInfo
- Publication number
- JPS6427490A JPS6427490A JP63105678A JP10567888A JPS6427490A JP S6427490 A JPS6427490 A JP S6427490A JP 63105678 A JP63105678 A JP 63105678A JP 10567888 A JP10567888 A JP 10567888A JP S6427490 A JPS6427490 A JP S6427490A
- Authority
- JP
- Japan
- Prior art keywords
- immuno
- glycoprotein
- mycelia
- aqueous solvent
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE:To produce a glycoprotein free from coagulation activity to human erythrocyte and having immuno-regulating activity and a specific molecular weight, by culturing mycelia of fungi belonging to Fomes genus, extracting the obtained mycelia with an aqueous solvent and purifying the extract. CONSTITUTION:Mycelia of fungi of Fomes genus are cultured by standing culture, shaking culture or suspension spinner culture. The obtained mycelia are extracted with an aqueous solvent and purified to obtain the objective glycoprotein. The obtained glycoprotein is free from coagulation activity to human erythrocyte and has an immuno-regulating activity and a molecular weight of 16,000-18,000 measured by SDS gel electrophoresis and 12,000-16,000 by tricine SDS gel electrophoresis. It has an isoelectric point of pH4.4-4.6 and contains about 0.3-3.0wt.% of sugars based on the protein content. The extraction with the aqueous solvent is preferably carried out at about <=80 deg.C and about pH6n8.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63105678A JPH0722516B2 (en) | 1987-04-28 | 1988-04-28 | Novel glycoprotein, method for producing the same, and immunosuppressant containing the same as an active ingredient |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10602587 | 1987-04-28 | ||
JP62-106025 | 1987-04-28 | ||
JP63105678A JPH0722516B2 (en) | 1987-04-28 | 1988-04-28 | Novel glycoprotein, method for producing the same, and immunosuppressant containing the same as an active ingredient |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6427490A true JPS6427490A (en) | 1989-01-30 |
JPH0722516B2 JPH0722516B2 (en) | 1995-03-15 |
Family
ID=26445924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63105678A Expired - Lifetime JPH0722516B2 (en) | 1987-04-28 | 1988-04-28 | Novel glycoprotein, method for producing the same, and immunosuppressant containing the same as an active ingredient |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0722516B2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03105473U (en) * | 1990-02-17 | 1991-10-31 | ||
JP2007535299A (en) * | 2003-09-17 | 2007-12-06 | 益生生抜▲開▼▲発▼股▲フン▼有限公司 | Fungal immunoregulatory protein (FIP) purified from microorganisms and uses thereof |
-
1988
- 1988-04-28 JP JP63105678A patent/JPH0722516B2/en not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03105473U (en) * | 1990-02-17 | 1991-10-31 | ||
JP2007535299A (en) * | 2003-09-17 | 2007-12-06 | 益生生抜▲開▼▲発▼股▲フン▼有限公司 | Fungal immunoregulatory protein (FIP) purified from microorganisms and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
JPH0722516B2 (en) | 1995-03-15 |
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