JPS6425758A - 1,4-dihydropyridine derivative - Google Patents
1,4-dihydropyridine derivativeInfo
- Publication number
- JPS6425758A JPS6425758A JP16908688A JP16908688A JPS6425758A JP S6425758 A JPS6425758 A JP S6425758A JP 16908688 A JP16908688 A JP 16908688A JP 16908688 A JP16908688 A JP 16908688A JP S6425758 A JPS6425758 A JP S6425758A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound expressed
- blood
- action
- depressing action
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound expressed by formula I (R<1> is lower alkoxyalkyl; R<2> is H or lower alkyl). EXAMPLE:4-(4-Methylthiophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-di carboxylic acid 3-methyl 5-cinnamylester. USE:An antihypertensive agent having strong vasodilatating action and blood depressing action, long in retaining time of the effect and expressing after delay in maximum blood depression of blood depressing action, exhibiting slow blood depressing action and useful in remedy for hypertension. PREPARATION:A compound expressed by formula II (A is 3-6C unsaturated aliphatic hydrocarbon; Ar<2> is aryl which may be substituted by alkyl, alkoxy, etc.) is reacted with a compound expressed by the formula Ar<1>-CHO (Ar<1> is Ar<2>) and compound expressed by formula III in a nonsolvent or inert solvent such as methanol at 50-150 deg.C for 0.5-15hr to provide the compound expressed by formula I.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16908688A JPS6425758A (en) | 1988-07-08 | 1988-07-08 | 1,4-dihydropyridine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16908688A JPS6425758A (en) | 1988-07-08 | 1988-07-08 | 1,4-dihydropyridine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6425758A true JPS6425758A (en) | 1989-01-27 |
Family
ID=15880068
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16908688A Pending JPS6425758A (en) | 1988-07-08 | 1988-07-08 | 1,4-dihydropyridine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6425758A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60120861A (en) * | 1983-12-02 | 1985-06-28 | Otsuka Pharmaceut Co Ltd | Dihydropyridine derivative |
-
1988
- 1988-07-08 JP JP16908688A patent/JPS6425758A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60120861A (en) * | 1983-12-02 | 1985-06-28 | Otsuka Pharmaceut Co Ltd | Dihydropyridine derivative |
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