JPS6425758A - 1,4-dihydropyridine derivative - Google Patents

1,4-dihydropyridine derivative

Info

Publication number
JPS6425758A
JPS6425758A JP16908688A JP16908688A JPS6425758A JP S6425758 A JPS6425758 A JP S6425758A JP 16908688 A JP16908688 A JP 16908688A JP 16908688 A JP16908688 A JP 16908688A JP S6425758 A JPS6425758 A JP S6425758A
Authority
JP
Japan
Prior art keywords
formula
compound expressed
blood
action
depressing action
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16908688A
Other languages
Japanese (ja)
Inventor
Teruo Kutsuma
Hiroshi Ikawa
Yoshiaki Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujirebio Inc
Original Assignee
Fujirebio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujirebio Inc filed Critical Fujirebio Inc
Priority to JP16908688A priority Critical patent/JPS6425758A/en
Publication of JPS6425758A publication Critical patent/JPS6425758A/en
Pending legal-status Critical Current

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  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound expressed by formula I (R<1> is lower alkoxyalkyl; R<2> is H or lower alkyl). EXAMPLE:4-(4-Methylthiophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-di carboxylic acid 3-methyl 5-cinnamylester. USE:An antihypertensive agent having strong vasodilatating action and blood depressing action, long in retaining time of the effect and expressing after delay in maximum blood depression of blood depressing action, exhibiting slow blood depressing action and useful in remedy for hypertension. PREPARATION:A compound expressed by formula II (A is 3-6C unsaturated aliphatic hydrocarbon; Ar<2> is aryl which may be substituted by alkyl, alkoxy, etc.) is reacted with a compound expressed by the formula Ar<1>-CHO (Ar<1> is Ar<2>) and compound expressed by formula III in a nonsolvent or inert solvent such as methanol at 50-150 deg.C for 0.5-15hr to provide the compound expressed by formula I.
JP16908688A 1988-07-08 1988-07-08 1,4-dihydropyridine derivative Pending JPS6425758A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16908688A JPS6425758A (en) 1988-07-08 1988-07-08 1,4-dihydropyridine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16908688A JPS6425758A (en) 1988-07-08 1988-07-08 1,4-dihydropyridine derivative

Publications (1)

Publication Number Publication Date
JPS6425758A true JPS6425758A (en) 1989-01-27

Family

ID=15880068

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16908688A Pending JPS6425758A (en) 1988-07-08 1988-07-08 1,4-dihydropyridine derivative

Country Status (1)

Country Link
JP (1) JPS6425758A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60120861A (en) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd Dihydropyridine derivative

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60120861A (en) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd Dihydropyridine derivative

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