JPS6422847A - Production of 2-(4-methylaminobutoxy)diphenylmethane hydrochloride - Google Patents

Production of 2-(4-methylaminobutoxy)diphenylmethane hydrochloride

Info

Publication number
JPS6422847A
JPS6422847A JP17807287A JP17807287A JPS6422847A JP S6422847 A JPS6422847 A JP S6422847A JP 17807287 A JP17807287 A JP 17807287A JP 17807287 A JP17807287 A JP 17807287A JP S6422847 A JPS6422847 A JP S6422847A
Authority
JP
Japan
Prior art keywords
diphenylmethane
methylaminobutoxy
dihalogenobutane
benzylphenol
1mol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP17807287A
Other languages
Japanese (ja)
Other versions
JP2506376B2 (en
Inventor
Kazunari Kinugasa
Eiichiro Tanaka
Fumiko Aoki
Hiroyuki Uura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Priority to JP62178072A priority Critical patent/JP2506376B2/en
Publication of JPS6422847A publication Critical patent/JPS6422847A/en
Application granted granted Critical
Publication of JP2506376B2 publication Critical patent/JP2506376B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Abstract

PURPOSE:To obtain the titled compound useful as an antidepressant in high quality and yield, suppressing the formation of by-product, by subjecting o- benzylphenol and a 1,4-dihalogenobutane to etherification, amination and addition salt-forming reaction under specific condition. CONSTITUTION:1mol. of o-benzylphenol is etherified with >=5mol. of a 1,4- dihalogenobutane at 20-80 deg.C in the presence of mono- or dialkyl ethers (e.g. polyethylene glycol) for the prevention of discoloration. 1mol. of the resultant 2-(4-halogenobutoxy)diphenylmethane is aminated with >=10mol. of methylamine in an alcoholic solvent at room temperature - 100 deg.C and the obtained 2-(4- methylaminobutoxy)diphenylmethane is made to react with hydrogen chloride in a solvent such as toluene to obtain the objective compound.
JP62178072A 1987-07-16 1987-07-16 Method for producing 2- (4-methylaminobutoxy) diphenylmethane hydrochloride Expired - Lifetime JP2506376B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62178072A JP2506376B2 (en) 1987-07-16 1987-07-16 Method for producing 2- (4-methylaminobutoxy) diphenylmethane hydrochloride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62178072A JP2506376B2 (en) 1987-07-16 1987-07-16 Method for producing 2- (4-methylaminobutoxy) diphenylmethane hydrochloride

Publications (2)

Publication Number Publication Date
JPS6422847A true JPS6422847A (en) 1989-01-25
JP2506376B2 JP2506376B2 (en) 1996-06-12

Family

ID=16042129

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62178072A Expired - Lifetime JP2506376B2 (en) 1987-07-16 1987-07-16 Method for producing 2- (4-methylaminobutoxy) diphenylmethane hydrochloride

Country Status (1)

Country Link
JP (1) JP2506376B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002004461A1 (en) * 2000-07-06 2002-01-17 Sankyo Company, Limited Hydropyridine derivative acid addition salts
CN112114051A (en) * 2019-06-20 2020-12-22 扬子江药业集团南京海陵药业有限公司 Method for detecting genotoxic impurity halogenated alkane in aripiprazole

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5455556A (en) * 1977-10-07 1979-05-02 Mitsubishi Chem Ind Ltd (-aminoalkoxy)bibenzyl
JPS5955829A (en) * 1982-09-22 1984-03-31 Eisai Co Ltd Agent for improvement and remedy of hyponoia caused by cerebral organic disorder

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5455556A (en) * 1977-10-07 1979-05-02 Mitsubishi Chem Ind Ltd (-aminoalkoxy)bibenzyl
JPS5955829A (en) * 1982-09-22 1984-03-31 Eisai Co Ltd Agent for improvement and remedy of hyponoia caused by cerebral organic disorder

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002004461A1 (en) * 2000-07-06 2002-01-17 Sankyo Company, Limited Hydropyridine derivative acid addition salts
US6693115B2 (en) 2000-07-06 2004-02-17 Sankyo Company, Limited Acid addition salts of hydropyridine derivatives
CZ302990B6 (en) * 2000-07-06 2012-02-08 Daiichi Sankyo Company, Limited Acid addition salts of hydropyridine derivatives with hydrochloric or maleic acid
CN112114051A (en) * 2019-06-20 2020-12-22 扬子江药业集团南京海陵药业有限公司 Method for detecting genotoxic impurity halogenated alkane in aripiprazole

Also Published As

Publication number Publication date
JP2506376B2 (en) 1996-06-12

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