JPS6419022A - Agent for promoting proliferation of human normal b-lymphocyte - Google Patents
Agent for promoting proliferation of human normal b-lymphocyteInfo
- Publication number
- JPS6419022A JPS6419022A JP62175504A JP17550487A JPS6419022A JP S6419022 A JPS6419022 A JP S6419022A JP 62175504 A JP62175504 A JP 62175504A JP 17550487 A JP17550487 A JP 17550487A JP S6419022 A JPS6419022 A JP S6419022A
- Authority
- JP
- Japan
- Prior art keywords
- lymphocyte
- casein
- agent
- human normal
- milk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000003719 b-lymphocyte Anatomy 0.000 title abstract 3
- 230000035755 proliferation Effects 0.000 title abstract 2
- 230000001737 promoting effect Effects 0.000 title abstract 2
- 108010076119 Caseins Proteins 0.000 abstract 4
- 102000011632 Caseins Human genes 0.000 abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 239000005018 casein Substances 0.000 abstract 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract 2
- 108010067454 caseinomacropeptide Proteins 0.000 abstract 2
- 235000021240 caseins Nutrition 0.000 abstract 2
- 235000020247 cow milk Nutrition 0.000 abstract 2
- 210000004698 lymphocyte Anatomy 0.000 abstract 2
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 abstract 1
- 108090000746 Chymosin Proteins 0.000 abstract 1
- 102000002068 Glycopeptides Human genes 0.000 abstract 1
- 108010015899 Glycopeptides Proteins 0.000 abstract 1
- 108090000284 Pepsin A Proteins 0.000 abstract 1
- 102000057297 Pepsin A Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 abstract 1
- 229940080701 chymosin Drugs 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 abstract 1
- 239000008267 milk Substances 0.000 abstract 1
- 210000004080 milk Anatomy 0.000 abstract 1
- GNOLWGAJQVLBSM-UHFFFAOYSA-N n,n,5,7-tetramethyl-1,2,3,4-tetrahydronaphthalen-1-amine Chemical compound C1=C(C)C=C2C(N(C)C)CCCC2=C1C GNOLWGAJQVLBSM-UHFFFAOYSA-N 0.000 abstract 1
- 229940111202 pepsin Drugs 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 235000019833 protease Nutrition 0.000 abstract 1
- 108010058314 rennet Proteins 0.000 abstract 1
- 229940108461 rennet Drugs 0.000 abstract 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 abstract 1
- 239000002699 waste material Substances 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
PURPOSE:To obtain an agent for promoting the proliferation of human normal B-lymphocyte and available in large quantity at a low cost, by using a K-casein glycomacropeptide originated from K-casein of cow's milk as an active component. CONSTITUTION:The objective agent contains a K-casein glycomacropeptide (a glycopeptide having a molecular weight of about 7,000-8,000, containing >=5% of sialic acid and produced by treating milk casein with a proteinase such as chymosin or pepsin) originated from K-casein of cow's milk as an active component. The agent is effective in selectively proliferating human normal lymphocyte by adding to a culture medium of the lymphocyte, easily producible from the waste liquid generated in the production of rennet casein curd and available in large quantity at a low cost. Accordingly, the agent is extremely effective for the mass culture of human normal B-lymphocyte.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62175504A JPH0818997B2 (en) | 1987-07-14 | 1987-07-14 | Human normal B lymphocyte proliferation promoter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62175504A JPH0818997B2 (en) | 1987-07-14 | 1987-07-14 | Human normal B lymphocyte proliferation promoter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6419022A true JPS6419022A (en) | 1989-01-23 |
| JPH0818997B2 JPH0818997B2 (en) | 1996-02-28 |
Family
ID=15997202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62175504A Expired - Fee Related JPH0818997B2 (en) | 1987-07-14 | 1987-07-14 | Human normal B lymphocyte proliferation promoter |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0818997B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2677850A1 (en) * | 1991-06-21 | 1992-12-24 | Snow Brand Milk Products Co Ltd | Hypoallergenic nutritive composition |
| CN110128522A (en) * | 2019-06-04 | 2019-08-16 | 海普诺凯营养品有限公司 | One kind, which has, adjusts active feta proteolysis peptide of bone-marrow-derived lymphocyte and preparation method thereof |
-
1987
- 1987-07-14 JP JP62175504A patent/JPH0818997B2/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2677850A1 (en) * | 1991-06-21 | 1992-12-24 | Snow Brand Milk Products Co Ltd | Hypoallergenic nutritive composition |
| CN110128522A (en) * | 2019-06-04 | 2019-08-16 | 海普诺凯营养品有限公司 | One kind, which has, adjusts active feta proteolysis peptide of bone-marrow-derived lymphocyte and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0818997B2 (en) | 1996-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |