JPS6413455A - Analysis and preparation of optical isomer - Google Patents
Analysis and preparation of optical isomerInfo
- Publication number
- JPS6413455A JPS6413455A JP62170376A JP17037687A JPS6413455A JP S6413455 A JPS6413455 A JP S6413455A JP 62170376 A JP62170376 A JP 62170376A JP 17037687 A JP17037687 A JP 17037687A JP S6413455 A JPS6413455 A JP S6413455A
- Authority
- JP
- Japan
- Prior art keywords
- carboxylic acid
- compd
- denotes
- pyridone carboxylic
- performance liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003287 optical effect Effects 0.000 title abstract 2
- 238000004128 high performance liquid chromatography Methods 0.000 abstract 3
- YSLIPUSJNFIFAB-UHFFFAOYSA-N 2-oxopyridine-1-carboxylic acid Chemical compound OC(=O)N1C=CC=CC1=O YSLIPUSJNFIFAB-UHFFFAOYSA-N 0.000 abstract 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 2
- 229940024606 amino acid Drugs 0.000 abstract 2
- 235000001014 amino acid Nutrition 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910021645 metal ion Inorganic materials 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 abstract 1
- PFRUBEOIWWEFOL-UHFFFAOYSA-N [N].[S] Chemical compound [N].[S] PFRUBEOIWWEFOL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 229910001431 copper ion Inorganic materials 0.000 abstract 1
- -1 cyclic amine Chemical class 0.000 abstract 1
- SHQSVMDWKBRBGB-UHFFFAOYSA-N cyclobutanone Chemical group O=C1CCC1 SHQSVMDWKBRBGB-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229960005190 phenylalanine Drugs 0.000 abstract 1
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PURPOSE:To separate a pyridone carboxylic acid compd. with high accuracy by using high-performance liquid chromatography in the presence of optically active amino acid and bivalent metal ions to separate said compd. CONSTITUTION:The (+ or -)-pyridone carboxylic acid compd. having the asymmetric carbon expressed by the formula is separated by the high-performance liquid chromatography. In the formula, X, Y denote hydrogen, halogen; Z denotes hydrogen, halogen, cyclic amine; A denotes oxygen, sulfur nitrogen, methylene, ethylene, ketone group; R<1> denotes an alkyl groups; (n) denotes 0, 1. The optically active amino acid (for example, L-phenyl alanine) and the bivalent metal ions (for example, copper ions) are added to the mobile phase at the time of this chromatography. The pyridone carboxylic acid compd. is thereby made into the optical antipode which is directly and easily separated and can be industrially dividable by the high-performance liquid chromatography. The (+ or -)-pyridone carboxylic acid compd. is, therefore, rapidly analyzed, dispensed and refined with the high accuracy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62170376A JP2603638B2 (en) | 1987-07-08 | 1987-07-08 | Analysis and preparative methods for optical isomers |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62170376A JP2603638B2 (en) | 1987-07-08 | 1987-07-08 | Analysis and preparative methods for optical isomers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6413455A true JPS6413455A (en) | 1989-01-18 |
| JP2603638B2 JP2603638B2 (en) | 1997-04-23 |
Family
ID=15903792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62170376A Expired - Lifetime JP2603638B2 (en) | 1987-07-08 | 1987-07-08 | Analysis and preparative methods for optical isomers |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2603638B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007141900A1 (en) * | 2006-06-02 | 2007-12-13 | Daiichi Pharmaceutical Co., Ltd. | Separation method |
| JP2009024892A (en) * | 2007-07-17 | 2009-02-05 | Mitsubishi Electric Corp | Remote controller for hot water storage type hot water supply system |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61189281A (en) * | 1985-02-15 | 1986-08-22 | Dainippon Pharmaceut Co Ltd | Pyridonecarboxylic acid derivative, and ester and salt thereof |
| JPS61243081A (en) * | 1985-04-19 | 1986-10-29 | Dainippon Pharmaceut Co Ltd | Pyridonecarboxylic acid derivative, and ester and salt thereof |
| JPS624284A (en) * | 1985-06-28 | 1987-01-10 | Kyorin Pharmaceut Co Ltd | Pyridonecarboxylic acid derivative and production thereof |
| JPS6219583A (en) * | 1985-07-17 | 1987-01-28 | Dainippon Pharmaceut Co Ltd | Pyridonecarboxylic acid derivative, ester and salt |
| JPS6236383A (en) * | 1985-08-08 | 1987-02-17 | Dainippon Pharmaceut Co Ltd | Pyridonecarboxylic acid derivative |
| JPS6272660A (en) * | 1985-09-27 | 1987-04-03 | Dainippon Pharmaceut Co Ltd | Pyrrolidine derivative and salt thereof |
-
1987
- 1987-07-08 JP JP62170376A patent/JP2603638B2/en not_active Expired - Lifetime
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61189281A (en) * | 1985-02-15 | 1986-08-22 | Dainippon Pharmaceut Co Ltd | Pyridonecarboxylic acid derivative, and ester and salt thereof |
| JPS61243081A (en) * | 1985-04-19 | 1986-10-29 | Dainippon Pharmaceut Co Ltd | Pyridonecarboxylic acid derivative, and ester and salt thereof |
| JPS624284A (en) * | 1985-06-28 | 1987-01-10 | Kyorin Pharmaceut Co Ltd | Pyridonecarboxylic acid derivative and production thereof |
| JPS6219583A (en) * | 1985-07-17 | 1987-01-28 | Dainippon Pharmaceut Co Ltd | Pyridonecarboxylic acid derivative, ester and salt |
| JPS6236383A (en) * | 1985-08-08 | 1987-02-17 | Dainippon Pharmaceut Co Ltd | Pyridonecarboxylic acid derivative |
| JPS6272660A (en) * | 1985-09-27 | 1987-04-03 | Dainippon Pharmaceut Co Ltd | Pyrrolidine derivative and salt thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007141900A1 (en) * | 2006-06-02 | 2007-12-13 | Daiichi Pharmaceutical Co., Ltd. | Separation method |
| JP2009024892A (en) * | 2007-07-17 | 2009-02-05 | Mitsubishi Electric Corp | Remote controller for hot water storage type hot water supply system |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2603638B2 (en) | 1997-04-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0938467T3 (en) | Process for preparing optically pure isomers of formoterol | |
| JPS5427520A (en) | Purification of crude acrylic acid | |
| MY116006A (en) | Process for a rectificative separation of (meth) acrylic acid from a hydrophobic mixture containing crude (meth) acrylic acid | |
| ES8700254A1 (en) | Aminoalkoxybenzopyranones and processes for the production thereof. | |
| ES8604126A1 (en) | A process for the preparation of p-isononanoyloxybenzenenesulphonate. | |
| FR2375212A1 (en) | AZABICYCLOHEXANES AND METHODS FOR THEIR PREPARATION | |
| ES2001703A6 (en) | Imidazolinyl derivatives, process for their preparation and agents with herbicidal activity containing them. | |
| JPS6413455A (en) | Analysis and preparation of optical isomer | |
| GR77487B (en) | ||
| KR840006626A (en) | Method for preparing keto compound | |
| JPS5210221A (en) | Process for preparation of perfluoroalkylethers containing fluorosulfo nyl group | |
| FI894119A0 (en) | Process for the preparation of the trisodium salt of isoserine N, N-diacetic acid | |
| ES486851A1 (en) | Process for the production of ursodesoxycholic acid | |
| ES2003738A6 (en) | Surfactants derived from succinic acid. | |
| JPS5223037A (en) | Process for preparation of optical active amino acid | |
| JPS5350109A (en) | Preparation of ethylamines | |
| IT1151532B (en) | PROCEDURE FOR THE PREPARATION OF P. CHLOROFENOSSIACETIL-PIPERONILPIPERAZINA | |
| JPS53130623A (en) | Preparation of n-hydroxyalkyl-substituted phosphoroamidate | |
| JPS5257123A (en) | Process for compound having protected amino group or hydrazing group | |
| JPS5259141A (en) | Process for preparation of optical active organic thiophosphoric acid | |
| JPS5416442A (en) | Optical resolution of 3-pheoxymandelic acid | |
| JPS56122386A (en) | Novel pyridoxamine compound and its preparation | |
| ES8300691A1 (en) | Process for preparing malononitrile. | |
| JPS548938A (en) | Forming method of magnetic bubble transfer path | |
| JPS6416747A (en) | Method for optically resolving (+-)-cis-permethric acid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term | ||
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20080129 Year of fee payment: 11 |