JPS6412245B2 - - Google Patents
Info
- Publication number
- JPS6412245B2 JPS6412245B2 JP56079442A JP7944281A JPS6412245B2 JP S6412245 B2 JPS6412245 B2 JP S6412245B2 JP 56079442 A JP56079442 A JP 56079442A JP 7944281 A JP7944281 A JP 7944281A JP S6412245 B2 JPS6412245 B2 JP S6412245B2
- Authority
- JP
- Japan
- Prior art keywords
- composition
- weight
- aluminum
- antiperspirant
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 claims description 44
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 claims description 28
- 230000001166 anti-perspirative effect Effects 0.000 claims description 25
- 239000003213 antiperspirant Substances 0.000 claims description 25
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 22
- -1 aluminum-zirconium hydroxychloride Chemical compound 0.000 claims description 16
- 239000004471 Glycine Substances 0.000 claims description 11
- 239000000126 substance Substances 0.000 claims description 10
- 239000000443 aerosol Substances 0.000 claims description 6
- 239000000460 chlorine Substances 0.000 claims description 5
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 5
- 239000000347 magnesium hydroxide Substances 0.000 claims description 5
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims description 5
- 239000006210 lotion Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 3
- 239000006260 foam Substances 0.000 claims description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 2
- 229910052801 chlorine Inorganic materials 0.000 claims description 2
- 229910052751 metal Inorganic materials 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 239000000395 magnesium oxide Substances 0.000 claims 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims 2
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims 2
- 230000000694 effects Effects 0.000 description 6
- 238000009472 formulation Methods 0.000 description 5
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 3
- JKXYOQDLERSFPT-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-octadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO JKXYOQDLERSFPT-UHFFFAOYSA-N 0.000 description 2
- 229910019440 Mg(OH) Inorganic materials 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 150000004677 hydrates Chemical class 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 2
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- HBXWUCXDUUJDRB-UHFFFAOYSA-N 1-octadecoxyoctadecane Chemical compound CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC HBXWUCXDUUJDRB-UHFFFAOYSA-N 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 239000001282 iso-butane Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910000000 metal hydroxide Inorganic materials 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000012170 montan wax Substances 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/28—Zirconium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Description
本発明は新規な抗発汗剤組成物に関し、更に詳
しくは活性成分として塩化アルミニウムとアルミ
ニウム−ジルコニウムヒドロキシ塩化物との組合
せ物を含む抗発汗剤組成物に関する。
塩化アルミニウムまたはアルミニウム−ジルコ
ニウムヒドロキシ塩化物を個々に抗発汗剤物質と
して使用することは当業技術で知られている。然
しながら、我々はこれらの物質を一緒に使用する
とそれらは相乗的に作用して予想外の高い活性お
よび感応速度を与えることを今や発見した。
それ故、本発明の目的は活性抗発汗剤物質とし
て塩化アルミニウムとアルミニウム−ジルコニウ
ムヒドロキシ塩化物との組合せ物を含む高性能の
抗発汗剤組成物を提供することにある。
また本発明の目的は塩化アルミニウムとアルミ
ニウム−ジルコニウムヒドロキシ塩化物との組合
せ物を活性抗発汗剤物質として含む組成物の抗発
汗剤としての有効量を対象体の皮膚に適用するこ
とによる対象体中の発汗を抑制する方法を提供す
ることにある。
本発明のその他のおよびより詳細な目的は以下
の記述および特許請求の範囲の記載から明らかで
あろう。
他に特別の記載のない限り、以下の記述におけ
る％は組成物の全重量を基準にした重量％であ
る。
ある種の人々が抗発汗剤塩のある種のものに感
応することは知られている。抗発汗剤パネルの60
〜70％以上がある一種の物質に感応することを見
出すのは異常なことである。然しながら、本発明
の活性成分の組合せ物を使用するとパネル参加者
の93％以上が有利に感応した。また、驚異的に高
い活性を記録し、88％がすぐれた活性を有してい
た。異種の塩の活性機構は異なるものであると常
に信じられてきた。こゝで発見したものは１機構
より多くのものからの活性感応を許す組合せ物で
ある。
ふつうにいえば、この組合せは、その溶液が非
常に酸性であるので、非常に刺戟性のものと人々
は予想するであろう。我々はまたPHのみを上昇さ
せてもこの刺戟感応を軽減するのに十分ではない
ことを見出した。然しながら我々はまた２価の酸
化物または水酸化物を少量のグリシンと組み合せ
て使用するとこの問題が解決されることを発見し
た。アルカリ土類金属塩単独またはグリシン単独
もこの刺戟性の問題をいくらか改善しうるけれど
も、この２価の金属酸化物または水酸化物を本発
明の発見の線にそつてグリシンと組み合せて使用
することによりそれが完全に消滅する。
本発明の組成物中に含有せしめうる塩化アルミ
ニウムの量はやや変化しうる。多くの場合、それ
は組成物の全重量を基準にして約５重量％〜約25
重量％好ましくは約7.5〜約15重量％を構成する。
ここに使用する“塩化アルミニウム”なる用語は
無水塩化アルミニウムならびにその水和物および
水酸化物体たとえばAlCl3・6H2OまたはAl2
（OH）5Clをいう。
本発明で使用するアルミニウム−ジルコニウム
ヒドロキシ塩化物は先行技術において周知であり
次の一般式で記述される。
Al4ZroＯ（OH）14-oClo・xH2O
（上式中、ｎは０〜14の値を有し、ｘは０〜20の
値を有する）
例示として次の化合物があげられる。
Al4ZrO（OH）11Cl3；AlZrO（OH）10Cl4；および
それらの対応する水和物。
本発明の組成物中に含有せしめうるアルミニウ
ム−ジルコニウムヒドロキシ塩化物の量もやや変
化しうる。然しながら、通常それは組成物の全重
量を基準にして約２重量％〜約20重量％好ましく
は約５重量％〜約10重量％を構成する。
本発明の組成物の重要な特徴は該組成物が含む
アルミニウム塩とAl／Zr塩との比である。この
比は約0.5〜約２の範囲にあり、好ましい範囲は
約1.25〜約1.75である。
本発明の組成物中のもう１つの重要な関係は金
属と塩素とのモル比である。抗発汗性に関するこ
の錯体のイオン性を保持するために、このモル比
は0.9より小さいことが重要である。
前述の如く、水酸化（または酸化）マグネシウ
ムとグリシンとの組合せを使用して本発明の組成
物のPHを調整するのが非常に有利である。この組
合せはPHを約2.5〜約4.5の範囲に調整するために
通常使用される。グリシンは組成物の全重量を基
準にして約0.25重量％〜約５重量％のレベルで使
用され、水酸化（または酸化）マグネシウムは約
１％〜約９％を構成する。グリシンと水酸化（ま
たは酸化）マグネシウムの比もまた重要な因子で
ある。この比は約0.025〜約５の範囲でありうる
が、約0.1〜約1.0の範囲の比を用いるのが好まし
い。
抗発汗剤物質の新規な組合せ物および上述のPH
調整剤は抗発汗剤物質を伝達するのに有用な種々
の調剤形体の任意のものに配合しうる。それら
は、ローシヨン中に、クリームまたはゲル中に、
発泡系中に、エアロゾル調剤系中に、抗発汗剤ス
チツクの部分として配合することができ、あるい
は適当な溶媒ビヒクル中の溶液の形体で伝達して
もよい。下記の配合物は本発明の組成物を活性抗
発汗剤物質として使用する配合物の種類の例示で
ある。
Ａ ロール・オン（ローシヨンおよびクリーム）
活性剤物質 25％
軟化剤 ２〜４％
表面活性剤 ２〜４％
緩衝剤系 ２〜７％
水を加えて100％に
Ｂ 懸濁物−無水物がエアロゾルおよびエアロゾ
ル発泡物の配合に使用しうる。
活性剤物質 25％
軟化剤 ５〜15％
懸濁剤 ２〜５％
緩衝剤 ２〜４％
水を加えて100％に
エアロゾール
上記 70〜80％
噴射剤 15〜30％
Ｃ スチツク
活性剤物質 25％
ゲル化剤 ２〜４％
ワツクス ５〜20％
軟化剤 ５〜20％
緩衝剤 ２〜４％
外相*を加えて100％に ＊−無水溶媒
次の実施例は本発明を更に説明するためのもの
であるが、本発明がこれらに限定されるものでは
ないことを理解すべきである。
実施例 １
ロール・オンローシヨン（水中油型エマルジヨ
ン）
重量％
AlCl3・6H2O 15.00
Mg（OH）2 3.75
Al／Zrトリクロロハイドレート(1) 10.00
Brij 72（ポリオキシエチレン２−ステアリルエー
テル） 3.00
Brij 78（ポリオキシエチレン20−ステアリルエー
テル） 1.00
グリシン 0.50
EDTA−２ナトリウム塩 0.10
ポリオキシプロピレン15ステアリルエーテル
（Arlamol Ｅ） 4.00
H2O 62.65
100.00
実施例 ２
透明水溶液（ポンプスプレー）
AlCl3・6H2O 15.00
Mg（OH）2 3.75
グリシン 0.50
Al／Zrトリクロロハイドレート(1) 10.00
H2O 65.75
プロセチルAWS（PPG−５セセス20） 5.00
100.00
実施例 ３
エアロゾル抗発汗剤
Al／錯体粉末(2) 6.00
Al／Zrトリクロロハイドレート(1) 4.00
ジブチルフタレート 11.00
カボシル Ｍ−５ 0.30
ベントン 34 0.10
イソブタン 78.60
100.00
実施例 ４
スチツク抗発汗剤
Al／錯体粉末(2) 15.00
Al／Zrトリクロロハイドレート(1) 10.00
ステアリルアルコール 20.00
ジブチルフタレート 41.00
プロセチル AWS（PPG−５セセス20） 10.00
モンタンワツクス 4.00
100.00
（注） (1) Al4ZrO（OH）11Cl3
(2) 重量比４：１：0.5のAlCl3；Mg
（OH）2およびグリシンを噴霧乾燥して
製造した製品
塩化アルミニウムとアルミニウム−ジルコニウ
ムヒドロキシ塩化物との組合せが抗発汗剤として
相乗的に作用することを示すために、組成物Ａ、
ＢおよびＣと呼ぶ３種の組成物を製造した。これ
らは活性抗発汗剤物質を除いてすべての点で同一
であつた。組成物Ａは25重量％のアルミニウム−
ジルコニウムヒドロキシ塩化物を含んでいた；組
成物Ｂは10重量％のアルミニウム−ジルコニウム
ヒドロキシ塩化物と15重量％塩化アルミニウムと
を含んでいた；そして組成物Ｃは25重量％の塩化
アルミニウムを含んでいた。これらの組成物のそ
れぞれを、抗発汗剤パネルとして奉仕する個人グ
ループについての抗発汗剤活性に関して試験し
た。使用した方法はFederal Register Vol.43、
No.196（1978年10月10日）に記載されている
Gravemetric Axillary Antiperspirant Testと
呼ばれるものであつた。
この試験の結果は下記の第１表にまとめてあ
る。そこには組成物Ａ、ＢおよびＣの配合ならび
にそれぞれの組成物について測定した抗発汗剤活
性が記載されている。
The present invention relates to novel antiperspirant compositions, and more particularly to antiperspirant compositions containing as active ingredients a combination of aluminum chloride and aluminum-zirconium hydroxychloride. The use of aluminum chloride or aluminum-zirconium hydroxychloride individually as antiperspirant materials is known in the art. However, we have now discovered that when these substances are used together they act synergistically to give unexpectedly high activity and response rates. It is therefore an object of the present invention to provide a high performance antiperspirant composition containing a combination of aluminum chloride and aluminum-zirconium hydroxychloride as the active antiperspirant substance. It is also an object of the present invention to apply to the skin of a subject an antiperspirant-effective amount of a composition comprising a combination of aluminum chloride and aluminum-zirconium hydroxychloride as an active antiperspirant substance. The purpose of the present invention is to provide a method for suppressing sweating. Other and more detailed objects of the invention will be apparent from the following description and claims. Unless otherwise specified, the percentages in the following description are by weight based on the total weight of the composition. It is known that certain people are sensitive to certain types of antiperspirant salts. 60 of antiperspirants panel
It is unusual to find that ~70% or more are sensitive to one substance. However, more than 93% of panel participants responded favorably when using the active ingredient combination of the invention. In addition, surprisingly high activity was recorded, with 88% having excellent activity. It has always been believed that the active mechanisms of different salts are different. What we have discovered is a combination that allows active response from more than one mechanism. Normally one would expect this combination to be very irritating since the solution is very acidic. We also found that increasing PH alone was not sufficient to alleviate this stimulus sensitivity. However, we have also discovered that using a divalent oxide or hydroxide in combination with a small amount of glycine solves this problem. Although alkaline earth metal salts alone or glycine alone may somewhat ameliorate this irritating problem, the use of this divalent metal oxide or hydroxide in combination with glycine is in line with the discoveries of the present invention. It completely disappears. The amount of aluminum chloride that can be included in the compositions of the invention can vary somewhat. Often it will range from about 5% to about 25% by weight based on the total weight of the composition.
% by weight preferably from about 7.5 to about 15% by weight.
As used herein, the term "aluminum chloride" refers to anhydrous aluminum chloride and its hydrates and hydroxides, such as AlCl 3 6H 2 O or Al 2
(OH) 5 Cl. The aluminum-zirconium hydroxychloride used in the present invention is well known in the prior art and is described by the following general formula. Al 4 Zr o O(OH) 14-o Cl o・xH 2 O (In the above formula, n has a value of 0 to 14, and x has a value of 0 to 20) The following compounds are given as examples. It will be done. Al4ZrO (OH) 11Cl3 ; AlZrO ( OH) 10Cl4 ; and their corresponding hydrates. The amount of aluminum-zirconium hydroxychloride that may be included in the compositions of the present invention may also vary somewhat. Usually, however, it will constitute from about 2% to about 20%, preferably from about 5% to about 10% by weight, based on the total weight of the composition. An important feature of the compositions of the invention is the ratio of aluminum salts to Al/Zr salts that they contain. This ratio ranges from about 0.5 to about 2, with a preferred range of about 1.25 to about 1.75. Another important relationship in the compositions of the present invention is the molar ratio of metal to chlorine. It is important that this molar ratio is less than 0.9 in order to preserve the ionic nature of this complex with regard to antiperspirant properties. As mentioned above, it is highly advantageous to use a combination of magnesium hydroxide (or oxide) and glycine to adjust the PH of the compositions of the invention. This combination is commonly used to adjust the PH to a range of about 2.5 to about 4.5. Glycine is used at a level of about 0.25% to about 5% by weight, and magnesium hydroxide (or oxide) comprises about 1% to about 9%, based on the total weight of the composition. The ratio of glycine to magnesium hydroxide (or oxide) is also an important factor. Although this ratio can range from about 0.025 to about 5, it is preferred to use a ratio ranging from about 0.1 to about 1.0. A novel combination of antiperspirant substances and the above-mentioned PH
Conditioning agents may be incorporated into any of a variety of dosage forms useful for delivering antiperspirant substances. They can be found in lotions, in creams or gels,
It can be incorporated into foam systems, aerosol formulations, as part of antiperspirant sticks, or delivered in the form of a solution in a suitable solvent vehicle. The formulations below are illustrative of the types of formulations using the compositions of this invention as active antiperspirant materials. A Roll-on (lotion and cream) Active agent substance 25% Softener 2-4% Surfactant 2-4% Buffer system 2-7% Add water to 100% B Suspension - Anhydrous aerosol and can be used in the formulation of aerosol foams. Activator substance 25% Softener 5-15% Suspension agent 2-5% Buffer 2-4% Add water to 100% aerosol above 70-80% Propellant 15-30% C Stick activator substance 25 % Gelling agent 2-4% Wax 5-20% Softener 5-20% Buffer 2-4% Add external phase * to 100% *-Anhydrous solvent The following examples serve to further illustrate the invention. However, it should be understood that the present invention is not limited thereto. Example 1 Roll-on lotion (oil-in-water emulsion) Weight % AlCl 3.6H 2 O 15.00 Mg(OH) 2 3.75 Al/Zr trichlorohydrate (1) 10.00 Brij 72 (polyoxyethylene 2-stearyl ether) 3.00 Brij 78 (Polyoxyethylene 20-stearyl ether) 1.00 Glycine 0.50 EDTA-disodium salt 0.10 Polyoxypropylene 15 stearyl ether (Arlamol E) 4.00 H 2 O 62.65 100.00 Example 2 Clear aqueous solution (pump spray) AlCl 3・6H 2 O 15.00 Mg(OH) 2 3.75 Glycine 0.50 Al/Zr trichlorohydrate (1) 10.00 H 2 O 65.75 Procetyl AWS (PPG-5 Secess 20) 5.00 100.00 Example 3 Aerosol antiperspirant Al/complex powder (2) 6.00 Al /Zr trichlorohydrate (1) 4.00 Dibutyl phthalate 11.00 Cabosyl M-5 0.30 Bentone 34 0.10 Isobutane 78.60 100.00 Example 4 Stick antiperspirant Al/complex powder (2) 15.00 Al/Zr trichlorohydrate (1) 10.00 Stearyl alcohol 20.00 Dibutyl phthalate 41.00 Procetyl AWS (PPG-5 Secess 20) 10.00 Montan wax 4.00 100.00 (Note) (1) Al 4 ZrO(OH) 11 Cl 3 (2) AlCl 3 in a weight ratio of 4:1:0.5; Mg
Products made by spray drying (OH) 2 and glycine To demonstrate that the combination of aluminum chloride and aluminum-zirconium hydroxychloride acts synergistically as an antiperspirant, compositions A,
Three compositions, designated B and C, were made. They were identical in all respects except for the active antiperspirant material. Composition A is 25% aluminum by weight.
Composition B contained 10% by weight aluminum-zirconium hydroxychloride and 15% by weight aluminum chloride; and Composition C contained 25% by weight aluminum chloride. . Each of these compositions was tested for antiperspirant activity on a group of individuals serving as an antiperspirant panel. The method used is Federal Register Vol.43,
No.196 (October 10, 1978)
It was called the Gravemetric Axillary Antiperspirant Test. The results of this test are summarized in Table 1 below. It describes the formulation of compositions A, B and C and the antiperspirant activity measured for each composition.
【表】
第１表からわかるように、塩化アルミニウムの
使用またはアルミニウム−ジルコニウムヒドロキ
シ塩化物の使用に比較して、塩化アルミニウムと
アルミニウム−ジルコニウムヒドロキシ塩化物と
の組合せ使用により20〜25％の抗発汗剤活性の増
強がえられた。
本発明をその特定の形体に関して説明したが、
本発明の精神から逸脱することなしに多くの変化
および変性をなしうることが理解されるであろ
う。[Table] As can be seen from Table 1, the combination use of aluminum chloride and aluminum-zirconium hydroxychloride provides 20-25% anti-perspirant benefits compared to the use of aluminum chloride or the use of aluminum-zirconium hydroxychloride. Enhancement of drug activity was obtained. Although the invention has been described in terms of a particular form thereof,
It will be understood that many changes and modifications may be made without departing from the spirit of the invention.
Claims (1)
アルミニウムとアルミニウム−ジルコニウムヒド
ロキシ塩化物との組合せからなる組成物であつ
て、該組成物がその組成物の全重量を基準にして
約５重量％〜約25重量％の塩化アルミニウムと約
２重量％〜約20重量％のアルミニウム−ジルコニ
ウムヒドロキシ塩化物とを含み、該組成物中のア
ルミニウム塩とAl／Zr塩との比が約0.5〜約２の
範囲にあり、そして金属と塩素とのモル比が0.9
より小さい、ことを特徴とする抗発汗剤組成物。 ２ PH調整剤として水酸化マグネシウムまたは酸
化マグネシウムとグリシンとの組合せ物質を含
み、該水酸化マグネシウムまたは酸化マグネシウ
ムが該組成物の約１重量％〜約９重量％を構成
し、グリシンが該組成物の約0.25重量％〜約５重
量％を構成する特許請求の範囲第１項記載の組成
物。 ３ ローシヨンの形体にある特許請求の範囲第１
項記載の組成物。 ４ 溶液の形体にある特許請求の範囲第１項記載
の組成物。 ５ スチツクの形体にある特許請求の範囲第１項
記載の組成物。 ６ エアロゾル組成物の形体にある特許請求の範
囲第１項記載の組成物。 ７ ポンプスプレー組成物の形体にある特許請求
の範囲第１項記載の組成物。 ８ クリームまたはゲルの形体にある特許請求の
範囲第１項記載の組成物。 ９ 発泡物の形体にある特許請求の範囲第１項記
載の組成物。Claims: 1. A composition comprising a carrier and a combination of aluminum chloride and aluminum-zirconium hydroxychloride as active antiperspirant substances, the composition comprising: about 5% to about 25% by weight aluminum chloride and about 2% to about 20% by weight aluminum-zirconium hydroxychloride, wherein the ratio of aluminum salt to Al/Zr salt in the composition is about 0.5 to about 2, and the metal to chlorine molar ratio is 0.9.
An antiperspirant composition characterized in that: 2. Magnesium hydroxide or a combination of magnesium oxide and glycine as a PH regulator, wherein the magnesium hydroxide or magnesium oxide constitutes from about 1% to about 9% by weight of the composition, and the glycine comprises about 1% to about 9% by weight of the composition. The composition of claim 1 comprising from about 0.25% to about 5% by weight of the composition. 3 Claim 1 in the form of lotion
Compositions as described in Section. 4. A composition according to claim 1 in the form of a solution. 5. A composition according to claim 1 in the form of a stick. 6. A composition according to claim 1 in the form of an aerosol composition. 7. A composition according to claim 1 in the form of a pump spray composition. 8. A composition according to claim 1 in the form of a cream or gel. 9. A composition according to claim 1 in the form of a foam.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15311380A | 1980-05-27 | 1980-05-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5711908A JPS5711908A (en) | 1982-01-21 |
| JPS6412245B2 true JPS6412245B2 (en) | 1989-02-28 |
Family
ID=22545825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7944281A Granted JPS5711908A (en) | 1980-05-27 | 1981-05-27 | Antiperspirant composition containing aluminum chloride and aluminum-zirconium hydroxychloride as active antiperspirant and use thereof |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS5711908A (en) |
| AU (1) | AU547530B2 (en) |
| BE (1) | BE888975A (en) |
| CA (1) | CA1140470A (en) |
| CH (1) | CH644755A5 (en) |
| DE (1) | DE3120742A1 (en) |
| FR (1) | FR2483230A1 (en) |
| GB (1) | GB2076289B (en) |
| GR (1) | GR75643B (en) |
| IT (1) | IT1170993B (en) |
| MX (1) | MX156358A (en) |
| NL (1) | NL8102540A (en) |
| NZ (1) | NZ197164A (en) |
| PH (1) | PH16329A (en) |
| PT (1) | PT73090B (en) |
| SE (1) | SE452107B (en) |
| ZA (1) | ZA813484B (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4774079A (en) * | 1980-12-15 | 1988-09-27 | Bristol-Myers Company | Antiperspirant composition containing aluminum chlorohydrate, aluminum chloride and an aluminum zirconium polychlorohydrate complex and method of use |
| CA1153313A (en) * | 1980-12-15 | 1983-09-06 | Chung T. Shin | Antiperspirant composition containing aluminum chlorohydrate, aluminum chloride and an aluminum zirconium polychlorohydrate complex and method of use |
| US4606915A (en) * | 1981-04-23 | 1986-08-19 | Bristol-Myers Company | Antiperspirant combination containing an aluminum halohydrate and a stannic halide |
| US5114705A (en) * | 1983-08-16 | 1992-05-19 | The Gillette Company | Antiperspirant composition |
| US4775528A (en) * | 1983-08-16 | 1988-10-04 | The Gillette Company | Antiperspirant composition |
| GB2144992A (en) * | 1983-08-16 | 1985-03-20 | Gillette Co | Antiperspirants |
| US5589196A (en) * | 1983-08-16 | 1996-12-31 | The Gillette Company | Antiperspirant composition |
| US4673570A (en) * | 1985-03-20 | 1987-06-16 | Carter-Wallace, Inc. | Gelled antiperspirant compositions |
| JPH05112440A (en) * | 1991-08-09 | 1993-05-07 | Sayuri Takemoto | Coating agent for deodorization |
| US6136302A (en) * | 1999-02-18 | 2000-10-24 | The Procter & Gamble Company | Process of making zirconium-aluminum antiperspirant active |
| US6375937B1 (en) | 2000-10-20 | 2002-04-23 | Colgate-Palmolive Company | Antiperspirant salts for enhanced cosmetic products |
| FR2828646B1 (en) | 2001-08-17 | 2004-11-26 | Oreal | ANHYDROUS ANTITRANSPIRANT STICK |
| US20040109833A1 (en) | 2002-12-09 | 2004-06-10 | Xiaozhong Tang | High efficacy, low irritation aluminum salts and related products |
| US7905673B2 (en) | 2003-11-17 | 2011-03-15 | The Procter & Gamble Company | Antiperspirant composition and applicator therefor |
| US8815222B2 (en) * | 2009-12-23 | 2014-08-26 | Colgate—Palmolive Company | Anhydrous liquid antiperspirant composition |
| RU2672245C1 (en) | 2013-11-18 | 2018-11-13 | Колгейт-Палмолив Компани, Сша | Antiperspirant composition |
| US10342749B2 (en) | 2014-12-15 | 2019-07-09 | Conopco, Inc. | Antiperspirant compositions comprising alums |
| US9572758B2 (en) | 2015-06-30 | 2017-02-21 | Gulbrandsen Technologies, Inc. | Method of making high performance activated aluminum sesquichlorohydrate powders |
| US20170128332A1 (en) * | 2015-11-09 | 2017-05-11 | Gulbrandsen Technologies, Inc. | Activation and stabilization of basic aluminum chloride solution by zinc |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2906668A (en) * | 1955-06-13 | 1959-09-29 | Reheis Company Inc | Zirconyl and aluminum halohydroxy complex |
| US3903258A (en) * | 1973-08-06 | 1975-09-02 | Gillette Co | Zirconium aluminum complexes and method of making the same |
| US3981986A (en) * | 1973-11-23 | 1976-09-21 | Armour Pharmaceutical Company | Zirconium-aluminum-polyol buffered anti-perspirant complexes |
| US4017599A (en) * | 1973-11-23 | 1977-04-12 | Armour Pharmaceutical Company | Aluminum-zirconium anti-perspirant systems with salts of amino acids |
| AU8303275A (en) * | 1974-07-17 | 1977-01-20 | Armour Pharma | Aluminum-zirconium antiperspirant systems with trace amounts of alkaline earth metals |
| JPS5454863A (en) * | 1977-10-03 | 1979-05-01 | Kubota Ltd | Stalk and straw conveying apparatus with safety cover |
-
1980
- 1980-07-09 CA CA000355786A patent/CA1140470A/en not_active Expired
-
1981
- 1981-05-21 NZ NZ197164A patent/NZ197164A/en unknown
- 1981-05-21 AU AU70928/81A patent/AU547530B2/en not_active Ceased
- 1981-05-22 FR FR8110236A patent/FR2483230A1/en active Granted
- 1981-05-22 NL NL8102540A patent/NL8102540A/en not_active Application Discontinuation
- 1981-05-22 GR GR65041A patent/GR75643B/el unknown
- 1981-05-25 ZA ZA00813484A patent/ZA813484B/en unknown
- 1981-05-25 DE DE19813120742 patent/DE3120742A1/en active Granted
- 1981-05-25 IT IT48527/81A patent/IT1170993B/en active
- 1981-05-26 PT PT73090A patent/PT73090B/en unknown
- 1981-05-26 CH CH345681A patent/CH644755A5/en not_active IP Right Cessation
- 1981-05-26 BE BE0/204911A patent/BE888975A/en not_active IP Right Cessation
- 1981-05-26 MX MX187478A patent/MX156358A/en unknown
- 1981-05-26 GB GB8116054A patent/GB2076289B/en not_active Expired
- 1981-05-27 JP JP7944281A patent/JPS5711908A/en active Granted
- 1981-05-27 PH PH25676A patent/PH16329A/en unknown
- 1981-05-27 SE SE8103369A patent/SE452107B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA1140470A (en) | 1983-02-01 |
| PH16329A (en) | 1983-09-05 |
| GB2076289B (en) | 1985-01-09 |
| AU7092881A (en) | 1981-12-03 |
| IT1170993B (en) | 1987-06-03 |
| SE452107B (en) | 1987-11-16 |
| FR2483230B1 (en) | 1985-01-04 |
| BE888975A (en) | 1981-11-26 |
| AU547530B2 (en) | 1985-10-24 |
| IT8148527A0 (en) | 1981-05-25 |
| JPS5711908A (en) | 1982-01-21 |
| GR75643B (en) | 1984-08-02 |
| DE3120742A1 (en) | 1982-03-18 |
| CH644755A5 (en) | 1984-08-31 |
| PT73090B (en) | 1983-02-08 |
| PT73090A (en) | 1981-06-01 |
| NL8102540A (en) | 1981-12-16 |
| MX156358A (en) | 1988-08-12 |
| DE3120742C2 (en) | 1988-10-27 |
| NZ197164A (en) | 1984-08-24 |
| GB2076289A (en) | 1981-12-02 |
| SE8103369L (en) | 1981-11-28 |
| FR2483230A1 (en) | 1981-12-04 |
| ZA813484B (en) | 1982-05-26 |
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