JPS6399866A - Lint cloth having drug coated surface and its production - Google Patents

Abstract

(57) [Abstract] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed Description of the Invention] (a) Industrial Application The present invention belongs to the field of pharmaceutical industry. It can be used in medical settings for skin wounds and inflammation. It is used as an anti-pruritic medicine for insect bites, etc. It is also used as a fungicide for insect bites, and as an analgesic for pain. Dissolve or mix the drug intended for this purpose in water and mix it with the aqueous solution containing the biological substance.
2.Adhere it and dry it. Then apply the drug.
The present invention relates to a method for producing a stabilized drug-coated ink lint cloth, and further relates to a method for preparing a drug-coated lint cloth for use in skin ailments. If this patch is applied, the drug will be coated on the surface of the lint cloth and will be rubbed off, causing skin irritation.
The present invention relates to the production of drug-coated ink-printed fabrics in which a small amount of bodily fluids that have oozed out or leaked from the body have coalesced.

(b) Conventional technology Lint cloth is originally used in medical settings to protect wounds - to hold casts on drugs, and to fix rings on patient's bones. 〜Flexible〜Durable〜
It is a material that has ventilation and natural properties, and moisture absorption and natural properties.

The range of special features characterized by iodoform ~ Individual compositions of the drugs listed in Section 3 ~ Sex dogs ~ Medicinal efficacy ~ BJ action number 2 tJ) The number of drugs that have already been used as medicines Since the Gf force is only 1, which is still in use today, it is important to produce effective f-power and safety.
;・:j）Warm;Publication 1:] ``The thing Gf force is 1.The thing Gf force A is the thing whose force is 1, and the fact that it is possible by the combination is confirmed) There are many things that are unknown.

Currently, it is a combination of lint cloth and medicine (A)
Poultice medicine and (B) water as represented by Aquanor Gauze No. 2? There are cotton cloths impregnated with raw chemicals.

The former (A) is an ointment spread on a lint cloth, and by applying it to the skin, the volatilization of the ingredients in the ointment is removed. It is absorbed through the skin by the muscle and exerts an analgesic effect (no comparison with the present invention.Also, once the compressed container is opened, it should not be used as a compress). Power (I can't do it and I'm healthy and I can't use it)
. HI] The method of maintaining and using stable lt raw material is limited (
do.

Most of the time, the ointment is still there.

A plaster agent similar to a poultice has a certain amount of force (same as a moisturizer), but the method of use is limited, and a support cloth that holds the agent. The difference is that it does not meet the requirements for lint cloth.

The latter (B) Z, a liquid drug is used on the skin! When using this ~ Medicinal power (simply used as a device to prevent it from washing away)
As a convenience, I use a lint cloth made of gauze.
.

Therefore, I have yet to find anything that coats a lint cloth with a drug and holds the drug in a stable physical state, making it useful immediately upon use.)
.

(c) Problems to be solved by the invention Therefore, conventional medicines that act directly on the skin and are coated on the surface of a lint cloth. If you try to create or use a lint cloth coated with a drug that acts directly on the skin, you will encounter the following problems.

(a) For the first grade of lint cloth'? Is that so? If the coating is made of a coating with a single strength or a strength of I, then name).

('b) The agent coated with the lint cloth and coach ink must have been peeled off or desorbed before use.)

(C) The coach-inked drug must remain in a safe and neutral state for a long period of time (1).

When using contact and [(d) skin injury sound vh number ko ~ speed and force) ζ ko effect must be exhibited.

(8) Even after the drug has achieved its medicinal effect, the lint cloth must continue to function as a lint cloth).

(After achieving 100 f-wave skin adhesion medicine number z=
c'z washing G) It's not easy to flush, and it's 4F (1)
.

Until these points are resolved, the conventional treatments for skin lesions8 drugs and lint have been used, and the convenience remains the same. (I can't even see any progress).

(d) Means for Solving Problems The present invention has succeeded in solving the problems of these conventional techniques and developing a drug useful in the medical field.

In other words, we focused on the fact that there are skin lesions (skin lesions, fading scars, and body fluids that seep and leak due to inflammation), and thought that it might be possible to utilize these phenomena, which are physiological reactions of the body throughout life. .

Next, while the oblate is solid, is it immediately water number two? If the wafer is a drug with medicinal properties, then applying it to the wound will have an effect. Shime A Shinagachi ~ Even if this was possible, I did not think it was an inventive step compared to applying the medicine directly to the affected area.

Therefore, the lint cloth that protects the affected area is coated with something like oblate.The convenience of being able to do two things at the same time: applying this medicine and protecting the affected area. I thought that if I could make something, I would have four pieces of each cod to carry and store. However, the experimental results show that each f ~ starch is the same as the insect vagina pool 1.
I have a problem with my 3-double work.
And the force involved was unbearable during use.

Physical property ζko (ffite I,%
However, I also experimented with using high amylostarch, which has a problem with its stability over time (as it is known to deteriorate in 4 to 5 weeks). .

A similar soluble substance (known as polyvinyl alcohol) is a viscous lint cloth that can easily be coated on the skin and leach out from the affected area. It has been found that the drug dissolves in a small amount of water such that it cannot be used alone (1.).

In addition, by mixing 62 kinds of ingredients (1) and ζ (drugs dissolve together), it turns out that the ingredients have changed little by little.

The IrieGf phenol and cresol are degraded and are unsuitable as components of coating agents.

After repeating these experiments, the coach ink agent prepared in this invention will not be absorbed into the fibers of the lint cloth, and the surface ζ knee or aluminum will be absorbed by the fibers of the lint cloth. The vapor-deposited lint cloth is coated with coach ink while being adhered to the surface of the aluminum foil.
The lint cloth force 1 is peeled off and removed (G). The lint cloth C 2 is attached to the 3 single force and I raw material), so the skin patient's tokuko is pasted on the skin ~ good girl C, :? Arbitrary) ~
Since pancreatic acid 1 is coated on the surface of the lint cloth, it can exert medicinal effects even in the case of exuded or drained body fluids.

The success of the present invention lies in the discovery of a method for producing an aqueous solution with optimal rheology, that is, a method that maintains its water content even after applying coach ink to a lint cloth and drying it. We have selected and verified a drug that can be effective against skin diseases without losing the vitality of the tongue by mixing with this aqueous solution.

The manufacturing method is characterized by the discovery of a method for coating the surface of a piece of lint cloth with a coating agent prepared by mixing a viscous aqueous solution and an effective drug without soaking the entire cloth. The power of invention (something that solves the problems of conventional technology)

(E) Reality 1 and Reality 1J Next, Itoyoshi results of the implementation method and experiment of the present invention are described in 1G and 1G, and the characteristics of the present invention are described (Invention 4). This is limited and there are no exceptions).

Practical Cod Series 1 (a) First, add triglucopolysaccharide (molecule ('b)
? 5C! Dissolve 4g of nipovidone iodine in 10ml of water and add to the viscous/IV stage, stirring for 1 hour. Z? '3
frlj! urge This is used as a coating agent.

(Pour the adjusted coach ink and medicine deep into the tray).

(d) Lint cloth (cloth grain strength beak ■ strength 1ku ~ many naps (none)
Prepare a roll of lint with a width of 30 cm (straight and planted).

(e) Create a roller with a mesh groove a little narrower than the width of the tray containing the coating agent and a depth of 30 mm on one surface, and the coating agent will be transmitted along the surface of the roller due to the rotation G of the roller. The device should be designed so that it can be used in a powerful manner.

(f

(g) Deposit the coach ink-agent on one side of the lint cloth by moving the lint cloth by feeding the lint cloth under one force between two rollers.

(h) By drying the lint cloth to which the coating agent has adhered using heat and air, the coating agent is fixed on the surface of the lint cloth and is coated.

(1) Since the lint can be cut at night after the coach ink is completed, it can be cut to a size according to the purpose.

When using vapor-deposited aluminum, add 1αX of water to triglucopolysaccharide (molecular weight)
25g and P-'V-P (polyvinylpyrrolidone)
A viscous aqueous solution is prepared by mixing in an amount of 10 g to 10 g and stirring at a low temperature.

Even if the force is the same as IJ-1 (the surface is uniform like a lint cloth with aluminum vapor deposited and there is no pile like a cloth surface and the coach ink is separated), In addition, it is possible to coat the coach ink well by applying lycerol on the surface of the lint cloth in advance.
The effect remains the same.

Depending on the use, there are cases where the effect is required to be applied quickly and slowly, and the effect may be sustained for a long period of time. These adjustments? It can be adjusted by the following method.

In order to increase the quick-acting property, (a) reduce the amount of Nishi-Ko-polysaccharide (,y
(b) Change the molecular weight of triglycopolysaccharide to something with a lower molecular weight.

(C) Example-1 (Shallow the depth of the mesh grooves on the surface of the roller described in order e. ■Creating a G1 coating) Producing slow action (slow movement/t) (a) Increasing the solubility of triglycopolysaccharide (increasing the mixing ratio of ykG) (1)) - Changing the molecular weight of triglycopolysaccharide to a higher one.

(C) Add polyvinyl pyrrolidone and polyvinyl alcohol.

(d) Example-1 (increase the depth of the mesh grooves on the surface of the roller described in order e. Create a thin coating) The following can be produced according to the method of CWW row 1.

The following experiment was conducted to confirm the sterilization-disinfection effect of the drug-coated lint cloth prepared by the method of IJ-1. How to confirm the medicinal efficacy of the various drug coach ink cloths. In some cases, it may be necessary to use the drug continuously for a long period of time on a patient and visit a doctor to confirm its effectiveness and side effects.

Therefore, the method for confirming the medicinal efficacy of the drug-coated lint cloth produced according to the present invention is limited to this experiment.

First, an agar medium was prepared in a petri dish, and the effect of inhibiting the growth of fFTB faecium - Staphylococcus aureus was measured using a known method (cup method) - a 10% aqueous solution of povidone-iodine, whose pharmacological effects are already known. I conducted a comparative experiment using it as a control drug. According to the experimental results, the bacterial growth inhibiting effect of the drug-coated lint cloth produced by the method of Example 1 was equivalent to that of the control drug.
It is shown that the distribution strength of the drug-coated ink produced by the method of the present invention is theoretically similar.

(f) Structure of the invention The elements constituting the present invention are as follows.

(a) Selection of lint cloth The lint cloth used in the medical field is subjected to various forces such as 1 force (thickness: If the force is too much, it will not be possible to coat the surface well; if it is too thick, the places where it can be used will be limited) Also, it has been found through experiments that fabrics (both non-woven and coarse) have a rough texture, and that the optimum thickness is 1 mm to 1-5 mm. What I was able to confirm for the first time.

(1)) Adjustment of coating agent There are many types of substances with viscoelasticity (rheology).It is possible to form a liquid coating on the surface of cloth by selecting the most suitable one by repeating several experiments. It was a great success to prepare a suitable coating agent. As a result, even though the finished blade is solid, it produces the same effect as a liquid, with less force than 1.

The representative number is Coach Inc. 5, No. A (reduced quantity blue ice 75g, triglucopolysaccharide (molecular weight 2).

7j) 25 g, povidone iodine 4 g). Typical Failure 4111: Coating agent G Reservoir purified water 75g ~ Triglucopolysaccharide C
Amount: 200,000) 25g.

(20ml of Talesol soap solution) was mixed with grt and a coagulated product appeared. Therefore, if the skin is affected, the patient should be treated with a medical treatment and the pancreas should be refilled. ■Items that do not undergo water decomposition - those that do not undergo force-pull decomposition - those that do not undergo photolysis - those that do not cause self-transformation Per ~ These are experimental G-based forces and forces 1
Contains many things.

(d) Coach ink method applying the printing technique fhote As a coating technique for cloth, the first thing that comes to mind is waterproofing, and then the printed pattern Y112-1TFZ. G) Even if there is a discrepancy, these technologies are
Once coated, f5f! ! Will you be able to do it?
8) I hope that there will be no peeling or desorption.

The surface force of the lint cloth is 1 when the applied coating agent is required according to the present invention. If you roll an 8 and separate it, you won't be able to get a 4-bo.

The power that sparked this demand was the preparation of a coating agent that demonstrated the power needed for gravure printing.
The viscosity of the ink to be reused is the same as that of the ink used.The coach ink's chemical agent is adjusted to the same level as the viscosity of the ink to be reused.
He invented that it was possible to run a 50-million-dollar coach company.

(e) Onnaguchi, which showed 11 tari in raw Shinobu Goguchi experiment example-1 (by the method of the present invention, it was confirmed by experiment that it was coach-ined once on lint cloth) be.

(f) Confirmation of stable lt production The drug-coated lint cloth produced according to the present invention was left at room temperature for 6 months. ~':IyA911-1
After confirming the effectiveness using the above method, we used a liquid chromatocooler to confirm changes over time and found that there was no change at all from the time of manufacture.

(g) A drug-coated lint cloth manufactured by Dapi Co., Ltd. from the present invention - Experimental Example-1 There is no such thing as a person who has been imprisoned with Yang as a living person - a person who is thought to be a false positive with a living being is confirmed to be safe in Itari.

(G) Effects of the Invention The present invention focuses on body fluids that seep out or leak from affected areas of the skin, and by utilizing these body fluids as water, it is possible to use drugs that can only be effective in liquid form. The most important feature is that it was successfully extracted from a solid state and liquefied when used.

As a result, hitherto unimagined uses have been developed in the medical field, and its effects will become increasingly common in the future, helping people suffering from skin diseases.

(1) Inconvenient handling of liquid drugs and easy spillage
I solved the problem of transportation ~ mobile phone.

(2) Solved the inconvenience of weighing liquid drugs.

(3) It is capable of mass production and is easy to store.

(4) Solve the problem of instability of liquid drugs and create something that is stable over time.

(5) Medical care is easy and drug administration and treatment can be performed once and the breeding rate can be improved.

(6) Very suitable as a dosage form for emergency drugs.

(7) The fl usage rate of the drug is high - when applying it on top of conventional ointments etc. to obtain the same effect - fewer raw materials are required.

This is a BI3 diagram.

Figure 2 is a perspective view of the roller for adhering the coating agent to the lint cloth from the force A in the tray. lint cloth) Enlarged cross-section of Figures 4 to 3 δ Perspective view Figure 5 ζ
Explanatory diagram of the drug-coached ink-lint cloth of the present invention 1 Roll of lint cloth 2 Tray 3 Coating agent 4 Roller with rubber surface 5 Roller with mesh grooves 6 Roller 7 Roller 8 Drying box 9 Lint cloth winding roller 10 Lint cloth 11 Aluminum foil 12 Coach ink 17 So δ /a // //? /

Claims (8)

[Claims] (1) When a drug is coated on the surface of a lint cloth and applied, body fluids seeping out or leaking from the affected area of the skin can cause
A drug-coated lint cloth and its manufacturing method, characterized in that the coated drug dissolves and the medicinal effect is directly applied to the affected skin area. (2) The product according to claim 1, wherein the lint cloth is gauze, cotton cloth, nonwoven fabric, collagen fiber cloth, or a material on which aluminum is vapor-deposited or adhered, or a resin is adhered to the surface. and manufacturing method (3) The drug is iodoform, povidone-iodine, hexachlorophene, acrinol, benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate, polyvinylpyrrolidone, vinyl acetate, alkylpolyaminoethylglycine hydrochloride, clotrimazole, miconazole nitrate, econazole nitrate, Domiphene bromide, indomethacin, ketobrofen, flurbibrofen, diclofenac, fradiomycin, procaine hydrochloride, lidocaine, ethyl aminobenzoate, dexamethasone, adrenochrome, dibucaine hydrochloride, polyvinyl alcohol, insulin, cyclodextrin, prostaglandin, chloride 1 from delicanium and triglucopolysaccharide
The product and manufacturing method of claim 1, which is a drug prepared with one or more drugs. (4) The product and manufacturing method according to claim 1, wherein the drug-coated lint cloth can be cut to any size and can be used in combination with adhesive tape, etc. (5) Medicinal effects include local antipruritic, analgesic, anti-inflammatory, and sterilizing effects on the affected skin area.
The product and manufacturing method according to claim 1, which is intended for disinfection. (6) The product and manufacturing method according to claim 1, in which the coating technology is an application of printing technology such as a gravure printing method, a basic technology such as a casting method or a roll coater method, and an application thereof. (7) The method according to claim 1, wherein the drug-coated lint cloth is within the range that requires manufacturing permission and approval as a medical drug or over-the-counter drug as stipulated by the Pharmaceutical Affairs Law. (8) The product and manufacturing method according to claims 1 and 2, wherein the lint cloth has a soft touch and excellent skin protection properties, and has hygroscopicity and cleanliness.