JPS6354390B2 - - Google Patents
Info
- Publication number
- JPS6354390B2 JPS6354390B2 JP58084072A JP8407283A JPS6354390B2 JP S6354390 B2 JPS6354390 B2 JP S6354390B2 JP 58084072 A JP58084072 A JP 58084072A JP 8407283 A JP8407283 A JP 8407283A JP S6354390 B2 JPS6354390 B2 JP S6354390B2
- Authority
- JP
- Japan
- Prior art keywords
- oxygen gas
- gas permeability
- resin
- skin
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229920005989 resin Polymers 0.000 claims description 11
- 239000011347 resin Substances 0.000 claims description 11
- 230000035699 permeability Effects 0.000 claims description 8
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 7
- 229910001882 dioxygen Inorganic materials 0.000 claims description 7
- 229920001296 polysiloxane Polymers 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 4
- 229920006026 co-polymeric resin Polymers 0.000 claims description 3
- 229920002050 silicone resin Polymers 0.000 claims description 3
- 239000000645 desinfectant Substances 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims 2
- 239000003899 bactericide agent Substances 0.000 claims 2
- 239000006172 buffering agent Substances 0.000 claims 2
- 239000002075 main ingredient Substances 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Natural products C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000010201 Exanthema Diseases 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 201000005884 exanthem Diseases 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 239000005061 synthetic rubber Substances 0.000 description 1
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Description
通常、我々が身体に擦傷、切傷等の傷害を受け
た時は殺菌剤入り薬（液体、軟膏）を傷口に塗る
か、絆創膏を貼るなどの処置を行う。
しかしながら、液体殺菌剤を皮膚に塗つた場合
皮膚から直ちに流れてしまう傾向があり、長期間
にわたる薬剤効果が十分に発揮されない。
一方、このような欠点をなくすべく軟膏等が考
案されているが、切傷等に塗り込んだ場合、皮膚
の表面がベト付き、衣類を汚す等の欠点を生ず
る。そこで、一般にこのような欠点を防止すべ
く、絆創膏を貼る等の処置を行うが、絆創膏を貼
つた場合、皮膚表面上の美観（特に顔等に貼つた
場合）をそこねる。さらに最大の欠点として、皮
膚表面の通気性が遮蔽され、肌荒れ、かぶれ等の
皮膚障害を生ずる。
本発明者はこのような各種欠点を改善又は解消
するため鋭意研究した結果、湿布剤が皮膚呼吸を
遮蔽することのない酸素ガス透過性を有し、伸縮
性のあるベト付きのない樹脂に殺菌剤、化膿止め
等を入れまた必要に応じ皮膚に合つた染料等を加
え、皮膚に塗つた時、長期間の薬剤効果を発揮
し、さらに美観を保つこともできる本発明の湿布
剤を完成した。
本発明の湿布剤に用いられる酸素ガス透過性及
び伸縮性を有する樹脂とは例えばシリコン樹脂、
シリコン−アクリル系樹脂、シリコン−ウレタン
系樹脂、シリコン−スチレン系樹脂、シリコン−
フツ素系樹脂等のシリコン・コーポリマー系樹脂
の少なくとも１つである。
又、本発明に於ては皮膚の密着性、伸縮性、た
れ防止性等を改善させるために例えば、アクリル
系、スチレン系、ウレタン系、エポキシ系、ポリ
エステル系、塩化ビニル系、天然合成ゴム等の一
種又は二種以上の樹脂を混合せしめることも可能
である。
既に述べたような本発明の湿布剤に用いられる
樹脂としては、水可溶性樹脂、エマルジヨン系樹
脂、溶剤可溶性樹脂等、各種性状のものが使用可
能である。
さらに本発明の湿布剤に用いられる溶媒は、身
体に対し、安全で、かつ低沸点溶剤、たとえばエ
チルアルコール、フツ素系溶剤又は水等が用いら
れる。更に必要に応じ、カオリン、ベントナイト
等の無機物粉末に、グリセリン、プロピレングリ
コール、ソルビトール等の湿潤剤、ゼラチン、ポ
リビニールアルコール等のゲル化剤を混練するこ
とも可能である。
本発明の湿布剤の皮膚に対する適用法としては
公知のすべての方法、例えば噴霧（エアゾール
式）、又は塗り（ロール式、ハケ塗り等）等あら
ゆる適用方法が可能である。
かくて、前述の溶媒は、飛散する。
溶媒の飛散後の、本発明の皮膚呼吸を損なわな
ち湿布剤は、酸素ガス透過係数30×10-10（cm3
（STP）cm／cm2・sec・cmHg）以上を有し、薬剤
を長期間にわたり皮膚の患部に塗布しておいて
も、肌荒れ、かぶれ等の障害が全く生じないとい
う優れた性能を有している。
以下に安全で優れた性能を有する本発明の湿布
剤の実施例として表−１の処方例１〜７、対照例
として表−１の処方例８〜10、ならびにそれらの
湿布剤としての性能試験結果を表−２にまとめて
示す。
Normally, when we sustain an injury such as an abrasion or cut on our body, we apply antiseptic medicine (liquid or ointment) to the wound or apply a bandage. However, when liquid disinfectants are applied to the skin, they tend to run off from the skin immediately, and the drug's long-term effects are not sufficiently exerted. On the other hand, ointments and the like have been devised to eliminate such drawbacks, but when applied to cuts etc., they cause drawbacks such as making the skin surface sticky and staining clothes. Therefore, in order to prevent such defects, measures such as applying a bandage are generally taken, but when a bandage is applied, the aesthetic appearance on the skin surface (particularly when applied to the face) is impaired. Furthermore, the biggest drawback is that the air permeability of the skin surface is blocked, causing skin disorders such as rough skin and rashes. As a result of intensive research to improve or eliminate these various drawbacks, the inventor of the present invention found that the poultice has oxygen gas permeability that does not block the skin's breathing, and is made of a stretchable, non-sticky resin that sterilizes the skin. We have completed the poultice of the present invention, which has a medicinal effect for a long period of time when applied to the skin by adding agents such as anti-inflammatory agents and anti-suppuration agents, as well as dyes suitable for the skin if necessary, and which can also maintain a beautiful appearance. . Examples of the resin having oxygen gas permeability and elasticity used in the poultice of the present invention include silicone resin,
Silicone - acrylic resin, silicone - urethane resin, silicone - styrene resin, silicone -
It is at least one of silicone copolymer resins such as fluorine resins. In addition, in the present invention, in order to improve skin adhesion, elasticity, anti-sagging properties, etc., for example, acrylic, styrene, urethane, epoxy, polyester, vinyl chloride, natural synthetic rubber, etc. It is also possible to mix one or more types of resins. As the resin used in the poultice of the present invention as described above, resins having various properties can be used, such as water-soluble resins, emulsion-based resins, and solvent-soluble resins. Furthermore, the solvent used in the poultice of the present invention is one that is safe for the body and has a low boiling point, such as ethyl alcohol, fluorinated solvents, or water. Furthermore, if necessary, it is also possible to knead a wetting agent such as glycerin, propylene glycol, or sorbitol, or a gelling agent such as gelatin or polyvinyl alcohol to the inorganic powder such as kaolin or bentonite. The poultice of the present invention can be applied to the skin by any known method, such as spraying (aerosol type) or coating (roll type, brushing, etc.). The aforementioned solvent is thus blown off. After scattering of the solvent, the skin respiration-impairing poultice of the present invention has an oxygen gas permeability coefficient of 30×10 -10 (cm 3
(STP)cm/ cm2・sec・cmHg) or more, and has excellent performance in that even if the drug is applied to the affected area of the skin for a long period of time, no problems such as rough skin or rashes will occur. ing. The following are formulation examples 1 to 7 in Table 1 as examples of poultices of the present invention having safe and excellent performance, formulation examples 8 to 10 in Table 1 as control examples, and performance tests of these as poultices. The results are summarized in Table 2.
【表】【table】
【表】【table】
【表】【table】
Claims (1)
な、シリコン樹脂及び／又はシリコン系コーポリ
マー樹脂ならびに溶媒を主成分とし、 さらに、殺菌剤、化膿止め剤、筋肉緩衝剤から
なる群から選ばれた少なくとも一つの薬剤を含有
してなり、かつ 該溶媒飛散後は酸素ガス透過係数30×10-10（cm3
（STP）cm／cm2・sec・cmHg）以上を有すること
を特徴とする湿布剤。 ２ 酸素ガス透過性ならびに伸縮性を有するよう
な、シリコン樹脂及び／又はシリコン系コーポリ
マー樹脂ならびに溶媒を主成分とし、 これに(イ)殺菌剤、化膿止め剤、筋肉緩衝剤から
なる群から選ばれた少なくとも一つの薬剤及び (ロ)密着性、伸縮性又はたれ防止性の少なくとも
一つの性能を改善することのできる樹脂を含有し
てなり、かつ 該溶媒飛散後は酸素ガス透過係数30×10-10（cm3
（STP）cm／cm2・sec・cmHg）以上を有すること
を特徴とする湿布剤。[Scope of Claims] 1 Main ingredients include silicone resin and/or silicone copolymer resin and solvent, which have oxygen gas permeability and elasticity, and further include a bactericide, an antiseptic agent, and a muscle buffering agent. containing at least one drug selected from the group consisting of at least one drug selected from the group, and having an oxygen gas permeability coefficient of 30×10 -10 (cm 3
(STP)cm/ cm2・sec・cmHg) or more. 2 The main ingredients are a silicone resin and/or a silicone copolymer resin that has oxygen gas permeability and elasticity, and a solvent, and (a) a disinfectant selected from the group consisting of a bactericidal agent, an antiseptic agent, and a muscle buffering agent. and (b) a resin capable of improving at least one of adhesion, elasticity, or anti-sag properties, and after the solvent scatters, the oxygen gas permeability coefficient is 30×10. -10 ( cm3
(STP)cm/ cm2・sec・cmHg) or more.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58084072A JPS59210014A (en) | 1983-05-16 | 1983-05-16 | Fomentation using resin having permeability to oxygen gas |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58084072A JPS59210014A (en) | 1983-05-16 | 1983-05-16 | Fomentation using resin having permeability to oxygen gas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59210014A JPS59210014A (en) | 1984-11-28 |
| JPS6354390B2 true JPS6354390B2 (en) | 1988-10-27 |
Family
ID=13820280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58084072A Granted JPS59210014A (en) | 1983-05-16 | 1983-05-16 | Fomentation using resin having permeability to oxygen gas |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59210014A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011108520A1 (en) * | 2010-03-02 | 2011-09-09 | 東レ株式会社 | Material for skin, and method for producing material for skin |
-
1983
- 1983-05-16 JP JP58084072A patent/JPS59210014A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS59210014A (en) | 1984-11-28 |
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