JPS635254A - Measuring apparatus - Google Patents
Measuring apparatusInfo
- Publication number
- JPS635254A JPS635254A JP61147155A JP14715586A JPS635254A JP S635254 A JPS635254 A JP S635254A JP 61147155 A JP61147155 A JP 61147155A JP 14715586 A JP14715586 A JP 14715586A JP S635254 A JPS635254 A JP S635254A
- Authority
- JP
- Japan
- Prior art keywords
- sensor
- signal output
- reference value
- signal
- immersed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000035945 sensitivity Effects 0.000 claims abstract description 23
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000001301 oxygen Substances 0.000 claims abstract description 16
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 16
- 102000004190 Enzymes Human genes 0.000 claims abstract description 13
- 108090000790 Enzymes Proteins 0.000 claims abstract description 13
- 239000007788 liquid Substances 0.000 claims description 6
- 238000005259 measurement Methods 0.000 abstract description 12
- 238000012545 processing Methods 0.000 abstract description 9
- 238000004364 calculation method Methods 0.000 description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 239000000523 sample Substances 0.000 description 3
- 230000007423 decrease Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 239000004065 semiconductor Substances 0.000 description 2
- 230000003321 amplification Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
Landscapes
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Abstract
Description
【発明の詳細な説明】 〔発明の目的〕 （産業上の利用分野） 本発明は、感度補正機能を備えた測定装置に関する。[Detailed description of the invention] [Purpose of the invention] (Industrial application field) The present invention relates to a measuring device equipped with a sensitivity correction function.
（従来の技術）
酵禦センサ、イオンセンサ、ガスセンサ等は、簡単にそ
れぞれの成分１度等を測定できるため広く分析装置や計
測装置に利用されるようになってきた。(Prior Art) Fermentation sensors, ion sensors, gas sensors, and the like have come to be widely used in analysis devices and measurement devices because they can easily measure the degree of each component.
しかし、各種センサの信号出力は経時変化によって変化
する場合が多くある時間の経過後あるいは測定前に信号
出力を所定の出力になるよう感度を調整してから計測を
開始している。又、センサの信号出力の個体差があるた
めセンサの交換をした時も常に所定の信号出力を得るた
めに、増幅器のゲインを調整しセンサ感度を合わせてい
る。以上の操作をしなければ、測定値に誤差を生じ、正
確な値を読取ることはできない。又、このような操作を
しているため作業性が非常に悪い等の問題点があった。However, the signal outputs of various sensors often change due to changes over time.Measurements are started after adjusting the sensitivity so that the signal outputs reach a predetermined level after a period of time or before measurement. Furthermore, since there are individual differences in the signal output of the sensor, even when the sensor is replaced, the gain of the amplifier is adjusted to match the sensor sensitivity in order to always obtain a predetermined signal output. If the above operations are not performed, errors will occur in the measured values and accurate values will not be read. Further, since such operations are performed, there are problems such as very poor workability.
さらにはセンサを複数個使って計測する場合には、セン
サ間のバラツキをなくするために感度がよくそろったセ
ンサをそろえて用いなければならなかった。Furthermore, when measuring using multiple sensors, it is necessary to use sensors with well-matched sensitivities in order to eliminate variations among the sensors.
（発明が解決しようとする問題点）
本発明は、このようなセンサ感度の問題に基づきなされ
たものでその目的とするところは、センサ信号出力の個
体差又はセンサの経時変化等によらず、常に所定のセン
サ感度を維持する装置を提供することにある。(Problems to be Solved by the Invention) The present invention was made based on the above-mentioned problem of sensor sensitivity, and its purpose is to solve the problem regardless of individual differences in sensor signal output or changes over time of the sensor. An object of the present invention is to provide a device that always maintains a predetermined sensor sensitivity.
（問題を解決するための手段）
すなわち本発明は、センサからの信号出力を基準値と比
較して、前記信号出力に感度補正を施す手段を具えたこ
とを特徴とする測定装置である。(Means for Solving the Problem) That is, the present invention is a measuring device characterized by comprising means for comparing a signal output from a sensor with a reference value and performing sensitivity correction on the signal output.
具体的ｌこは、試料液中に浸漬された酵素センサからの
信号出力を基準値とし、前記試料液中に浸漬された酸素
センサからの信号出力を前記基準値と比較して、感度補
正を施すあるいはこの逆に酸素センサからの信号出力を
基準値として用いる等があげられる。Specifically, the signal output from the enzyme sensor immersed in the sample liquid is taken as a reference value, and the signal output from the oxygen sensor immersed in the sample liquid is compared with the reference value to perform sensitivity correction. Alternatively, the signal output from the oxygen sensor may be used as a reference value.
（作用）
測定対象となる試料液あるいはセンサの較正液中では、
その溶存酸素濃度が常に空気中の酸素濃度に対応した値
を有するとは限らず、むしろ少ない場合も多い。このよ
うな状態で、例えば酵素センサを用いてグルコース濃度
を計測した場合に哄本来不必要な酸素濃度の信号が測定
対象となるグルコースの濃度に重畳して計測されてしま
う。しかしながら、本発明の測定装置でそのセンサから
の信号出力を、基準値例えば同じ試料液に浸漬した酵素
センサからの出力を基準値として補正することにより感
度調整が行なわれて、もって簡便に精度の高い測定が可
能となる。そして本発明の測定装置では、感度の補正す
る手段により経時変化や製造時のバラツキ等によるセン
サ出力の個体差による測定値の変動に補正がなされるの
で、常に所定のセンサ感度が維持される。(Function) In the sample liquid to be measured or the calibration liquid of the sensor,
The dissolved oxygen concentration does not always have a value that corresponds to the oxygen concentration in the air, and is often lower. In such a state, when the glucose concentration is measured using an enzyme sensor, for example, an unnecessary oxygen concentration signal is superimposed on the glucose concentration to be measured. However, in the measuring device of the present invention, the sensitivity can be adjusted by correcting the signal output from the sensor using a reference value, for example, the output from an enzyme sensor immersed in the same sample solution, thereby easily improving the accuracy. Highly accurate measurements are possible. In the measuring device of the present invention, the sensitivity correction means corrects for fluctuations in measured values due to individual differences in sensor output due to changes over time, manufacturing variations, etc., so a predetermined sensor sensitivity is always maintained.
（実施例）
以下、図面を参照しながら本発明の実施例について説明
する。(Example) Hereinafter, an example of the present invention will be described with reference to the drawings.
定する。各センサの出力側には増幅器４，５．６が接続
され半導体スイッチ７により任意の信号が選択される。to be determined. Amplifiers 4, 5.6 are connected to the output side of each sensor, and a semiconductor switch 7 selects an arbitrary signal.
信号はＡ／Ｄ変換された後に信号処理演算部９へ取込ま
れる。信号処理演算部９には、マイクロコンピュータが
組込まれ較正、測定時の制御や、データの記憶、演算等
の処理を実施している。信号処理演算部９での演算結果
を表示器１１により計測値が読取れる。表示器１１は、
数字で表示してもよく、レベル等の表示でもよい。The signal is taken into the signal processing calculation section 9 after being A/D converted. A microcomputer is incorporated in the signal processing calculation section 9 to carry out processes such as calibration, control during measurement, data storage, and calculations. The measurement result of the calculation result in the signal processing calculation section 9 can be read on the display 11. The display 11 is
It may be displayed numerically or as a level.
そして酵素センサｌの信号出力を基準とし酸素センサ２
の信号出力との差を信号処理演算部９で求めその差がゼ
ロになるような信号がＤ／Ａ変換器へ入力される。こう
して得られたアナログ信号へ変換された電圧に対応して
、フォトカプラ（ＬＥＤ−１−Ｃｄｓ）のＬＥＤに電流
が流れ、増幅器のゲインが変化し感度が変わる。このフ
ォトカプラ１２は、ＬＥＤに流す電流によってＣｄｓの
抵抗値が連続的に変化するものである。−般的に電流が
多いと抵抗値は下がり、電流が少ないと抵抗値は上がる
特性を有している。この特性を利用して増幅器のゲイン
を決定している箇所にこの抵抗を用いて連続的に可変し
感度を所定の値にしている。Then, using the signal output of the enzyme sensor 1 as a reference, the oxygen sensor 2
The signal processing unit 9 calculates the difference between the signal output and the signal output, and a signal such that the difference becomes zero is input to the D/A converter. Corresponding to the voltage converted into the analog signal obtained in this way, current flows through the LED of the photocoupler (LED-1-Cds), and the gain of the amplifier changes to change the sensitivity. In this photocoupler 12, the resistance value of Cds changes continuously depending on the current flowing through the LED. -Generally, when the current is large, the resistance value decreases, and when the current is small, the resistance value increases. Utilizing this characteristic, this resistor is used at the location where the gain of the amplifier is determined, and is continuously varied to set the sensitivity to a predetermined value.
例えば、定常状態で酵素センサｌに対して酸素センサ２
の信号出力が大きいとすると、信号処理演算部９で演算
された信号によりフォトカプラ１２のＬＥＤに流れる電
流が減少し、Ｃｄｓの抵抗値が上がる。増幅器４のゲイ
ンは、抵抗１３゜１４をそれぞれＲ１，Ｒ２とするとＲ
ｚ ／Ｒ１で設定できる。攬即ちＣｄｓの抵抗なので増
幅器４のゲインは下がり酵素センサ１と同じ感度にする
ことができる。この状態でゲインをロックし計測を開始
すると、酵素センサ１と酸素センサ２の感度が所定の値
になっているのでセンサ間の変動のない精度の高いグル
コース濃度を得ることができる。測定終了すると自動的
にゲインのロックは解かれ、常に酵素センサ１の感度に
酸素センサ２の感度に追従する。尚、酵素センサ１に対
して酸素センサ２の感度が小さい時は、上記と逆の動作
をする。さらに本実施例では温度センサ３で温度を検出
し、信号処理演算部９で温度補正を含めた演算を行ない
表示器でグルコース濃度を読取る。なお、こうした増幅
器のゲインを変化させる素子は、上記以外のものでもよ
く、また、ゲインを変化させる回路も上記以外でもよい
。あるいは第２図に示したように、第１図の測定回路に
、差動増幅器１６と一次微分回路１７を付加して酵素セ
ンサ１と基準値を発生する酸素センサ２との出力差をと
って、センサの変化速度を計測するために一次微分回路
１７に入力しても良い。その他の動作は、第１図で示し
た装置と同じである。また、この基準値としては、セン
サからの信号出力を用いる他に、あらかじめ設定した値
を用いても良い。For example, in steady state, oxygen sensor 2 is
If the signal output is large, the current flowing through the LED of the photocoupler 12 decreases due to the signal calculated by the signal processing calculation section 9, and the resistance value of Cds increases. The gain of the amplifier 4 is R, assuming that the resistors 13 and 14 are R1 and R2, respectively.
Can be set with z/R1. In other words, because of the resistance of Cds, the gain of the amplifier 4 is lowered and the same sensitivity as the enzyme sensor 1 can be achieved. When the gain is locked and measurement is started in this state, the sensitivities of the enzyme sensor 1 and the oxygen sensor 2 are at predetermined values, so it is possible to obtain a highly accurate glucose concentration without fluctuation between the sensors. When the measurement is completed, the gain lock is automatically released, and the sensitivity of the enzyme sensor 1 and the sensitivity of the oxygen sensor 2 are always followed. Incidentally, when the sensitivity of the oxygen sensor 2 is lower than that of the enzyme sensor 1, the operation is reversed to that described above. Furthermore, in this embodiment, the temperature sensor 3 detects the temperature, the signal processing calculation section 9 performs calculations including temperature correction, and the glucose concentration is read on the display. Note that the elements for changing the gain of such an amplifier may be other than those described above, and the circuit for changing the gain may also be other than those described above. Alternatively, as shown in FIG. 2, a differential amplifier 16 and a first-order differentiation circuit 17 are added to the measurement circuit of FIG. 1, and the output difference between the enzyme sensor 1 and the oxygen sensor 2 that generates the reference value is calculated. , may be input to the first-order differentiation circuit 17 in order to measure the rate of change of the sensor. Other operations are the same as the device shown in FIG. Moreover, as this reference value, in addition to using the signal output from the sensor, a preset value may be used.
本発明によれば、センサの経時変化や、センサ信号出力
の個体差等によらず精度の良い測定結果を得ることがで
きる。According to the present invention, highly accurate measurement results can be obtained regardless of changes in the sensor over time, individual differences in sensor signal output, and the like.
第１図、第２図は本発明に係る実施例のブロック図であ
る。
１・・・酵素センサ、２・・・酸素センサ、３・・・温
度センサ、４，５．６・・・増幅回路、７・・・半導体
スイッチ、８・・・Ａ ／ Ｄコンバータ、９・・・信
号処理演算部、１０・・・Ｄ／Ａコンバータ、１１・・
・表示器、１２・・・フォトカプラ、１３．１４・・・
抵抗、１５・・・測定開始スイッチ、１６・・・差動増
幅回路、１７・・・−次微分回路。
代理人 弁理士 則 近 憲 佑
同 竹 花 冨久男1 and 2 are block diagrams of embodiments according to the present invention. DESCRIPTION OF SYMBOLS 1... Enzyme sensor, 2... Oxygen sensor, 3... Temperature sensor, 4,5.6... Amplification circuit, 7... Semiconductor switch, 8... A/D converter, 9. ...Signal processing calculation unit, 10...D/A converter, 11...
・Display device, 12... Photocoupler, 13.14...
Resistor, 15... Measurement start switch, 16... Differential amplifier circuit, 17... -th order differential circuit. Agent Patent Attorney Nori Chika Yudo Tomikuo Takehana
Claims (2)
信号出力に感度補正を施す手段を具えたことを特徴とす
る測定装置。(1) A measuring device characterized by comprising means for comparing a signal output from a sensor with a reference value and performing sensitivity correction on the signal output.
を基準値とし、前記試料液中に浸漬された酸素センサか
らの信号出力を前記基準値と比較して、感度補正を施す
手段を具えたことを特徴とする特許請求の範囲第１項記
載の測定装置。(2) Means for performing sensitivity correction by setting the signal output from the enzyme sensor immersed in the sample liquid as a reference value and comparing the signal output from the oxygen sensor immersed in the sample liquid with the reference value. A measuring device according to claim 1, characterized in that the measuring device comprises:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61147155A JPS635254A (en) | 1986-06-25 | 1986-06-25 | Measuring apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61147155A JPS635254A (en) | 1986-06-25 | 1986-06-25 | Measuring apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS635254A true JPS635254A (en) | 1988-01-11 |
Family
ID=15423829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61147155A Pending JPS635254A (en) | 1986-06-25 | 1986-06-25 | Measuring apparatus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS635254A (en) |
-
1986
- 1986-06-25 JP JP61147155A patent/JPS635254A/en active Pending
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